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Article ; Online: Airborne allergic contact dermatitis caused by artichoke.

Samaran, Quentin / Clark, Evangeline / Dereure, Olivier / Sparsa, Agnès / Du-Thanh, Aurélie / Raison-Peyron, Nadia

2020 Volume 82, Issue 6, Page(s) 395–397

MeSH term(s)	Adult ; Aged ; Cynara scolymus/adverse effects ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Allergic Contact/etiology ; Facial Dermatoses/diagnosis ; Facial Dermatoses/etiology ; Female ; Humans ; Male ; Patch Tests
Language	English
Publishing date	2020-02-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.13480
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Zs.A 1116: Show issues

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Article ; Online: Early neurosyphilis with etanercept treatment.

Assikar, Safae / Doffoel-Hantz, Valérie / Sparsa, Agnès / Bonnetblanc, Jean-Marie

European journal of dermatology : EJD

2013 Volume 23, Issue 6, Page(s) 901–902

MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Etanercept ; Humans ; Immunoglobulin G/adverse effects ; Male ; Middle Aged ; Neurosyphilis/chemically induced ; Neurosyphilis/diagnosis ; Receptors, Tumor Necrosis Factor ; Spondylitis, Ankylosing/drug therapy
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Immunoglobulin G ; Receptors, Tumor Necrosis Factor ; Etanercept (OP401G7OJC)
Language	English
Publishing date	2013-11
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2013.2181
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Zs.A 3484: Show issues

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Article ; Online: Therapeutic alliance is associated to treatment adherence in children with juvenile idiopathic arthritis.

Lohse, Anne / Lemelle, Irène / Pillet, Pascal / Duquesne, Agnès / Ballot, Claire / Tran, Tu-Anh / Sparsa, Laetitia / Goumy, Laurence / Reumaux, Héloïse / Rossi, Linda / Solau-Gervais, Elisabeth / Arbault, Anais / Alleyrat, Camille / Guillemin, Francis / Devauchelle-Pensec, Valérie

Joint bone spine

2021 Volume 88, Issue 4, Page(s) 105151

Abstract: Objectives: Therapeutic alliance (TA) is the agreement between caregiver and patient during the care process. Therapeutic adherence is a major issue for the management of Juvenile Idiopathic Arthritis (JIA) requiring child's strong ability to follow ... ...

Abstract	Objectives: Therapeutic alliance (TA) is the agreement between caregiver and patient during the care process. Therapeutic adherence is a major issue for the management of Juvenile Idiopathic Arthritis (JIA) requiring child's strong ability to follow treatments. The aim of this study was to evaluate the relationship between TA and adherence in patients with JIA. Methods: Observational, cross-sectional, multicenter study. Children, with JIA, aged 8-16, were included. Children, parents and physicians completed the Helping Alliance Questionnaire (HAQ-CP) for assessing TA. Adherence was measured using the Child/Parent Adherence Report Questionnaire (CARQ & PARQ). Demographic data, disease characteristics, current treatments and social environment were collected. The univariate relationship between TA and adherence, was studied by Pearson correlation coefficient. The multivariate analysis used a multiple linear regression model. Results: A total of 119 patients were included: 68.9% girls, mean age (SD) 12.4 (2.9) years, disease duration 73.1 (48.2) months. JIA was in remission (52%), in low activity (32%) and active (16%). TA scores were high (≥80/100) for children, parents and physicians. HAQCP was highly correlated with CARQ (r=0.31; P<0.001) PARQ (r=0.37; P<0.001). In univariate analysis, disease activity (P<0.05), place of residence (P<0.01) and family status (P<0.01) were associated with child's TA. In multivariate analysis, only the place of residence (P<0.001) and the family status (P<0.05) remained associated with TA. Conclusion: TA strongly influences therapeutic adherence and therefore may be important for treatment effectiveness.
MeSH term(s)	Adolescent ; Arthritis, Juvenile/diagnosis ; Arthritis, Juvenile/drug therapy ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Surveys and Questionnaires ; Therapeutic Alliance ; Treatment Adherence and Compliance
Language	English
Publishing date	2021-02-06
Publishing country	France
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2021.105151
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Zs.A 4590: Show issues

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Article ; Online: Unusual cutaneous manifestations of late Lyme borreliosis.

