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Article: Inflammation-associated premetastatic niche formation.

Deguchi, Atsuko / Maru, Yoshiro

2022 Volume 42, Issue 1, Page(s) 22

Abstract: Metastasis remains the leading cause of cancer-related death. In 1889, Stephen Paget originally proposed the theory "seed-and-soil." Both cancer cell-intrinsic properties ("seed") and fertile microenvironment ("soil") are essential for metastasis ... ...

Abstract	Metastasis remains the leading cause of cancer-related death. In 1889, Stephen Paget originally proposed the theory "seed-and-soil." Both cancer cell-intrinsic properties ("seed") and fertile microenvironment ("soil") are essential for metastasis formation. To date, accumulating evidences supported the theory using mouse models. The formation of a premetastatic niche has been widely accepted as an accel for metastasis. Similar to tumor microenvironment, various types of cells, such as immune cells, endothelial cells, and fibroblasts are involved in premetastatic niche formation. We have discovered that primary tumors hijack Toll-like receptor 4 (TLR4) signaling to establish a premetastatic niche in the lung by utilizing the endogenous ligands. In this review, we discuss the mechanisms that underlie inflammation-associated premetastatic niche formation upon metastasis, focusing especially on myeloid cells and macrophages as the cells executing and mediating complicated processes.
Language	English
Publishing date	2022-07-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2051471-2
ISSN	1880-9693 ; 0389-4290
ISSN	1880-9693 ; 0389-4290
DOI	10.1186/s41232-022-00208-8
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Article ; Online: Curcumin targets in inflammation and cancer.

Deguchi, Atsuko

Endocrine, metabolic & immune disorders drug targets

2015 Volume 15, Issue 2, Page(s) 88–96

Abstract: Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is commonly used as a spice, food additive or dietary pigment. Accumulating evidence suggests that curcumin has several pharmacologic effects, including anti-inflammatory, anti- ... ...

Abstract	Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is commonly used as a spice, food additive or dietary pigment. Accumulating evidence suggests that curcumin has several pharmacologic effects, including anti-inflammatory, anti-oxidant and anti-cancer activities. The molecular mechanisms underlying the targets of curcumin are diverse and involve combinations of multiple signaling pathways, including NF-κB and STAT3 signaling. Thus, curcumin is one of the most promising phytochemicals that target various cancers and inflammation-mediated diseases. Clinical trials have been ongoing or completed for various cancers, including breast, pancreatic and colorectal cancers, and multiple myeloma. In this review, the molecular mechanisms and the issue of bioavailability are mainly discussed.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacokinetics ; Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents, Phytogenic/pharmacokinetics ; Antineoplastic Agents, Phytogenic/therapeutic use ; Biological Availability ; Curcumin/pharmacokinetics ; Curcumin/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Signal Transduction/drug effects
Chemical Substances	Anti-Inflammatory Agents ; Antineoplastic Agents, Phytogenic ; Inflammation Mediators ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2015-03-09
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530315666150316120458
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Zs.A 5824: Show issues

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Article ; Online: Long-term Stimulation of α7 Nicotinic Acetylcholine Receptor Rescues Hemorrhagic Neuron Loss via Apoptosis of M1 Microglia.

Ohnishi, Masatoshi / Machida, Aoi / Deguchi, Moemi / Takiyama, Nami / Kurose, Yuri / Inoue, Atsuko

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

2023 Volume 18, Issue 1-2, Page(s) 160–168

Abstract: We previously revealed that long-term treatment with nicotine suppresses microglial activation, resulting in a protective effect against thrombin-induced shrinkage of the striatal tissue in organotypic slice cultures. Here, the effect of nicotine on ... ...

