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Article ; Online: M2 exosomes modified by hydrogen sulfide promoted bone regeneration by moesin mediated endocytosis.

Zhou, Yi-Kun / Han, Chun-Shan / Zhu, Zi-Lu / Chen, Peng / Wang, Yi-Ming / Lin, Shuai / Chen, Liu-Jing / Zhuang, Zi-Meng / Zhou, Yan-Heng / Yang, Rui-Li

Bioactive materials

2023 Volume 31, Page(s) 192–205

Abstract: Bone defects caused by trauma or tumor led to high medical costs and poor life quality for patients. The exosomes, micro vesicles of 30-150 nm in diameter, derived from macrophages manipulated bone regeneration. However, the role of hydrogen sulfide ( ... ...

Abstract	Bone defects caused by trauma or tumor led to high medical costs and poor life quality for patients. The exosomes, micro vesicles of 30-150 nm in diameter, derived from macrophages manipulated bone regeneration. However, the role of hydrogen sulfide (H
Language	English
Publishing date	2023-08-12
Publishing country	China
Document type	Journal Article
ISSN	2452-199X
ISSN (online)	2452-199X
DOI	10.1016/j.bioactmat.2023.08.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Distribution characteristics of microbial necromass carbon along soil profiles in different restoration periods of

Zhang, Yu-Han / Li, Yao / Zhou, Yue / Liu, Chun-Hui / An, Shao-Shan

Ying yong sheng tai xue bao = The journal of applied ecology

2024 Volume 35, Issue 1, Page(s) 161–168

Abstract: Microbial necromass, an important and stable source of soil organic carbon (SOC), is an important index to evaluate the contribution of microorganisms to SOC transformation and accumulation. It is not clear about the accumulation of microbial necromass ... ...

Title translation	宁南山区不同恢复年限柠条林地土壤微生物残体碳沿剖面分布特征.
Abstract	Microbial necromass, an important and stable source of soil organic carbon (SOC), is an important index to evaluate the contribution of microorganisms to SOC transformation and accumulation. It is not clear about the accumulation of microbial necromass in deep soil layer and its contribution to SOC during the restoration process of
MeSH term(s)	Soil ; Carbon/analysis ; Caragana ; Forests ; China ; Soil Microbiology
Chemical Substances	Soil ; Carbon (7440-44-0)
Language	Chinese
Publishing date	2024-03-21
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202401.017
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Article ; Online: Detoxification of corn stover prehydrolysate by different biochars and its effect on lactic acid fermentation.

Wang, Chun / Shan, Yu / Shen, Yuli / Fu, Weng / Li, Jing / Blersch, David / Wu, Wei / Shi, Suan / Han, Lujia

RSC advances

2024 Volume 14, Issue 7, Page(s) 4315–4323

Abstract: During the utilization of lignocellulosic biomass such as corn stover, many by-products are produced in the pretreatment process that can severely inhibit the activity of microbes in the fermentation step. To achieve efficient biomass conversion, ... ...

Abstract	During the utilization of lignocellulosic biomass such as corn stover, many by-products are produced in the pretreatment process that can severely inhibit the activity of microbes in the fermentation step. To achieve efficient biomass conversion, detoxification is usually required before microbial fermentation. In this study, the prehydrolysate from dilute acid pretreatment of corn stover was used as a lactic acid fermentation substrate. Biochars made from corn stover (CSB), cow manure (CMB), and a mixture of corn stover and cow manure (MB) were applied for the detoxification of the prehydrolysate. All three types of biochar had a porous structure with a specific surface area ranging from 4.08 m
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra08055b
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Article ; Online: Stem Cells From Human Exfoliated Deciduous Teeth Alleviate Liver Cirrhosis

Chen, Peng / Zhou, Yi-Kun / Han, Chun-Shan / Chen, Liu-Jing / Wang, Yi-Ming / Zhuang, Zi-Meng / Lin, Shuai / Zhou, Yan-Heng / Jiang, Jiu-Hui / Yang, Rui-Li

Frontiers in immunology

2022 Volume 13, Page(s) 860225

Abstract: Liver cirrhosis represents a type of end-stage liver disease with few effective therapies, which was characterized by damaged functional liver tissue due to long-term inflammation. Gasdermin D (GSDMD)-executed programmed necrosis is reported to be ... ...