Rigot, Emilie / Hantz, Valerie Doffoel / Labrousse, François / Martin, Christian / Dubos, Maria / Assikar, Safae / Sparsa, Agnès / Bonnetblanc, Jean-Marie / Bedane, Christophe

European journal of dermatology : EJD

2015 Volume 25, Issue 3, Page(s) 277–279

MeSH term(s)	Acrodermatitis/microbiology ; Acrodermatitis/pathology ; Aged ; Anetoderma/microbiology ; Anetoderma/pathology ; Female ; Humans ; Lyme Disease/pathology ; Male ; Middle Aged ; Skin/pathology
Language	English
Publishing date	2015-05
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2015.2536
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Article ; Online: Facial purpura associated with Capnocytophaga canimorsus septicaemia; role of sunlight?

Kennel, Céline / Barraud, Olivier / Lapebie, François-Xavier / Sparsa, Agnes / Duvoid, Tiffany / Chapellas, Catherine / Hidri, Nadia / Francois, Bruno

European journal of dermatology : EJD

2013 Volume 23, Issue 3, Page(s) 427–428

MeSH term(s)	Capnocytophaga ; Facial Dermatoses/microbiology ; Gram-Negative Bacterial Infections/etiology ; Humans ; Male ; Middle Aged ; Purpura Fulminans/microbiology ; Sepsis/etiology ; Sunlight/adverse effects
Language	English
Publishing date	2013-05
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2013.2032
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Article: Aldolase levels in dermatomyositis and polymyositis with normal creatine kinase levels.

Liozon, Eric / Vidal, Elisabeth / Sparsa, Agnes

The Journal of rheumatology

2003 Volume 30, Issue 9, Page(s) 2077–8; author repliies 2078

MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Cohort Studies ; Creatine Kinase/blood ; Dermatomyositis/diagnosis ; Dermatomyositis/enzymology ; Female ; Fructose-Bisphosphate Aldolase/blood ; Humans ; Male ; Middle Aged ; Polymyositis/diagnosis ; Polymyositis/enzymology ; Prognosis ; Retrospective Studies ; Sensitivity and Specificity ; Severity of Illness Index
Chemical Substances	Biomarkers ; Creatine Kinase (EC 2.7.3.2) ; Fructose-Bisphosphate Aldolase (EC 4.1.2.13)
Language	English
Publishing date	2003-09
Publishing country	Canada
Document type	Comment ; Comparative Study ; Letter
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 135: Show issues

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Article ; Online: Photodynamic therapy can improve warts' discomfort in renal transplant patients prospective multicenter study.

Sparsa, Agnès / Blaise, Sophie / Tack, Brigitte / Dalmay, François / Leroy, Dominique / Bonnetblanc, Jean-Marie / Béani, Jean-Claude / Bédane, Christophe

Photochemistry and photobiology

2012 Volume 88, Issue 4, Page(s) 1023–1026

Abstract: Many studies have been conducted showing that aminolevulinic acid (ALA)-photodynamic therapy (PDT) can be an alternative treatment for recalcitrant warts. Recently, we performed a study evaluating methyl-aminolevulinic acid (MAL)-PDT for the treatment of ...

