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Article ; Online: Recent topics in X-ray fluorescence spectrometry.

Nakano, Kazuhiko

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

2023 Volume 39, Issue 11, Page(s) 1789–1790

Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	1483376-1
ISSN	1348-2246 ; 1348-2246
ISSN (online)	1348-2246
ISSN	1348-2246
DOI	10.1007/s44211-023-00426-1
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Article ; Online: Panoramic Radiograph Generation and Image Reconstruction from Latent Vectors Using a Generative Adversarial Network.

Kokomoto, Kazuma / Okawa, Rena / Nakano, Kazuhiko / Nozaki, Kazunori

Studies in health technology and informatics

2024 Volume 310, Page(s) 1499–1500

Abstract: In this study, StyleGAN2 was trained with panoramic radiographs, and original images were projected into the latent space of StyleGAN2. The resulting latent vectors were input into StyleGAN2, and corresponding images were generated to reconstruct the ... ...

Abstract	In this study, StyleGAN2 was trained with panoramic radiographs, and original images were projected into the latent space of StyleGAN2. The resulting latent vectors were input into StyleGAN2, and corresponding images were generated to reconstruct the original images. The original and reconstructed images were evaluated by pediatric dentists and found to be similar. Our results suggest that StyleGAN2 could be applied to the anonymization and data compression of medical images.
MeSH term(s)	Child ; Humans ; Radiography, Panoramic ; Dentists ; Image Processing, Computer-Assisted
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI231263
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Article: Characterization of the unique oral microbiome of children harboring

Ogaya, Yuko / Kadota, Tamami / Hamada, Masakazu / Nomura, Ryota / Nakano, Kazuhiko

Journal of oral microbiology

2024 Volume 16, Issue 1, Page(s) 2339158

Abstract: Objective: Helicobacter pylori: Methods: Bacterial DNA was extracted from 41 adult and 21 child saliva specimens, and H. pylori was detected using PCR. 16S rRNA gene amplification was performed for next-generation sequencing. Bioinformatic analyses ... ...

Abstract	Objective: Helicobacter pylori Methods: Bacterial DNA was extracted from 41 adult and 21 child saliva specimens, and H. pylori was detected using PCR. 16S rRNA gene amplification was performed for next-generation sequencing. Bioinformatic analyses were conducted using Quantitative Insights into Microbial Ecology 2 (QIIME 2). Results: Faith's phylogenetic diversity analysis showed a significant difference between H. pylori-negative adult and child specimens in terms of α-diversity ( Conclusion: These results suggest unique oral microbiome characteristics in children with H. pylori infection in the oral cavity.
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2523919-3
ISSN	2000-2297
ISSN	2000-2297
DOI	10.1080/20002297.2024.2339158
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Article: Dental manifestation and management of hypophosphatasia.

Okawa, Rena / Nakano, Kazuhiko

The Japanese dental science review

2022 Volume 58, Page(s) 208–216

Abstract: Hypophosphatasia is an inherited metabolic disorder characterized by defective mineralization of bones and teeth with a wide variety of manifestations, ranging from stillbirth to dental symptoms alone. Recently, the prognosis of severe hypophosphatasia ... ...

Abstract	Hypophosphatasia is an inherited metabolic disorder characterized by defective mineralization of bones and teeth with a wide variety of manifestations, ranging from stillbirth to dental symptoms alone. Recently, the prognosis of severe hypophosphatasia patients has been greatly improved by the introduction of enzyme replacement therapy. The typical dental manifestation is early exfoliation of primary teeth due to disturbed cementum formation, so dentures are recommended to ensure that important oral functions are acquired. Some studies have shown that enzyme replacement therapy improves dental mineralization, resulting in the stabilization of periodontal tissues and better growth of tooth roots. A nationwide Japanese survey revealed the common genetic and dental manifestations of patients with mild hypophosphatasia, which markedly differ from those of the severe forms. There may be many undiagnosed mild patients, so dentists should contribute to the early diagnosis by screening possible cases based on the typical finding of early exfoliation of primary teeth. Early diagnosis is important for patients to receive early intervention in both medical and dental fields. The establishment of fundamental dental therapy to solve the dental problems is still underway and is eagerly anticipated.
Language	English
Publishing date	2022-07-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2439945-0
ISSN	1882-7616
ISSN	1882-7616
DOI	10.1016/j.jdsr.2022.06.002
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Article ; Online: Impact of Age on Prescribing Patterns of Cardiovascular Medications in Older Japanese Patients with Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Study.

