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  1. Article ; Online: C-C σ-Bond Oxidative Addition and Hydrofunctionalization by a Macrocycle-Supported Diiron Complex.

    Liu, Tianchang / Murphy, Ryan P / Carroll, Patrick J / Gau, Michael R / Tomson, Neil C

    Journal of the American Chemical Society

    2022  Volume 144, Issue 31, Page(s) 14037–14041

    Abstract: This report describes the first examples of unassisted C(sp)-C(sp ...

    Abstract This report describes the first examples of unassisted C(sp)-C(sp
    MeSH term(s) Alkynes ; Ligands ; Oxidation-Reduction ; Oxidative Stress
    Chemical Substances Alkynes ; Ligands
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c06266
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  2. Article ; Online: An untethered C

    Carroll, Timothy G / Hunt, Camden / Garwick, Rachel / Wu, Guang / Dobrovetsky, Roman / Ménard, Gabriel

    Chemical communications (Cambridge, England)

    2017  Volume 55, Issue 26, Page(s) 3761–3764

    Abstract: A para-substituted triphenylphosphine oxide with terminal vanadocene centers has been prepared and is, to our knowledge, the first example of an untethered C3v-symmetric triarylphosphine oxide in the solid state. Crystallographic and DFT studies suggest ... ...

    Abstract A para-substituted triphenylphosphine oxide with terminal vanadocene centers has been prepared and is, to our knowledge, the first example of an untethered C3v-symmetric triarylphosphine oxide in the solid state. Crystallographic and DFT studies suggest this locked conformation is due to intermolecular H-bonding interactions. Electrochemical measurements suggest these interactions may persist in solution. A monometallic variant, adopting the standard C3 propeller geometry, has also been synthesized for comparison.
    Language English
    Publishing date 2017-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c9cc01128e
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  3. Article ; Online: Evidence for Involvement of Protein Kinase C in Germinal Vesicle Breakdown in Chaetopterus: (protein kinase C/phorbol ester/oocyte maturation).

    Eckberg, William R / Carroll, Alan G

    Development, growth & differentiation

    2023  Volume 29, Issue 5, Page(s) 489–496

    Abstract: We have examined the possible involvement of protein kinase C (C-kinase) in the initiation ... 2-acetylglycerol), potent activators of C-Kinase, triggered GVBD. Two other phorbol esters (phorbol ... 13-monoacetate and 4α-phorbol-12, 13-didecanoate), which do not activate C-kinase, were inactive ...

    Abstract We have examined the possible involvement of protein kinase C (C-kinase) in the initiation of germinal vesicle breakdown (GVBD) in Chaetopterus oocytes. Two tumor-promoting phorbol esters (phorbol-12, 13-dibezoate and 12-0-tetradecanoylphorbol-13-acetate [TPA]) and a permeant diacylglycerol (1-oleoyl-2-acetylglycerol), potent activators of C-Kinase, triggered GVBD. Two other phorbol esters (phorbol-13-monoacetate and 4α-phorbol-12, 13-didecanoate), which do not activate C-kinase, were inactive. Three C-kinase antagonists (W-7, H-7 and retinol) inhibited both naturally-and TPA-induced GVBD, whereas W-5, a much less inhibitory W-7 analog, had no effect on GVBD. Triggering of GVBD by TPA was independent of extracellular Ca
    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/j.1440-169X.1987.00489.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Camaldulensals A-C, the First Meroterpenoids Possessing Two Spatially Separated Formyl Phloroglucinols Conjugated to a Terpene Core from the Leaves of

    Daus, Mareena / Hayton, Joshua B / Holland, Darren C / Voravuthikunchai, Supayang P / Carroll, Anthony R / Chakthong, Suda

    Journal of natural products

    2023  Volume 86, Issue 8, Page(s) 1994–2005

    Abstract: Three new bis-formyl phloroglucinol-meroterpenoids ( ...

