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  1. Article: Scavenger of the faculty. Joshua Ward (1685-1761).

    Hill, B

    The Practitioner

    1969  Volume 203, Issue 218, Page(s) 820–825

    MeSH term(s) History, 17th Century ; History, 18th Century ; London ; Quackery/history
    Language English
    Publishing date 1969-12
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 124095-x
    ISSN 0032-6518
    ISSN 0032-6518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 228: Show issues Location:
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  2. Article ; Online: Understanding the clinical significance of cytomegalovirus viremia after chimeric antigen receptor T-cell therapy: Should we be treating a value?

    Kampouri, Eleftheria / Boeckh, Michael J / Hill, Joshua A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae030
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  3. Article ; Online: Humoral Immunity After mRNA SARS-CoV-2 Vaccination in Allogeneic HCT Recipients-Room for Improvement and Much to Learn.

    Hill, Joshua A

    JAMA network open

    2021  Volume 4, Issue 9, Page(s) e2127454

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunity, Humoral ; RNA, Messenger ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2021-09-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.27454
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  4. Article: Biophysical carbon concentrating mechanisms in land plants: insights from reaction-diffusion modeling.

    Kaste, Joshua A M / Walker, Berkley J / Shachar-Hill, Yair

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Carbon Concentrating Mechanisms (CCMs) have evolved numerous times in photosynthetic organisms. They elevate the concentration of ... ...

    Abstract Carbon Concentrating Mechanisms (CCMs) have evolved numerous times in photosynthetic organisms. They elevate the concentration of CO
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.04.574220
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  5. Article ; Online: Human Herpes Virus-6 (HHV-6) Reactivation after Hematopoietic Cell Transplant and Chimeric Antigen Receptor (CAR)- T Cell Therapy: A Shifting Landscape.

    Kampouri, Eleftheria / Handley, Guy / Hill, Joshua A

    Viruses

    2024  Volume 16, Issue 4

    Abstract: HHV-6B reactivation affects approximately half of all allogeneic hematopoietic cell transplant (HCT) recipients. HHV-6B is the most frequent infectious cause of encephalitis following HCT and is associated with pleiotropic manifestations in this setting, ...

    Abstract HHV-6B reactivation affects approximately half of all allogeneic hematopoietic cell transplant (HCT) recipients. HHV-6B is the most frequent infectious cause of encephalitis following HCT and is associated with pleiotropic manifestations in this setting, including graft-versus-host disease, myelosuppression, pneumonitis, and CMV reactivation, although the causal link is not always clear. When the virus inserts its genome in chromosomes of germ cells, the chromosomally integrated form (ciHHV6) is inherited by offspring. The condition of ciHHV6 is characterized by the persistent detection of HHV-6 DNA, often confounding diagnosis of reactivation and disease-this has also been associated with adverse outcomes. Recent changes in clinical practice in the field of cellular therapies, including a wider use of post-HCT cyclophosphamide, the advent of letermovir for CMV prophylaxis, and the rapid expansion of novel cellular therapies require contemporary epidemiological studies to determine the pathogenic role and spectrum of disease of HHV-6B in the current era. Research into the epidemiology and clinical significance of HHV-6B in chimeric antigen receptor T cell (CAR-T cell) therapy recipients is in its infancy. No controlled trials have determined the optimal treatment for HHV-6B. Treatment is reserved for end-organ disease, and the choice of antiviral agent is influenced by expected toxicities. Virus-specific T cells may provide a novel, less toxic therapeutic modality but is more logistically challenging. Preventive strategies are hindered by the high toxicity of current antivirals. Ongoing study is needed to keep up with the evolving epidemiology and impact of HHV-6 in diverse and expanding immunocompromised patient populations.
    MeSH term(s) Herpesvirus 6, Human/immunology ; Herpesvirus 6, Human/genetics ; Herpesvirus 6, Human/physiology ; Humans ; Hematopoietic Stem Cell Transplantation/adverse effects ; Virus Activation ; Roseolovirus Infections/virology ; Roseolovirus Infections/immunology ; Roseolovirus Infections/therapy ; Receptors, Chimeric Antigen/immunology ; Receptors, Chimeric Antigen/genetics ; Immunotherapy, Adoptive/methods ; Immunotherapy, Adoptive/adverse effects ; Graft vs Host Disease/immunology ; Graft vs Host Disease/etiology
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16040498
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  6. Article ; Online: Letter to the Editor Regarding "Once-Daily Foscarnet Is Effective for Human Herpesvirus 6 Reactivation after Hematopoietic Stem Cell Transplantation".

    Handley, Guy / Pasikhova, Yanina / Hill, Joshua A

    Transplantation and cellular therapy

    2023  Volume 29, Issue 10, Page(s) 645–646

    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Letter
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2023.08.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5082: Show issues Location:
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  7. Article ; Online: Model Validation and Selection in Metabolic Flux Analysis and Flux Balance Analysis.

    Kaste, Joshua A M / Shachar-Hill, Yair

    ArXiv

    2023  

    Abstract: 13C-Metabolic Flux Analysis (13C-MFA) and Flux Balance Analysis (FBA) are widely used to investigate the operation of biochemical networks in both biological and biotechnological research. Both of these methods use metabolic reaction network models of ... ...

