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Article ; Online: Is oral Streptococcus mutans with collagen-binding protein a risk factor for intracranial aneurysm rupture or formation?

Nakatogawa, Hirokazu / Hokamura, Kazuya / Nomura, Ryota / Nakano, Kazuhiko / Umemura, Kazuo / Morita, Akio / Homma, Yoichiro / Tanaka, Tokutaro

Cerebrovascular diseases (Basel, Switzerland)

2024

Abstract: Objective: Streptococcus mutans (SM) with the collagen-binding protein Cnm is a unique member of the oral resident flora because it causes hemorrhagic vascular disorders. In the multicenter study, we examined the relationship between Cnm-positive SM (CP- ...

Abstract	Objective: Streptococcus mutans (SM) with the collagen-binding protein Cnm is a unique member of the oral resident flora because it causes hemorrhagic vascular disorders. In the multicenter study, we examined the relationship between Cnm-positive SM (CP-SM) and intracranial aneurysm (IA) rupture, which remains unknown. Methods: Between May 2013 and June 2018, we collected whole saliva samples from 431 patients with ruptured IAs (RIAs) and 470 patients with unruptured IAs (UIAs). Data were collected on age, sex, smoking and drinking habits, family history of subarachnoid hemorrhage, aneurysm size, number of teeth, and comorbidities of lifestyle disease. Results: There was no difference in the positivity rate of patients with CP-SM between the patients with RIAs (17.2%) and those with UIAs (19.4%). The rate of positivity for CP-SM was significantly higher in all IAs <5 mm than in those ≥10 mm in diameter (P=0.0304). In the entire cohort, the rate of positivity for CP-SM was lower in larger aneurysms than in smaller aneurysms (P=0.0393). Conclusions: The rate of positivity for CP-SM was lower among patients with large UIAs. These findings are consistent with the hypothesis that CP-SM plays a role in the formation of vulnerable IAs that tend to rupture before becoming larger.
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000536203
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Zs.A 3181: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 226: Show issues

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Article ; Online: Author Correction: Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia.

Imai, Ryo / Makino, Hiroshi / Katoh, Takasumi / Kimura, Tetsuro / Kurita, Tadayoshi / Hokamura, Kazuya / Umemura, Kazuo / Nakajima, Yoshiki

Scientific reports

2021 Volume 11, Issue 1, Page(s) 6019

Language	English
Publishing date	2021-03-09
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-84378-4
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Article ; Online: Dietary Iron Restriction Protects against Aneurysm Rupture in a Mouse Model of Intracranial Aneurysm.

Kawakatsu, Toru / Kamio, Yoshinobu / Makino, Hiroshi / Hokamura, Kazuya / Imai, Ryo / Sugimura, Sho / Kimura, Tetsuro / Hiramatsu, Hisaya / Umemura, Kazuo / Hashimoto, Tomoki / Kurozumi, Kazuhiko

Cerebrovascular diseases (Basel, Switzerland)

2023 Volume 53, Issue 2, Page(s) 191–197

Abstract: Introduction: Iron accumulation in vessel walls induces oxidative stress and inflammation, which can cause cerebrovascular damage, vascular wall degeneration, and intracranial aneurysmal formation, growth, and rupture. Subarachnoid hemorrhage from ... ...