Abstract	We previously revealed that long-term treatment with nicotine suppresses microglial activation, resulting in a protective effect against thrombin-induced shrinkage of the striatal tissue in organotypic slice cultures. Here, the effect of nicotine on impaired M1 and protective M2 microglial polarization was investigated using the BV-2 microglial cell line in the presence or absence of thrombin. Following nicotine treatment, α7 nicotinic acetylcholine receptor expression transiently increased and then gradually decreased until 14 days. Treatment with nicotine for 14 days slightly polarized M0 microglia to M2b and d subtypes. Co-exposure of thrombin and low concentration of interferon-γ recruited inducible NO synthase (iNOS)- and interleukin-1β-double-positive M1 microglia in a thrombin-concentration-dependent manner. Treatment with nicotine for 14 days significantly decreased the thrombin-induced increase of iNOS mRNA levels and conversely showed a tendency to increase arginase1 mRNA levels. Moreover, treatment with nicotine for 14 days suppressed thrombin-induced phosphorylation of p38 MAPK through the α7 receptor. Repeated intraperitoneal administration of α7 agonist PNU-282987 for 14 days selectively evoked the apoptosis of iNOS-positive M1 microglia at the perihematomal area and showed a neuroprotective effect in an in vivo intracerebral hemorrhage model. These findings revealed that long-term stimulation of α7 receptor causes suppression of thrombin-induced activation of p38 MAPK followed by apoptosis in neuropathic M1 microglia.
MeSH term(s)	alpha7 Nicotinic Acetylcholine Receptor/metabolism ; Nicotine/pharmacology ; Nicotine/metabolism ; Microglia ; Thrombin/metabolism ; Apoptosis ; Neurons ; RNA, Messenger/metabolism ; RNA, Messenger/pharmacology ; p38 Mitogen-Activated Protein Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/pharmacology
Chemical Substances	alpha7 Nicotinic Acetylcholine Receptor ; Nicotine (6M3C89ZY6R) ; Thrombin (EC 3.4.21.5) ; RNA, Messenger ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2227405-4
ISSN	1557-1904 ; 1557-1890
ISSN (online)	1557-1904
ISSN	1557-1890
DOI	10.1007/s11481-023-10065-y
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Article ; Online: S100A8 may govern hyper-inflammation in severe COVID-19.

Deguchi, Atsuko / Yamamoto, Tomoko / Shibata, Noriyuki / Maru, Yoshiro

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2021 Volume 35, Issue 9, Page(s) e21798

Abstract: The coronavirus disease 2019 (COVID-19) pandemic threatens human species with mortality rate of roughly 2%. We can hardly predict the time of herd immunity against and end of COVID-19 with or without success of vaccine. One way to overcome the situation ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic threatens human species with mortality rate of roughly 2%. We can hardly predict the time of herd immunity against and end of COVID-19 with or without success of vaccine. One way to overcome the situation is to define what delineates disease severity and serves as a molecular target. The most successful analogy is found in BCR-ABL in chronic myeloid leukemia, which is the golden biomarker, and simultaneously, the most effective molecular target. We hypothesize that S100 calcium-binding protein A8 (S100A8) is one such molecule. The underlying evidence includes accumulating clinical information that S100A8 is upregulated in severe forms of COVID-19, pathological similarities of the affected lungs between COVID-19 and S100A8-induced acute respiratory distress syndrome (ARDS) model, homeostatic inflammation theory in which S100A8 is an endogenous ligand for endotoxin sensor Toll-like receptor 4/Myeloid differentiation protein-2 (TLR4/MD-2) and mediates hyper-inflammation even after elimination of endotoxin-producing extrinsic pathogens, analogous findings between COVID-19-associated ARDS and pre-metastatic lungs such as S100A8 upregulation, pulmonary recruitment of myeloid cells, increased vascular permeability, and activation coagulation cascade. A successful treatment in an animal COVID-19 model is given with a reagent capable of abrogating interaction between S100A8/S100A9 and TLR4. In this paper, we try to verify our hypothesis that S100A8 governs COVID-19-associated ARDS.
MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/physiology ; Animals ; Antiviral Agents/pharmacology ; COVID-19/complications ; COVID-19/genetics ; COVID-19/pathology ; Calgranulin A/blood ; Calgranulin A/genetics ; Calgranulin A/physiology ; Chemokine CXCL11/blood ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/genetics ; Cytokine Release Syndrome/pathology ; Disaccharides/pharmacology ; Disaccharides/therapeutic use ; Disease Models, Animal ; Drug Discovery ; Epithelial Cells/metabolism ; Epithelial Cells/virology ; Humans ; Inflammation/etiology ; Inflammation/genetics ; Inflammation/pathology ; Lung/metabolism ; Lung/pathology ; Lung/virology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/secondary ; Lymphocyte Antigen 96/physiology ; Macaca mulatta ; Mice ; Mice, Transgenic ; Models, Biological ; Mutation ; Pandemics ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/genetics ; Respiratory Distress Syndrome/metabolism ; SARS-CoV-2/genetics ; Species Specificity ; Sugar Phosphates/pharmacology ; Sugar Phosphates/therapeutic use ; Toll-Like Receptor 4/physiology ; Up-Regulation ; Virus Internalization
Chemical Substances	Antiviral Agents ; CXCL11 protein, human ; Calgranulin A ; Chemokine CXCL11 ; Disaccharides ; LY96 protein, human ; Lymphocyte Antigen 96 ; S100A8 protein, human ; Sugar Phosphates ; TLR4 protein, human ; Toll-Like Receptor 4 ; eritoran (551541VI0Y) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202101013
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway.