    Abstract Three new bis-formyl phloroglucinol-meroterpenoids (
    MeSH term(s) Terpenes/chemistry ; Eucalyptus/chemistry ; Phloroglucinol/pharmacology ; Phloroglucinol/chemistry ; Methicillin-Resistant Staphylococcus aureus ; Plant Leaves/chemistry ; Molecular Structure
    Chemical Substances Terpenes ; Phloroglucinol (DHD7FFG6YS)
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c00443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Corrected Structure of Natural Hyacinthacine C

    Carroll, Anthony W / Willis, Anthony C / Hoshino, Masako / Kato, Atsushi / Pyne, Stephen G

    Journal of natural products

    2019  Volume 82, Issue 2, Page(s) 358–367

    Abstract: Hyacinthacines C ...

    Abstract Hyacinthacines C
    MeSH term(s) Animals ; Glycoside Hydrolases/antagonists & inhibitors ; Humans ; Pyrrolizidine Alkaloids/chemical synthesis ; Pyrrolizidine Alkaloids/chemistry ; Pyrrolizidine Alkaloids/pharmacology ; Rats ; Stereoisomerism
    Chemical Substances Pyrrolizidine Alkaloids ; hyacinthacine C1 ; Glycoside Hydrolases (EC 3.2.1.-)
    Language English
    Publishing date 2019-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.8b00879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction to Corrected Structure of Natural Hyacinthacine C

    Carroll, Anthony W / Willis, Anthony C / Hoshino, Masako / Kato, Atsushi / Pyne, Stephen G

    Journal of natural products

    2020  Volume 83, Issue 5, Page(s) 1733

    Language English
    Publishing date 2020-04-21
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c00389
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  7. Article ; Online: Cost minimization analysis of short-duration antiviral prophylaxis for hepatitis C positive donor kidney transplants.

    Jay, Jessica S / Patterson, Julie A / Zhang, Yiran / Ijioma, Stephen C / Carroll, Norman V / Holdford, David A / Sterling, Richard K / Gupta, Gaurav / Yakubu, Idris

    Journal of the American Pharmacists Association : JAPhA

    2023  Volume 63, Issue 6, Page(s) 1700–1705.e4

    Abstract: ... hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant recipients (D+/R ...

    Abstract Background: Trials describing 4-12 week courses of direct-acting antiviral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant recipients (D+/R-transplants), may be limited in application by costs and delayed access to expensive DAAs. A short prophylactic strategy may be safer and cost-effective. Here, we report a cost minimization analysis using the health system perspective to determine the least expensive DAA regimen, using available published strategies.
    Objectives: To conduct cost-minimization analyses (CMAs) from the health system perspective of four DAA regimens to prevent and/or treat HCV transmission from D+/R-kidney transplants.
    Methods: CMAs comparing 4 strategies: 1) 7-day prophylaxis with generic sofosbuvir/velpatasvir (SOF/VEL), with 12-week branded glecaprevir/pibrentasvir (G/P) for those with transmission; 2) 8-day branded G/P prophylaxis, with 12-week branded SOF/VEL/voxilaprevir for those with transmission; 3) 4-week perioperative generic SOF/VEL prophylaxis, with 12-week branded G/P for those with transmission; and 4) 8-week branded G/P "transmit-and-treat." We included data from published literature to estimate the probability of viral transmission in patients who received DAA prophylaxis, and assumed a 100% transmission rate for those who received the "transmit-and-treat" approach.
    Results: In base-case analyses, strategies 1 (expected cost [EC]: $2326) and 2 (expected cost: $2646) were less expensive than strategies 3 (EC: $4859) and 4 (EC: $18,525). Threshold analyses for 7-day SOF/VEL versus 8-day G/P suggested that there were reasonable input levels at which the 8-day strategy may be least costly. The threshold values for the SOF/VEL prophylaxis strategies (7-day vs. 4- week) indicated that the 4-week strategy is unlikely to be less costly under any reasonable value of the input variables.
    Conclusions: Short duration DAA prophylaxis using 7 days of SOF/VEL or 8 days of G/P has the potential to yield significant cost savings for D+/R- kidney transplants.
    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; Hepacivirus ; Hepatitis C, Chronic ; Kidney Transplantation ; Sofosbuvir/therapeutic use ; Hepatitis C/drug therapy ; Hepatitis C/prevention & control ; Drug Therapy, Combination ; Costs and Cost Analysis ; Genotype ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Sofosbuvir (WJ6CA3ZU8B)
    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2118585-2
    ISSN 1544-3450 ; 1544-3191 ; 1086-5802
    ISSN (online) 1544-3450
    ISSN 1544-3191 ; 1086-5802
    DOI 10.1016/j.japh.2023.06.027
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  8. Article ; Online: Unusual cyanide and methyl binding modes at a dicobalt macrocycle following acetonitrile C-C bond activation.