Abstract	Introduction: Iron accumulation in vessel walls induces oxidative stress and inflammation, which can cause cerebrovascular damage, vascular wall degeneration, and intracranial aneurysmal formation, growth, and rupture. Subarachnoid hemorrhage from intracranial aneurysm rupture results in significant morbidity and mortality. This study used a mouse model of intracranial aneurysm to evaluate the effect of dietary iron restriction on aneurysm formation and rupture. Methods: Intracranial aneurysms were induced using deoxycorticosterone acetate-salt-induced hypertension and a single injection of elastase into the cerebrospinal fluid of the basal cistern. Mice were fed an iron-restricted diet (n = 23) or a normal diet (n = 25). Aneurysm rupture was detected by neurological symptoms, while the presence of intracranial aneurysm with subarachnoid hemorrhage was confirmed by post-mortem examination. Results: The aneurysmal rupture rate was significantly lower in iron-restricted diet mice (37%) compared with normal diet mice (76%; p < 0.05). Serum oxidative stress, iron accumulation, macrophage infiltration, and 8-hydroxy-2'-deoxyguanosine in the vascular wall were lower in iron-restricted diet mice (p < 0.01). The areas of iron positivity were similar to the areas of CD68 positivity and 8-hydroxy-2'-deoxyguanosine in both normal diet and iron-restricted diet mouse aneurysms. Conclusions: These findings suggest that iron is involved in intracranial aneurysm rupture via vascular inflammation and oxidative stress. Dietary iron restriction may have a promising role in preventing intracranial aneurysm rupture.
MeSH term(s)	Animals ; Mice ; Intracranial Aneurysm ; Subarachnoid Hemorrhage/complications ; Iron, Dietary/adverse effects ; Iron ; 8-Hydroxy-2'-Deoxyguanosine/adverse effects ; Disease Models, Animal ; Aneurysm, Ruptured/etiology ; Inflammation/complications
Chemical Substances	Iron, Dietary ; Iron (E1UOL152H7) ; 8-Hydroxy-2'-Deoxyguanosine (88847-89-6)
Language	English
Publishing date	2023-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000531431
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Zs.A 3181: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 226: Show issues

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Article ; Online: Effects of volatile anesthetics on circadian rhythm in mice: a comparative study of sevoflurane, desflurane, and isoflurane.

Sugimura, Sho / Imai, Ryo / Katoh, Takasumi / Makino, Hiroshi / Hokamura, Kazuya / Kurita, Tadayoshi / Suzuki, Yasuhito / Aoki, Yoshitaka / Kimura, Tetsuro / Umemura, Kazuo / Nakajima, Yoshiki

Journal of anesthesia

2023 Volume 38, Issue 1, Page(s) 10–18

Abstract: Purpose: Volatile anesthetics affect the circadian rhythm of mammals, although the effects of different types of anesthetics are unclear. Here, we anesthetized mice using several volatile anesthetics at two different times during the day. Our objective ... ...

Abstract	Purpose: Volatile anesthetics affect the circadian rhythm of mammals, although the effects of different types of anesthetics are unclear. Here, we anesthetized mice using several volatile anesthetics at two different times during the day. Our objective was to compare the effects of these anesthetics on circadian rhythm. Methods: Male adult C57BL/6 J mice were divided into eight groups (n = 8 each) based on the anesthetic (sevoflurane, desflurane, isoflurane, or no anesthesia) and anesthesia time (Zeitgeber time [ZT] 6-12 or ZT18-24). Mice were anesthetized for 6 h using a 0.5 minimum alveolar concentration (MAC) dose under constant dark conditions. The difference between the start of the active phase before and after anesthesia was measured as a phase shift. Clock genes were measured by polymerase chain reaction in suprachiasmatic nucleus (SCN) samples removed from mouse brain after anesthesia (n = 8-9 each). Results: Phase shift after anesthesia at ZT6-12 using sevoflurane (- 0.49 h) was smaller compared with desflurane (- 1.1 h) and isoflurane (- 1.4 h) (p < 0.05). Clock mRNA (ZT6-12, p < 0.05) and Per2 mRNA (ZT18-24, p < 0.05) expression were different between the groups after anesthesia. Conclusion: 0.5 MAC sevoflurane anesthesia administered during the late inactive to early active phase has less impact on the phase shift of circadian rhythm than desflurane and isoflurane. This may be due to differences in the effects of volatile anesthetics on the expression of clock genes in the SCN, the master clock of the circadian rhythm.
MeSH term(s)	Male ; Animals ; Mice ; Isoflurane/pharmacology ; Sevoflurane/pharmacology ; Desflurane ; Anesthetics, Inhalation/pharmacology ; Methyl Ethers ; Mice, Inbred C57BL ; Circadian Rhythm ; RNA, Messenger ; Mammals
Chemical Substances	Isoflurane (CYS9AKD70P) ; Sevoflurane (38LVP0K73A) ; Desflurane (CRS35BZ94Q) ; Anesthetics, Inhalation ; Methyl Ethers ; RNA, Messenger
Language	English
Publishing date	2023-09-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1107821-2
ISSN	1438-8359 ; 0913-8668
ISSN (online)	1438-8359
ISSN	0913-8668
DOI	10.1007/s00540-023-03262-9
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Zs.A 3408: Show issues

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Article ; Online: Different exercises can modulate the differentiation/maturation of neural stem/progenitor cells after photochemically induced focal cerebral infarction.

