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  1. Article ; Online: Socio-demographic Heterogeneity in Prevalence of SARS-COV-2 Infection and Death Rate: Relevance to Black College Student Knowledge of COVID-19 and SARS-COV-2.

    Emrani, Jahangir / Hefner, Elia Nichelle

    Journal of racial and ethnic health disparities

    2022  Volume 10, Issue 1, Page(s) 14–31

    Abstract: Black and Brown communities are affected disproportionately by COVID-19. In an attempt to learn if young Black college students unknowingly contribute to the spread of the COVID-19 in their communities, using surveys, this pilot study gauges the general ... ...

    Abstract Black and Brown communities are affected disproportionately by COVID-19. In an attempt to learn if young Black college students unknowingly contribute to the spread of the COVID-19 in their communities, using surveys, this pilot study gauges the general safety knowledge and basic scientific knowledge of Black college students about SARS-COV-2 virus and COVID-19 at an HBCU. We also investigated whether students enrolled in chemistry courses designed for STEM (Science, Technology, and Engineering Majors) majors displayed increased knowledge of SARS-COV-2 and COVID-19 in comparison to their non-STEM major peers. Two sets of surveys with multiple choice questions, one with 25 and the other with 34 questions, were designed to assess general safety knowledge and basic scientific knowledge of the students about COVID-19 and the SARS-COV-2 virus. Survey questions were administered through Blackboard learning management system to one hundred eighty-seven (187) students in the summer of 2020 to two freshman non-science majors and in the fall of 2020 to one freshman non-science-major class, two freshmen STEM-major classes, and one senior STEM-major class. All students self-registered in the 6 chemistry classes at North Carolina A&T State University at random with no predetermined criteria. Results of the study show that regardless of their year of study, majority (> 90%) of the students possess basic scientific knowledge and are aware of the safety precautions concerning SARS-COV-2 virus and COVID-19. Majority of non-science major freshmen answered the basic safety questions correctly but were not able to choose the correct answers for the more specific scientific questions concerning SARS-COV-2 and COVID-19. Surprisingly, there was no significant difference in basic scientific knowledge regarding SARS-COV-2 and COVID-19 between STEM and non-STEM student populations, and first year STEM students were just as knowledgeable as senior STEM students. Based on these data, we speculate that students surveyed here have an acceptable basic understanding of how SARS-CoV-2 is transmitted, and therefore, they may not be a source of COVID-19 transmission to Black and Brown communities as this study confirms they are receiving accurate information about SARS-COV-2 and COVID-19. Possession of crucial timely and accurate knowledge about the health and safety is important in fighting racism and to gain equity within the society at large. By sharing the acquired knowledge, students can serve as positive role models for others in the community thus encouraging them to pursue science. Education brings equity, sharing the acquired knowledge encourages others to continue their education and succeed in obtaining higher degrees and better jobs as remedies for social inequality. Spread of accurate knowledge on various aspects of COVID-19 will also help remove fears of vaccination and hesitation towards visits to health clinics to resolve health issues. Relying on the results of this pilot study, we plan to explore these important factors further in our next study.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Prevalence ; Pilot Projects ; Students
    Language English
    Publishing date 2022-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-021-01193-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: SARS-COV-2, infection, transmission, transcription, translation, proteins, and treatment: A review

    Emrani, Jahangir / Ahmed, Maryam / Jeffers-Francis, Liesl / Teleha, John C. / Mowa, Nathan / Newman, Robert H. / Thomas, Misty D.

    International journal of biological macromolecules. 2021 Dec. 15, v. 193

    2021  

    Abstract: In this review, we describe the key molecular entities involved in the process of infection by SARS-CoV-2, while also detailing how those key entities influence the spread of the disease. We further introduce the molecular mechanisms of preventive and ... ...

    Abstract In this review, we describe the key molecular entities involved in the process of infection by SARS-CoV-2, while also detailing how those key entities influence the spread of the disease. We further introduce the molecular mechanisms of preventive and treatment strategies including drugs, antibodies, and vaccines.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; antibodies ; disease transmission ; journals ; proteins ; vaccines
    Language English
    Dates of publication 2021-1215
    Size p. 1249-1273.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2021.10.172
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: SARS-COV-2, infection, transmission, transcription, translation, proteins, and treatment: A review.