    Abstract 13C-Metabolic Flux Analysis (13C-MFA) and Flux Balance Analysis (FBA) are widely used to investigate the operation of biochemical networks in both biological and biotechnological research. Both of these methods use metabolic reaction network models of metabolism operating at steady state, so that reaction rates (fluxes) and the levels of metabolic intermediates are constrained to be invariant. They provide estimated (MFA) or predicted (FBA) values of the fluxes through the network
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
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  8. Article ; Online: Human herpesvirus-6, HHV-8 and parvovirus B19 after allogeneic hematopoietic cell transplant: the lesser-known viral complications.

    Kampouri, Eleftheria / Little, Jessica S / Crocchiolo, Roberto / Hill, Joshua A

    Current opinion in infectious diseases

    2024  

    Abstract: Purpose of review: Viral infections continue to burden allogeneic hematopoietic cell transplant (HCT) recipients. We review the epidemiology, diagnosis, and management of human herpesvirus (HHV)-6, HHV-8 and parvovirus B19 following HCT.: Recent ... ...

    Abstract Purpose of review: Viral infections continue to burden allogeneic hematopoietic cell transplant (HCT) recipients. We review the epidemiology, diagnosis, and management of human herpesvirus (HHV)-6, HHV-8 and parvovirus B19 following HCT.
    Recent findings: Advances in HCT practices significantly improved outcomes but impact viral epidemiology: post-transplant cyclophosphamide for graft-versus-host disease prevention increases HHV-6 reactivation risk while the impact of letermovir for CMV prophylaxis - and resulting decrease in broad-spectrum antivirals - is more complex. Beyond the well established HHV-6 encephalitis, recent evidence implicates HHV-6 in pneumonitis. Novel less toxic therapeutic approaches (brincidofovir, virus-specific T-cells) may enable preventive strategies in the future. HHV-8 is the causal agent of Kaposi's sarcoma, which is only sporadically reported after HCT, but other manifestations are possible and not well elucidated. Parvovirus B19 can cause severe disease post-HCT, frequently manifesting with anemia, but can also be easily overlooked due to lack of routine screening and ambiguity of manifestations.
    Summary: Studies should establish the contemporary epidemiology of HHV-6, and other more insidious viruses, such as HHV-8 and parvovirus B19 following HCT and should encompass novel cellular therapies. Standardized and readily available diagnostic methods are key to elucidate epidemiology and optimize preventive and therapeutic strategies to mitigate the burden of infection.
    Language English
    Publishing date 2024-05-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000001020
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    Zs.A 2462: Show issues Location:
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  9. Article ; Online: The Role of the National Institute of Mental Health in Promoting Diversity in the Psychiatric Research Workforce.

    Hill, Lauren D / Avenevoli, Shelli / Gordon, Joshua A

    Child and adolescent psychiatric clinics of North America

    2023  Volume 33, Issue 1, Page(s) 77–86

    Abstract: The mission of the National Institute of Mental Health (NIMH) is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. This mission can only be realized if ...

    Abstract The mission of the National Institute of Mental Health (NIMH) is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. This mission can only be realized if full participation in the research enterprise is open to all. Nevertheless, systemic racism and other barriers remain significant obstacles to achieving a diverse workforce. To address these barriers, NIMH must ensure a just and equitable funding process, support diversity-focused training opportunities, and encourage research into mental health disparities and other areas of interest to a diverse array of scientists.
    MeSH term(s) United States ; Humans ; National Institute of Mental Health (U.S.) ; Mental Disorders/therapy ; Physicians ; Workforce
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1313996-4
    ISSN 1558-0490 ; 1056-4993
    ISSN (online) 1558-0490
    ISSN 1056-4993
    DOI 10.1016/j.chc.2023.06.009
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  10. Article ; Online: Integrative teaching of metabolic modeling and flux analysis with interactive python modules.

    Kaste, Joshua A M / Green, Antwan / Shachar-Hill, Yair

    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

    2023  Volume 51, Issue 6, Page(s) 653–661

    Abstract: The modeling of rates of biochemical reactions-fluxes-in metabolic networks is widely used for both basic biological research and biotechnological applications. A number of different modeling methods have been developed to estimate and predict fluxes, ... ...

    Abstract The modeling of rates of biochemical reactions-fluxes-in metabolic networks is widely used for both basic biological research and biotechnological applications. A number of different modeling methods have been developed to estimate and predict fluxes, including kinetic and constraint-based (Metabolic Flux Analysis and flux balance analysis) approaches. Although different resources exist for teaching these methods individually, to-date no resources have been developed to teach these approaches in an integrative way that equips learners with an understanding of each modeling paradigm, how they relate to one another, and the information that can be gleaned from each. We have developed a series of modeling simulations in Python to teach kinetic modeling, metabolic control analysis, 13C-metabolic flux analysis, and flux balance analysis. These simulations are presented in a series of interactive notebooks with guided lesson plans and associated lecture notes. Learners assimilate key principles using models of simple metabolic networks by running simulations, generating and using data, and making and validating predictions about the effects of modifying model parameters. We used these simulations as the hands-on computer laboratory component of a four-day metabolic modeling workshop and participant survey results showed improvements in learners' self-assessed competence and confidence in understanding and applying metabolic modeling techniques after having attended the workshop. The resources provided can be incorporated in their entirety or individually into courses and workshops on bioengineering and metabolic modeling at the undergraduate, graduate, or postgraduate level.
    MeSH term(s) Humans ; Metabolic Flux Analysis/methods ; Metabolic Networks and Pathways ; Kinetics ; Models, Biological
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2039717-3
    ISSN 1539-3429 ; 1470-8175
    ISSN (online) 1539-3429
    ISSN 1470-8175
    DOI 10.1002/bmb.21777
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