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Article ; Online: The management of osteoarthritis symptomatology through nanotechnology: a patent review.

Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Nascimento Júnior, José Adão Carvalho / Andrade, Tatianny De Araujo / Rajkumar, Gomathi / Frank, Luiza Abrahão / Serafini, Mairim Russo

Journal of microencapsulation

2023 Volume 40, Issue 7, Page(s) 475–490

Abstract: Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for ... ...

Abstract	Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation. A total of 651 patents were identified for preliminary assessment and 16 were selected for full reading and discussion. The evaluated patents are focused on the intraarticular route, oral route, and topical route for osteoarthritis treatment. The intraarticular route presented a higher patent number, followed by the oral and topical routes, respectively. The development of new technologies allows us to envision a promising and positive future in osteoarthritis treatment.
MeSH term(s)	Humans ; Drug Delivery Systems ; Nanotechnology ; Osteoarthritis/drug therapy
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	843632-0
ISSN	1464-5246 ; 0265-2048
ISSN (online)	1464-5246
ISSN	0265-2048
DOI	10.1080/02652048.2023.2258955
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Article ; Online: Antibacterial drugs and cyclodextrin inclusion complexes: a patent review.

Santos, Anamaria Mendonça / Carvalho Santana Júnior, Cláudio / Nascimento Júnior, José Adão Carvalho / Andrade, Tatianny de Araujo / Shanmugam, Saravanan / Thangaraj, Parimelazhagan / Frank, Luiza Abrahão / Serafini, Mairim Russo

Expert opinion on drug delivery

2023 Volume 20, Issue 3, Page(s) 349–366

Abstract: Introduction: Bacterial antibiotic resistance occurs when bacteria mutate and escape the effect of antibiotics, which makes the antibiotics no longer effective in treating infections. New solutions for bacterial infections are a persistent need ... ...

Abstract	Introduction: Bacterial antibiotic resistance occurs when bacteria mutate and escape the effect of antibiotics, which makes the antibiotics no longer effective in treating infections. New solutions for bacterial infections are a persistent need including the identification of drugs with better pharmacological profiles, more potent, and safer. Cyclodextrins inclusion complexes have been able to improve the physicochemical and pharmacological properties of the formulation molecules, resulting in new alternatives with better efficacy. Areas covered: The patents analyzed in the review used treatments based on antibiotics already on the market, natural products, and synthesized molecules composed of the formulation with cyclodextrins. The combination between cyclodextrin and nanostructures also were presented in the patents review process. Moreover, inclusion complexes have been an alternative in developing treatment mainly in China by the pharmaceutical industries in several countries such as Germany, Hungary, the United States of America, Japan and China. Expert opinion: This review is broad and complete since it considers the first patent involving cyclodextrins and antibacterial drugs. Therefore, the various inclusion complexes and antibacterial drugs alternatives presented in this review offer therapeutic options to fight bacterial infections. If shown to be effective, these drugs may be extremely important in the current clinical practice.
MeSH term(s)	Cyclodextrins/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Solubility
Chemical Substances	Cyclodextrins ; Anti-Bacterial Agents
Language	English
Publishing date	2023-02-15
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2167286-6
ISSN	1744-7593 ; 1742-5247
ISSN (online)	1744-7593
ISSN	1742-5247
DOI	10.1080/17425247.2023.2175815
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Article ; Online: Terpenes with Antitumor Activity: A Patent Review.

de Vasconcelos Cerqueira Braz, Juliana / Carvalho Nascimento Júnior, José Adão / Serafini, Mairim Russo

Recent patents on anti-cancer drug discovery

2020 Volume 15, Issue 4, Page(s) 321–328

Abstract: Background: Cancer is a major public health concern, and is one of the leading causes of death globally. Surgical removal, chemotherapy or hormonal therapy, radiation therapy, or a combination of them are treatment for cancer, many of which are ... ...

