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  1. Article ; Online: Clinical Remission in Severe Asthma: How to Move From Theory to Practice.

    Menzies-Gow, Andrew N / Price, David B

    Chest

    2023  Volume 164, Issue 2, Page(s) 296–298

    MeSH term(s) Humans ; Asthma/drug therapy ; Anti-Asthmatic Agents/therapeutic use ; Biological Products/therapeutic use
    Chemical Substances Anti-Asthmatic Agents ; Biological Products
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Investigational approaches for unmet need in severe asthma.

    Watchorn, David / Menzies-Gow, Andrew

    Expert review of respiratory medicine

    2022  Volume 16, Issue 6, Page(s) 661–678

    Abstract: Introduction: Molecular antibodies (mAb) targeting inflammatory mediators are effective in T2-high asthma. The recent approval of Tezepelumab presents a novel mAb therapeutic option for those with T2-low asthma.: Areas covered: We discuss a number of ...

    Abstract Introduction: Molecular antibodies (mAb) targeting inflammatory mediators are effective in T2-high asthma. The recent approval of Tezepelumab presents a novel mAb therapeutic option for those with T2-low asthma.
    Areas covered: We discuss a number of clinical problems pertinent to severe asthma that are less responsive to current therapies, such as persistent airflow obstruction and airway hyperresponsiveness. We discuss selected investigational approaches, including a number of candidate therapies under investigation in two adaptive platform trials currently in progress, with particular reference to this unmet need, as well as their potential in phenotypes such as neutrophilic asthma and obese asthma, which may or may not overlap with a T2-high phenotype.
    Expert opinion: The application of discrete targeting approaches to T2-low molecular phenotypes, including those phenotypes in which inflammation may not arise within the airway, has yielded variable results to date. Endotypes associated with T2-low asthma are likely to be diverse but await validation. Investigational therapeutic approaches must, likewise, be diverse if the goal of remission is to become attainable for all those living with asthma.
    MeSH term(s) Asthma/diagnosis ; Asthma/drug therapy ; Humans ; Inflammation ; Inflammation Mediators/therapeutic use ; Lung ; Respiratory Hypersensitivity
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2022-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2022.2096593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: FeNO in Asthma.

    Loewenthal, Lola / Menzies-Gow, Andrew

    Seminars in respiratory and critical care medicine

    2022  Volume 43, Issue 5, Page(s) 635–645

    Abstract: Asthma is a common disease affecting 350 million people worldwide, which is characterized by airways inflammation and hyperreactivity. Historically diagnosis and treatment have been mainly based on symptoms, which have the potential to result in ... ...

    Abstract Asthma is a common disease affecting 350 million people worldwide, which is characterized by airways inflammation and hyperreactivity. Historically diagnosis and treatment have been mainly based on symptoms, which have the potential to result in misdiagnosis and inappropriate treatment. Nitric oxide (NO) is exhaled in human breath and is a marker of airways inflammation. Levels of NO are increased in the exhaled breath of patients with type 2 asthma and fractional exhaled nitric oxide (FeNO) provides an objective biomarker of airway inflammation. FeNO testing is an accessible, noninvasive, and easy-to-use test. Cut-off values have been established by the American Thoracic Society (ATS), the Global Initiative for Asthma (GINA), and the National Institute for Health and Care Excellence (NICE) but vary between guidance. FeNO levels have been shown to be predictive of blood and sputum eosinophil levels but should not be used in isolation and current guidance emphasizes the importance of incorporating clinical symptoms and testing when utilizing FeNO results. The inclusion of FeNO testing can increase diagnostic accuracy of asthma, while high levels in asthmatic patients can help predict response to inhaled corticosteroids (ICS) and suppression of levels with ICS to monitor adherence. FeNO levels are also a predictor of asthma risk with increased exacerbation rates and accelerated decline in lung function associated with high levels as well as having an emerging role in predicting response to some biologic therapies in severe asthma. FeNO testing is cost-effective and has been shown, when combined with clinical assessment, to improve asthma management.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Biomarkers ; Breath Tests ; Humans ; Inflammation/diagnosis ; Nitric Oxide/therapeutic use
    Chemical Substances Adrenal Cortex Hormones ; Biomarkers ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1743290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1555: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online: Mountain Masculinity: The Life and Writing of Nello "Tex" Vernon-Wood in the Canadian Rockies, 1906-1938

    Gow, Andrew / Rak, Julie

    2008  

    Abstract: ... of the frontier that blended the West of his guiding experiences with the West as a literary object. Editors Gow ...

    Abstract In 1906, Nello Vernon-Wood (1882-1978) reinvented himself as Tex Wood, Banff hunting guide and writer of "yarns of the wilderness by a competent outdoorsman." His homespun stories of a vanishing world, in such periodicals as The Sportsman, Hunting and Fishing, and the Canadian Alpine Journal, have much to tell us about the west as envisioned by those who wanted to leave the early 20th century behind-or at least read about others who had done so. In the writings of his persona " Tex," Vernon-Wood created an image of the frontier that blended the West of his guiding experiences with the West as a literary object. Editors Gow and Rak, for their part, guide the reader with a framing introduction to the work, as well as to each article
    Size 1 electronic resource (237 p.)
    Publisher Athabasca University Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020087168
    ISBN 9781897425022 ; 9781897425152 ; 1897425023 ; 1897425155
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Oral corticosteroid stewardship for asthma: Time to move from theory to routine clinical practice.

    Watchorn, David / Menzies-Gow, Andrew

    Respirology (Carlton, Vic.)

