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Article ; Online: SARS-COV-2 and infectivity: Possible increase in infectivity associated to integrin motif expression.

Tresoldi, Ilaria / Sangiuolo, Carla F / Manzari, Vittorio / Modesti, Andrea

2020 Volume 92, Issue 10, Page(s) 1741–1742

MeSH term(s)	COVID-19/virology ; Humans ; Integrins/genetics ; Pandemics ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Integrins ; Spike Glycoprotein, Coronavirus
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Letter
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.25831
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-COV-2 and infectivity: Possible increase in infectivity associated to integrin motif expression

Tresoldi, Ilaria / Sangiuolo, Carla F / Manzari, Vittorio / Modesti, Andrea

J. med. virol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #87350
Database	COVID19

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Article ; Online: Dataset of immune responses induced in swine by an inactivated Porcine Circovirus 2b vaccine.

Guarneri, Flavia / Tresoldi, Enrico Tommaso / Sarli, Giuseppe / Boniotti, Maria Beatrice / Lelli, Davide / Barbieri, Ilaria / Bacci, Barbara / D'Annunzio, Giulia / Amadori, Massimo

Data in brief

2021 Volume 35, Page(s) 106906

Abstract: A whole virus, inactivated, Porcine Circovirus 2b (PCV2b) vaccine was submitted to a quantal assay of potency, as explained in detail in our companion paper [1]. To this purpose, twenty, 45-day old piglets, checked for maternally-derived antibody (MDA), ... ...

Abstract	A whole virus, inactivated, Porcine Circovirus 2b (PCV2b) vaccine was submitted to a quantal assay of potency, as explained in detail in our companion paper [1]. To this purpose, twenty, 45-day old piglets, checked for maternally-derived antibody (MDA), were allocated to four groups of 5 animals each; these were vaccinated with 800/266/88/0 nanograms, respectively, of an inactivated PCV2b strain, consisting of two distinct virion populations. Twenty-six days later, all the pigs were challenged intranasally with the homologous PCV2b strain. In the presence of a clear dose-dependent protection in terms of viremia, no such effect was observed in terms of weight gain after challenge. The 800 and 266-ng payloads were associated with neutralizing antibody titers above the MDA levels in oral fluids. Higher levels of viremia in control and 88-ng groups [1] coincided with a higher Natural Killer activity of tracheobronchial lymph node cells from PCV2-infected pigs. The PCV2 ORF2-specific ELISPOT assay for IFN-g- secreting cells showed very few (2-4) ORF2-specific cells/10
Language	English
Publishing date	2021-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2021.106906
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Clear cell hidradenoma of the hand: A case report in an 83-year old patient.

Efremov, Kristian / Caterini, Alessandro / Petrungaro, Lidio / De Maio, Fernando / Di Prete, Monia / Ferlosio, Amedeo / Tresoldi, Ilaria / Farsetti, Pasquale

International journal of surgery case reports

2020 Volume 75, Page(s) 307–310

Abstract: Introduction: Clear cell hidradenoma (CCH) is a superficial adnexal tumor of the sweat glands. It generally appears on the trunk or scalp and is uncommon on the upper and lower limbs; it is extremely rare on the hand. CCH tend to be benign, with low ... ...

Abstract	Introduction: Clear cell hidradenoma (CCH) is a superficial adnexal tumor of the sweat glands. It generally appears on the trunk or scalp and is uncommon on the upper and lower limbs; it is extremely rare on the hand. CCH tend to be benign, with low malignancy risk. Treatment is based on complete surgical excision. We report a rare case of a CCH of the palm of the hand in an 83-year old patient. Presentation of case: An 83-year old male patient presented with a small mass on the palmar surface of his left hand, which was progressively increasing over 5 years. The tumor was surgically excised after sonography and sent for histologic examination, based on which diagnosis of CCH was made. Three months after surgery, the patient had no recurrence and was symptom free. Discussion: CCH is a rare tumor of the distal extremities and to the best of our knowledge, only one case of this tumor on the hand has been reported. Our case represents a rare CCH located at the palm of the hand, which was successfully surgical excised without recurrence. Therefore, CCH needs to be considered in the differential diagnosis when encountering masses on the distal extremities. Hidradenocarcinoma is the malignant variant that arises from the same cells. Conclusion: We report the second case of CCH on the palmar surface of the hand. Treatment of choice is surgical excision, followed by histological analysis and close follow-up for recurrence.
Language	English
Publishing date	2020-09-19
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.09.111
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synovial cyst of the acromioclavicular joint with and without rotator cuff tear: A case series of two patients.

