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  1. Article ; Online: Mucus Plugging in Primary Ciliary Dyskinesia.

    Adaikalam, Stephanie / Gaston, Benjamin

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 4, Page(s) 514–515

    MeSH term(s) Humans ; Child ; Kartagener Syndrome/diagnosis ; Ciliary Motility Disorders ; Respiration Disorders ; Genotype ; Mucus
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202301-021ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5828: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Thirty-two steps for getting your R01: advice to early career investigators.

    Gaston, Benjamin / Bearer, Cynthia F

    Pediatric research

    2022  Volume 93, Issue 4, Page(s) 738–739

    MeSH term(s) Humans ; United States ; Research Personnel ; Biomedical Research ; Career Mobility
    Language English
    Publishing date 2022-03-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-022-02017-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  3. Article: In Vivo Analysis of Tissue S-Nitrosothiols in Pediatric Sepsis.

    Cater, Daniel T / Clem, Charles / Marozkina, Nadzeya / Gaston, Benjamin

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: S-nitrosothiols are endogenous, bioactive molecules. S-nitrosothiols are implicated in many diseases, including sepsis. It is currently cumbersome to measure S-nitrosothiols clinically. We have previously developed an instrument to measure tissue S- ... ...

    Abstract S-nitrosothiols are endogenous, bioactive molecules. S-nitrosothiols are implicated in many diseases, including sepsis. It is currently cumbersome to measure S-nitrosothiols clinically. We have previously developed an instrument to measure tissue S-nitrosothiols non-invasively using ultraviolet light. We have performed a prospective case control study of controls and children with sepsis admitted to the PICU. We hypothesized that tissue S-nitrosothiols would be higher in septic patients than controls. Controls were patients with no cardiopulmonary instability. Cases were patients with septic shock. We measured S-nitrosothiols, both at diagnosis and after resolution of shock. A total of 44 patients were enrolled: 21 controls and 23 with sepsis. At baseline, the controls were younger [median age 5 years (IQR 0, 9) versus 11 years (IQR: 6, 16),
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13030263
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  4. Article ; Online: Leiomioma de ciego: una causa inusual de oclusión intestinal en adultos.

    Muratore, Lucas / Gramática, Luis / Moretti, Gastón Benjamín

    Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

    2022  Volume 79, Issue 4, Page(s) 383–386

    Abstract: Introduction: Cecal leiomyoma is a very rare benign tumor of the colon, constituted by a proliferative process of smooth muscle that originates from the muscularis propria or the muscularis of the cecum mucosa. These are often asymptomatic tumors that ... ...

    Title translation Ceccum leiomyoma: an unusual cause of intestinal occlusion in adults
    Abstract Introduction: Cecal leiomyoma is a very rare benign tumor of the colon, constituted by a proliferative process of smooth muscle that originates from the muscularis propria or the muscularis of the cecum mucosa. These are often asymptomatic tumors that are found incidentally during screening studies or in the context of some other pathology. In cases with clinical expression, it commonly presents as chronic abdominal pain or a palpable abdominal mass. Infrequently it manifests as complications such as intestinal perforation, intestinal bleeding, or intestinal obstruction that require surgical treatment.
    Method: We present the case of a 25-year-old woman who came to the Central Guard service of the institution for abdominal colic pain of 48 hours of evolution associated with vomiting and abdominal distention. The videolaparoscopic surgical approach was decided in which an abdominal mass was identified at the level of the ileoceccal valve. Conventional right hemicolectomy with proximal loop ileostomy was performed with good postoperative evolution. Histopathological examination of the resected specimen revealed a benign ceccum leiomyoma.
    Results: The patient resolved her acute abdominal symptoms without complications and was discharged on the 5° postoperative day.
    Conclusion: The scarcity of studies and bibliography related to this infrequent pathology denotes the need to elaborate new studies of greater scope that offer answers to the questions and controversial aspects that still persist in relation to the clinical, diagnostic and therapeutic management of benign cecal tumors of mesenchymal lineage.
    MeSH term(s) Humans ; Adult ; Female ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Leiomyoma/complications ; Leiomyoma/surgery ; Colon ; Abdominal Pain ; Colectomy/adverse effects
    Language Spanish
    Publishing date 2022-12-21
    Publishing country Argentina
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 390127-0
    ISSN 1853-0605 ; 0014-6722 ; 0301-7281
    ISSN (online) 1853-0605
    ISSN 0014-6722 ; 0301-7281
    DOI 10.31053/1853.0605.v79.n4.30740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2644: Show issues Location:
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  5. Article ; Online: Building on the essential foundation of physiology.