Abstract	Liver cirrhosis represents a type of end-stage liver disease with few effective therapies, which was characterized by damaged functional liver tissue due to long-term inflammation. Gasdermin D (GSDMD)-executed programmed necrosis is reported to be involved in inflammation. However, the role of GSDMD in liver cirrhosis remains unclear. In this study, we used a CCl
MeSH term(s)	Caspase 1/metabolism ; Hepatocytes/metabolism ; Humans ; Inflammation ; Intracellular Signaling Peptides and Proteins/metabolism ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/therapy ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Phosphate-Binding Proteins/metabolism ; Pyroptosis ; Stem Cells/metabolism ; Tooth, Deciduous
Chemical Substances	Intracellular Signaling Peptides and Proteins ; NLR Family, Pyrin Domain-Containing 3 Protein ; Phosphate-Binding Proteins ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.860225
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Article ; Online: Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA3.

Huang, Hua-Ming / Han, Chun-Shan / Cui, Sheng-Jie / Zhou, Yi-Kun / Xin, Tian-Yi / Zhang, Ting / Zhu, Song-Biao / Zhou, Yan-Heng / Yang, Rui-Li

Stem cell reports

2022 Volume 17, Issue 8, Page(s) 1842–1858

Abstract: Exosomes play a critical role in intracellular communication. The biogenesis and function of exosomes are regulated by multiple biochemical factors. In the present study, we find that mechanical force promotes the biogenesis of exosomes derived from ... ...

Abstract	Exosomes play a critical role in intracellular communication. The biogenesis and function of exosomes are regulated by multiple biochemical factors. In the present study, we find that mechanical force promotes the biogenesis of exosomes derived from periodontal ligament stem cells (PDLSCs) and alters the exosomal proteome profile to induce osteoclastic differentiation. Mechanistically, mechanical force increases the level of exosomal proteins, especially annexin A3 (ANXA3), which facilitates exosome internalization to activate extracellular signal-regulated kinase (ERK), thus inducing osteoclast differentiation. Moreover, the infusion of exosomes derived from PDLSCs into mice promotes mechanical force-induced tooth movement and increases osteoclasts in the periodontal ligament. Collectively, this study demonstrates that mechanical force treatment promotes the biogenesis of exosomes from PDLSCs and increases exosomal protein ANXA3 to facilitate exosome internalization, which activates ERK phosphorylation, thus inducing osteoclast differentiation. Our findings shed light on new mechanisms for how mechanical force regulates the biology of exosomes and bone metabolism.
MeSH term(s)	Animals ; Annexin A3/metabolism ; Cell Differentiation/physiology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Mice ; Osteoclasts ; Osteogenesis/physiology ; Periodontal Ligament ; Stem Cells/metabolism
Chemical Substances	Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Annexin A3 (EC 3.1.4.43)
Language	English
Publishing date	2022-07-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2022.06.006
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Article ; Online: Sleep and internalizing problems in primary school children with attention-deficit hyperactivity disorder.

Dong, Han-Yu / Miao, Chun-Yue / Xue, Yang / Zhang, Yu / Shan, Ling / Jia, Fei-Yong / Du, Lin

Pediatric research

2024

Abstract: Background: Internalizing and externalizing problems have received great attention, and children with ADHD exhibit high rates of comorbid internalizing and externalizing disorders. This study aimed to explore the relationship between sleep and ... ...