    2021  Volume 26, Issue 12, Page(s) 1094–1095

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Asthma/drug therapy ; Humans
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-10-19
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4957: Show issues Location:
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  6. Article ; Online: Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation.

    Wilkinson, Melissa L / Gow, Andrew J

    Innate immunity

    2021  Volume 27, Issue 5, Page(s) 353–364

    Abstract: Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via ...

    Abstract Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine thiols. Nitrated fatty acids (NO
    MeSH term(s) Alkanes/metabolism ; Animals ; Fatty Acids/metabolism ; Humans ; Immunity, Innate ; Lung/immunology ; Lung Injury/immunology ; Macrophage Activation ; Macrophages/immunology ; Nitro Compounds/metabolism ; Signal Transduction
    Chemical Substances Alkanes ; Fatty Acids ; Nitro Compounds
    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2381250-3
    ISSN 1753-4267 ; 1753-4259
    ISSN (online) 1753-4267
    ISSN 1753-4259
    DOI 10.1177/17534259211015330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: The Jesuit Order as a Synagogue of Jews : Jesuits of Jewish Ancestry and Purity-of-Blood Laws in the Early Society of Jesus

    Maryks, Robert Aleksander / Gow, Andrew Colin

    2009  

    Keywords Humanities ; History ; General
    Size 1 Online-Ressource
    Publisher Brill
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021031398
    ISBN 9789047444114 ; 9047444116
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices.

    Bellomo, Alyssa / Herbert, Julia / Kudlak, Melissa J / Laskin, Jeffrey D / Gow, Andrew J / Laskin, Debra L

    Toxicology and applied pharmacology

    2024  , Page(s) 116941

    Abstract: Nitrogen mustard (NM; mechlorethamine) is a cytotoxic vesicant known to cause acute lung injury which can progress to chronic disease. Due to the complex nature of NM injury, it has been difficult to analyze early responses of resident lung cells that ... ...

    Abstract Nitrogen mustard (NM; mechlorethamine) is a cytotoxic vesicant known to cause acute lung injury which can progress to chronic disease. Due to the complex nature of NM injury, it has been difficult to analyze early responses of resident lung cells that initiate inflammation and disease progression. To investigate this, we developed a model of acute NM toxicity using murine precision cut lung slices (PCLS), which contain all resident lung cell populations. PCLS were exposed to NM (1-100 μM) for 0.5-3 h and analyzed 1 and 3 d later. NM caused a dose-dependent increase in cytotoxicity and a reduction in metabolic activity, as measured by LDH release and WST-1 activity, respectively. Optimal responses were observed with 50 μM NM after 1 h incubation and these conditions were used in further experiments. Analysis of PCLS bioenergetics using an Agilent Seahorse showed that NM impaired both glycolytic activity and mitochondrial respiration. This was associated with injury to the bronchial epithelium and a reduction in methacholine-induced airway contraction. NM was also found to cause DNA damage in bronchial epithelial cells in PCLS, as measured by expression of ɣ-H2AX, and to induce oxidative stress, which was evident by a reduction in glutathione levels and upregulation of the antioxidant enzyme catalase. Cleaved caspase-3 was also upregulated in airway smooth muscle cells indicating apoptotic cell death. Characterizing early events in NM toxicity is key in identifying therapeutic targets for the development of efficacious countermeasures.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2024.116941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 14: Show issues Location:
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  9. Article ; Online: Holy Grail: the journey towards disease modification in asthma.

    Busse, William W / Melén, Erik / Menzies-Gow, Andrew N

    European respiratory review : an official journal of the European Respiratory Society

    2022  Volume 31, Issue 163

    Abstract: At present, there is no cure for asthma, and treatment typically involves therapies that prevent or reduce asthma symptoms, without modifying the underlying disease. A "disease-modifying" treatment can be classed as able to address the pathogenesis of a ... ...

    Abstract At present, there is no cure for asthma, and treatment typically involves therapies that prevent or reduce asthma symptoms, without modifying the underlying disease. A "disease-modifying" treatment can be classed as able to address the pathogenesis of a disease, preventing progression or leading to a long-term reduction in symptoms. Such therapies have been investigated and approved in other indications,
    MeSH term(s) Adult ; Asthma/therapy ; Biological Products ; Child ; Humans
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0183-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3265: Show issues Location:
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  10. Article: Cell Origin and iNOS Function Are Critical to Macrophage Activation Following Acute Lung Injury.

    Golden, Thea N / Venosa, Alessandro / Gow, Andrew J

    Frontiers in pharmacology

    2022  Volume 12, Page(s) 761496

    Abstract: In the intratracheal bleomycin (ITB) model of acute lung injury (ALI), macrophages are recruited to the lung and participate in the inflammation and resolution that follows injury. Macrophage origin is influential in determining activation; however, the ... ...

    Abstract In the intratracheal bleomycin (ITB) model of acute lung injury (ALI), macrophages are recruited to the lung and participate in the inflammation and resolution that follows injury. Macrophage origin is influential in determining activation; however, the specific phenotype of recruited and resident macrophages is not known. Inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of ALI; however, the effects of its inhibition are mixed. Here we examined how macrophage origin determines the phenotypic response to ALI. Further, we hypothesize cell specific iNOS is key to determining activation and recruitment. Using a chimeric mouse approach, we have identified recruited and resident macrophage populations. We also used the chimeric mouse approach to create either pulmonary or bone marrow NOS2
    Language English
    Publishing date 2022-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.761496
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