    Ren, Clement L / Gaston, Benjamin

    Pediatric pulmonology

    2020  Volume 55, Issue 10, Page(s) 2492

    MeSH term(s) Child ; Health Workforce ; Humans ; Pediatrics
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24950
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    Zs.A 2143: Show issues Location:
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  6. Article: Respiratory Distress in the Newborn with Primary Ciliary Dyskinesia.

    Machogu, Evans / Gaston, Benjamin

    Children (Basel, Switzerland)

    2021  Volume 8, Issue 2

    Abstract: Primary ciliary dyskinesia (PCD) is inherited in a predominantly autosomal recessive manner with over 45 currently identified causative genes. It is a clinically heterogeneous disorder that results in a chronic wet cough and drainage from the paranasal ... ...

    Abstract Primary ciliary dyskinesia (PCD) is inherited in a predominantly autosomal recessive manner with over 45 currently identified causative genes. It is a clinically heterogeneous disorder that results in a chronic wet cough and drainage from the paranasal sinuses, chronic otitis media with hearing impairment as well as male infertility. Approximately 50% of patients have situs inversus totalis. Prior to the development of chronic oto-sino-pulmonary symptoms, neonatal respiratory distress occurs in more than 80% of patients as a result of impaired mucociliary clearance and mucus impaction causing atelectasis and lobar collapse. Diagnosis is often delayed due to overlapping symptoms with other causes of neonatal respiratory distress. A work up for PCD should be initiated in the newborn with compatible clinical features, especially those with respiratory distress, consistent radiographic findings or persistent oxygen requirement and/or organ laterality defects.
    Language English
    Publishing date 2021-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children8020153
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  7. Article ; Online: S-Nitroso-l-cysteine and ventilatory drive: A pediatric perspective.

    Hubbard, Dallin / Tutrow, Kaylee / Gaston, Benjamin

    Pediatric pulmonology

    2022  Volume 57, Issue 10, Page(s) 2291–2297

    Abstract: Though endogenous S-nitroso-l-cysteine (l-CSNO) signaling at the level of the carotid body increases minute ventilation ( ... ...

    Abstract Though endogenous S-nitroso-l-cysteine (l-CSNO) signaling at the level of the carotid body increases minute ventilation (v̇
    MeSH term(s) Child ; Cysteine/analogs & derivatives ; Cysteine/metabolism ; Hemoglobins ; Humans ; Nitric Oxide/metabolism ; Nitric Oxide Synthase ; Respiratory System Agents ; S-Nitrosothiols/metabolism
    Chemical Substances Hemoglobins ; Respiratory System Agents ; S-Nitrosothiols ; Nitric Oxide (31C4KY9ESH) ; S-nitrosocysteine (926P2322P4) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2022-07-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26036
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2143: Show issues Location:
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  8. Article ; Online: Defining and Promoting Pediatric Pulmonary Health: Developing Biomarkers for Pulmonary Health.

    Davis, Michael D / Zein, Joe G / Carraro, Silvia / Gaston, Benjamin

    Pediatrics

    2023  Volume 152, Issue Suppl 2

    Abstract: Children with inherited and/or acquired respiratory disorders often arrive in adolescence and adulthood with diminished lung function that might have been detected and prevented had better mechanisms been available to identify and to assess progression ... ...