Abstract	Background: Internalizing and externalizing problems have received great attention, and children with ADHD exhibit high rates of comorbid internalizing and externalizing disorders. This study aimed to explore the relationship between sleep and internalizing problems in children with attention-deficit hyperactivity disorder (ADHD) and the probable mediating role of externalizing problems. Methods: A total of 203 primary school children diagnosed with ADHD for the first time were recruited for this study. Children with ADHD were evaluated by Children's Sleep Habits Questionnaire (CSHQ), Strengths and Difficulties Questionnaire (SDQ). Internalizing problems were represented by emotional symptoms and peer problems of SDQ, and externalizing problems were represented by conduct problems and hyperactivity-inattention problems of SDQ. Multi-step linear regression analysis was used to investigate the mediating effect of externalizing problems on the relationship between sleep and internalizing problems. Results: Sleep in children with ADHD was associated with emotional problems in internalizing problems, and conduct problems in externalizing problems mediated the association between sleep and emotional problems. Conclusion: For children with ADHD, when it is difficult to identify internalizing problems, especially emotional problems, we can take sleep and externalizing problems as clues to improve our clinical ability to recognize and deal with emotional problems. Impact: 1. We first explored the possible mediating role of conduct problems between sleep and emotional problems in primary school children with ADHD. 2. When it is difficult to identify internalizing problems, especially emotional problems, we can take sleep and externalizing problems as clues to improve our clinical ability to recognize emotional problems for children with ADHD. 3. For children with ADHD with potential internalizing problems, especially emotional problems, interventions for their sleep and externalizing problems may be the possible methods to deal with.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-024-03213-4
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Esophageal hiatal hernia: risk, diagnosis and management.

Yu, Hai-Xiang / Han, Chun-Shan / Xue, Jin-Ru / Han, Zhi-Feng / Xin, Hua

Expert review of gastroenterology & hepatology

2018 Volume 12, Issue 4, Page(s) 319–329

Abstract: Introduction: Esophageal hiatal hernia involves abnormal abdominal entry into thoracic cavity. It is classified based on orientation between esophageal junction and diaphragm. Sliding hiatal hernia (Type-I) comprises the most frequent category, ... ...

Abstract	Introduction: Esophageal hiatal hernia involves abnormal abdominal entry into thoracic cavity. It is classified based on orientation between esophageal junction and diaphragm. Sliding hiatal hernia (Type-I) comprises the most frequent category, emanating from right crus of diaphragm. Type-II esophageal hernia engages both left and right muscular crura. Type-III and IV additionally include the left crus. Age and increased body mass index are key risk factors, and congenital skeletal aberrations trigger pathogenesis through intestinal malrotations. Familiar manifestations include gastric reflux, nausea, bloating, chest and epigastric discomfort, pharyngeal and esophageal expulsion and dysphagia. Weight loss and colorectal bleeding are severe symptoms. Areas covered: This review summarizes updated evidence of pathophysiology, risk factors, diagnosis and management of hiatal hernias. Laparoscopy and oesophagectomy procedures have been discussed as surgical procedures. Expert commentary: Endoscopy identifies untreatable gastric reflux; radiology is better for pre-operative assessments; manometry measures esophageal peristalsis, and CT scanning detects gastric volvulus and associated organ ruptures. Gastric reflux disease is mitigated using antacids and proton pump and histamine-2-receptor blockers. Severe abdominal penetration into chest cavity demands surgical approaches. Hence, esophagectomy has chances of post-operative morbidity, while minimally invasive laparoscopy entails fewer postoperative difficulties and better visualization of hernia and related vascular damages.
MeSH term(s)	Antacids/therapeutic use ; Esophagectomy/adverse effects ; Gastroesophageal Reflux/epidemiology ; Gastroesophageal Reflux/physiopathology ; Gastroesophageal Reflux/therapy ; Hernia, Hiatal/diagnosis ; Hernia, Hiatal/epidemiology ; Hernia, Hiatal/physiopathology ; Hernia, Hiatal/therapy ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Humans ; Laparoscopy/adverse effects ; Proton Pump Inhibitors ; Risk Factors ; Treatment Outcome
Chemical Substances	Antacids ; Proton Pump Inhibitors
Language	English
Publishing date	2018-02-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2481021-6
ISSN	1747-4132 ; 1747-4124
ISSN (online)	1747-4132
ISSN	1747-4124
DOI	10.1080/17474124.2018.1441711
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Zs.A 6978: Show issues

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Article: The challenges of screen time in children with typical development and children with developmental disorders during COVID-19 pandemic.

