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  1. Article ; Online: Development of a Psychological Scale for Measuring Disruptive Clinician Behavior.

    Fujimoto, Manabu / Shimamura, Mika / Miyazaki, Hiroaki / Inaba, Kazuto

    Journal of patient safety

    2023  Volume 19, Issue 8, Page(s) 564–572

    Abstract: Objectives: Disruptive clinician behavior worsens communication, information transfer, and teamwork, all of which negatively affect patient safety. Improving safety in medical care requires an accurate assessment of the damage caused by disruptive ... ...

    Abstract Objectives: Disruptive clinician behavior worsens communication, information transfer, and teamwork, all of which negatively affect patient safety. Improving safety in medical care requires an accurate assessment of the damage caused by disruptive clinician behavior. Psychometric scales complement case reports, but existing scales have significant limitations. Therefore, this study developed a psychometric scale based on the psychological paradigm to assess disruptive clinician behavior.
    Methods: The scale was developed through a sequence of steps. First, we used an open-ended questionnaire targeting 712 nurses, content analysis, and content validity assessment by 5 experts to determine valid items for disruptive clinical behavior. Next, an Internet questionnaire survey targeting 1000 health care staff, exploratory factor analysis, and subfactor analysis was conducted to identify necessary and sufficient factors. Then, we calculated difficulty level and discriminative power. We also conducted a field questionnaire survey targeting 84 staff in a hospital. Finally, we calculated ω coefficients and then used confirmatory factor analysis to verify the fit of the hypothesized model.
    Results: Our open-ended survey involving 478 nurses identified 47 codes in 9 categories. The questionnaire survey involving hospital 1000 medical staff identified 6 factors, with 1 factor subdivided into 4 subfactors and 1 into 2 subfactors. The goodness of fit of the hypothesized 10-factor models with factor pairs and groups was confirmed.
    Conclusions: We developed a psychometric scale measuring subjective assessments of harm covering various disruptive clinician behaviors. The scale complements interviews and case reports by generating valid, reliable scores for various disruptive clinician behaviors in health care institutions.
    MeSH term(s) Humans ; Problem Behavior ; Surveys and Questionnaires ; Patient Care ; Medical Staff, Hospital/psychology ; Psychometrics ; Reproducibility of Results
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394324-5
    ISSN 1549-8425 ; 1549-8417
    ISSN (online) 1549-8425
    ISSN 1549-8417
    DOI 10.1097/PTS.0000000000001162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: JAMBIO and Its Coastal Organism Joint Surveys: Network of Marine Stations Explores Japanese Coastal Biota.

    Nakano, Hiroaki / Isowa, Yukinobu / Inaba, Kazuo

    Zoological science

    2022  Volume 39, Issue 1, Page(s) 1–6

    Abstract: Marine stations have continued to contribute significantly to understanding the physiology, taxonomy, development, ecology, and evolution of animals. There are more than 50 marine stations of national universities in Japan, and historically their ... ...

    Abstract Marine stations have continued to contribute significantly to understanding the physiology, taxonomy, development, ecology, and evolution of animals. There are more than 50 marine stations of national universities in Japan, and historically their establishments were closely related to the initial stage of zoology in the country. More than 10 years ago, Japanese Association for Marine Biology (JAMBIO) was established to facilitate the collaboration among marine stations in the activities of research, education and administration. One of the successful activities of JAMBIO that contribute to zoology is the JAMBIO Coastal Organism Joint Surveys, in which scientists and students at multiple marine stations, as well as those from research institutes or museums, stay at a marine station for a few days, and collect and make a record of marine organisms. As of 2021, 22 surveys have been performed and new species have been reported from taxa such as Cnidaria, Nematoda, Platyhelminthes, Annelida, Mollusca, Arthropoda, and Echinodermata.
    MeSH term(s) Animals ; Annelida ; Aquatic Organisms ; Biota ; Echinodermata ; Japan ; Nematoda
    Language English
    Publishing date 2022-02-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038883-4
    ISSN 2212-3830 ; 0289-0003
    ISSN (online) 2212-3830
    ISSN 0289-0003
    DOI 10.2108/zs210069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Synthesis and Coordination Behavior of 9,10-Diarsatriptycene