    Abstract Children with inherited and/or acquired respiratory disorders often arrive in adolescence and adulthood with diminished lung function that might have been detected and prevented had better mechanisms been available to identify and to assess progression of disease. Fortunately, advances in genetic assessments, low-cost diagnostics, and minimally- invasive novel biomarkers are being developed to detect and to treat respiratory diseases before they give rise to loss of life or lung function. This paper summarizes the Developing Biomarkers for Pulmonary Health sessions of the National Heart, Lung, and Blood Institute- sponsored 2021 Defining and Promoting Pediatric Pulmonary Health workshop. These sessions discussed genetic testing, pulse oximetry, exhaled nitric oxide, and novel biomarkers related to childhood lung diseases.
    MeSH term(s) Adolescent ; Child ; Humans ; Respiratory Insufficiency ; Academies and Institutes ; Biomarkers ; Genetic Testing ; Lung
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2023-062292C
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    Um IV Zs.131: Show issues Location:
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    Zs.MO 357: Show issues

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  9. Article: An Update on Thiol Signaling: S-Nitrosothiols, Hydrogen Sulfide and a Putative Role for Thionitrous Acid.

    Marozkina, Nadzeya / Gaston, Benjamin

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 3

    Abstract: Long considered vital to antioxidant defenses, thiol chemistry has more recently been recognized to be of fundamental importance to cell signaling. S-nitrosothiols-such as S-nitrosoglutathione (GSNO)-and hydrogen sulfide ( ... ...

    Abstract Long considered vital to antioxidant defenses, thiol chemistry has more recently been recognized to be of fundamental importance to cell signaling. S-nitrosothiols-such as S-nitrosoglutathione (GSNO)-and hydrogen sulfide (H
    Language English
    Publishing date 2020-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9030225
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  10. Article ; Online: Erythrocytic metabolism of ATLX-0199: An agent that increases minute ventilation.

    Krasinkiewicz, Jonathan M / Hubbard, Dallin / Perez de Guzman, Nicholas / Masters, Andi / Zhao, Yi / Gaston, Herbert / Gaston, Benjamin

    Biochemical and biophysical research communications

    2023  Volume 680, Page(s) 171–176

    Abstract: Both L- and D-isomers of S-nitrosocysteine (CSNO) can bind to the intracellular domain of voltage-gated potassium channels in vitro. CSNO binding inhibits these channels in the carotid body, leading to increased minute ventilation in vivo. However, only ... ...

    Abstract Both L- and D-isomers of S-nitrosocysteine (CSNO) can bind to the intracellular domain of voltage-gated potassium channels in vitro. CSNO binding inhibits these channels in the carotid body, leading to increased minute ventilation in vivo. However, only the l-isomer is active in vivo because it requires the l-amino acid transporter (LAT) for transmembrane transport. In rodents and dogs, the esterified D-CSNO precursor-d-cystine dimethyl ester (ATLX-0199)-overcomes opioid- and benzodiazepine-induced respiratory depression while maintaining analgesia. Although ATLX-0199 can enter cells independently of LAT because it is an ester, its stability in plasma is limited by the presence of esterases. Here, we hypothesized that the drug could be sequestered in erythrocytes to avoid de-esterification in circulation. We developed a liquid chromatography-mass spectrometry method for detecting ATLX-0199 and characterized a new metabolite, S-nitroso-d-cysteine monomethyl ester (DNOCE), which is also a D-CSNO precursor. We found that both ATLX-0199 and DNOCE readily enter erythrocytes and neurons and remain stable over 20 min; thus ATLX-0199 can enter cells where the ester is stable, but the thiol is reduced. Depending on hemoglobin conformation, the reduced ester can be S-nitrosylated and enter carotid body neurons, where it then increases minute ventilation. These data may help explain the paradox that ATLX-0199, a dimethyl ester, can avoid de-esterification in plasma and exert its effects at the level of the carotid body.
    MeSH term(s) Animals ; Dogs ; S-Nitrosothiols/metabolism ; S-Nitrosothiols/pharmacology ; Cysteine/metabolism ; Erythrocytes/metabolism ; Sulfhydryl Compounds ; Esters
    Chemical Substances S-Nitrosothiols ; Cysteine (K848JZ4886) ; Sulfhydryl Compounds ; Esters
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.09.030
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
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