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Article ; Online: Extracellular vesicle-mediated transfer of miRNA-1 from primary tumors represses the growth of distant metastases.

Kim, Chae-Yi / Lee, Kang-Hoon / Son, Keun Hong / Shin, Tae-Jin / Cho, Je-Yoel

2024 Volume 56, Issue 3, Page(s) 734–746

Abstract: Metastases originate from primary tumors and reach distant organs. Growing evidence suggests that metastases are under the control of primary tumors even outside the primary site; however, the mechanisms by which primary tumors remotely control ... ...

Abstract	Metastases originate from primary tumors and reach distant organs. Growing evidence suggests that metastases are under the control of primary tumors even outside the primary site; however, the mechanisms by which primary tumors remotely control metastases remain unclear. Here, we discovered a molecular mechanism by which primary tumors suppress metastatic growth. Interestingly, we found that extracellular vesicles (EVs) derived from the primary tumor can inhibit the growth of metastases both in vitro and in vivo. miR-1 was particularly enriched in primary tumor-derived EVs (pTDEs) and was found to be responsible for the suppression of metastatic growth. Mechanistically, intracellular reactive oxygen species (ROS) production and DNA damage were induced, which led to cell cycle arrest. Collectively, our data demonstrate that primary tumors restrict the growth of distant metastases via miR-1 in pTDEs and that miR-1 could potentially be used as an antimetastatic agent.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Extracellular Vesicles/metabolism ; Neoplasms/metabolism
Chemical Substances	MicroRNAs
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-024-01181-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photoluminescence enhancement in quantum-dot-polymer films with CO

Zhang, Yi / Yoo, Jae-In / Kim, Hyo-Bin / Kim, Kang-Hoon / Kang, Sung-Cheon / Choi, Eun-Young / Parani, Sundararajan / Song, Jang-Kun

Journal of colloid and interface science

2023 Volume 649, Page(s) 132–139

Abstract: Quantum-dot (QDs) polymer composite films, which are key components in recent display applications, require improved photoluminescence (PL) intensity and color conversion efficiency for better display quality and low power consumption. In this study, we ... ...

Abstract	Quantum-dot (QDs) polymer composite films, which are key components in recent display applications, require improved photoluminescence (PL) intensity and color conversion efficiency for better display quality and low power consumption. In this study, we developed a novel approach to improve the photoluminescence (PL) of quantum dot (QDs)-polymer nanocomposite films. This was achieved by incorporating CO
Language	English
Publishing date	2023-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.06.093
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Article: A Comprehensive Analysis of Potential Complications after OLIF : A Review of Postoperative Magnetic Resonance Scans in Over 400 Cases.

Lee, Kang-Hoon / Lee, Su-Hun / Lee, Jun-Seok / Kim, Young-Ha / Sung, Soon-Ki / Son, Dong-Wuk / Lee, Sang-Weon / Song, Geun-Sung

Journal of Korean Neurosurgical Society

2024

Abstract: Objective: This study focuses on identifying potential complications following oblique lumbar interbody fusion (OLIF) through routine magnetic resonance (MR) scans.: Methods: From 650 patients who underwent OLIF from April 2018 to April 2022, this ... ...

Abstract	Objective: This study focuses on identifying potential complications following oblique lumbar interbody fusion (OLIF) through routine magnetic resonance (MR) scans. Methods: From 650 patients who underwent OLIF from April 2018 to April 2022, this study included those with MR scans taken one-week post-operatively, and only for indirect decompression patients. The analysis evaluated postoperative MR images for hematoma, cage insertion angles, and indirect decompression efficiency. Patient demographics, post-operatively symptoms, and complications were also evaluated. Results: Out of 401 patients enrolled, most underwent 1- or 2-level OLIF. Common findings included approach site hematoma (65.3%) and contralateral psoas hematoma (19%). The caudal level OLIF was related with less orthogonality and deep insertion of cage. Incomplete indirect decompression occurred in 4.66% of cases but did not require additional surgery. Rare but symptomatic complications included remnant disc rupture (4 cases, 1%) and synovial cyst rupture (4 cases, 1%). Conclusion: This study has identified potential complications associated with OLIF, including approach site hematoma, contralateral psoas hematoma, cage malposition risk at caudal levels, and radiologically insufficient indirect decompression. Additionally, it highlights rare, yet symptomatic complications such as remnant disc rupture and synovial cyst rupture. These findings contribute insights into the relatively under-explored area of OLIF complications.
Language	English
Publishing date	2024-02-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2253817-3
ISSN	1598-7876 ; 2005-3711 ; 1225-8245
ISSN (online)	1598-7876
ISSN	2005-3711 ; 1225-8245
DOI	10.3340/jkns.2023.0238
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Article ; Online: CXCL5 inhibits excessive oxidative stress by regulating white adipocyte differentiation

