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  1. Book: Rupatadine in allergic rhinitis and chronic urticaria

    Mullol, J. / Bousquet, J.

    (Allergy : Supplement ; 87)

    2008  

    Author's details J. Mullol ; J. Bousquet
    Series title Allergy : Supplement ; 87
    Allergy
    Allergy ; Supplement
    Collection Allergy
    Allergy ; Supplement
    Language English
    Size 28 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Oxford
    Publishing country Denmark
    Document type Book
    HBZ-ID HT015509332
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 150 -Suppl.87- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Chronic Rhinosinusitis: Forward!

    Rank, Matthew / Mullol, Joaquim

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 6, Page(s) 1472–1473

    MeSH term(s) Chronic Disease ; Humans ; Rhinitis/epidemiology ; Sinusitis/diagnosis
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.01.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Probing active nematics with in situ microfabricated elastic inclusions.

    Vélez-Cerón, Ignasi / Guillamat, Pau / Sagués, Francesc / Ignés-Mullol, Jordi

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 11, Page(s) e2312494121

    Abstract: In this work, we report a direct measurement of the forces exerted by a tubulin/kinesin active nematic gel as well as its complete rheological characterization, including the quantification of its shear viscosity, ...

    Abstract In this work, we report a direct measurement of the forces exerted by a tubulin/kinesin active nematic gel as well as its complete rheological characterization, including the quantification of its shear viscosity,
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2312494121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Decade of Clinical Advances in Chronic Rhinosinusitis: 2012-2022.

    Naclerio, Robert / Mullol, Joaquim / Stevens, Whitney W

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 1, Page(s) 43–50

    Abstract: The field of chronic rhinosinusitis (CRS) is constantly evolving. In the past 10 years, key advancements in basic and translational research as well as clinical studies have improved our understanding and management of CRS. Notably, treatment options ... ...

    Abstract The field of chronic rhinosinusitis (CRS) is constantly evolving. In the past 10 years, key advancements in basic and translational research as well as clinical studies have improved our understanding and management of CRS. Notably, treatment options have expanded to include novel therapeutic drugs, devices, and surgical techniques. Assessments of patient symptoms and their impact on quality of life have become more standardized. Progress has also been made in both determining the true prevalence of CRS and recognizing comorbidities that can impact CRS severity. Practice guidelines have also shifted from expert opinion to more data-driven analyses. This review highlights major clinical advancements made in the field of CRS over the past 10 years as well as identifies current gaps in knowledge that can form the basis for new areas of study over the next decade.
    MeSH term(s) Humans ; Rhinitis/epidemiology ; Rhinitis/therapy ; Rhinitis/diagnosis ; Quality of Life ; Nasal Polyps/epidemiology ; Sinusitis/diagnosis ; Sinusitis/epidemiology ; Sinusitis/therapy ; Comorbidity ; Chronic Disease
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.10.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Twelve-year long-term postoperative outcomes in patients with chronic rhinosinusitis with nasal polyps.

    Arancibia, C / Langdon, C / Mullol, J / Alobid, I

    Rhinology

    2022  Volume 60, Issue 4, Page(s) 261–269

    Abstract: Background: Evidence regarding long-term postoperative follow-up of chronic rhinosinusitis with nasal polyps (CRSwNP) patients is scarce in the literature. The objective of the present study was to report long-term 12-year postoperative outcomes for ... ...

    Abstract Background: Evidence regarding long-term postoperative follow-up of chronic rhinosinusitis with nasal polyps (CRSwNP) patients is scarce in the literature. The objective of the present study was to report long-term 12-year postoperative outcomes for CRSwNP patients.
    Methods: CRSwNP patients were prospectively followed after endoscopic sinus surgery. Sinonasal symptoms, nasal polyp score (NPS), Barcelona Smell Test 24 (BAST-24), Lund-Mackay Score (LMS), and Medical Outcome Study Short Form-36 (SF-36) questionnaire were assessed before and 12 years after surgery.
    Results: At long-term follow-up (median, 12 years), a strong improvement was noted for all patients (N=76) in nasal symptoms score, NPS, BAST-24, and LMS scores compared with baseline. No long-term improvement in SF-36 was found.
    Conclusion: Patients with CRSwNP have a long-term 12-year postoperative improvement in nasal symptoms, polyp size, computed tomography, and olfaction.
    MeSH term(s) Chronic Disease ; Endoscopy/methods ; Humans ; Nasal Polyps/complications ; Nasal Polyps/surgery ; Rhinitis/complications ; Rhinitis/surgery ; Sinusitis/complications ; Sinusitis/surgery
    Language English
    Publishing date 2022-08-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin21.148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1080: Show issues Location:
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  6. Article: Twelve-year long-term postoperative outcomes in patients with chronic rhinosinusitis with nasal polyps.