Morishita, Saho / Hokamura, Kazuya / Yoshikawa, Akira / Agata, Nobuhide / Tsutsui, Yoshihiro / Umemura, Kazuo / Kumada, Tatsuro

Brain and behavior

2020 Volume 10, Issue 3, Page(s) e01535

Abstract: Introduction: Exercise therapies during rehabilitation significantly promote recovery from various deficits after cerebral infarction, which is mediated by neuronal plasticity with distinct inputs. Although adult neurogenesis can also be modulated by ... ...

Abstract	Introduction: Exercise therapies during rehabilitation significantly promote recovery from various deficits after cerebral infarction, which is mediated by neuronal plasticity with distinct inputs. Although adult neurogenesis can also be modulated by neuronal activity before synaptogenesis, how distinct exercises contribute to the neurological reorganization of the injured cerebral cortex remains unclear. In the present study, we aimed to elucidate the effects of different exercise therapies on motor recovery and neuronal reorganization after photochemically induced focal cerebral infarction. Methods: Here, we examined the effects of three different exercises-(a) forced lower-intensity and (b) higher-intensity treadmill exercises, and (c) voluntary exercise with wheel running-on motor recovery and adult neurogenesis in a rat model of focal cerebral infarction. Photochemically induced thrombosis (PIT) was used to generate focal infarction in rats that was mostly confined to their motor cortices. Results: Beam walking tests showed that recovery after PIT-induced cortical infarction differed in acute and chronic stages and was influenced by the type of exercise. Furthermore, forced low-intensity training had more positive effects on functional recovery than other exercises or control. To evaluate the production of newly generated cells including de novo neurogenesis, we performed lineage analysis with BrdU labeling and immunofluorescence experiments. Lower-intensity treadmill exercise increased the number of BrdU/NeuN colabeled cells, but not total BrdU-retaining or BrdU/Sox2-colabeled cells, in the peri-infarct region of the ipsilateral cortex. In contrast, high-intensity treadmill or voluntary exercises had the opposite effects. Conclusions: These results suggest that neuronal maturation can be differently modulated by distinct exercises and that low-intensity treadmill exercise could result in more potent generation of mature neurons. This also suggests the possibility that the generation of neural stem/progenitor cells and differentiation might be modulated by rehabilitation-mediated neural plasticity.
MeSH term(s)	Animals ; Cell Differentiation/physiology ; Cerebral Infarction/physiopathology ; Male ; Motor Activity/physiology ; Motor Cortex/physiopathology ; Neural Stem Cells/physiology ; Neurogenesis/physiology ; Neuronal Plasticity/physiology ; Neurons/physiology ; Physical Conditioning, Animal/physiology ; Rats ; Rats, Sprague-Dawley ; Recovery of Function/physiology
Language	English
Publishing date	2020-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.1535
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Article ; Online: Author Correction

Ryo Imai / Hiroshi Makino / Takasumi Katoh / Tetsuro Kimura / Tadayoshi Kurita / Kazuya Hokamura / Kazuo Umemura / Yoshiki Nakajima

Scientific Reports, Vol 11, Iss 1, Pp 1-

Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia

2021 Volume 1

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In Reply to "Streptococcus mutans with Collagen-Binding Protein: From Oral Cavity to Brain".

Tanaka, Tokutaro / Nomura, Ryota / Hokamura, Kazuya / Hamasaki, Toshimitsu / Inenaga, Chikanori / Umemura, Kazuo / Nakano, Kazuhiko

World neurosurgery

2018 Volume 115, Page(s) 487

MeSH term(s)	Brain ; Carrier Proteins ; Collagen ; Mouth ; Streptococcus mutans
Chemical Substances	Carrier Proteins ; Collagen (9007-34-5)
Language	English
Publishing date	2018
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2018.04.154
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Zs.A 1159: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia.