Tanaka, Shigeru / Kitamura, Hiromasa / Tsuruya, Kazuhiko / Kitazono, Takanari / Nakano, Toshiaki

Journal of atherosclerosis and thrombosis

2024

Abstract: Aim: Older patients with chronic kidney disease (CKD) are more likely to be excluded from clinical trials. This exclusion affects the quality of cardiovascular disease (CVD) prevention in this population.: Methods: Baseline data from the Fukuoka ... ...

Abstract	Aim: Older patients with chronic kidney disease (CKD) are more likely to be excluded from clinical trials. This exclusion affects the quality of cardiovascular disease (CVD) prevention in this population. Methods: Baseline data from the Fukuoka Kidney Disease Registry (FKR) cohort, which included 4476 adult patients with CKD stages G1-G5, were cross-sectionally analyzed to compare the use of recommended drugs for preventing CVD in each age group. Results: Different prescribing patterns were observed according to age for the cardiovascular drug classes. Older patients with CKD were less likely to receive renin-angiotensin system (RAS) inhibitors and were more likely to receive calcium channel blockers. The proportion of anticoagulation prescriptions for patients with CKD and atrial fibrillation decreased in the older age group (≥ 75 years). However, the proportion of antiplatelet therapy in patients with ischemic CVD increased linearly with age, even in the very old group aged ≥ 85 years. These findings suggest a severe cardiovascular burden in patients with CKD. Notably, RAS inhibitor use was avoided in the older group despite a severe cardiovascular burden, such as a high prevalence of CVD history and massive albuminuria ＞300 mg/g creatinine. This finding indicates that an older age independently contributed to the non-use of RAS inhibitors, even after adjusting for other covariates. Conclusions: This study suggests that age is a potential barrier to the treatment of patients with CKD and highlights the need to establish individualized treatment strategies for cardiovascular protection in this population.
Language	English
Publishing date	2024-04-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.64798
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Article: Different Dental Manifestations in Sisters with the Same

Kadota, Tamami / Ochiai, Marin / Okawa, Rena / Nakano, Kazuhiko

Children (Basel, Switzerland)

2022 Volume 9, Issue 12

Abstract: Hypophosphatasia (HPP) is an inherited disease caused by mutation of the alkaline phosphatase ( ...

Abstract	Hypophosphatasia (HPP) is an inherited disease caused by mutation of the alkaline phosphatase (
Language	English
Publishing date	2022-11-28
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9121850
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Article ; Online: Relationships of Weight Change from 20 Years of Age with the Risks of All-Cause and Cardiovascular Mortality in Patients with Chronic Kidney Disease.

Okamura, Kazuhiro / Tanaka, Shigeru / Kitamura, Hiromasa / Hiyamuta, Hiroto / Tsuruya, Kazuhiko / Nakano, Toshiaki / Kitazono, Takanari

Journal of atherosclerosis and thrombosis

2024

Abstract: Aims: Weight changes from a young age are known to be associated with poor life outcomes in the general population. However, little is known about the association between weight change from a young age and life expectancy in patients with chronic kidney ...