    Spentzos, Ariana Z / Gau, Michael R / Carroll, Patrick J / Tomson, Neil C

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 67, Page(s) 9675–9678

    Abstract: This communication describes the C-C bond activation of acetonitrile and the trapping of the methyl ...

    Abstract This communication describes the C-C bond activation of acetonitrile and the trapping of the methyl and cyanide fragments by macrocyclic, dicobalt complexes. Both products display unique structural features as a result of the constraints imposed by the macrocycle. The bridged species [(
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc03521a
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  9. Article: C–C σ-Bond Oxidative Addition and Hydrofunctionalization by a Macrocycle-Supported Diiron Complex

    Liu, Tianchang / Murphy, Ryan P. / Carroll, Patrick J. / Gau, Michael R. / Tomson, Neil C.

    Journal of the American Chemical Society. 2022 July 26, v. 144, no. 31

    2022  

    Abstract: This report describes the first examples of unassisted C(sp)–C(sp²) and C(sp)–C(sp³) bond oxidative ... C(sp)–C(sp²) bond oxidative addition products. When Ph–C≡C–R substrates were used as substrates (R ... Me, Et, ⁱPr, ᵗBu), products of either C(sp)–C(sp²) or C(sp)–C(sp³) bond activation were obtained ...

    Abstract This report describes the first examples of unassisted C(sp)–C(sp²) and C(sp)–C(sp³) bond oxidative addition reactions to give thermodynamically favorable products. Treatment of a diiron complex supported by a geometrically and electronically flexible macrocyclic ligand, (³PDI₂)Fe₂(μ-N₂)(PPh₃)₂ ([Fe₂N₂]⁰), with stoichiometric amounts of various 4,4′-disubstituted diphenylacetylenes (ArX–C≡C–ArX; X = OMe, H, F, CF₃) yielded C(sp)–C(sp²) bond oxidative addition products. When Ph–C≡C–R substrates were used as substrates (R = Me, Et, ⁱPr, ᵗBu), products of either C(sp)–C(sp²) or C(sp)–C(sp³) bond activation were obtained, with the less sterically encumbering alkynes exclusively undergoing C(sp)–C(sp³) bond activation. Treatment of the C–C activation species with either H₂ or HBpin was found to form products of C–C σ-bond hydrofunctionalization. In both the hydrogenation and hydroboration schemes, the diiron species was observed to return to [Fe₂N₂]⁰, thereby completing synthetic cycles for C–C σ-bond functionalization.
    Keywords alkynes ; hydrogenation ; ligands ; stoichiometry ; thermodynamics
    Language English
    Dates of publication 2022-0726
    Size p. 14037-14041.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c06266
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Total Synthesis of Natural Hyacinthacine C

    Carroll, Anthony W / Savaspun, Kongdech / Willis, Anthony C / Hoshino, Masako / Kato, Atsushi / Pyne, Stephen G

    The Journal of organic chemistry

    2018  Volume 83, Issue 10, Page(s) 5558–5576

    Abstract: The total synthesis of natural (+)-hyacinthacine C ...

    Abstract The total synthesis of natural (+)-hyacinthacine C
    MeSH term(s) Animals ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Biological Products/pharmacology ; Dose-Response Relationship, Drug ; Intestines/enzymology ; Molecular Conformation ; Pyrrolizidine Alkaloids/chemical synthesis ; Pyrrolizidine Alkaloids/chemistry ; Pyrrolizidine Alkaloids/pharmacology ; Rats ; Stereoisomerism ; Structure-Activity Relationship ; alpha-Glucosidases/metabolism
    Chemical Substances Biological Products ; Pyrrolizidine Alkaloids ; hyacinthacine C5 ; alpha-Glucosidases (EC 3.2.1.20)
    Language English
    Publishing date 2018-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.8b00585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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