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  1. Article ; Online: Routine use of Point-of-Care lung ultrasound during the COVID-19 pandemic.

    Antúnez-Montes, O Y / Buonsenso, D

    Medicina intensiva

    2022  Volume 46, Issue 1, Page(s) 42–45

    MeSH term(s) COVID-19 ; Humans ; Lung ; Pandemics ; Point-of-Care Systems ; SARS-CoV-2
    Language English
    Publishing date 2022-01-06
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medine.2020.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Routine use of Point-of-Care lung ultrasound during the COVID-19 pandemic.

    Antúnez-Montes, O Y / Buonsenso, D

    Medicina intensiva

    2020  Volume 46, Issue 1, Page(s) 42–45

    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 731753-0
    ISSN 1578-6749 ; 0210-5691
    ISSN (online) 1578-6749
    ISSN 0210-5691
    DOI 10.1016/j.medin.2020.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Routine use of Point-of-Care lung ultrasound during the COVID-19 pandemic

    Antúnez-Montes, O.Y. / Buonsenso, D.

    Medicina Intensiva ; ISSN 0210-5691

    2020  

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.medin.2020.04.010
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: COVID-19 and Multisystem Inflammatory Syndrome in Latin American children: a multinational study

    Antunez-Montes, O. Y. / Escamilla, M. I. / Figueroa-Uribe, A. F. / Arteaga-Menchaca, E. / Lavariega-Sarachaga, M. / Salcedo-Lozada, P. / Melchior, P. / de Oliveira, R. B. / Tirado Caballero, J. C. / Pinzon Redondo, H. / Montes Fontalvo, L. V. / Hernandez, R. / Chavez, C. / Campos, F. E. / Uribe, F. / del Aguila, O. / RIOS AIDA, J. A. / Parra Buitrago, A. / Betancur Londono, L. M. /
    Mendoza Vega, L. F. / Almeida Hernandez, C. / Sali, M. / HIGUITA PALACIO, J. / Gomez-Vargas, J. / Yock Corrales, A. / Buonsenso, D.

    Abstract: Background To date, there are no comprehensive data on pediatric COVID19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS C) in Latin American children, in order to appropriately plan and allocate ... ...

    Abstract Background To date, there are no comprehensive data on pediatric COVID19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS C) in Latin American children, in order to appropriately plan and allocate resources to face the pandemic on a local and International lever Methods Ambispective multicentre cohort study from five Latin American countries. Children aged 18 years or younger with microbiologically confirmed SARS CoV 2 infection were included. Findings 409 children were included, with a median age of 53.0 years (IQR 0.6 9.0). Of these, 95 191 (23.2%) were diagnosed with MIS C. 191 (46.7%) children were admitted to hospital and 52 (12.7%) required admission to a Pediatric Intensive Care Unite (PICU). 92 (22.5%) patients required oxygen support: 8 (2%) were started on continuous positive airway pressure (CPAP) and 29 (7%) on mechanical ventilation. 35 (8.5%) patients required inotropic support. The following factors were associated with PICU admission: pre-existing medical condition (P < 0.0001), immunodeficiency (P = 0.01), lower respiratory tract infection (P< 0.0001), gastrointestinal symptoms (P = 0.006), radiological changes suggestive of pneumonia and acute respiratory distress syndrome (P< 0.0001), low socioeconomic conditions (P 0.009). Conclusions This study shows a generally more severe form of COVID 19 and a high number of MIS C in Latin American children, compared with studies from China, Europe and North America, and support current evidence of a more severe disease in Latin/Hyspanic children or in people of lower socioeconomic level. The findings highlight an urgent need of more data of COVID 19 in South America.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.08.29.20184242
    Database COVID19

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  6. Article ; Online: New insights into the genetic etiology of Alzheimer's disease and related dementias.

