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Article ; Online: Phytochemical Study on Seeds of

Klontza, Vithleem / Graikou, Konstantia / Cheilari, Antigoni / Kasapis, Vasilios / Ganos, Christos / Aligiannis, Nektarios / Chinou, Ioanna

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: In this study, the black fertile (BSs) and the red unfertile seeds (RSs) of the Greek ... ...

Abstract	In this study, the black fertile (BSs) and the red unfertile seeds (RSs) of the Greek endemic
MeSH term(s)	Antioxidants/chemistry ; Paeonia/chemistry ; Monophenol Monooxygenase ; Luteolin ; Monoterpenes/analysis ; Plant Extracts/chemistry ; Phenols/analysis ; Glycosides/chemistry ; Phytochemicals/analysis ; Seeds/chemistry
Chemical Substances	Antioxidants ; gnetin H (2RXU4J2Z19) ; peoniflorin (21AIQ4EV64) ; Monophenol Monooxygenase (EC 1.14.18.1) ; Luteolin (KUX1ZNC9J2) ; Monoterpenes ; Plant Extracts ; Phenols ; Glycosides ; Phytochemicals
Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054935
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phytochemical Study on Seeds of Paeonia clusii subsp. rhodia —Antioxidant and Anti-Tyrosinase Properties

Vithleem Klontza / Konstantia Graikou / Antigoni Cheilari / Vasilios Kasapis / Christos Ganos / Nektarios Aligiannis / Ioanna Chinou

International Journal of Molecular Sciences, Vol 24, Iss 4935, p

2023 Volume 4935

Abstract: In this study, the black fertile (BSs) and the red unfertile seeds (RSs) of the Greek endemic Paeonia clusii subsp. rhodia (Stearn) Tzanoud were studied for the first time. Nine phenolic derivatives, trans -resveratol, trans -resveratrol-4′-O-β- d - ... ...

Abstract	In this study, the black fertile (BSs) and the red unfertile seeds (RSs) of the Greek endemic Paeonia clusii subsp. rhodia (Stearn) Tzanoud were studied for the first time. Nine phenolic derivatives, trans -resveratol, trans -resveratrol-4′-O-β- d -glucopyranoside, trans - ε -viniferin, trans -gnetin H, luteolin, luteolin 3′-O-β- d -glucoside, luteolin 3′,4′-di-O-β- d -glucopyranoside, and benzoic acid, along with the monoterpene glycoside paeoniflorin, have been isolated and structurally elucidated. Furthermore, 33 metabolites have been identified from BSs through UHPLC-HRMS, including 6 monoterpene glycosides of the paeoniflorin type with the characteristic cage-like terpenic skeleton found only in plants of the genus Paeonia , 6 gallic acid derivatives, 10 oligostilbene compounds, and 11 flavonoid derivatives. From the RSs, through HS-SPME and GC-MS, 19 metabolites were identified, among which nopinone, myrtanal, and cis -myrtanol have been reported only in peonies’ roots and flowers to date. The total phenolic content of both seed extracts (BS and RS) was extremely high (up to 289.97 mg GAE/g) and, moreover, they showed interesting antioxidative activity and anti-tyrosinase properties. The isolated compounds were also biologically evaluated. Especially in the case of trans -gnetin H, the expressed anti-tyrosinase activity was higher than that of kojic acid, which is a well-known whitening agent standard.
Keywords	Paeoniaceae ; Paeonia clusii subsp. rhodia (Stearn) Tzanoud ; seeds ; stilbenes ; flavonoids ; monoterpenic glucosides ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Kasapis, Christos / Gurm, Hitinder S

Current cardiology reviews

2010 Volume 5, Issue 4, Page(s) 296–311

Abstract: Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 5 million adults in the United States, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. ...

Abstract	Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 5 million adults in the United States, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. In this article we focus on lower extremity PAD and specifically on the superficial femoral and proximal popliteal artery (SFPA), which are the most common anatomic locations of lower extremity atherosclerosis. We summarize current evidence and perform a systematic review on the diagnostic evaluation as well as the medical, endovascular and surgical management of SFPA disease.
Language	English
Publishing date	2010-08-01
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6557
ISSN (online)	1875-6557
DOI	10.2174/157340309789317823
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Article: Use of the electrocardiogram in optimizing reperfusion for ST-elevation myocardial infarction: a new role for an old tool?

Kasapis, Christos / Nallamothu, Brahmajee K

European heart journal

2007 Volume 28, Issue 24, Page(s) 2957–2959

MeSH term(s)	Electrocardiography/methods ; Humans ; Myocardial Infarction/diagnosis ; Myocardial Infarction/drug therapy ; Myocardial Infarction/therapy ; Myocardial Reperfusion/methods ; Risk Assessment ; Risk Factors ; Thrombolytic Therapy/methods
Language	English
Publishing date	2007-12
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehm512
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Cardiovascular flashlight. Percutaneous treatment of a giant right coronary artery pseudoaneurysm in Adamantiades-Behcet's syndrome.

