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  1. Article: Therapeutic Strategies to Activate p53.

    Aguilar, Angelo / Wang, Shaomeng

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 16, Issue 1

    Abstract: The p53 protein has appropriately been named the "guardian of the genome". In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of ... ...

    Abstract The p53 protein has appropriately been named the "guardian of the genome". In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulators MDM2 and/or MDMX. We review herein the progress made on different therapeutic strategies for targeting p53.
    Language English
    Publishing date 2022-12-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16010024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Therapeutic Strategies to Activate p53

    Angelo Aguilar / Shaomeng Wang

    Pharmaceuticals, Vol 16, Iss 24, p

    2022  Volume 24

    Abstract: The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of ... ...

    Abstract The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulators MDM2 and/or MDMX. We review herein the progress made on different therapeutic strategies for targeting p53.
    Keywords wild-type p53 ; mutant p53 ; activators ; MDM2 ; MDMX ; Y220C ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Multiple Effects of High Surface Area Hollow Nanospheres Assembled by Nickel Cobaltate Nanosheets on Soluble Lithium Polysulfides.

    Pu, Jun / Zhu, Xiaomei / Wang, Jie / Yu, Shaomeng

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 4

    Abstract: Inhibiting the shuttle effect of soluble polysulfides and improving slow reaction kinetics are key factors for the future development of Li-S batteries. Herein, edelweiss shaped ... ...

    Abstract Inhibiting the shuttle effect of soluble polysulfides and improving slow reaction kinetics are key factors for the future development of Li-S batteries. Herein, edelweiss shaped NiCo
    MeSH term(s) Nanospheres ; Lithium ; Nickel ; Binding Sites
    Chemical Substances polysulfide (9080-49-3) ; Lithium (9FN79X2M3F) ; Nickel (7OV03QG267)
    Language English
    Publishing date 2023-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28041539
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  4. Article ; Online: CD-Net: Cascaded 3D Dilated convolutional neural network for pneumonia lesion segmentation.

    Zhang, Jinli / Wang, Shaomeng / Jiang, Zongli / Chen, Zhijie / Bai, Xiaolu

    Computers in biology and medicine

    2024  Volume 173, Page(s) 108311

    Abstract: COVID-19 is a global pandemic that has caused significant global, social, and economic disruption. To effectively assist in screening and monitoring diagnosed cases, it is crucial to accurately segment lesions from Computer Tomography (CT) scans. Due to ... ...

    Abstract COVID-19 is a global pandemic that has caused significant global, social, and economic disruption. To effectively assist in screening and monitoring diagnosed cases, it is crucial to accurately segment lesions from Computer Tomography (CT) scans. Due to the lack of labeled data and the presence of redundant parameters in 3D CT, there are still significant challenges in diagnosing COVID-19 in related fields. To address the problem, we have developed a new model called the Cascaded 3D Dilated convolutional neural network (CD-Net) for directly processing CT volume data. To reduce memory consumption when cutting volume data into small patches, we initially design a cascade architecture in CD-Net to preserve global information. Then, we construct a Multi-scale Parallel Dilated Convolution (MPDC) block to aggregate features of different sizes and simultaneously reduce the parameters. Moreover, to alleviate the shortage of labeled data, we employ classical transfer learning, which requires only a small amount of data while achieving better performance. Experimental results conducted on the different public-available datasets verify that the proposed CD-Net has reduced the negative-positive ratio and outperformed other existing segmentation methods while requiring less data.
    MeSH term(s) Humans ; Image Processing, Computer-Assisted/methods ; Neural Networks, Computer ; Tomography, X-Ray Computed ; COVID-19/diagnostic imaging ; Pneumonia
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108311
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    Zs.A 653: Show issues Location:
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  5. Article ; Online: Therapeutic Strategies to Target the Androgen Receptor.

    Xiang, Weiguo / Wang, Shaomeng

    Journal of medicinal chemistry

    2022  Volume 65, Issue 13, Page(s) 8772–8797

    Abstract: The androgen receptor (AR) plays a key role in the maintenance of muscle and bone and the support of male sexual-related functions, as well as in the progression of prostate cancer. Accordingly, AR-targeted therapies have been developed for the treatment ...