    Emrani, Jahangir / Ahmed, Maryam / Jeffers-Francis, Liesl / Teleha, John C / Mowa, Nathan / Newman, Robert H / Thomas, Misty D

    International journal of biological macromolecules

    2021  Volume 193, Issue Pt B, Page(s) 1249–1273

    Abstract: In this review, we describe the key molecular entities involved in the process of infection by SARS-CoV-2, while also detailing how those key entities influence the spread of the disease. We further introduce the molecular mechanisms of preventive and ... ...

    Abstract In this review, we describe the key molecular entities involved in the process of infection by SARS-CoV-2, while also detailing how those key entities influence the spread of the disease. We further introduce the molecular mechanisms of preventive and treatment strategies including drugs, antibodies, and vaccines.
    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; COVID-19 Vaccines/therapeutic use ; Humans ; SARS-CoV-2/metabolism
    Chemical Substances Antiviral Agents ; COVID-19 Vaccines
    Language English
    Publishing date 2021-10-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2021.10.172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Moringa oleifera and vesicular stomatitis virus: A combination approach for the treatment of cervical cancers

    Brown, Audrey / Emrani, Jahangir / Mowa, C. Nathan / Ahmed, Maryam

    SAAB South African journal of botany. 2019,

    2019  

    Abstract: Vesicular stomatitis virus (VSV) is a promising oncolytic agent due to its natural ability to target and kill a variety of susceptible cancer cells. However, some cancer cells exhibit inherent resistance to VSV and thus, strategies to potentiate ... ...

    Abstract Vesicular stomatitis virus (VSV) is a promising oncolytic agent due to its natural ability to target and kill a variety of susceptible cancer cells. However, some cancer cells exhibit inherent resistance to VSV and thus, strategies to potentiate treatment responses are currently being investigated. This study seeks to determine whether the oncolytic activity of VSV may be augmented by treating cells with natural compounds with known anti-cancer properties, such as Moringa oleifera (MO). Five different extracts from the leaves of MO were prepared and tested for their biological activities against cervical cancer cells in conjunction with VSV. In addition, the mechanism of oncolytic VSV and MO targeting and killing of cancer cells was analyzed through measurement of protein levels and activation status of key apoptotic and antiviral factors. Of the five extracts of MO examined (aqueous, butanolic, ethanolic, hydroethanolic, and methanolic), the ethanolic extract inhibited the proliferation of C4-II and HeLa cervical cancer cells. This inhibition correlated with decreased levels of NF-κB and Bcl-xL in these cells. In conjunction with VSV, the ethanolic extract enhanced the ability of a wild-type strain of VSV (rwt virus) to kill cells, perhaps by inducing expression of the pro-apoptotic protein, Bax. The methanolic extract promoted killing of SiHa cervical cancer cells by a M (matrix) protein mutant strain of VSV, but did not affect the proliferation of cells. Furthermore, STAT1 levels decreased in VSV-infected cells pretreated with MO suggesting that MO may inhibit induction of an antiviral response and promote VSV replication in these cells prior to immune detection. These results indicate that MO may synergize with VSV for the treatment of cervical cancers through modulation of pathways involved in cell proliferation, apoptosis and antiviral responses.
    Keywords Moringa oleifera ; Vesiculovirus ; antineoplastic activity ; apoptosis ; cell proliferation ; leaves ; mutants ; neoplasm cells ; pro-apoptotic proteins ; protein content ; transcription factor NF-kappa B ; uterine cervical neoplasms ; viruses
    Language English
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 2126918-X
    ISSN 0254-6299
    ISSN 0254-6299
    DOI 10.1016/j.sajb.2019.10.003
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Substituent effects on the Cope rearrangement

    Joseph J. Gajewski / Neal D. Conrad / Jahangir Emrani / Kevin E. Gilbert

    ARKIVOC, Vol 2002, Iss 4, Pp 18-

    neither centaurs nor chameleons can characterize them

    2001  Volume 29

    Keywords Organic chemistry ; QD241-441
    Language English
    Publishing date 2001-12-01T00:00:00Z
    Publisher Arkat USA, Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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