Kasapis, Christos / Grossman, Paul Michael / Chetcuti, Stanley J

European heart journal

2009 Volume 30, Issue 21, Page(s) 2630

MeSH term(s)	Adult ; Aneurysm, False/complications ; Aneurysm, False/therapy ; Angioplasty, Balloon, Coronary ; Behcet Syndrome/complications ; Coronary Stenosis/complications ; Coronary Stenosis/therapy ; Coronary Thrombosis/complications ; Coronary Thrombosis/therapy ; Female ; Humans ; Stents
Language	English
Publishing date	2009-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehp340
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Current and emerging strategies for the treatment of acute pericarditis: a systematic review.

Sheth, Samar / Wang, Dee Dee / Kasapis, Christos

Journal of inflammation research

2010 Volume 3, Page(s) 135–142

Abstract: Pericarditis is a common disorder that has multiple causes and presents in various primary-care and secondary-care settings. It is diagnosed in 0.1% of all hospital admissions and in 5% of emergency room visits for chest pain. Despite the advance of new ... ...

Abstract	Pericarditis is a common disorder that has multiple causes and presents in various primary-care and secondary-care settings. It is diagnosed in 0.1% of all hospital admissions and in 5% of emergency room visits for chest pain. Despite the advance of new diagnostic techniques, pericarditis is most commonly idiopathic, and radiation therapy, cardiac surgery, and percutaneous procedures have become important causes. Pericarditis is frequently benign and self-limiting. Nonsteroidal anti-inflammatory agents remain the first-line treatment for uncomplicated cases. Integrated use of new imaging methods facilitates accurate detection and management of complications such as pericardial effusion or constriction. In this article, we perform a systematic review on the etiology, clinical presentation, diagnostic evaluation, and management of acute pericarditis. We summarize current evidence on contemporary and emerging treatment strategies.
Language	English
Publishing date	2010-11-25
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031 ; 1178-7031
ISSN (online)	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S10268
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Article: The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review.

Kasapis, Christos / Thompson, Paul D

Journal of the American College of Cardiology

2005 Volume 45, Issue 10, Page(s) 1563–1569

Abstract: Physical activity is associated with a reduced incidence of coronary disease, but the mechanisms mediating this effect are not defined. There has been considerable recent interest in inflammation in the pathogenesis of cardiovascular disease. Some of the ...

Abstract	Physical activity is associated with a reduced incidence of coronary disease, but the mechanisms mediating this effect are not defined. There has been considerable recent interest in inflammation in the pathogenesis of cardiovascular disease. Some of the beneficial role of physical activity may result from its effects on the inflammatory process. We searched PubMed for articles published between 1975 through May 2004 using the terms exercise, physical activity, or physical fitness combined with C-reactive protein, inflammation, inflammatory markers, or cytokines. The review revealed 19 articles on the acute inflammatory response to exercise, 18 on cross-sectional comparisons of subjects by activity levels, and 5 examining prospectively the effects of exercise training on the inflammatory process. Exercise produces a short-term, inflammatory response, whereas both cross-sectional comparisons and longitudinal exercise training studies demonstrate a long-term "anti-inflammatory" effect. This anti-inflammatory response may contribute to the beneficial effects of habitual physical activity.
MeSH term(s)	C-Reactive Protein/metabolism ; Coronary Disease/immunology ; Coronary Disease/prevention & control ; Cross-Sectional Studies ; Cytokines/blood ; Exercise/physiology ; Female ; Humans ; Inflammation Mediators/blood ; Longitudinal Studies ; Male ; Physical Fitness ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/immunology
Chemical Substances	Cytokines ; Inflammation Mediators ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2005-05-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2004.12.077
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Spontaneous hemopericardium in a patient with hemophilia B: a case report and review of the literature.

Wang, Dee Dee / Kasapis, Christos / Nallamothu, Brahmajee K

The Journal of invasive cardiology

2008 Volume 20, Issue 10, Page(s) E296–300

Abstract: Spontaneous hemopericardium is extremely rare in patients with hemophilia and has never been reported in hemophilia B-factor IX deficiency. We report a patient with hemophilia B who presented with spontaneous hemopericardium and tamponade requiring ... ...

Abstract	Spontaneous hemopericardium is extremely rare in patients with hemophilia and has never been reported in hemophilia B-factor IX deficiency. We report a patient with hemophilia B who presented with spontaneous hemopericardium and tamponade requiring emergent pericardiocentesis. As advances in therapies improve the longevity and quality of life of patients with hemophilia, it is likely that adult interventional cardiologists will increasingly encounter these patients in the cardiac catheterization laboratory. We review the clinical challenges raised by this group of patients undergoing cardiac procedures and present a stepwise approach to optimal management during the periprocedural period.
MeSH term(s)	HIV Infections/physiopathology ; Hemophilia B/diagnosis ; Hemophilia B/physiopathology ; Hemophilia B/surgery ; Humans ; Male ; Middle Aged ; Pericardial Effusion/diagnosis ; Pericardial Effusion/pathology ; Pericardial Effusion/surgery ; Pericardiocentesis ; Time Factors
Language	English
Publishing date	2008-10
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Zs.A 3701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 272: Show issues
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Article ; Online: Current and emerging strategies for the treatment of acute pericarditis

Samar Sheth / Dee Dee Wang / Christos Kasapis

Journal of Inflammation Research, Vol 2010, Iss default, Pp 135-

a systematic review

2010 Volume 142

Abstract: Samar Sheth1, Dee Dee Wang3, Christos Kasapis21Department of Internal Medicine, 2Division ...