Dong, Han-Yu / Jia, Fei-Yong / Shan, Ling / Miao, Chun-Yue / Zhang, Yu / Du, Lin

Translational pediatrics

2023 Volume 12, Issue 5, Page(s) 977–990

Abstract: Background: The significant lifestyle changes that occurred during the lockdown period associated with the COVID-19 pandemic may have had many potential adverse effects on children, in particular, sedentary screen exposure among children, including ... ...

Abstract	Background: The significant lifestyle changes that occurred during the lockdown period associated with the COVID-19 pandemic may have had many potential adverse effects on children, in particular, sedentary screen exposure among children, including those with developmental disorders. We conducted a cross-sectional study to investigate and compare the screen time and outdoor activity time of children with typically development (TD) and those with developmental disorders during and before the emergence of COVID-19, and identified the risk factors related to screen time during the COVID-19 pandemic. Methods: A total of 496 children were surveyed via online questionnaires. Parents or/and children filled in the online questionnaire, including basic characteristics, screen time, outdoor activity time, and other related factors. The Statistical Product and Service Solutions software was used to analyze all data. Results: Children spent less time outdoors (t=14.774, P<0.001) and more time on electronic screens (t=-14.069, P<0.001) during the lockdown period of COVID-19, compared to the periods before COVID-19. Age (P=0.037), pre-COVID-19 screen time (P=0.005), screen time used for learning/education (P<0.001), screen time of siblings (P=0.007), and use of screen devices as electronic babysitters (P=0.005) were risk factors for screen time during the COVID-19 pandemic, while restrictive use of electronic devices by parents (P<0.05) was a protective factor. The screen time of children with autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD) was significantly longer than children with TD before COVID-19 pandemic, but there is no statistical difference during the COVID-19 pandemic. Conclusions: During the COVID-19 pandemic, children's screen exposure time increased, and outdoor activities decreased significantly. This represents a significant challenge, and we should focus our efforts on managing children's screen time and promoting healthier lifestyles, including children with typical development, as well as those with developmental disorders.
Language	English
Publishing date	2023-05-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2901309-4
ISSN	2224-4344 ; 2224-4344 ; 2224-4336
ISSN (online)	2224-4344
ISSN	2224-4344 ; 2224-4336
DOI	10.21037/tp-23-162
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Article ; Online: Factors associated with depression among healthcare workers during the COVID-19 pandemic: a systematic review and meta-analysis.

Tian, Haoyu / Qiao, Tianci / Teng, Jing / Kang, Chen / Ke, Jia / Shan, Lili / Li, Mengting / Shen, Chun / Han, Yan

Psychological medicine

2023 , Page(s) 1–10

Abstract: The COVID-19 pandemic has had a profound impact on the mental health of healthcare workers (HCWs). We aimed to identify the factors associated with depression among HCWs during the pandemic. We conducted literature search using eight electronic databases ...

Abstract	The COVID-19 pandemic has had a profound impact on the mental health of healthcare workers (HCWs). We aimed to identify the factors associated with depression among HCWs during the pandemic. We conducted literature search using eight electronic databases up to July 27 2022. Observational studies with more than 200 participants investigating correlates of depression in HCWs after COVID-19 outbreak were included. We used fixed- and random-effects models to pool odds ratios (ORs) across studies, and Cochran's chi-squared test and
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291723002271
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Zs.B 1003: Show issues

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Article ; Online: Retraction Note: Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia.

Han, Xin-Rui / Wen, Xin / Wang, Yong-Jian / Wang, Shan / Shen, Min / Zhang, Zi-Feng / Fan, Shao-Hua / Shan, Qun / Wang, Liang / Li, Meng-Qiu / Hu, Bin / Sun, Chun-Hui / Wu, Dong-Mei / Lu, Jun / Zheng, Yuan-Lin

Molecular medicine (Cambridge, Mass.)

2023 Volume 29, Issue 1, Page(s) 105

Language	English
Publishing date	2023-08-07
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-023-00708-4
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Zs.A 4456: Show issues

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