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  1. Article ; Online: Which caries removal method to select?

    Fraser, Jacqueline / MacInnes, Andrew

    Evidence-based dentistry

    2024  Volume 25, Issue 1, Page(s) 29–30

    Abstract: Data sources: Searches were carried out using PubMed/MEDLINE and Web of Science databases between January 2008 and January 2023. Only articles in English language were included. Boolean operators were used to search: "permanent teeth" OR "permanent ... ...

    Abstract Data sources: Searches were carried out using PubMed/MEDLINE and Web of Science databases between January 2008 and January 2023. Only articles in English language were included. Boolean operators were used to search: "permanent teeth" OR "permanent tooth" OR "permanent dentition" AND "deep caries" OR "stepwise" AND "partial caries removal OR "stepwise caries removal" OR "pulp vitality" OR "healing rate".
    Study selection: Inclusion criteria were randomised controlled trials, which compared the total removal of carious tissue with either a selective or stepwise removal in permanent teeth with deep carious lesions. Criteria also required a follow up of at least 6 months and publications in English. Exclusion criteria were articles in other languages, articles not comparing different types of total or selective caries removal and articles published before January 2008.
    Data extraction and synthesis: Data extraction followed PRISMA guidelines. Two reviewers independently screened articles, analysing titles and abstracts using Rayyan's Intelligent Systematic Review Platform. They also collected data and risk of bias assessed using the Cochrane Risk of Bias Tool for Randomised Trials, dividing articles into high risk of bias, few concerns and low risk of bias. A third researcher resolved conflict or doubt in case of divided opinions.
    Results: In total, 105 articles were identified, and 10 duplicates removed. 95 articles were reviewed by title and abstract and 75 of these did not meet the inclusion criteria. 20 articles were then read, excluding a further 15 due to comparing only partial removal or non-selective caries removal or absence of numerical data. This left 5 articles which met eligibility criteria. These were randomised controlled trials between 2010 and 2021. Follow up ranged from 1 month to 5 years. The inclusion and exclusion criteria in all studies had similar clinical parameters. 3 studies performed management only on permanent molars, whilst the rest also included management on permanent incisors/canines/premolars and molars. Management of caries was divided into non-selective caries removal vs partial caries removal (either selective or stepwise). All but 2 studies included specific information about the materials used. Liners were calcium hydroxide or Dycal, provisional restorations were glass ionomer cements or Ketax Molar and definitive restorations were Herculite Tetric N-Ceram resin, Ivolclar Vivadent or amalgam. Clinical success or failure was measured using pulp vitality, absence of periapical lesions, radiographic analysis and lack of symptoms. Clinical follow up was evaluated by external examiners, although 2 studies did not specify this clearly. There were a variety of tools used for statistical analysis in each study.
    Conclusions: When comparing non-selective caries removal with either selective or stepwise, 3 studies proposed statistically significant differences in terms of longevity, marginal integrity and success rate of restorations. 1 study stated inexistence of statistically relevant divergences between procedures. Non-selective caries removal is not highly recommended for deep carious lesions and may be considered invasive and risks pulpal exposure. Both selective and stepwise removal are considered conservative approaches. Selective removal is considered the best management option in the short term (with 1.5 years follow up), predominantly related to a lower risk of pulpal exposure. At 5 years, however, the results of selective were similar to those of non-selective, accepting the null hypothesis. There were also no differences in success rates for materials used for definitive restorations.
    MeSH term(s) Humans ; Dental Caries Susceptibility ; Dental Caries/prevention & control ; Dentition, Permanent ; Molar ; Dental Amalgam
    Chemical Substances Dental Amalgam (8049-85-2)
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1457588-7
    ISSN 1476-5446 ; 1462-0049
    ISSN (online) 1476-5446
    ISSN 1462-0049
    DOI 10.1038/s41432-024-00973-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Promoter-centred chromatin interactions associated with EVI1 expression in EVI1+3q- myeloid leukaemia cells.

    Ng, Han Leng / Robinson, Mark E / May, Philippa C / Innes, Andrew J / Hiemeyer, Christina / Feldhahn, Niklas

    British journal of haematology

    2024  Volume 204, Issue 3, Page(s) 945–958

    Abstract: EVI1 expression is associated with poor prognosis in myeloid leukaemia, which can result from Chr.3q alterations that juxtapose enhancers to induce EVI1 expression via long-range chromatin interactions. More often, however, EVI1 expression occurs ... ...