    Bellenguez, Céline / Küçükali, Fahri / Jansen, Iris E / Kleineidam, Luca / Moreno-Grau, Sonia / Amin, Najaf / Naj, Adam C / Campos-Martin, Rafael / Grenier-Boley, Benjamin / Andrade, Victor / Holmans, Peter A / Boland, Anne / Damotte, Vincent / van der Lee, Sven J / Costa, Marcos R / Kuulasmaa, Teemu / Yang, Qiong / de Rojas, Itziar / Bis, Joshua C /
    Yaqub, Amber / Prokic, Ivana / Chapuis, Julien / Ahmad, Shahzad / Giedraitis, Vilmantas / Aarsland, Dag / Garcia-Gonzalez, Pablo / Abdelnour, Carla / Alarcón-Martín, Emilio / Alcolea, Daniel / Alegret, Montserrat / Alvarez, Ignacio / Álvarez, Victoria / Armstrong, Nicola J / Tsolaki, Anthoula / Antúnez, Carmen / Appollonio, Ildebrando / Arcaro, Marina / Archetti, Silvana / Pastor, Alfonso Arias / Arosio, Beatrice / Athanasiu, Lavinia / Bailly, Henri / Banaj, Nerisa / Baquero, Miquel / Barral, Sandra / Beiser, Alexa / Pastor, Ana Belén / Below, Jennifer E / Benchek, Penelope / Benussi, Luisa / Berr, Claudine / Besse, Céline / Bessi, Valentina / Binetti, Giuliano / Bizarro, Alessandra / Blesa, Rafael / Boada, Mercè / Boerwinkle, Eric / Borroni, Barbara / Boschi, Silvia / Bossù, Paola / Bråthen, Geir / Bressler, Jan / Bresner, Catherine / Brodaty, Henry / Brookes, Keeley J / Brusco, Luis Ignacio / Buiza-Rueda, Dolores / Bûrger, Katharina / Burholt, Vanessa / Bush, William S / Calero, Miguel / Cantwell, Laura B / Chene, Geneviève / Chung, Jaeyoon / Cuccaro, Michael L / Carracedo, Ángel / Cecchetti, Roberta / Cervera-Carles, Laura / Charbonnier, Camille / Chen, Hung-Hsin / Chillotti, Caterina / Ciccone, Simona / Claassen, Jurgen A H R / Clark, Christopher / Conti, Elisa / Corma-Gómez, Anaïs / Costantini, Emanuele / Custodero, Carlo / Daian, Delphine / Dalmasso, Maria Carolina / Daniele, Antonio / Dardiotis, Efthimios / Dartigues, Jean-François / de Deyn, Peter Paul / de Paiva Lopes, Katia / de Witte, Lot D / Debette, Stéphanie / Deckert, Jürgen / Del Ser, Teodoro / Denning, Nicola / DeStefano, Anita / Dichgans, Martin / Diehl-Schmid, Janine / Diez-Fairen, Mónica / Rossi, Paolo Dionigi / Djurovic, Srdjan / Duron, Emmanuelle / Düzel, Emrah / Dufouil, Carole / Eiriksdottir, Gudny / Engelborghs, Sebastiaan / Escott-Price, Valentina / Espinosa, Ana / Ewers, Michael / Faber, Kelley M / Fabrizio, Tagliavini / Nielsen, Sune Fallgaard / Fardo, David W / Farotti, Lucia / Fenoglio, Chiara / Fernández-Fuertes, Marta / Ferrari, Raffaele / Ferreira, Catarina B / Ferri, Evelyn / Fin, Bertrand / Fischer, Peter / Fladby, Tormod / Fließbach, Klaus / Fongang, Bernard / Fornage, Myriam / Fortea, Juan / Foroud, Tatiana M / Fostinelli, Silvia / Fox, Nick C / Franco-Macías, Emlio / Bullido, María J / Frank-García, Ana / Froelich, Lutz / Fulton-Howard, Brian / Galimberti, Daniela / García-Alberca, Jose Maria / García-González, Pablo / Garcia-Madrona, Sebastian / Garcia-Ribas, Guillermo / Ghidoni, Roberta / Giegling, Ina / Giorgio, Giaccone / Goate, Alison M / Goldhardt, Oliver / Gomez-Fonseca, Duber / González-Pérez, Antonio / Graff, Caroline / Grande, Giulia / Green, Emma / Grimmer, Timo / Grünblatt, Edna / Grunin, Michelle / Gudnason, Vilmundur / Guetta-Baranes, Tamar / Haapasalo, Annakaisa / Hadjigeorgiou, Georgios / Haines, Jonathan L / Hamilton-Nelson, Kara L / Hampel, Harald / Hanon, Olivier / Hardy, John / Hartmann, Annette M / Hausner, Lucrezia / Harwood, Janet / Heilmann-Heimbach, Stefanie / Helisalmi, Seppo / Heneka, Michael T / Hernández, Isabel / Herrmann, Martin J / Hoffmann, Per / Holmes, Clive / Holstege, Henne / Vilas, Raquel Huerto / Hulsman, Marc / Humphrey, Jack / Biessels, Geert Jan / Jian, Xueqiu / Johansson, Charlotte / Jun, Gyungah R / Kastumata, Yuriko / Kauwe, John / Kehoe, Patrick G / Kilander, Lena / Ståhlbom, Anne Kinhult / Kivipelto, Miia / Koivisto, Anne / Kornhuber, Johannes / Kosmidis, Mary H / Kukull, Walter A / Kuksa, Pavel P / Kunkle, Brian W / Kuzma, Amanda B / Lage, Carmen / Laukka, Erika J / Launer, Lenore / Lauria, Alessandra / Lee, Chien-Yueh / Lehtisalo, Jenni / Lerch, Ondrej / Lleó, Alberto / Longstreth, William / Lopez, Oscar / de Munain, Adolfo Lopez / Love, Seth / Löwemark, Malin / Luckcuck, Lauren / Lunetta, Kathryn L / Ma, Yiyi / Macías, Juan / MacLeod, Catherine A / Maier, Wolfgang / Mangialasche, Francesca / Spallazzi, Marco / Marquié, Marta / Marshall, Rachel / Martin, Eden R / Montes, Angel Martín / Rodríguez, Carmen Martínez / Masullo, Carlo / Mayeux, Richard / Mead, Simon / Mecocci, Patrizia / Medina, Miguel / Meggy, Alun / Mehrabian, Shima / Mendoza, Silvia / Menéndez-González, Manuel / Mir, Pablo / Moebus, Susanne / Mol, Merel / Molina-Porcel, Laura / Montrreal, Laura / Morelli, Laura / Moreno, Fermin / Morgan, Kevin / Mosley, Thomas / Nöthen, Markus M / Muchnik, Carolina / Mukherjee, Shubhabrata / Nacmias, Benedetta / Ngandu, Tiia / Nicolas, Gael / Nordestgaard, Børge G / Olaso, Robert / Orellana, Adelina / Orsini, Michela / Ortega, Gemma / Padovani, Alessandro / Paolo, Caffarra / Papenberg, Goran / Parnetti, Lucilla / Pasquier, Florence / Pastor, Pau / Peloso, Gina / Pérez-Cordón, Alba / Pérez-Tur, Jordi / Pericard, Pierre / Peters, Oliver / Pijnenburg, Yolande A L / Pineda, Juan A / Piñol-Ripoll, Gerard / Pisanu, Claudia / Polak, Thomas / Popp, Julius / Posthuma, Danielle / Priller, Josef / Puerta, Raquel / Quenez, Olivier / Quintela, Inés / Thomassen, Jesper Qvist / Rábano, Alberto / Rainero, Innocenzo / Rajabli, Farid / Ramakers, Inez / Real, Luis M / Reinders, Marcel J T / Reitz, Christiane / Reyes-Dumeyer, Dolly / Ridge, Perry / Riedel-Heller, Steffi / Riederer, Peter / Roberto, Natalia / Rodriguez-Rodriguez, Eloy / Rongve, Arvid / Allende, Irene Rosas / Rosende-Roca, Maitée / Royo, Jose Luis / Rubino, Elisa / Rujescu, Dan / Sáez, María Eugenia / Sakka, Paraskevi / Saltvedt, Ingvild / Sanabria, Ángela / Sánchez-Arjona, María Bernal / Sanchez-Garcia, Florentino / Juan, Pascual Sánchez / Sánchez-Valle, Raquel / Sando, Sigrid B / Sarnowski, Chloé / Satizabal, Claudia L / Scamosci, Michela / Scarmeas, Nikolaos / Scarpini, Elio / Scheltens, Philip / Scherbaum, Norbert / Scherer, Martin / Schmid, Matthias / Schneider, Anja / Schott, Jonathan M / Selbæk, Geir / Seripa, Davide / Serrano, Manuel / Sha, Jin / Shadrin, Alexey A / Skrobot, Olivia / Slifer, Susan / Snijders, Gijsje J L / Soininen, Hilkka / Solfrizzi, Vincenzo / Solomon, Alina / Song, Yeunjoo / Sorbi, Sandro / Sotolongo-Grau, Oscar / Spalletta, Gianfranco / Spottke, Annika / Squassina, Alessio / Stordal, Eystein / Tartan, Juan Pablo / Tárraga, Lluís / Tesí, Niccolo / Thalamuthu, Anbupalam / Thomas, Tegos / Tosto, Giuseppe / Traykov, Latchezar / Tremolizzo, Lucio / Tybjærg-Hansen, Anne / Uitterlinden, Andre / Ullgren, Abbe / Ulstein, Ingun / Valero, Sergi / Valladares, Otto / Broeckhoven, Christine Van / Vance, Jeffery / Vardarajan, Badri N / van der Lugt, Aad / Dongen, Jasper Van / van Rooij, Jeroen / van Swieten, John / Vandenberghe, Rik / Verhey, Frans / Vidal, Jean-Sébastien / Vogelgsang, Jonathan / Vyhnalek, Martin / Wagner, Michael / Wallon, David / Wang, Li-San / Wang, Ruiqi / Weinhold, Leonie / Wiltfang, Jens / Windle, Gill / Woods, Bob / Yannakoulia, Mary / Zare, Habil / Zhao, Yi / Zhang, Xiaoling / Zhu, Congcong / Zulaica, Miren / Farrer, Lindsay A / Psaty, Bruce M / Ghanbari, Mohsen / Raj, Towfique / Sachdev, Perminder / Mather, Karen / Jessen, Frank / Ikram, M Arfan / de Mendonça, Alexandre / Hort, Jakub / Tsolaki, Magda / Pericak-Vance, Margaret A / Amouyel, Philippe / Williams, Julie / Frikke-Schmidt, Ruth / Clarimon, Jordi / Deleuze, Jean-François / Rossi, Giacomina / Seshadri, Sudha / Andreassen, Ole A / Ingelsson, Martin / Hiltunen, Mikko / Sleegers, Kristel / Schellenberg, Gerard D / van Duijn, Cornelia M / Sims, Rebecca / van der Flier, Wiesje M / Ruiz, Agustín / Ramirez, Alfredo / Lambert, Jean-Charles

    Nature genetics

    2022  Volume 54, Issue 4, Page(s) 412–436

    Abstract: Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association ... ...

    Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
    MeSH term(s) Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Cognitive Dysfunction/psychology ; Genome-Wide Association Study ; Humans ; tau Proteins/genetics
    Chemical Substances tau Proteins
    Language English
    Publishing date 2022-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-022-01024-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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