Abstract	Background: Cancer is a major public health concern, and is one of the leading causes of death globally. Surgical removal, chemotherapy or hormonal therapy, radiation therapy, or a combination of them are treatment for cancer, many of which are ineffective or have serious side effects. In view of this, there is a search for new, more effective alternatives for cancer prevention and treatment. One possible source of compounds are natural products; among them, terpenes, a large class of organic compounds, have shown promise due to their anti-inflammatory, anti-tumorigenic, and hypolipidemic properties, among others recorded in the literature. Objective: The study aims to use a patent review to evaluate the development and use of terpenes, or formulations containing terpenes, in new therapeutic options for the treatment of various types of cancer. Methods: This patent review was carried out using the specialized patent databases of WIPO and Espacenet. The selection of patents was based on the following inclusion criteria which included pre-clinical and/or clinical trials, and demonstrated anti-tumor effects. Results: Eight patents were identified, six from China, and two from Japan. In this review, all patents confirmed having good antitumor activity for many types of cancer cells. In addition, the inventors indicate more studies pre-clinical and clinical trials giving greater clarity and accurate reflection of the activity of the products studied. Conclusion: Natural products are an important source of compounds for use in the fight against cancer that can act synergistically, and help in the treatment of cancer.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; Biological Products/chemistry ; Biological Products/therapeutic use ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Patents as Topic ; Terpenes/therapeutic use
Chemical Substances	Anti-Inflammatory Agents ; Biological Products ; Terpenes
Language	English
Publishing date	2020-11-02
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2250820-X
ISSN	2212-3970 ; 1574-8928
ISSN (online)	2212-3970
ISSN	1574-8928
DOI	10.2174/1574892815666201002162315
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Article ; Online: SARS, MERS and SARS-CoV-2 (COVID-19) treatment: a patent review.

Nascimento Junior, José Adão Carvalho / Santos, Anamaria Mendonça / Quintans-Júnior, Lucindo José / Walker, Cristiani Isabel Banderó / Borges, Lysandro Pinto / Serafini, Mairim Russo

Expert opinion on therapeutic patents

2020 Volume 30, Issue 8, Page(s) 567–579

Abstract: Introduction: Coronavirus has been responsible for several virus outbreaks since 2003, caused by SARS-CoV-1, MERS-CoV, and currently SARS-CoV-2 (COVID-19), the causative agent of coronavirus disease in 2019. COVID-19 has become a global public health ... ...

Abstract	Introduction: Coronavirus has been responsible for several virus outbreaks since 2003, caused by SARS-CoV-1, MERS-CoV, and currently SARS-CoV-2 (COVID-19), the causative agent of coronavirus disease in 2019. COVID-19 has become a global public health emergency because of its high virulence and mortality capacity. This patent review aims to provide an overview of the patents that present possible treatments for SARS-CoV-1, SARS-CoV-2 and MERS-CoV. Areas covered: To treat SARS, MERS and SARS-CoV-2, researchers have filed patents for a number of therapeutic agents. Most of the treatments found were protease inhibitors aimed at proteases such as PLpro, 3 CLpro, RNA helicase, and Spike protein, or used monoclonal antibodies and interferons. In addition, the use of Chinese folk medicine and its multitude of medicinal plants with strong antiviral properties was reinforced. Thus, these therapies used in previous epidemics can serve as an aid in the new pandemic by SARS-CoV-2 and be a starting point for new treatments. Expert opinion: The various antiviral alternatives presented in this review offer therapeutic options to fight coronavirus infections. If shown to be effective, these drugs may be extremely important in the current pandemic.
MeSH term(s)	Animals ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Drug Development ; Drug Discovery ; Host-Pathogen Interactions ; Humans ; Middle East Respiratory Syndrome Coronavirus/drug effects ; Middle East Respiratory Syndrome Coronavirus/pathogenicity ; Pandemics ; Patents as Topic ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS Virus/drug effects ; SARS Virus/pathogenicity ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/virology ; Treatment Outcome
Chemical Substances	Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-06-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1186201-4
ISSN	1744-7674 ; 0962-2594 ; 1354-3776
ISSN (online)	1744-7674
ISSN	0962-2594 ; 1354-3776
DOI	10.1080/13543776.2020.1772231
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mapping of New Pharmacological Alternatives in the Face of the Emergence of Antibiotic Resistance in COVID-19 Patents Treated for Opportunistic Respiratory Bacterial Pathogens.