Dabin Lee / Kang-Hoon Lee / Dong Wook Kim / Sanghyuk Yoon / Je-Yoel Cho

Redox Biology, Vol 54, Iss , Pp 102359- (2022)

2022

Abstract: Chemokines have been well-documented as a major factor in immune cell migration and the regulation of immune responses. However, recent studies have reported that chemokines have diverse roles, both in immune cells and other cell types, including ... ...

Abstract	Chemokines have been well-documented as a major factor in immune cell migration and the regulation of immune responses. However, recent studies have reported that chemokines have diverse roles, both in immune cells and other cell types, including adipocytes. This study investigated the molecular functions of C-X-C motif chemokine ligand 5 (CXCL5) in white adipose cells using Cxcl5 knock-out (KO) mice fed a high-fat diet (HFD). The expression of Cxcl5 decreased by 90% during adipocyte differentiation and remained at a low level in mature adipocytes. Moreover, adipogenesis was enhanced when adipocytes were differentiated from the stromal vascular fraction (SFV) of Cxcl5 KO mice. Feeding an HFD increased the generation of reactive oxygen species (ROS) and promoted abnormal adipogenesis in Cxcl5 KO mice. Oxidative stress and insulin resistance occurred in Cxcl5 KO mice due to decreased antioxidant enzymes and failure to remove ROS. These results indicate the principal roles of CXCL5 in adipogenesis and ROS regulation in adipose tissue, further suggesting that CXCL5 is a valuable chemokine for metabolic disease research.
Keywords	Chemokine ; CXCL5 ; KO mice ; Fat cell ; Adipogenesis ; Oxidative stress ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: METTL8 mRNA Methyltransferase Enhances Cancer Cell Migration via Direct Binding to ARID1A.

Lee, Shin-Ae / Lee, Kang-Hoon / Kim, Huisu / Cho, Je-Yoel

International journal of molecular sciences

2021 Volume 22, Issue 11

Abstract: The association of RNA modification in cancer has recently been highlighted. Methyltransferase like 8 (METTL8) is an enzyme and its role in mRNA m3C modification has barely been studied. In this study, we found that METTL8 expression was significantly up- ...

Abstract	The association of RNA modification in cancer has recently been highlighted. Methyltransferase like 8 (METTL8) is an enzyme and its role in mRNA m3C modification has barely been studied. In this study, we found that METTL8 expression was significantly up-regulated in canine mammary tumor and investigated its functional roles in the tumor process, including cancer cell proliferation and migration. METTL8 expression was up-regulated in most human breast cancer cell lines tested and decreased by Yin Yang 1 (YY1) transcription factor knockdown, suggesting that YY1 is a regulating transcription factor. The knockdown of METTL8 attenuated tumor cell growth and strongly blocked tumor cell migration. AT-rich interactive domain-containing protein 1A (ARID1A) was identified as a candidate mRNA by METTL8. ARID1A mRNA binds to METTL8 protein. ARID1A mRNA expression was not changed by METTL8 knockdown, but ARID1A protein level was significantly increased. Collectively, our study indicates that METTL8 up-regulated by YY1 in breast cancer plays an important role in cancer cell migration through the mRNA modification of ARID1A, resulting in the attenuation of its translation.
MeSH term(s)	Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; DNA-Binding Proteins/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; MCF-7 Cells ; Methyltransferases/genetics ; RNA, Messenger/genetics ; Transcription Factors/genetics ; Up-Regulation/genetics ; YY1 Transcription Factor/genetics
Chemical Substances	ARID1A protein, human ; DNA-Binding Proteins ; RNA, Messenger ; Transcription Factors ; YY1 Transcription Factor ; Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2021-05-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22115432
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CXCL5 inhibits excessive oxidative stress by regulating white adipocyte differentiation.