Deguchi, Atsuko / Watanabe-Takahashi, Miho / Mishima, Taishi / Omori, Tsutomu / Ohto, Umeharu / Arashiki, Nobuto / Nakamura, Fumio / Nishikawa, Kiyotaka / Maru, Yoshiro

Cancer gene therapy

2023 Volume 30, Issue 7, Page(s) 973–984

Abstract: The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8, an endogenous ligand of Toll-like receptor 4 (TLR4), is known as a key molecule in the tumor microenvironment and premetastatic niche formation. ...

Abstract	The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8, an endogenous ligand of Toll-like receptor 4 (TLR4), is known as a key molecule in the tumor microenvironment and premetastatic niche formation. We firstly generated a novel multivalent S100A8 competitive inhibitory peptide (divalent peptide3A5) against TLR4/MD-2, using the alanine scanning. Divalent peptide3A5 suppressed S100A8-mediated interleukin-8 and vascular endothelial growth factor production in human colorectal tumor SW480 cells. Using SW480-transplanted xenograft models, divalent peptide3A5 suppressed tumor progression in a dose-dependent manner. We demonstrated that combination therapy with divalent peptide3A5 and bevacizumab synergistically suppressed tumor growth in SW480 xenograft models. Using syngeneic mouse models, we found that divalent peptide3A5 improved the efficacy of anti-programmed death (PD)1 antibody, and lung metastasis. In addition, by using multivalent peptide library screening based on peptide3A5, we then isolated two more candidates; divalent ILVIK, and tetravalent ILVIK. Of note, multivalent ILVIK, but not monovalent ILVIK showed competitive inhibitory activity against TLR4/MD-2 complex, and anti-tumoral activity in SW480 xenograft models. As most tumor cells including SW480 cells also express TLR4, S100A8 inhibitory peptides would target both the tumor microenvironment and tumor cells. Thus, multivalent S100A8 inhibitory peptides would provide new pharmaceutical options for aggressive cancers.
MeSH term(s)	Animals ; Mice ; Humans ; Calgranulin B/metabolism ; Toll-Like Receptor 4 ; Vascular Endothelial Growth Factor A/metabolism ; Calgranulin A/metabolism ; Peptides/pharmacology ; Peptides/metabolism
Chemical Substances	Calgranulin B ; Toll-Like Receptor 4 ; Vascular Endothelial Growth Factor A ; Calgranulin A ; Peptides ; TLR4 protein, human
Language	English
Publishing date	2023-03-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212513-1
ISSN	1476-5500 ; 0929-1903
ISSN (online)	1476-5500
ISSN	0929-1903
DOI	10.1038/s41417-023-00604-3
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Article ; Online: Combination of compressed sensing and parallel imaging for T2-weighted imaging of the oral cavity in healthy volunteers: comparison with parallel imaging.

Tomita, Hayato / Deguchi, Yuki / Fukuchi, Hirofumi / Fujikawa, Atsuko / Kurihara, Yoshiko / Kitsukawa, Kaoru / Mimura, Hidefumi / Kobayashi, Yasuyuki

European radiology

2021 Volume 31, Issue 8, Page(s) 6305–6311

Abstract: Objective: Compressed sensing (CS) and parallel imaging (PI) are magnetic resonance (MR) imaging acceleration techniques. Image quality of two-dimensional fast spin echo imaging of the oral cavity using CS or combined CS and PI has not been evaluated. ... ...