Santos, Anamaria Mendonça / Santos, Mariana Mendonça / Nascimento Júnior, José Adão Carvalho / Brito, João Rafael Lisboa Rêgo / de Araújo Andrade, Tatianny / Frank, Luiza Abrahão / Serafini, Mairim Russo

Recent advances in anti-infective drug discovery

2022 Volume 17, Issue 1, Page(s) 34–53

Abstract: Background: The increase in bacterial resistance against antibiotics is thought to be another type of pandemic after COVID-19. Emergency treatment based on antibiotics is a major influence in increasing this resistance. Bacteria, such as Klebsiella ... ...

Abstract	Background: The increase in bacterial resistance against antibiotics is thought to be another type of pandemic after COVID-19. Emergency treatment based on antibiotics is a major influence in increasing this resistance. Bacteria, such as Klebsiella pneumoniae, are the most affected by the indiscriminate use of antibiotics, since they are resistant to most antibiotics currently available on the market. Objective: This review aimed to evaluate patents of new drugs and formulations, for the treatment of infections caused by Klebsiella pneumoniae. Methods: The present patent review was carried out through a specialized search database Espacenet. The selection was based on the criteria of patents published from 2010 to May 2021, in any language, and containing the keywords in title or abstract. Also, a research was performed on the PubMed database, using the inclusion criteria. Results: Twenty-two patents were selected for the analysis according to the aim of the study. The advance of new patents has been mostly observed in the World Intellectual Property Organization, China, and United States. The results showed that the main approach was the drug association, followed by drug carriers, new isolated products, and vaccines. Conclusion: It has been observed that few studies use new drug alternatives for the treatment, probably due to the higher cost of the development and lack of investments. The effectiveness and safety of these therapies depend on the acceptance, the correct prescription, and rational use of medicines. Therefore, this review can further develop new treatments as alternatives against Klebsiella pneumoniae and pneumonia caused by it.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria ; COVID-19/drug therapy ; Drug Carriers ; Drug Resistance, Microbial ; Humans ; Klebsiella pneumoniae
Chemical Substances	Anti-Bacterial Agents ; Drug Carriers
Language	English
Publishing date	2022-05-20
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	2772-4352
ISSN (online)	2772-4352
DOI	10.2174/1574891X16666220518142347
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mapping the technological landscape of SARS, MERS, and SARS-CoV-2 vaccines.

Nascimento Júnior, José Adão Carvalho / Santos, Anamaria Mendonça / Cavalcante, Rafael Ciro Marques / Quintans-Júnior, Lucindo José / Walker, Cristiani Isabel Banderó / Borges, Lysandro Pinto / Frank, Luiza Abrahão / Serafini, Mairim Russo

Drug development and industrial pharmacy

2021 Volume 47, Issue 4, Page(s) 673–684

Abstract: Purpose: The last two decades have seen the emergence of several viral outbreaks. Some of them are the severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and severe acute respiratory syndrome 2 (SARS-CoV2) - the cause of ... ...