Abstract	Aims: Weight changes from a young age are known to be associated with poor life outcomes in the general population. However, little is known about the association between weight change from a young age and life expectancy in patients with chronic kidney disease (CKD). Methods: Data of 2,806 nondialysis CKD patients who participated in the Fukuoka Kidney Disease Registry (FKR) Study, a multicenter observational study, were analyzed. The primary outcome was all-cause death, whereas the secondary outcome was cardiovascular mortality. The covariate of interest was weight change, defined as the difference between body weight at study enrollment and at 20 years old. Cox proportional-hazards models were used to estimate the risks of mortality for participants with weight changes of ≥ 5 or ＜5 kg compared with those with stable weights. Results: During the 5-year observation period, 243 participants died from all causes and 62 from cardiovascular disease. The risk of all-cause mortality in the weight-loss group was significantly higher than that in the stable-weight group (multivariable-adjusted hazard ratio, 2.11; 95% confidence interval [CI], 1.52-2.93). Conversely, the risk of cardiovascular mortality in the weight-loss group was significantly higher than that in the stable-weight group (multivariable-adjusted hazard ratio, 2.48; 95% CI, 1.32-4.64). However, no significant association was observed between weight gain and the risks of all-cause and cardiovascular mortalities. Conclusion: Weight loss from 20 years of age was found to be associated with higher risks of all-cause and cardiovascular mortalities in patients with CKD.
Language	English
Publishing date	2024-01-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.64571
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Article ; Online: Automatic dental age calculation from panoramic radiographs using deep learning: a two-stage approach with object detection and image classification.

Kokomoto, Kazuma / Kariya, Rina / Muranaka, Aya / Okawa, Rena / Nakano, Kazuhiko / Nozaki, Kazunori

BMC oral health

2024 Volume 24, Issue 1, Page(s) 143

Abstract: Background: Dental age is crucial for treatment planning in pediatric and orthodontic dentistry. Dental age calculation methods can be categorized into morphological, biochemical, and radiological methods. Radiological methods are commonly used because ... ...

Abstract	Background: Dental age is crucial for treatment planning in pediatric and orthodontic dentistry. Dental age calculation methods can be categorized into morphological, biochemical, and radiological methods. Radiological methods are commonly used because they are non-invasive and reproducible. When radiographs are available, dental age can be calculated by evaluating the developmental stage of permanent teeth and converting it into an estimated age using a table, or by measuring the length between some landmarks such as the tooth, root, or pulp, and substituting them into regression formulas. However, these methods heavily depend on manual time-consuming processes. In this study, we proposed a novel and completely automatic dental age calculation method using panoramic radiographs and deep learning techniques. Methods: Overall, 8,023 panoramic radiographs were used as training data for Scaled-YOLOv4 to detect dental germs and mean average precision were evaluated. In total, 18,485 single-root and 16,313 multi-root dental germ images were used as training data for EfficientNetV2 M to classify the developmental stages of detected dental germs and Top-3 accuracy was evaluated since the adjacent stages of the dental germ looks similar and the many variations of the morphological structure can be observed between developmental stages. Scaled-YOLOv4 and EfficientNetV2 M were trained using cross-validation. We evaluated a single selection, a weighted average, and an expected value to convert the probability of developmental stage classification to dental age. One hundred and fifty-seven panoramic radiographs were used to compare automatic and manual human experts' dental age calculations. Results: Dental germ detection was achieved with a mean average precision of 98.26% and dental germ classifiers for single and multi-root were achieved with a Top-3 accuracy of 98.46% and 98.36%, respectively. The mean absolute errors between the automatic and manual dental age calculations using single selection, weighted average, and expected value were 0.274, 0.261, and 0.396, respectively. The weighted average was better than the other methods and was accurate by less than one developmental stage error. Conclusion: Our study demonstrates the feasibility of automatic dental age calculation using panoramic radiographs and a two-stage deep learning approach with a clinically acceptable level of accuracy.
MeSH term(s)	Humans ; Child ; Radiography, Panoramic ; Deep Learning ; Tooth ; Age Determination by Teeth/methods ; Dental Pulp
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-024-03928-0
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Article ; Online: Investigation of potential anthropogenic pollution of rare metals in Tama River followed by establishment of a comprehensive multielement analysis of major-to-ultratrace elements in river water and sewage treatment effluent.

Yaida, Akane / Otsuka, Riko / Yamada, Asaki / Nakano, Kazuhiko / Itoh, Akihide

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

2023 Volume 39, Issue 6, Page(s) 867–882

Abstract: In this study, comprehensive multi-element analysis of at least 53 elements, including 40 rare metals, in river water at all points from upstream to the estuary in urban rivers and sewage treatment effluent was established using three analytical methods ... ...