Abstract	Objective: Compressed sensing (CS) and parallel imaging (PI) are magnetic resonance (MR) imaging acceleration techniques. Image quality of two-dimensional fast spin echo imaging of the oral cavity using CS or combined CS and PI has not been evaluated. The aim of this study was to compare the acquisition time and image quality between T2-weighted imaging (T2WI) with CS and PI (CSPI-T2WI) and T2WI with PI (PI-T2WI) of the oral cavity. Materials and methods: Twenty healthy volunteers who underwent CSPI-T2WI and PI-T2WI of the oral cavity on a 3 T MR scanner were enrolled in the study. Contrast ratios of fat/muscle and bone/muscle on CSPI-T2WI and PI-T2WI were measured. Overall image quality, 4 kinds of artifacts, and visualization of 18 anatomical structures were independently evaluated by two radiologists with grading scales. The quantitative and qualitative measurements were compared between CSPI-T2WI and PI-T2WI by using the Wilcoxon signed-rank test. Results: Mean acquisition time of CSPI-T2WI and PI-T2WI was 72 s and 136 s, respectively (p < .001). CSPI-T2WI showed a significantly higher contrast ratio of fat/muscle than PI-T2WI (p < .01). There were no significant differences in the overall image quality, artifacts, and visualization of anatomical structures between CSPI-T2WI and PI-T2WI. Conclusions: CSPI-T2WI of the oral cavity in healthy volunteers can provide a reduction in acquisition time without impaired image quality compared to PI-T2WI. Key points: • The acquisition time of T2WI with the combined CS and PI provided a 47% reduction in acquisition time compared with T2WI with PI. • T2WI with the combined CS and PI did not show impaired image quality compared with T2WI with PI. • Combined CS and PI can be a useful technology to evaluate the oral cavity with high-speed acquisition.
MeSH term(s)	Artifacts ; Healthy Volunteers ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Mouth
Language	English
Publishing date	2021-01-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-021-07699-y
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Article ; Online: Lung Tumor Cell Recruitment Assay.

Tomita, Takeshi / Ieguchi, Katsuaki / Deguchi, Atsuko / Takita, Morichika / Tsukahara, Fujiko / Hiratsuka, Sachie / Maru, Yoshiro

Journal of visualized experiments : JoVE

2019 , Issue 144

Abstract: To investigate the molecular mechanisms governing tumor metastasis, various assays using the mouse as a model animal have been proposed. Here, we demonstrate a simple assay to evaluate tumor cell extravasation or micrometastasis. In this assay, tumor ... ...

Abstract	To investigate the molecular mechanisms governing tumor metastasis, various assays using the mouse as a model animal have been proposed. Here, we demonstrate a simple assay to evaluate tumor cell extravasation or micrometastasis. In this assay, tumor cells were injected through the tail vein, and after a short period, the lungs were dissected and digested to count the accumulated labeled tumor cells. This assay skips the initial step of primary tumor invasion into the blood vessel and facilitates the study of events in the distant organ where tumor metastasis occurs. The number of cells injected into the blood vessel can be optimized to observe a limited number of metastases. It has been reported that stromal cells in the distant organ contribute to metastasis. Thus, this assay could be a useful tool to explore potential therapeutic drugs or devices for prevention of tumor metastasis.
MeSH term(s)	Animals ; Disease Models, Animal ; Humans ; Lung/pathology ; Mice ; Neoplasm Metastasis
Language	English
Publishing date	2019-02-26
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/53172
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Article ; Online: Multiple yellowish white papules on the trunk and upper arms.

Nakajima, Mami / Shinkuma, Satoru / Yokoyama, Rei / Deguchi, Tokiko / Aizawa, Atsuko / Tomiyama, Katsuhiro / Abe, Riichiro

International journal of dermatology

2018 Volume 58, Issue 5, Page(s) 543–544

MeSH term(s)	Adult ; Arm ; Biopsy ; Connective Tissue Diseases/diagnosis ; Connective Tissue Diseases/pathology ; Elastic Tissue/pathology ; Humans ; Male ; Skin/pathology ; Skin Diseases/diagnosis ; Skin Diseases/pathology ; Torso
Language	English
Publishing date	2018-10-16
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.14273
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Article ; Online: Risk Factors for Lymph Node Metastasis and Recurrence in T1 Colorectal Cancer: Analysis of 801 Patients in a Single Institute.