Abstract	Samar Sheth1, Dee Dee Wang3, Christos Kasapis21Department of Internal Medicine, 2Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA; 3Henry Ford Hospital, Division of Cardiovascular Medicine, Detroit, MI, USAAbstract: Pericarditis is a common disorder that has multiple causes and presents in various primary-care and secondary-care settings. It is diagnosed in 0.1% of all hospital admissions and in 5% of emergency room visits for chest pain. Despite the advance of new diagnostic techniques, pericarditis is most commonly idiopathic, and radiation therapy, cardiac surgery, and percutaneous procedures have become important causes. Pericarditis is frequently benign and self-limiting. Nonsteroidal anti-inflammatory agents remain the first-line treatment for uncomplicated cases. Integrated use of new imaging methods facilitates accurate detection and management of complications such as pericardial effusion or constriction. In this article, we perform a systematic review on the etiology, clinical presentation, diagnostic evaluation, and management of acute pericarditis. We summarize current evidence on contemporary and emerging treatment strategies.Keywords: pericarditis, pericardial disease, treatment strategies
Keywords	Pathology ; RB1-214 ; Medicine ; R ; DOAJ:Pathology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2010-11-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
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Article: Cholestatic jaundice as a paraneoplastic manifestation of prostate adenocarcinoma.

Karakolios, Apostolos / Kasapis, Christos / Kallinikidis, Theofilos / Kalpidis, Panagiotis / Grigoriadis, Nikolaos

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2004 Volume 1, Issue 6, Page(s) 480–483

Abstract: Malignancies may cause cholestatic jaundice through well-recognized mechanisms (e.g., bile duct obstruction or widespread hepatic infiltration). Paraneoplastic syndromes associated with malignancy, particularly with renal cell carcinoma (Stauffer's ... ...

Abstract	Malignancies may cause cholestatic jaundice through well-recognized mechanisms (e.g., bile duct obstruction or widespread hepatic infiltration). Paraneoplastic syndromes associated with malignancy, particularly with renal cell carcinoma (Stauffer's syndrome) and malignant lymphoproliferative diseases, can induce a reversible form of cholestasis through an unclear pathogenetic mechanism. Prostate cancer presenting initially with cholestatic jaundice without any obvious cause (i.e., obstruction or infiltration) has been reported in 2 cases in the medical literature. We report a patient who presented with pruritus and cholestatic jaundice. During the diagnostic work-up, prostate cancer was diagnosed. Conjugated bilirubin and alkaline phosphatase levels were increased markedly with modest increases of gamma-glutamyltranspeptidase and transaminase levels. The results of appropriate investigations performed during the patient's hospitalizations indicated no evidence of hepatic metastases or extrahepatic biliary obstruction. After treatment with flutamide and leuprolide, the patient's symptoms and the laboratory abnormalities reversed rapidly. We regard the cholestatic jaundice of this patient as part of a paraneoplastic syndrome; the cause of cholestasis remains an enigma. Patients with unexplained cholestasis should be investigated for malignancies, including prostate cancer.
MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/drug therapy ; Adenocarcinoma/metabolism ; Aged ; Alkaline Phosphatase/metabolism ; Antineoplastic Agents, Hormonal/therapeutic use ; Bilirubin/metabolism ; Biomarkers, Tumor/analysis ; Cholangiopancreatography, Endoscopic Retrograde ; Diagnosis, Differential ; Flutamide/therapeutic use ; Humans ; Jaundice, Obstructive/diagnosis ; Jaundice, Obstructive/drug therapy ; Jaundice, Obstructive/metabolism ; Leuprolide/therapeutic use ; Male ; Paraneoplastic Syndromes/diagnosis ; Paraneoplastic Syndromes/drug therapy ; Paraneoplastic Syndromes/metabolism ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Pruritus/diagnosis ; Pruritus/drug therapy ; Pruritus/metabolism ; Tomography, X-Ray Computed ; Transaminases/metabolism ; gamma-Glutamyltransferase/metabolism
Chemical Substances	Antineoplastic Agents, Hormonal ; Biomarkers, Tumor ; Flutamide (76W6J0943E) ; gamma-Glutamyltransferase (EC 2.3.2.2) ; Transaminases (EC 2.6.1.-) ; Alkaline Phosphatase (EC 3.1.3.1) ; Leuprolide (EFY6W0M8TG) ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2004-03-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/s1542-3565(03)00227-1
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