Lee, Dabin / Lee, Kang-Hoon / Kim, Dong Wook / Yoon, Sanghyuk / Cho, Je-Yoel

Redox biology

2022 Volume 54, Page(s) 102359

Abstract	Chemokines have been well-documented as a major factor in immune cell migration and the regulation of immune responses. However, recent studies have reported that chemokines have diverse roles, both in immune cells and other cell types, including adipocytes. This study investigated the molecular functions of C-X-C motif chemokine ligand 5 (CXCL5) in white adipose cells using Cxcl5 knock-out (KO) mice fed a high-fat diet (HFD). The expression of Cxcl5 decreased by 90% during adipocyte differentiation and remained at a low level in mature adipocytes. Moreover, adipogenesis was enhanced when adipocytes were differentiated from the stromal vascular fraction (SFV) of Cxcl5 KO mice. Feeding an HFD increased the generation of reactive oxygen species (ROS) and promoted abnormal adipogenesis in Cxcl5 KO mice. Oxidative stress and insulin resistance occurred in Cxcl5 KO mice due to decreased antioxidant enzymes and failure to remove ROS. These results indicate the principal roles of CXCL5 in adipogenesis and ROS regulation in adipose tissue, further suggesting that CXCL5 is a valuable chemokine for metabolic disease research.
MeSH term(s)	Adipocytes, White/physiology ; Adipogenesis ; Animals ; Cell Differentiation ; Chemokine CXCL5/physiology ; Diet, High-Fat ; Fatty Acids/metabolism ; Insulin Resistance ; Mice, Knockout ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species ; Mice
Chemical Substances	Chemokine CXCL5 ; Cxcl5 protein, mouse ; Fatty Acids ; Reactive Oxygen Species
Language	English
Publishing date	2022-06-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2022.102359
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The landscape of PBMC methylome in canine mammary tumors reveals the epigenetic regulation of immune marker genes and its potential application in predicting tumor malignancy.

Nam, A-Reum / Heo, Min / Lee, Kang-Hoon / Kim, Ji-Yoon / Won, Sung-Ho / Cho, Je-Yoel

BMC genomics

2023 Volume 24, Issue 1, Page(s) 403

Abstract: Background: Genome-wide dysregulation of CpG methylation accompanies tumor progression and characteristic states of cancer cells, prompting a rationale for biomarker development. Understanding how the archetypic epigenetic modification determines ... ...

Abstract	Background: Genome-wide dysregulation of CpG methylation accompanies tumor progression and characteristic states of cancer cells, prompting a rationale for biomarker development. Understanding how the archetypic epigenetic modification determines systemic contributions of immune cell types is the key to further clinical benefits. Results: In this study, we characterized the differential DNA methylome landscapes of peripheral blood mononuclear cells (PBMCs) from 76 canines using methylated CpG-binding domain sequencing (MBD-seq). Through gene set enrichment analysis, we discovered that genes involved in the growth and differentiation of T- and B-cells are highly methylated in tumor PBMCs. We also revealed the increased methylation at single CpG resolution and reversed expression in representative marker genes regulating immune cell proliferation (BACH2, SH2D1A, TXK, UHRF1). Furthermore, we utilized the PBMC methylome to effectively differentiate between benign and malignant tumors and the presence of mammary gland tumors through a machine-learning approach. Conclusions: This research contributes to a better knowledge of the comprehensive epigenetic regulation of circulating immune cells responding to tumors and suggests a new framework for identifying benign and malignant cancers using genome-wide methylome.
MeSH term(s)	Animals ; Dogs ; Epigenesis, Genetic ; DNA Methylation ; Epigenome ; Leukocytes, Mononuclear/metabolism ; Neoplasms/genetics ; Biomarkers/metabolism ; CpG Islands
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09471-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photoluminescence enhancement in quantum-dot-polymer films with CO2 micropores through KHCO3 decomposition

Zhang, Yi / Yoo, Jae-In / Kim, Hyo-Bin / Kim, Kang-hoon / Kang, Sung-Cheon / Choi, Eun-young / Parani, Sundararajan / Song, Jang-Kun