Abstract	Purpose: The last two decades have seen the emergence of several viral outbreaks. Some of them are the severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and severe acute respiratory syndrome 2 (SARS-CoV2) - the cause of the coronavirus disease 2019 (COVID-19). Ever, vaccines for emergency use have been authorized for the control and prevention of COVID-19. Currently, there is an urgent need to develop a vaccine for prophylaxis of COVID-19 and for other future epidemics. Methods: This review describes patented vaccines for SARS and MERS-CoV and vaccines developed and approved for emergency use against the new coronavirus (COVID-19). The European Patent Office and the World Intellectual Property Organization were the patent databases used using specific terms. In addition, another search was carried out in the Clinical Trials in search of ongoing clinical studies focused on the COVID-19 vaccine. Results: The patent search showed that most vaccines are based on viral vector platforms, nucleic acids, or protein subunits. The review also includes an overview of completed and ongoing clinical trials for SARS-CoV-2 in several countries. Conclusion: The information provided here lists vaccines for other types of coronavirus that have been used in the development of vaccines for COVID-19.
MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Humans ; RNA, Viral ; SARS-CoV-2 ; Vaccines
Chemical Substances	COVID-19 Vaccines ; RNA, Viral ; Vaccines
Language	English
Publishing date	2021-04-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	751874-2
ISSN	1520-5762 ; 0363-9045
ISSN (online)	1520-5762
ISSN	0363-9045
DOI	10.1080/03639045.2021.1908343
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Article ; Online: Technological Scenario for Masks in Patent Database During Covid-19 Pandemic.

de Araújo Andrade, Tatianny / Nascimento Junior, José Adão Carvalho / Santos, Anamaria Mendonça / Borges, Lysandro Pinto / Quintans-Júnior, Lucindo José / Walker, Cristiani Isabel Banderó / Frank, Luiza Abrahão / Serafini, Mairim Russo

AAPS PharmSciTech

2021 Volume 22, Issue 2, Page(s) 72

Abstract: Since January 2020, the World Health Organization announces COVID-19 outbreak a case of public health emergency of international interest, and declaring it a pandemic on March. Due to the high transmission of this disease, rate precautions have been ... ...

Abstract	Since January 2020, the World Health Organization announces COVID-19 outbreak a case of public health emergency of international interest, and declaring it a pandemic on March. Due to the high transmission of this disease, rate precautions have been implemented, such as the use of masks by the population, personal protective equipment (PPE), and safety protocols, mainly to health workers. Thus, we performed a patent review to evaluate the current patents related to the protective mask. The review was carried out in the patent database in the period of May 2019 to May 2020. After the process of screening and eligibility, 563 patents were selected for our analysis according to the aim of the study which used masks such as a PPE against dust particles and pathogens, mostly when it is about airborne transmission, such as viruses and bacteria. Here, an overview of the main materials used in the mask manufacturing and their efficiency was described. The results of the review showed that most of the masks used cotton, nylon, silver fiber fabrics, among others as fabrics to develop the masks. It also makes an analysis of masks composed of nanotechnology which provide high filtration efficiency. Moreover, the review also brought possibilities of masking the population, which already have been done in countries such as China and Korea and ways of sterilization for reuse of PPE during COVID-19 outbreak. Thus, this review can further researchers in the developing of masks to decrease the spread of a pandemic disease. Graphical abstract.
MeSH term(s)	COVID-19 ; Databases, Factual ; Humans ; Masks ; Pandemics ; Patients ; Personal Protective Equipment
Language	English
Publishing date	2021-02-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-021-01918-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS, MERS and SARS-CoV-2 (COVID-19) treatment

Nascimento Junior, José Adão Carvalho / Santos, Anamaria Mendonça / Quintans-Júnior, Lucindo José / Walker, Cristiani Isabel Banderó / Borges, Lysandro Pinto / Serafini, Mairim Russo

Expert Opinion on Therapeutic Patents

a patent review

2020 Volume 30, Issue 8, Page(s) 567–579

Keywords	Pharmacology ; Drug Discovery ; General Medicine ; covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ZDB-ID	1186201-4
ISSN	1744-7674 ; 1354-3776
ISSN (online)	1744-7674
ISSN	1354-3776
DOI	10.1080/13543776.2020.1772231
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Trends in MERS-CoV, SARS-CoV, and SARS-CoV-2 (COVID-19) Diagnosis Strategies: A Patent Review.