Abstract	Many studies have been conducted showing that aminolevulinic acid (ALA)-photodynamic therapy (PDT) can be an alternative treatment for recalcitrant warts. Recently, we performed a study evaluating methyl-aminolevulinic acid (MAL)-PDT for the treatment of hand warts in a population of renal transplant patients. Two symmetrical targets were selected on each hand and randomly assigned to chemical keratolytic treatment followed by three cycles of ALA-PDT (75 J cm(-2) red light). Patients were evaluated after 3 months and a second run of PDT was performed if the total area and number of warts decreased less than 50%, with evaluation every 3 months for 1 year. Twenty patients were included and 16 were evaluable (9 M, 7 F). After 6 months the reduction of warts' area was 48.4% on the treated side versus 18.4% in the control area (P = 0.021). The decrease in the total number of warts was 41%versus 19.4% (P = NS). The global tolerance of the treatment was good with acceptable pain during irradiation. These results suggest that ALA-PDT is a safe and efficient treatment for transplanted patient warts. The improvement between treated and control zone is 20% due to the decrease in untreated warts' area and number.
MeSH term(s)	Adult ; Aminolevulinic Acid/administration & dosage ; Aminolevulinic Acid/analogs & derivatives ; Female ; Hand/virology ; Humans ; Immunocompromised Host ; Kidney Transplantation/immunology ; Light ; Male ; Middle Aged ; Photochemotherapy ; Photosensitizing Agents/administration & dosage ; Prospective Studies ; Treatment Outcome ; Warts/drug therapy ; Warts/immunology ; Warts/virology
Chemical Substances	Photosensitizing Agents ; methyl 5-aminolevulinate (585NM85KYM) ; Aminolevulinic Acid (88755TAZ87)
Language	English
Publishing date	2012-07
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	123540-0
ISSN	1751-1097 ; 0031-8655
ISSN (online)	1751-1097
ISSN	0031-8655
DOI	10.1111/j.1751-1097.2012.01114.x
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Zs.B 1686: Show issues

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Article ; Online: Photodynamic treatment induces cell death by apoptosis or autophagy depending on the melanin content in two B16 melanoma cell lines.

Sparsa, Agnès / Bellaton, Solenn / Naves, Thomas / Jauberteau, Marie-Odile / Bonnetblanc, Jean-Marie / Sol, Vincent / Verdier, Mireille / Ratinaud, Marie-Hélène

Oncology reports

2012 Volume 29, Issue 3, Page(s) 1196–1200

Abstract: Photodynamic therapy (PDT) is now a well-established treatment modality for cutaneous carcinomas and is based on the administration of a light-activated drug followed by illumination of the pathological area. The treatment of ... ...

Abstract	Photodynamic therapy (PDT) is now a well-established treatment modality for cutaneous carcinomas and is based on the administration of a light-activated drug followed by illumination of the pathological area. The treatment of metastatic melanoma remains a therapeutic challenge. To define the possible role of melanin in relative phototoxicity of 5-aminolevulinic acid (5-ALA), a photosensitizer used in PDT in vivo, we studied cell death in two variants (with or without melanin, B16F10 and B16G4F cells, respectively) of a melanoma cell line. Concentrations of 5-Ala up to 10 mM induced similar cytostatic effects in the B16G4F and B16F10 cells. PDT and high 5-ALA concentrations induced photocytotoxicity in both melanoma cell lines (at 10 mM for B16F10 cells and at 5 mM for B16G4F cells). Cell death corresponded to p53-dependent apoptotic signaling in pigmented B16F10 cells, whereas an autophagic response leading to a caspase-independent death was detected in non-pigmented B16G4F cells. Therefore, the PDT-induced cell death pathway appeared to correlate with melanin synthesis capacity in melanoma cells. To reduce the cytotoxicity of 5-ALA without irradiation, a low drug concentration could be used. Consequently, in combination with current therapeutics, a moderate concentration of 5-ALA and PDT may constitute a supplementary promising approach to eliminate metastatic melanoma.
MeSH term(s)	Aminolevulinic Acid/pharmacology ; Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/metabolism ; Autophagy/drug effects ; Beclin-1 ; Caspases/metabolism ; Cathepsin B/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Melanins/metabolism ; Melanoma, Experimental ; Mice ; Microtubule-Associated Proteins/metabolism ; Photochemotherapy ; Photosensitizing Agents/pharmacology ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Apoptosis Regulatory Proteins ; Beclin-1 ; Becn1 protein, mouse ; Map1lc3b protein, mouse ; Melanins ; Microtubule-Associated Proteins ; PUMA protein, mouse ; Photosensitizing Agents ; Tumor Suppressor Protein p53 ; Tumor Suppressor Proteins ; Aminolevulinic Acid (88755TAZ87) ; Caspases (EC 3.4.22.-) ; Cathepsin B (EC 3.4.22.1) ; Ctsb protein, mouse (EC 3.4.22.1)
Language	English
Publishing date	2012-12-14
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2012.2190
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Zs.A 4213: Show issues

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Article ; Online: Controlling the digital ulcerative disease in systemic sclerosis is associated with improved hand function.