    Inaba, Ryoto / Kikuchi, Takashi / Imoto, Hiroaki / Naka, Kensuke

    Synlett

    2023  Volume 35, Issue 04, Page(s) 437–440

    Abstract: Herein, 9,10-diheterotriptycenes (DHTs) containing heavy pnictogens (Pn, Pn = As, Sb, and Bi) are synthesized without using the dangerous chemicals used in conventional synthetic methods: tert -butyllithium, organomercury reagents, or trichloroarsine. ... ...

    Abstract Herein, 9,10-diheterotriptycenes (DHTs) containing heavy pnictogens (Pn, Pn = As, Sb, and Bi) are synthesized without using the dangerous chemicals used in conventional synthetic methods: tert -butyllithium, organomercury reagents, or trichloroarsine. In particular, 9,10-diarsatriptycene is obtained in relatively high yield and is stable under oxidation and coordination reactions. Additionally, the gold chloride complex 9,10-diarsatriptycene forms a one-dimensional supramolecular polymer constructed through coordination and aurophilic interactions.
    Keywords diheterotriptycene ; pnictogen ; practical synthesis ; oxidation ; coordination ; supramolecular polymer
    Language English
    Publishing date 2023-06-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/a-2112-9605
    Database Thieme publisher's database

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  4. Article ; Online: Heme-substituted protein assembly bridged by synthetic porphyrin: achieving controlled configuration while maintaining rotational freedom.

    Inaba, Hiroaki / Shisaka, Yuma / Ariyasu, Shinya / Sakakibara, Erika / Ueda, Garyo / Aiba, Yuichiro / Shimizu, Nobutaka / Sugimoto, Hiroshi / Shoji, Osami

    RSC advances

    2024  Volume 14, Issue 13, Page(s) 8829–8836

    Abstract: The use of biological host-guest interactions, specifically the binding of hemoprotein to heme, has attracted significant research interest in the design of artificial protein assemblies. However, because of the inherent flexibility of the propionic acid ...

    Abstract The use of biological host-guest interactions, specifically the binding of hemoprotein to heme, has attracted significant research interest in the design of artificial protein assemblies. However, because of the inherent flexibility of the propionic acid group of heme, it is difficult to control the positioning and orientation of the protein unit and to construct well-ordered structures. Herein, we report a heme-substituted protein dimer composed of the native hemoprotein HasA, which accommodates a tetraphenylporphyrin bearing an additional metal coordination site. The specific binding of the tetraphenylporphyrin with an additional metal coordination site that protrudes in a fixed direction confines the configuration of the dimer structure to a defined bent form. The small-angle X-ray scattering profile shows the dimer structure with a bent form and suggests dynamic rotational behavior while keeping its bent-core structure, resembling a bevel gear. This unique dimer structure demonstrates that the design of heme-substituted protein assemblies can be expanded to protein assemblies while maintaining the rotational freedom of the individual protein units.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra01042f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A New Species of Acoela Possessing a Middorsal Appendage with a Possible Sensory Function.

    Asai, Masashi / Miyazawa, Hideyuki / Yanase, Ryuji / Inaba, Kazuo / Nakano, Hiroaki

    Zoological science

    2022  Volume 39, Issue 1, Page(s) 147–156

    Abstract: Acoels, belonging to Xenacoelomorpha, are small worms with a relatively simple body plan and are considered a critical clade for understanding the evolution of bilaterians. Despite acoels' importance, however, many undiscovered species are predicted to ... ...