Nascimento Junior, José Adão Carvalho / Santos, Anamaria Mendonça / Oliveira, Ana Maria Santos / Guimarães, Adriana Gibara / Quintans-Júnior, Lucindo José / Coutinho, Henrique Douglas Melo / Martins, Natália / Borges, Lysandro Pinto / Serafini, Mairim Russo

Frontiers in public health

2020 Volume 8, Page(s) 563095

Abstract: The emergence of a new coronavirus (SARS-CoV-2) outbreak represents a challenge for the diagnostic laboratories responsible for developing test kits to identify those infected with SARS-CoV-2. Methods with rapid and accurate detection are essential to ... ...

Abstract	The emergence of a new coronavirus (SARS-CoV-2) outbreak represents a challenge for the diagnostic laboratories responsible for developing test kits to identify those infected with SARS-CoV-2. Methods with rapid and accurate detection are essential to control the sources of infection, to prevent the spread of the disease and to assist decision-making by public health managers. Currently, there is a wide variety of tests available with different detection methodologies, levels of specificity and sensitivity, detection time, and with an extensive range of prices. This review therefore aimed to conduct a patent search in relation to tests for the detection of SARS-CoV, MERS-CoV, and SARS-CoV-2. The greatest number of patents identified in the search were registered between 2003 and 2011, being mainly deposited by China, the Republic of Korea, and the United States. Most of the patents used the existing RT-PCR, ELISA, and isothermal amplification methods to develop simple, sensitive, precise, easy to use, low-cost tests that reduced false-negative or false-positive results. The findings of this patent search show that an increasing number of materials and diagnostic tests for the coronavirus are being produced to identify infected individuals and combat the growth of the current pandemic; however, there is still a question in relation to the reliability of the results of these tests.
MeSH term(s)	COVID-19 ; China ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; Reproducibility of Results ; Republic of Korea ; SARS-CoV-2 ; Sensitivity and Specificity
Keywords	covid19
Language	English
Publishing date	2020-10-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2711781-9
ISSN	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2020.563095
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pharmaceuticals agents for preventing NSAID-induced gastric ulcers: a patent review.

Teixeira, Daiane Franco / Santos, Anamaria Mendonça / Oliveira, Ana Maria Santos / Nascimento Júnior, José Adão Carvalho / Frank, Luiza Abrahão / Santana Souza, Marilia Trindade De / Camargo, Enilton Aparecido / Serafini, Mairim Russo

Expert review of clinical pharmacology

2021 Volume 14, Issue 6, Page(s) 677–686

Abstract: Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs widely used due to their pharmacological potential, demonstrating anti-inflammatory, analgesic, or antipyretic activity. However, prolonged use of these medications can ... ...

Abstract	Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs widely used due to their pharmacological potential, demonstrating anti-inflammatory, analgesic, or antipyretic activity. However, prolonged use of these medications can lead to the development of gastric ulcers in patients. This review aimed to find patents for drugs with an anti-inflammatory and gastroprotective character to treat NSAID-induced gastric ulcers. Areas covered: For the treatment of NSAID-induced gastric ulcers, formulations with different action mechanisms were found, including donors of nitric oxide, heterocyclic compounds, and natural products. Expert opinion: Many of the structures found have already been used in clinic settings and others, and according to the results found, they are promising for the treatment of gastric ulcers.
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Ulcer Agents/administration & dosage ; Anti-Ulcer Agents/pharmacology ; Biological Products/administration & dosage ; Biological Products/pharmacology ; Heterocyclic Compounds/administration & dosage ; Heterocyclic Compounds/pharmacology ; Humans ; Nitric Oxide Donors/administration & dosage ; Nitric Oxide Donors/pharmacology ; Patents as Topic ; Stomach Ulcer/chemically induced ; Stomach Ulcer/prevention & control
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Anti-Ulcer Agents ; Biological Products ; Heterocyclic Compounds ; Nitric Oxide Donors
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article ; Review
ISSN	1751-2441
ISSN (online)	1751-2441
DOI	10.1080/17512433.2021.1909475
Database	MEDical Literature Analysis and Retrieval System OnLINE

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