    Arancibia, C / Langdon, C / Mullol, J / Alobid, I

    Rhinology

    2022  Volume 60, Issue 2, Page(s) 109–117

    Abstract: Background: Evidence regarding long-term postoperative follow-up of chronic rhinosinusitis with nasal polyps (CRSwNP) patients is scarce in the literature. The objective of the present study was to report long-term 12-year postoperative outcomes for ... ...

    Abstract Background: Evidence regarding long-term postoperative follow-up of chronic rhinosinusitis with nasal polyps (CRSwNP) patients is scarce in the literature. The objective of the present study was to report long-term 12-year postoperative outcomes for CRSwNP patients.
    Methods: CRSwNP patients were prospectively followed after endoscopic sinus surgery. Sinonasal symptoms, nasal polyp score (NPS), Barcelona Smell Test 24 (BAST-24), Lund-Mackay Score (LMS), and Medical Outcome Study Short Form-36 (SF-36) questionnaire were assessed before and 12 years after surgery.
    Results: At long-term follow-up (median, 12 years), a strong improvement was noted for all patients (N=76) in nasal symptoms score, NPS, BAST-24, and LMS scores compared with baseline. No long-term improvement in SF-36 was found.
    Conclusion: Patients with CRSwNP have a long-term 12-year postoperative improvement in nasal symptoms, polyp size, computed tomography, and olfaction.
    MeSH term(s) Chronic Disease ; Endoscopy/methods ; Humans ; Nasal Polyps/complications ; Nasal Polyps/surgery ; Rhinitis/complications ; Rhinitis/surgery ; Sinusitis/complications ; Sinusitis/surgery
    Language English
    Publishing date 2022-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin21.148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations.

    Marin, Concepció / Alobid, Isam / López-Chacón, Mauricio / VanStrahlen, Camilo R / Mullol, Joaquim

    Current allergy and asthma reports

    2024  Volume 24, Issue 4, Page(s) 211–219

    Abstract: Purpose of review: Neurogenesis occurring in the olfactory epithelium is critical to continuously replace olfactory neurons to maintain olfactory function, but is impaired during chronic type 2 and non-type 2 inflammation of the upper airways. In this ... ...

    Abstract Purpose of review: Neurogenesis occurring in the olfactory epithelium is critical to continuously replace olfactory neurons to maintain olfactory function, but is impaired during chronic type 2 and non-type 2 inflammation of the upper airways. In this review, we describe the neurobiology of olfaction and the olfactory alterations in chronic rhinosinusitis with nasal polyps (type 2 inflammation) and post-viral acute rhinosinusitis (non-type 2 inflammation), highlighting the role of immune response attenuating olfactory neurogenesis as a possibly mechanism for the loss of smell in these diseases.
    Recent findings: Several studies have provided relevant insights into the role of basal stem cells as direct participants in the progression of chronic inflammation identifying a functional switch away from a neuro-regenerative phenotype to one contributing to immune defense, a process that induces a deficient replacement of olfactory neurons. The interaction between olfactory stem cells and immune system might critically underlie ongoing loss of smell in type 2 and non-type 2 inflammatory upper airway diseases. In this review, we describe the neurobiology of olfaction and the olfactory alterations in type 2 and non-type 2 inflammatory upper airway diseases, highlighting the role of immune response attenuating olfactory neurogenesis, as a possibly mechanism for the lack of loss of smell recovery.
    MeSH term(s) Humans ; Smell/physiology ; Anosmia/metabolism ; Inflammation/metabolism ; Olfactory Mucosa/metabolism ; Sinusitis ; Olfaction Disorders ; Chronic Disease ; Rhinitis
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-024-01137-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5548: Show issues Location:
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  8. Article ; Online: Multimodal fluorescence microscope with fast adaptive polarimetry.

    Martínez-Prat, Berta / Arteaga, Oriol / Sagués, Francesc / Ignés-Mullol, Jordi

    HardwareX

    2023  Volume 16, Page(s) e00480

    Abstract: Polarized light microscopy is a widely used technique to observe specimens that are optically anisotropic, or birefringent. It has a broad applicability in the study of minerals, soft materials such as polymers, complex fluids or liquid crystals, and ... ...