Abstract	In this study, comprehensive multi-element analysis of at least 53 elements, including 40 rare metals, in river water at all points from upstream to the estuary in urban rivers and sewage treatment effluent was established using three analytical methods of ICP-MS, chelating solid-phase extraction (SPE)/ICP-MS, and reflux-type heating acid decomposition/chelating SPE/ICP-MS. Recoveries of some elements for sewage treatment effluent in chelating SPE were improved by being combined with reflux-type heating acid decomposition, because organic substances, such as EDTA, in sewage treatment effluent could be effectively decomposed. In particular, the reflux-type heating acid decomposition/chelating SPE/ICP-MS method enabled the determination of Co, In, Eu, Pr, Sm, Tb, and Tm, which had been difficult to determine in chelating SPE/ICP-MS without this decomposition procedure. A potential anthropogenic pollution (PAP) of rare metals in Tama River was investigated by the established analytical methods. As a result, 25 elements in river water samples from the inflow area of sewage treatment effluent were several to several dozen times higher than those in the clean area. In particular, the concentrations of Mn, Co, Ni, Ge, Rb, Mo, Cs, Gd, and Pt increased by more than one order of magnitude compared to the river water from clean area. These elements were suggested to be PAP. The concentrations of Gd in the effluents from five sewage treatment plants ranged from 60 to 120 ng L
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1483376-1
ISSN	1348-2246 ; 1348-2246
ISSN (online)	1348-2246
ISSN	1348-2246
DOI	10.1007/s44211-023-00287-8
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Article ; Online: Emerging cross-talks between chronic kidney disease-mineral and bone disorder (CKD-MBD) and malnutrition-inflammation complex syndrome (MICS) in patients receiving dialysis.

Yamada, Shunsuke / Tsuruya, Kazuhiko / Kitazono, Takanari / Nakano, Toshiaki

Clinical and experimental nephrology

2022 Volume 26, Issue 7, Page(s) 613–629

Abstract: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a systemic disorder that affects multiple organs and systems and increases the risk of morbidity and mortality in patients with CKD, especially those receiving dialysis therapy. CKD-MBD is ... ...

Abstract	Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a systemic disorder that affects multiple organs and systems and increases the risk of morbidity and mortality in patients with CKD, especially those receiving dialysis therapy. CKD-MBD is highly prevalent in CKD patients, and its treatment is gaining attention from healthcare providers who manage these patients. Additional important pathologies often observed in CKD patients are chronic inflammation and malnutrition/protein-energy wasting (PEW). These two pathologies coexist to form a vicious cycle that accelerates the progression of various other pathologies in CKD patients. This concept is integrated into the term "malnutrition-inflammation-atherosclerosis syndrome" or "malnutrition-inflammation complex syndrome (MICS)". Recent basic and clinical studies have shown that CKD-MBD directly induces inflammation as well as malnutrition/PEW. Indeed, higher circulating levels of inorganic phosphate, fibroblast growth factor 23, parathyroid hormone, and calciprotein particles, as markers for critical components and effectors of CKD-MBD, were shown to directly induce inflammatory responses, thereby leading to malnutrition/PEW, cardiovascular diseases, and clinically relevant complications. In this short review, we discuss the close interplay between CKD-MBD and MICS and emphasize the significance of simultaneous control of these two seemingly distinct pathologies in patients with CKD, especially those receiving dialysis therapy, for better management of the CKD/hemodialysis population.
MeSH term(s)	Chronic Kidney Disease-Mineral and Bone Disorder/complications ; Chronic Kidney Disease-Mineral and Bone Disorder/therapy ; Humans ; Inflammation/complications ; Malnutrition/complications ; Malnutrition/etiology ; Parathyroid Hormone/metabolism ; Renal Dialysis/adverse effects ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/therapy
Chemical Substances	Parathyroid Hormone
Language	English
Publishing date	2022-03-30
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-022-02216-x
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