Imai, Ryo / Makino, Hiroshi / Katoh, Takasumi / Kimura, Tetsuro / Kurita, Tadayoshi / Hokamura, Kazuya / Umemura, Kazuo / Nakajima, Yoshiki

Scientific reports

2020 Volume 10, Issue 1, Page(s) 18273

Abstract: Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with ... ...

Abstract	Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with desflurane. In the present study, we examined the rest/activity rhythm of mice by counting the number of running wheel rotations, and we found that desflurane anesthesia caused a phase shift in the circadian rhythm that was dependent on the time of day of anesthesia. We also found that desflurane anesthesia altered the relative mRNA expression of four major clock genes (Per2, Bmal, Clock, and Cry1) in the suprachiasmatic nucleus (SCN). These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Further studies on the relationship between anesthesia and circadian rhythm may lead to the prevention and treatment of postoperative complications related to circadian rhythms.
MeSH term(s)	ARNTL Transcription Factors/genetics ; Anesthetics, Inhalation/administration & dosage ; Anesthetics, Inhalation/pharmacology ; Animals ; CLOCK Proteins/genetics ; Circadian Rhythm/drug effects ; Cryptochromes/genetics ; Desflurane/administration & dosage ; Desflurane/pharmacology ; Gene Expression Regulation/drug effects ; Male ; Mice ; Period Circadian Proteins/genetics ; Suprachiasmatic Nucleus/chemistry ; Time
Chemical Substances	ARNTL Transcription Factors ; Anesthetics, Inhalation ; Bmal1 protein, mouse ; Cry1 protein, mouse ; Cryptochromes ; Per2 protein, mouse ; Period Circadian Proteins ; Desflurane (CRS35BZ94Q) ; CLOCK Proteins (EC 2.3.1.48) ; Clock protein, mouse (EC 2.3.1.48)
Language	English
Publishing date	2020-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-75434-6
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Article ; Online: [

Iwaki, Takayuki / Mizuma, Hiroshi / Hokamura, Kazuya / Onoe, Hirotaka / Umemura, Kazuo

BioMed research international

2016 Volume 2016, Page(s) 8609274

Abstract: Atherosclerosis is a self-sustaining inflammatory fibroproliferative disease that progresses in discrete stages and involves a number of cell types and effector molecules. Recently, [ ...

Abstract	Atherosclerosis is a self-sustaining inflammatory fibroproliferative disease that progresses in discrete stages and involves a number of cell types and effector molecules. Recently, [
MeSH term(s)	Animals ; Aorta/diagnostic imaging ; Aorta/metabolism ; Cholesterol/adverse effects ; Cholesterol/pharmacology ; Dietary Fats/adverse effects ; Dietary Fats/pharmacology ; Disease Models, Animal ; Glucose-6-Phosphate/analogs & derivatives ; Glucose-6-Phosphate/pharmacokinetics ; Glucose-6-Phosphate/pharmacology ; Macaca fascicularis ; Male ; Muscle, Smooth, Vascular/diagnostic imaging ; Muscle, Smooth, Vascular/metabolism ; Plaque, Atherosclerotic/chemically induced ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/metabolism ; Positron-Emission Tomography/methods ; Rabbits
Chemical Substances	Dietary Fats ; 2-fluoro-2-deoxyglucose-6-phosphate (40871-47-4) ; Glucose-6-Phosphate (56-73-5) ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2016/8609274
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Article ; Online: Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia

Ryo Imai / Hiroshi Makino / Takasumi Katoh / Tetsuro Kimura / Tadayoshi Kurita / Kazuya Hokamura / Kazuo Umemura / Yoshiki Nakajima

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 9

Abstract: Abstract Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this ... ...

Abstract	Abstract Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with desflurane. In the present study, we examined the rest/activity rhythm of mice by counting the number of running wheel rotations, and we found that desflurane anesthesia caused a phase shift in the circadian rhythm that was dependent on the time of day of anesthesia. We also found that desflurane anesthesia altered the relative mRNA expression of four major clock genes (Per2, Bmal, Clock, and Cry1) in the suprachiasmatic nucleus (SCN). These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Further studies on the relationship between anesthesia and circadian rhythm may lead to the prevention and treatment of postoperative complications related to circadian rhythms.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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