    Abstract EVI1 expression is associated with poor prognosis in myeloid leukaemia, which can result from Chr.3q alterations that juxtapose enhancers to induce EVI1 expression via long-range chromatin interactions. More often, however, EVI1 expression occurs unrelated to 3q alterations, and it remained unclear if, in these cases, EVI1 expression is similarly caused by aberrant enhancer activation. Here, we report that, in EVI1+3q- myeloid leukaemia cells, the EVI1 promoter interacts via long-range chromatin interactions with promoters of distally located, active genes, rather than with enhancer elements. Unlike in 3q+ cells, EVI1 expression and long-range interactions appear to not depend on CTCF/cohesin, though EVI1+3q- cells utilise an EVI1 promoter-proximal site to enhance its expression that is also involved in CTCF-mediated looping in 3q+ cells. Long-range interactions in 3q- cells connect EVI1 to promoters of multiple genes, whose transcription correlates with EVI1 in EVI1+3q- cell lines, suggesting a shared mechanism of transcriptional regulation. In line with this, CRISPR interference-induced silencing of two of these sites minimally, but consistently reduced EVI1 expression. Together, we provide novel evidence of features associated with EVI1 expression in 3q- leukaemia and consolidate the view that EVI1 in 3q- leukaemia is largely promoter-driven, potentially involving long-distance promoter clustering.
    MeSH term(s) Humans ; Transcription Factors/genetics ; DNA-Binding Proteins/genetics ; Chromatin ; MDS1 and EVI1 Complex Locus Protein/genetics ; Leukemia, Myeloid/genetics ; Proto-Oncogenes
    Chemical Substances Transcription Factors ; DNA-Binding Proteins ; Chromatin ; MDS1 and EVI1 Complex Locus Protein
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Joint Modelling of Latent Cognitive Mechanisms Shared Across Decision-Making Domains.

    Stevenson, Niek / Innes, Reilly J / Boag, Russell J / Miletić, Steven / Isherwood, Scott J S / Trutti, Anne C / Heathcote, Andrew / Forstmann, Birte U

    Computational brain & behavior

    2024  Volume 7, Issue 1, Page(s) 1–22

    Abstract: Decision-making behavior is often understood using the framework of evidence accumulation models (EAMs). Nowadays, EAMs are applied to various domains of decision-making with the underlying assumption that the latent cognitive constructs proposed by EAMs ...

    Abstract Decision-making behavior is often understood using the framework of evidence accumulation models (EAMs). Nowadays, EAMs are applied to various domains of decision-making with the underlying assumption that the latent cognitive constructs proposed by EAMs are consistent across these domains. In this study, we investigate both the extent to which the parameters of EAMs are related between four different decision-making domains and across different time points. To that end, we make use of the novel joint modelling approach, that explicitly includes relationships between parameters, such as covariances or underlying factors, in one combined joint model. Consequently, this joint model also accounts for measurement error and uncertainty within the estimation of these relations. We found that EAM parameters were consistent between time points on three of the four decision-making tasks. For our between-task analysis, we constructed a joint model with a factor analysis on the parameters of the different tasks. Our two-factor joint model indicated that information processing ability was related between the different decision-making domains. However, other cognitive constructs such as the degree of response caution and urgency were only comparable on some domains.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2933718-5
    ISSN 2522-087X ; 2522-0861
    ISSN (online) 2522-087X
    ISSN 2522-0861
    DOI 10.1007/s42113-023-00192-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Foraging behaviour and ecology of transient killer whales within a deep submarine canyon system.

    McInnes, Josh D / Lester, Kevin M / Dill, Lawrence M / Mathieson, Chelsea R / West-Stap, Peggy J / Marcos, Stephanie L / Trites, Andrew W

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0299291

    Abstract: Transient killer whales have been documented hunting marine mammals across a variety of habitats. However, relatively little has been reported about their predatory behaviours near deep submarine canyons and oceanic environments. We used a long-term ... ...