Ishikawa, Shintaro / Hirano, Yasumitsu / Deguchi, Katsuya / Ishii, Toshimasa / Ishiyama, Yasuhiro / Okazaki, Naoto / Fujii, Takatsugu / Kataoka, Atsuko / Sasaki, Megumi / Shimamura, Satoshi / Yonezawa, Hiroki

The American surgeon

2022 Volume 89, Issue 12, Page(s) 5312–5317

Abstract: Objective: To identify risk factors for lymph node metastasis and postoperative recurrence of pT1 colorectal cancer by clinicopathological study of surgically resected cases.: Methods: In 801 patients with pT1 colorectal cancer who underwent surgical ...

Abstract	Objective: To identify risk factors for lymph node metastasis and postoperative recurrence of pT1 colorectal cancer by clinicopathological study of surgically resected cases. Methods: In 801 patients with pT1 colorectal cancer who underwent surgical resection with lymph node dissection between April 2007 and January 2021, we evaluated clinicopathological factors (age, gender, BMI, serum CEA level, tumor localization, additional resection after endoscopic treatment, operation time, blood loss, histological type, tumor size, vascular invasion, and central lymph node dissection). We performed univariate and multivariate analyses to examine risk factors for lymph node metastasis. We also examined risk factors for recurrence in 583 patients up to December 2017. Results: Lymph node metastasis was observed in 100/801 patients (12.5%). Multivariate analysis of lymph node metastasis showed that patients with positive lymphatic invasion (odds ratio 2.57, 95% CI 1.62-4.04, Discussion: In this study, venous invasion, lymphatic invasion, and histologically poorly differentiated type were identified as risk factors for lymph node metastasis in T1 colorectal cancer, and positive venous invasion, positive lymph node metastasis, and preoperative endoscopic treatment were identified as risk factors for recurrence. We hope that large prospective study will lead to the development of a more specific treatment strategy, including endoscopic treatment and additional surgical resection.
MeSH term(s)	Humans ; Lymphatic Metastasis/pathology ; Prospective Studies ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/pathology ; Risk Factors ; Lymph Node Excision ; Neoplasm Invasiveness/pathology ; Retrospective Studies ; Lymph Nodes/surgery ; Lymph Nodes/pathology
Language	English
Publishing date	2022-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348221146975
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Article ; Online: Short-term results of robot-assisted colorectal cancer surgery using Senhance Digital Laparoscopy System.

Sasaki, Megumi / Hirano, Yasumitsu / Yonezawa, Hiroki / Shimamura, Satoshi / Kataoka, Atsuko / Fujii, Takatsugu / Okazaki, Naoto / Ishikawa, Shintaro / Ishii, Toshimasa / Deguchi, Katsuya / Sato, Hiroshi / Sakuramoto, Shinichi / Okamoto, Kojun / Koyama, Isamu

Asian journal of endoscopic surgery

2022 Volume 15, Issue 3, Page(s) 613–618

Abstract: Background: The Senhance Digital Laparoscopy System (Asensus Surgical Inc, Morrisville, NC, United States), which was introduced for the first time in Japan by our hospital, is a new surgical assistive robot following the da Vinci Surgical System. We ... ...

Abstract	Background: The Senhance Digital Laparoscopy System (Asensus Surgical Inc, Morrisville, NC, United States), which was introduced for the first time in Japan by our hospital, is a new surgical assistive robot following the da Vinci Surgical System. We herein report the short-term outcomes of 55 colorectal cancer surgery cases using this system at our hospital to assess the feasibility and safety of our procedures. Materials and methods: We retrospectively reviewed the patient backgrounds and surgical outcomes of 55 patients who underwent Senhance-assisted laparoscopic colorectal cancer surgery. Results: The median age was 71 years. There were 31 males and 24 females, and the median body mass index was 23.1 kg/m Conclusion: The short-term results of 55 colorectal cancer surgery cases using the Senhance Digital Laparoscopy System were excellent and the system was introduced and surgery was safely performed.
MeSH term(s)	Aged ; Colorectal Neoplasms/surgery ; Female ; Humans ; Laparoscopy/methods ; Male ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Robotics ; Treatment Outcome
Language	English
Publishing date	2022-04-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2503256-2
ISSN	1758-5910 ; 1758-5902
ISSN (online)	1758-5910
ISSN	1758-5902
DOI	10.1111/ases.13064
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