    Abstract Acoels, belonging to Xenacoelomorpha, are small worms with a relatively simple body plan and are considered a critical clade for understanding the evolution of bilaterians. Despite acoels' importance, however, many undiscovered species are predicted to be present worldwide. Here, we describe a new marine acoel species,
    MeSH term(s) Animal Structures/anatomy & histology ; Animals ; Male ; Phylogeny ; Sensation
    Language English
    Publishing date 2022-02-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038883-4
    ISSN 2212-3830 ; 0289-0003
    ISSN (online) 2212-3830
    ISSN 0289-0003
    DOI 10.2108/zs210058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Treatment of hepatocellular carcinoma with a portal vein tumor thrombus and pulmonary metastases of rectal cancer with microsatellite stability using atezolizumab plus bevacizumab.

    Inaba, Yoshitaka / Chatani, Shohei / Murata, Shinichi / Sato, Yozo / Imamine, Rinpei / Kato, Mina / Onaya, Hiroaki / Yamaura, Hidekazu

    Clinical journal of gastroenterology

    2024  Volume 17, Issue 2, Page(s) 286–291

    Abstract: Herein, we report the successful treatment using atezolizumab plus bevacizumab of a patient with hepatocellular carcinoma (HCC) with a portal vein tumor thrombus and multiple pulmonary metastases from rectal cancer with microsatellite stability. This ... ...

    Abstract Herein, we report the successful treatment using atezolizumab plus bevacizumab of a patient with hepatocellular carcinoma (HCC) with a portal vein tumor thrombus and multiple pulmonary metastases from rectal cancer with microsatellite stability. This patient developed rectal cancer with synchronous pulmonary metastases and HCC. After resecting the primary lesion of the rectal cancer, transcatheter arterial chemoembolization was performed for the HCC. Drug therapy was planned for multiple pulmonary metastases of rectal cancer; however, the early development of recurrent HCC with portal vein tumor thrombus had to be highly prioritized, and atezolizumab plus bevacizumab was introduced. Following the disappearance of the recurrent HCC lesion, the metastatic pulmonary nodules shrunk into scar-like spots. The treatment for both HCC and pulmonary metastases of rectal cancer were considered to result in clinical complete response.
    MeSH term(s) Humans ; Bevacizumab/therapeutic use ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/drug therapy ; Portal Vein ; Chemoembolization, Therapeutic ; Liver Neoplasms/drug therapy ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Rectal Neoplasms/complications ; Rectal Neoplasms/drug therapy ; Microsatellite Repeats ; Antibodies, Monoclonal, Humanized
    Chemical Substances atezolizumab (52CMI0WC3Y) ; Bevacizumab (2S9ZZM9Q9V) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-02-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-024-01921-2
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  7. Article ; Online: Transcriptomic analysis of Porphyromonas gingivalis-infected head and neck cancer cells: Identification of PLAU as a candidate prognostic biomarker.

    Hamada, Masakazu / Inaba, Hiroaki / Nishiyama, Kyoko / Yoshida, Sho / Yura, Yoshiaki / Matsumoto-Nakano, Michiyo / Uzawa, Narikazu

    Journal of cellular and molecular medicine

    2024  Volume 28, Issue 4

    Abstract: Periodontal disease is a risk factor for head and neck squamous cell carcinoma (HNSCC), and Porphyromonas gingivalis, a major periodontal pathogen, has been identified as a specific and potentially independent microbial factor that increases the risk of ... ...