    Abstract Transient killer whales have been documented hunting marine mammals across a variety of habitats. However, relatively little has been reported about their predatory behaviours near deep submarine canyons and oceanic environments. We used a long-term database of sightings and encounters with these predators in and around the Monterey Submarine Canyon, California to describe foraging behaviour, diet, seasonal occurrence, and habitat use patterns. Transient killer whales belonging to the outer coast subpopulation were observed within the study area 261 times from 2006-2021. Occurrences, behaviours, and group sizes all varied seasonally, with more encounters occurring in the spring as grey whales migrated northward from their breeding and calving lagoons in Mexico (March-May). Groups of killer whales foraged exclusively in open water, with individuals within the groups following the contours of the submarine canyon as they searched for prey. Focal follows revealed that killer whales spent 51% of their time searching for prey (26% of their time along the shelf-break and upper slope of the canyon, and 25% in open water). The remainder of their time was spent pursuing prey (10%), feeding (23%), travelling (9%), socializing (6%), and resting (1%). Prey species during 87 observed predation events included California sea lions, grey whale calves, northern elephant seals, minke whales, common dolphins, Pacific white-sided dolphins, Dall's porpoise, harbour porpoise, harbour seals, and sea birds. The calculated kill rates (based on 270 hours of observing 50 predation events) were 0.26 California sea lions per killer whale over 24 hours, 0.11 grey whale calves, and 0.15 for all remaining prey species combined. These behavioural observations provide insights into predator-prey interactions among apex predators over submarine canyons and deep pelagic environments.
    MeSH term(s) Animals ; Whale, Killer ; Sea Lions ; Whales ; Predatory Behavior ; Caniformia ; Phoca ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: IMR90 ER:RAS: A Cell Model of Oncogene-Induced Senescence.

    Innes, Andrew J / Gil, Jesús

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1896, Page(s) 83–92

    Abstract: Oncogene-induced senescence (OIS) is a cellular response that limits the replication of cells expressing oncogenes. As a result, OIS is a potent tumor suppressor mechanism limiting cancer progression. Here we describe IMR90 ER:RAS, a widely used model to ...

    Abstract Oncogene-induced senescence (OIS) is a cellular response that limits the replication of cells expressing oncogenes. As a result, OIS is a potent tumor suppressor mechanism limiting cancer progression. Here we describe IMR90 ER:RAS, a widely used model to study OIS in cell culture. This model takes advantage of IMR90 human primary fibroblast infected with a 4-hydroxy-tamoxifen (4-OHT) inducible ER:RAS construct. RAS activation upon 4-OHT treatment results in a coordinated induction of senescence, recapitulating different aspects of the phenotype such as the growth arrest and the establishment of a senescence-associated secretory phenotype (SASP).
    MeSH term(s) Cells, Cultured ; Cellular Senescence ; Estrogen Antagonists/pharmacology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Phenotype ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Signal Transduction ; Tamoxifen/pharmacology ; ras Proteins/genetics ; ras Proteins/metabolism
    Chemical Substances Estrogen Antagonists ; Receptors, Estrogen ; Tamoxifen (094ZI81Y45) ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2018-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8931-7_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Red cell fragments can mask severe thrombocytopenia.

    Innes, Andrew J / Matthey, Francis

    Blood

    2017  Volume 130, Issue 12, Page(s) 1484

    MeSH term(s) Adult ; Artifacts ; Diagnostic Errors ; Dielectric Spectroscopy ; Erythrocytes/ultrastructure ; False Positive Reactions ; Fatal Outcome ; Humans ; Malaria/blood ; Male ; Particle Size ; Platelet Count ; Purpura, Thrombotic Thrombocytopenic/blood ; Purpura, Thrombotic Thrombocytopenic/diagnosis
    Language English
    Publishing date 2017-09-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-06-790477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The outcome of post-transplant asciminib in patients with chronic myeloid leukaemia.

    Fernando, Fiona / Innes, Andrew J / Claudiani, Simone / Pryce, Angharad / Hayden, Chloe / Byrne, Jenny / Gallipoli, Paolo / Copland, Mhairi / Apperley, Jane F / Milojkovic, Dragana

    Bone marrow transplantation

    2023  Volume 58, Issue 7, Page(s) 826–828

    MeSH term(s) Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myeloid ; Pyrazoles ; Niacinamide ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances asciminib ; Pyrazoles ; Niacinamide (25X51I8RD4) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-023-01975-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Towards a Better Understanding of Cohesin Mutations in AML.

    Cuartero, Sergi / Innes, Andrew J / Merkenschlager, Matthias

    Frontiers in oncology

    2019  Volume 9, Page(s) 867

    Abstract: Classical driver mutations in acute myeloid leukemia (AML) typically affect regulators of cell proliferation, differentiation, and survival. The selective advantage of increased proliferation, improved survival, and reduced differentiation on leukemia ... ...