    Abstract Polarized light microscopy is a widely used technique to observe specimens that are optically anisotropic, or birefringent. It has a broad applicability in the study of minerals, soft materials such as polymers, complex fluids or liquid crystals, and organic tissues in biology and medicine. Most of these observations are qualitative in nature, as it is not obvious to quantify the spatial distribution of optical anisotropy of specimens. Moreover, existing commercial implementations for quantitative polarimetry are costly and slow in nature, precluding real time observation of dynamical processes. Here, we present a custom-made implementation of an optical microscope for quantitative polarimetry at the cost of a standard scientific polarizing microscope. The instrument allows to extract the local optical axis and birefringence of transparent materials with a frequency of several Hz. The instrument is built using off-the-shelf optomechanical components, which optimizes cost, availability, and modularity. An example of the latter is the fact that we combine the polarimetry measurements with simultaneous fluorescence microscopy, which results in a powerful multimodal instrument with broad potential applications.
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ISSN 2468-0672
    ISSN (online) 2468-0672
    DOI 10.1016/j.ohx.2023.e00480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pheno-Endotyping Antrochoanal Nasal Polyposis.

    Garaycochea, Octavio / Van Strahlen, Camilo Rodríguez / Alobid, Isam / Mullol, Joaquim

    Current allergy and asthma reports

    2023  Volume 23, Issue 3, Page(s) 165–180

    Abstract: Purpose of review: Antrochoanal polyps (ACPs) are benign polypoid lesions arising from the inner wall of the maxillary sinus and extending into the choana. Although the diagnosis and treatment strategies of ACP have changed since this entity was first ... ...

    Abstract Purpose of review: Antrochoanal polyps (ACPs) are benign polypoid lesions arising from the inner wall of the maxillary sinus and extending into the choana. Although the diagnosis and treatment strategies of ACP have changed since this entity was first described, the underlying pathogenic mechanism of APC is poorly understood. This article reviews the current knowledge of the etiology, inflammatory parameters, and microscopic findings of ACP.
    Recent findings: The inflammatory pattern of ACP appears to center around a neutrophilic inflammation T1-dominant endotype. Apart from the inflammatory component of ACP, at the microscopic level, the presence of tissue remodeling, mostly fibrin deposition and edema, and cysts in the epithelium and lamina propria has been described. Although the origin of this T1-dominant endotype immune response of ACPs is not entirely clear, it could be related to a lymphatic obstruction mechanism. This review serves to define a phenotype of ACP with potential endotypes based on the characteristics of the inflammatory parameters, microscopic findings, and hypotheses about the pathogenesis of ACP.
    MeSH term(s) Humans ; Nasal Polyps/etiology ; Inflammation/pathology ; Maxillary Sinus/pathology
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-023-01066-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mechanisms by which dupilumab normalizes eicosanoid metabolism and restores aspirin-tolerance in AERD: A hypothesis.

    Picado, César / Mullol, Joaquim / Roca-Ferrer, Jordi

    The Journal of allergy and clinical immunology

    2022  Volume 151, Issue 2, Page(s) 310–313

    Abstract: Aspirin-exacerbated respiratory disease (AERD) is associated with overproduction of proinflammatory cysteinyl leukotrienes (CysLTs), defective generation of anti-inflammatory prostaglandin ... ...

    Abstract Aspirin-exacerbated respiratory disease (AERD) is associated with overproduction of proinflammatory cysteinyl leukotrienes (CysLTs), defective generation of anti-inflammatory prostaglandin E
    MeSH term(s) Humans ; Aspirin/pharmacology ; Aspirin/therapeutic use ; Cyclooxygenase 2 ; Interleukin-4 ; Asthma, Aspirin-Induced/drug therapy ; Asthma, Aspirin-Induced/metabolism ; Leukotrienes ; Dinoprostone/metabolism ; Asthma/drug therapy ; Prostaglandin-E Synthases/genetics ; Receptors, Prostaglandin E, EP2 Subtype/metabolism ; Receptors, Interleukin-1
    Chemical Substances Aspirin (R16CO5Y76E) ; dupilumab (420K487FSG) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Interleukin-4 (207137-56-2) ; cysteinyl-leukotriene ; Leukotrienes ; Dinoprostone (K7Q1JQR04M) ; Prostaglandin-E Synthases (EC 5.3.99.3) ; Receptors, Prostaglandin E, EP2 Subtype ; Receptors, Interleukin-1
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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