Journal of Colloid And Interface Science. 2023 Nov., v. 649 p.132-139

2023

Abstract	Quantum-dot (QDs) polymer composite films, which are key components in recent display applications, require improved photoluminescence (PL) intensity and color conversion efficiency for better display quality and low power consumption. In this study, we developed a novel approach to improve the photoluminescence (PL) of quantum dot (QDs)–polymer nanocomposite films. This was achieved by incorporating CO₂ micropores and scattering particles into QD-embedded photopolymerizable polymer films. CO₂ micropores were generated by the decomposition of KHCO₃ in the film. The CO₂ micropores, along with the partially decomposed KHCO₃ microparticles, act as a scattering medium that increases the photon absorbance and improves the PL intensity. The effect of KHCO₃ annealing temperature on various optical properties is investigated, and it is found that a large number of uniform micropores are created in the film at an optimal temperature, 110 ℃. Compared to an ordinary QD-polymer film, the PL of the QD-hybrid-foamed polymer film increases by 4.2 times. This method is fast and economically efficient, and provides insights into the design of high-performance optoelectronic devices.
Keywords	absorbance ; carbon dioxide ; color ; energy use and consumption ; micropores ; nanocomposites ; photoluminescence ; photons ; polymers ; quantum dots ; temperature ; Polymer-nanocomposite films ; Color conversion efficiency ; Scattering particles ; CO2 micropores
Language	English
Dates of publication	2023-11
Size	p. 132-139.
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.06.093
Database	NAL-Catalogue (AGRICOLA)

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Article: Ferulic Acid Induces Keratin 6α via Inhibition of Nuclear β-Catenin Accumulation and Activation of Nrf2 in Wound-Induced Inflammation.

Kim, Kang-Hoon / Jung, Ji Hoon / Chung, Won-Seok / Lee, Chang-Hun / Jang, Hyeung-Jin

Biomedicines

2021 Volume 9, Issue 5

Abstract: Injured tissue triggers complex interactions through biological process associated with keratins. Rapid recovery is most important for protection against secondary infection and inflammatory pain. For rapid wound healing with minimal pain and side ... ...

Abstract	Injured tissue triggers complex interactions through biological process associated with keratins. Rapid recovery is most important for protection against secondary infection and inflammatory pain. For rapid wound healing with minimal pain and side effects, shilajit has been used as an ayurvedic medicine. However, the mechanisms of rapid wound closure are unknown. Here, we found that shilajit induced wound closure in an acute wound model and induced migration in skin explant cultures through evaluation of transcriptomics via microarray testing. In addition, ferulic acid (FA), as a bioactive compound, induced migration via modulation of keratin 6α (K6α) and inhibition of β-catenin in primary keratinocytes of skin explant culture and injured full-thickness skin, because accumulation of β-catenin into the nucleus acts as a negative regulator and disturbs migration in human epidermal keratinocytes. Furthermore, FA alleviated wound-induced inflammation via activation of nuclear factor erythroid-2-related factor 2 (Nrf2) at the wound edge. These findings show that FA is a novel therapeutic agent for wound healing that acts via inhibition of β-catenin in keratinocytes and by activation of Nrf2 in wound-induced inflammation.
Language	English
Publishing date	2021-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9050459
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of benzalkonium chloride as a cationic surfactant on the physicochemical properties of adlay millet starch films.

Kim, Minjun / Kang, Ji-Hoon

Food science and biotechnology

2023 Volume 33, Issue 2, Page(s) 355–362

Abstract: The effects of benzalkonium chloride (BC) as a cationic surfactant on the mechanical, water barrier, microstructural, and thermal properties of adlay millet starch (AS) films were investigated in this study. With increasing BC concentration, tensile ... ...

Abstract	The effects of benzalkonium chloride (BC) as a cationic surfactant on the mechanical, water barrier, microstructural, and thermal properties of adlay millet starch (AS) films were investigated in this study. With increasing BC concentration, tensile strength (from 5.93 to 6.15 MPa) and elongation at break (from 41.39 to 45.48%) of AS-BC films significantly increased, whereas their moisture content, water solubility, and water vapor permeability were reduced, indicating water resistance improvement. Fourier transform infrared spectroscopy and scanning electron microscopy analysis showed that BC at concentrations below 1% did not cause noticeable changes in the microstructure of AS-BC films. In addition, the thermal stability of AS-BC films was not affected by BC, indicating good miscibility between AS and BC. Therefore, BC could improve the physicochemical properties of starch films, and AS-BC films developed in this study can be applied as novel biodegradable packaging materials in the food packaging industry. Supplementary information: The online version contains supplementary material available at 10.1007/s10068-023-01383-1.
Language	English
Publishing date	2023-07-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2000008-X
ISSN	2092-6456 ; 1226-7708
ISSN (online)	2092-6456
ISSN	1226-7708
DOI	10.1007/s10068-023-01383-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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