    Abstract Classical driver mutations in acute myeloid leukemia (AML) typically affect regulators of cell proliferation, differentiation, and survival. The selective advantage of increased proliferation, improved survival, and reduced differentiation on leukemia progression is immediately obvious. Recent large-scale sequencing efforts have uncovered numerous novel AML-associated mutations. Interestingly, a substantial fraction of the most frequently mutated genes encode general regulators of transcription and chromatin state. Understanding the selective advantage conferred by these mutations remains a major challenge. A striking example are mutations in genes of the cohesin complex, a major regulator of three-dimensional genome organization. Several landmark studies have shown that cohesin mutations perturb the balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPC). Emerging data now begin to uncover the molecular mechanisms that underpin this phenotype. Among these mechanisms is a role for cohesin in the control of inflammatory responses in HSPCs and myeloid cells. Inflammatory signals limit HSPC self-renewal and drive HSPC differentiation. Consistent with this, cohesin mutations promote resistance to inflammatory signals, and may provide a selective advantage for AML progression. In this review, we discuss recent progress in understanding cohesin mutations in AML, and speculate whether vulnerabilities associated with these mutations could be exploited therapeutically.
    Language English
    Publishing date 2019-09-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2019.00867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reply.

    Innes, Hamish / McAuley, Andrew / Goldberg, David / Hutchinson, Sharon J

    Hepatology (Baltimore, Md.)

    2018  Volume 67, Issue 3, Page(s) 1173

    Language English
    Publishing date 2018-01-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.29749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hydronephrosis severity clarifies prognosis and guides management for emergency department patients with acute ureteral colic.

    Innes, Grant D / Scheuermeyer, Frank X / McRae, Andrew D / Teichman, Joel M H / Lane, Daniel J

    CJEM

    2021  Volume 23, Issue 5, Page(s) 687–695

    Abstract: Objective: In emergency department patients with ureteral colic, the prognostic value of hydronephrosis is unclear. Our goal was to determine whether hydronephrosis can differentiate low-risk patients appropriate for trial of spontaneous passage from ... ...

    Abstract Objective: In emergency department patients with ureteral colic, the prognostic value of hydronephrosis is unclear. Our goal was to determine whether hydronephrosis can differentiate low-risk patients appropriate for trial of spontaneous passage from those with clinically important stones likely to experience passage failure.
    Methods: We used administrative data and structured chart review to evaluate a consecutive cohort of patients with ureteral stones who had a CT at nine Canadian hospitals in two cities. We used CT, the gold standard for stone imaging, to assess hydronephrosis and stone size. We described classification accuracy of hydronephrosis severity for detecting large (≥ 5 mm) stones. In patients attempting spontaneous passage we used hierarchical Bayesian regression to determine the association of hydronephrosis with passage failure, defined by the need for rescue intervention within 60 days. To illustrate prognostic utility, we reported pre-test probability of passage failure among all eligible patients (without hydronephrosis guidance) to post-test probability of passage failure in each hydronephrosis group.
    Results: Of 3251 patients, 70% male and mean age 51, 38% had a large stone, including 23%, 29%, 53% and 72% with absent, mild, moderate and severe hydronephrosis. Passage failure rates were 15%, 20%, 28% and 43% in the respective hydronephrosis categories, and 23% overall. "Absent or mild" hydronephrosis identified a large subset of patients (64%) with low passage failure rates. Moderate hydronephrosis predicted slightly higher, and severe hydronephrosis substantially higher passage failure risk.
    Conclusions: Absent and mild hydronephrosis identify low-risk patients unlikely to experience passage failure, who may be appropriate for trial of spontaneous passage without CT imaging. Moderate hydronephrosis is weakly associated with larger stones but not with significantly greater passage failure. Severe hydronephrosis is an important finding that warrants definitive imaging and referral. Differentiating "moderate-severe" from "absent-mild" hydronephrosis provides risk stratification value. More granular hydronephrosis grading is not prognostically helpful.
    MeSH term(s) Bayes Theorem ; Canada ; Emergency Service, Hospital ; Female ; Humans ; Hydronephrosis/diagnostic imaging ; Male ; Middle Aged ; Prognosis ; Renal Colic/diagnostic imaging
    Language English
    Publishing date 2021-07-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-021-00168-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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