Mouthon, Luc / Carpentier, Patrick H / Lok, Catherine / Clerson, Pierre / Gressin, Virginie / Hachulla, Eric / Bérezné, Alice / Diot, Elisabeth / Van Kien, Aurélie Khau / Jego, Patrick / Agard, Christian / Duval-Modeste, Anne-Bénédicte / Sparsa, Agnès / Puzenat, Eve / Richard, Marie-Aleth

Seminars in arthritis and rheumatism

2017 Volume 46, Issue 6, Page(s) 759–766

Abstract: Objectives: Ischemic digital ulcers (DU) represent a major complication of systemic sclerosis (SSc). We investigated the impact of controlling the ulcerative disease on disability, pain, and quality of life in SSc patients receiving bosentan.: Methods! ...

Abstract	Objectives: Ischemic digital ulcers (DU) represent a major complication of systemic sclerosis (SSc). We investigated the impact of controlling the ulcerative disease on disability, pain, and quality of life in SSc patients receiving bosentan. Methods: ECLIPSE (Study AC-052-517) is a 2-year prospective, multicenter, and observational study. Patients with SSc who experienced at least 1 DU in the previous year and received bosentan were included between October 2009 and March 2011. Disability scores [Cochin Hand Function Scale (CHFS) and Health Assessment Questionnaire Disability Index (HAQ-DI)], pain scores (visual analog scale), and quality-of-life scores (SF-36) were collected at inclusion and 1 year later (primary endpoint). A controlled ulcerative disease was defined by the absence of ongoing/new DU episode between inclusion and 1-year follow-up. Results: Data were available at 1 year for 120 patients out of 190 included. During follow-up, 46 (38.3%) patients experienced a new DU episode. The number of DU per patient decreased from 1.4 ± 1.8 at inclusion to 0.6 ± 1.6 (p < 0.0001) at 1 year. Disability scores decreased from 1.0 ± 0.7 to 0.9 ± 0.7 (p = 0.04) for the HAQ-DI and from 29 ± 20 to 25 ± 20 (p = 0.005) for the CHFS; the pain score decreased from 4.3 ± 3.1 to 2.9 ± 2.8 (p < 0.0001). This improvement was attributed to patients with a controlled ulcerative disease (48.3%), who significantly improved HAQ-DI (p = 0.04), CHFS (p = 0.04), and pain score (p = 0.046). Conclusions: In patients with SSc, control of the ulcerative disease for 1 year was associated with significant attenuation of hand disability.
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	120247-9
ISSN	1532-866X ; 0049-0172
ISSN (online)	1532-866X
ISSN	0049-0172
DOI	10.1016/j.semarthrit.2017.01.001
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Zs.A 790: Show issues

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Article: Lymphoedema: a rare complication of inflammatory rheumatism. Successful treatment with etanercept.

Doffoël-Hantz, Valérie / Sparsa, Agnès / Verbeke, Sandrine / Tricard, Marie-Jeanne / Bonnetblanc, Jean-Marie / Bédane, Christophe

European journal of dermatology : EJD

2007 Volume 17, Issue 4, Page(s) 337–338

MeSH term(s)	Etanercept ; Humans ; Immunoglobulin G/therapeutic use ; Inflammation/complications ; Lymphedema/drug therapy ; Lymphedema/etiology ; Male ; Middle Aged ; Receptors, Tumor Necrosis Factor/therapeutic use ; Remission Induction ; Rheumatic Diseases/complications ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Chemical Substances	Immunoglobulin G ; Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factor-alpha ; Etanercept (OP401G7OJC)
Language	English
Publishing date	2007-07
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2007.0213
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