    Abstract Periodontal disease is a risk factor for head and neck squamous cell carcinoma (HNSCC), and Porphyromonas gingivalis, a major periodontal pathogen, has been identified as a specific and potentially independent microbial factor that increases the risk of cancer mortality. Gene expression in HNSCC due to P. gingivalis infection and how changes in gene expression affect the prognosis of HNSCC patients are not clarified. When P. gingivalis was cultured with HNSCC cells, it efficiently adhered to these cells and enhanced their invasive ability. A transcriptome analysis of P. gingivalis -infected HNSCC cells showed that genes related to migration, including CCL20, CITED2, CTGF, C8orf44-SGK3, DUSP10, EGR3, FUZ, HBEGF, IL1B, IL24, JUN, PLAU, PTGS2, P2RY1, SEMA7A, SGK1 and SIX2, were highly up- or down-regulated. The expression of up-regulated genes was examined using the expression data of HNSCC patients obtained from The Cancer Genome Atlas (TCGA) database, and the expression of 5 genes, including PLAU, was found to be higher in cancer tissue than in solid normal tissue. An analysis of protein-protein interactions revealed that these 5 genes formed a dense network. A Cox regression analysis showed that high PLAU expression levels were associated with a poor prognosis in patients with TCGA-HNSCC. Furthermore, the prognostic impact correlated with tumour size and the presence or absence of lymph node metastasis. Collectively, these results suggest the potential of PLAU as a molecular prognostic marker in HNSCC patients. Further in vivo and in vitro studies are needed to verify the findings of this study.
    MeSH term(s) Humans ; Biomarkers, Tumor/genetics ; Dual-Specificity Phosphatases/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/microbiology ; Mitogen-Activated Protein Kinase Phosphatases/genetics ; Porphyromonas gingivalis/isolation & purification ; Prognosis ; Repressor Proteins/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/microbiology ; Trans-Activators/genetics ; Membrane Proteins/genetics
    Chemical Substances Biomarkers, Tumor ; CITED2 protein, human ; Dual-Specificity Phosphatases (EC 3.1.3.48) ; DUSP10 protein, human (EC 3.1.3.16) ; Mitogen-Activated Protein Kinase Phosphatases (EC 3.1.3.16) ; Repressor Proteins ; Trans-Activators ; PLAU protein, human ; Membrane Proteins
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.18167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Systematic Study of Pnictogen-Fused Heterofluorenes.

    Inaba, Ryoto / Oka, Kouki / Iwami, Takahiro / Miyake, Yusuke / Tajima, Kunihiko / Imoto, Hiroaki / Naka, Kensuke

    Inorganic chemistry

    2022  Volume 61, Issue 19, Page(s) 7318–7326

    Abstract: Heteroatom-fused π-conjugated molecules have attracted considerable attention, and various elements for such fusion have been investigated. Herein, we focused on pnictogen-fused heterofluorenes. The structures, reactivity with ... ...

    Abstract Heteroatom-fused π-conjugated molecules have attracted considerable attention, and various elements for such fusion have been investigated. Herein, we focused on pnictogen-fused heterofluorenes. The structures, reactivity with O
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c00158
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  9. Article ; Online: Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer.

    Hamada, Masakazu / Inaba, Hiroaki / Nishiyama, Kyoko / Yoshida, Sho / Yura, Yoshiaki / Matsumoto-Nakano, Michiyo / Uzawa, Narikazu

    International journal of molecular sciences

    2023  Volume 24, Issue 20

    Abstract: The tumor microbiome, a relatively new research field, affects tumor progression through several mechanisms. The Cancer Microbiome Atlas (TCMA) database was recently published. In the present study, we used TCMA and The Cancer Genome Atlas and examined ... ...

    Abstract The tumor microbiome, a relatively new research field, affects tumor progression through several mechanisms. The Cancer Microbiome Atlas (TCMA) database was recently published. In the present study, we used TCMA and The Cancer Genome Atlas and examined microbiome profiling in head and neck squamous cell carcinoma (HNSCC), the role of the intratumoral microbiota in the prognosis of HNSCC patients, and differentially expressed genes in tumor cells in relation to specific bacterial infections. We investigated 18 microbes at the genus level that differed between solid normal tissue (
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Head and Neck Neoplasms/genetics ; Signal Transduction ; Microbiota/genetics ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Biomarkers, Tumor
    Language English
    Publishing date 2023-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242015456
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  10. Article: Possible association of

    Shirahata, So / Iwashita, Naoki / Sasaki, Rie / Nomura, Ryota / Murakami, Masaru / Yasuda, Junya / Yasuda, Hidemi / Nakajima, Kuniyasu / Inaba, Hiroaki / Matsumoto-Nakano, Michiyo / Nakano, Kazuhiko / Uchiyama, Jumpei / Fukuyama, Tomoki

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1022838

    Abstract: Previous research has demonstrated ... ...

    Abstract Previous research has demonstrated that
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1022838
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