    Abstract The androgen receptor (AR) plays a key role in the maintenance of muscle and bone and the support of male sexual-related functions, as well as in the progression of prostate cancer. Accordingly, AR-targeted therapies have been developed for the treatment of related human diseases and conditions. AR agonists are an important class of drugs in the treatment of bone loss and muscle atrophy. AR antagonists have also been developed for the treatment of prostate cancer, including metastatic castration-resistant prostate cancer (mCRPC). Additionally, selective AR degraders (SARDs) have been reported. More recently, heterobifunctional degrader molecules of AR have been developed, and four such compounds are now in clinical development for the treatment of human prostate cancer. This review attempts to summarize the different types of compounds designed to target AR and the current frontiers of research on this important therapeutic target.
    MeSH term(s) Androgen Antagonists ; Androgen Receptor Antagonists/pharmacology ; Androgen Receptor Antagonists/therapeutic use ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Receptors, Androgen
    Chemical Substances Androgen Antagonists ; Androgen Receptor Antagonists ; Receptors, Androgen
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.2c00716
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    Zs.B 151: Show issues Location:
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  6. Article ; Online: A Message from the Editors-in-Chief.

    Wang, Shaomeng / Georg, Gunda I

    Journal of medicinal chemistry

    2019  Volume 62, Issue 5, Page(s) 2215–2216

    MeSH term(s) Animals ; Chemistry, Pharmaceutical ; Editorial Policies ; Humans ; Publishing
    Language English
    Publishing date 2019-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.9b00235
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    Zs.B 151: Show issues Location:
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  7. Article ; Online: Trajectory Tracking Control of Pneumatic Servo System: A Variable Gain ADRC Approach.

    Zhang, Jinhui / Cui, Congfeng / Gu, Shaomeng / Wang, Tao / Zhao, Ling

    IEEE transactions on cybernetics

    2023  Volume 53, Issue 11, Page(s) 6977–6986

    Abstract: In this article, a novel error-driven variable gain active disturbance rejection control (ADRC) approach is developed for pneumatic servo system, and the desired performance of trajectory tracking and the disturbance rejection can be guaranteed. The ... ...

    Abstract In this article, a novel error-driven variable gain active disturbance rejection control (ADRC) approach is developed for pneumatic servo system, and the desired performance of trajectory tracking and the disturbance rejection can be guaranteed. The proposed variable gain ADRC includes three parts: 1) variable gain tracking differentiator (TD); 2) variable gain extended state observer (ESO); and 3) variable gain error feedback controller (EFC). The proposed variable gain TD is noise tolerant and possesses a variable gain, which can be dynamically adjusted according to the tracking error, and the performance for tracking the reference signal and extracting its derivative is improved. The variable gain ESO is also equipped with a variable gain driven by estimation errors to improve the estimation performance. Then, the variable gain EFC is further designed to improve control accuracy. Finally, simulations and experimental results are presented to verify the efficiency of the proposed methods.
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2022.3174613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Laminaria japonica

    Wang, Chengwei / Chen, Wenning / Xu, Yun / Fu, Shaomeng / Fu, Jiamin / Huang, Xiaohong / Xiao, Junfeng / Liu, Tao / Jiang, Xianren

    Veterinary sciences

    2023  Volume 11, Issue 1

    Abstract: The aim of this experiment was to investigate the effect ... ...

    Abstract The aim of this experiment was to investigate the effect of
    Language English
    Publishing date 2023-12-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci11010011
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  9. Article ; Online: Selectively Targeting Tropomyosin Receptor Kinase A (TRKA) via PROTACs.

    Xiang, Weiguo / Wang, Shaomeng

    Journal of medicinal chemistry

    2020  Volume 63, Issue 23, Page(s) 14560–14561

    Abstract: Tropomyosin receptor kinases (TRKs) are promising cancer therapeutic targets. Chen ( ...

    Abstract Tropomyosin receptor kinases (TRKs) are promising cancer therapeutic targets. Chen (
    MeSH term(s) Animals ; Cell Line ; Cell Proliferation/drug effects ; Humans ; Mice ; Protein Kinase Inhibitors/pharmacology ; Proteolysis ; Proteomics ; Receptor, trkA/antagonists & inhibitors ; Receptor, trkA/metabolism
    Chemical Substances NTRK1 protein, human ; Protein Kinase Inhibitors ; Receptor, trkA (EC 2.7.10.1)
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.0c01947
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    Zs.B 151: Show issues Location:
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  10. Article ; Online: Corrigendum to 'Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment' Neoplasia, Volume 22, Issue 2 (2020) 111-119.

    Kregel, Steven / Wang, Chao / Han, Xin / Xiao, Lanbo / Fernandez-Salas, Ester / Bawa, Pushpinder / McCollum, Brooke L / Wilder-Romans, Kari / Apel, Ingrid J / Cao, Xuhong / Speers, Corey / Wang, Shaomeng / Chinnaiyan, Arul M

    Neoplasia (New York, N.Y.)

    2024  Volume 51, Page(s) 100986

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1483840-0
    ISSN 1476-5586 ; 1522-8002
    ISSN (online) 1476-5586
    ISSN 1522-8002
    DOI 10.1016/j.neo.2024.100986
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    Zs.A 5203: Show issues Location:
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