De Maio, Fernando / Di Marcantonio, Arianna / De Luna, Vincenzo / Caterini, Alessandro / Tresoldi, Ilaria / Farsetti, Pasquale

International journal of surgery case reports

2020 Volume 75, Page(s) 390–393

Abstract: Introduction: Acromioclavicular joint cyst (AJC) is a very uncommon condition of the shoulder observed in elderly patients, caused by a degenerative acromioclavicular (AC) joint, frequently associated to a rotator cuff tendon tear. There are two ... ...

Abstract	Introduction: Acromioclavicular joint cyst (AJC) is a very uncommon condition of the shoulder observed in elderly patients, caused by a degenerative acromioclavicular (AC) joint, frequently associated to a rotator cuff tendon tear. There are two possible cause for the cyst formation. We report two different cases of a AC synovial cyst, with and without rotator cuff tear. Presentation of cases: We report two cases, in patients aged respectively 80 and 77 years, with a very large AJC. In one case, the cyst was associated to a rotator cuff tear, while in the other case, the rotator cuff did not present any evident lesion. Both cysts were successfully surgical excised and a distal clavicle resection was performed. Discussion: AJC is a rare complication observed in degenerative AC joint and in the majority of cases is associated to a rotator cuff tear. The diagnosis may be made by ultrasound and conventional radiographic examination, although MRI of the shoulder is generally preferred as it allows to better identify the condition of the rotator cuff. Generally, local aspiration of the cyst and corticosteroid injection fails with recurrence of the cyst and surgically treatment is indicated, especially in painful cases. Conclusion: Painful AJC should be surgically treated by excision of the cyst associated to a lateral clavicle resection; when a symptomatic massive rotator cuff is present, a reverse total shoulder arthroplasty may be considered. However, in elderly patients, who have no discomfort, watchful waiting may be the treatment of choice.
Language	English
Publishing date	2020-09-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.09.084
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Protective immunity in swine induced by Porcine Circovirus 2b inactivated vaccines with different antigen payload.

Guarneri, Flavia / Tresoldi, Enrico Tommaso / Sarli, Giuseppe / Boniotti, Maria Beatrice / Lelli, Davide / Barbieri, Ilaria / Bacci, Barbara / D'Annunzio, Giulia / Amadori, Massimo

Veterinary microbiology

2020 Volume 252, Page(s) 108887

Abstract: Porcine Circovirus 2 (PCV2) vaccines are poorly standardized in terms of antigen payload and correlates of protection. Therefore, twenty, 45-day old piglets were divided into four groups of 5 animals each and vaccinated with 800 / 266 / 88 / 0 nanograms, ...

Abstract	Porcine Circovirus 2 (PCV2) vaccines are poorly standardized in terms of antigen payload and correlates of protection. Therefore, twenty, 45-day old piglets were divided into four groups of 5 animals each and vaccinated with 800 / 266 / 88 / 0 nanograms, respectively, of an inactivated PCV2b strain formulated in the same oil adjuvant. Twenty-six days later, all the pigs were challenged intranasally with the homologous PCV2b strain. No clinical signs were observed in the pigs under study. Viremia was observed after challenge in all the control pigs, as well as in 3 pigs of the 266 and 88-ng groups (one and two, respectively). No pigs of the 800-ng group developed viremia. On the basis of post challenge viremia, the PCV2b vaccine under study had a titer of 11 Protective Doses (PD) 50 %, and 1 PD
MeSH term(s)	Animals ; Antibodies, Viral/blood ; Antigens, Viral/immunology ; Circoviridae Infections/prevention & control ; Circoviridae Infections/veterinary ; Circoviridae Infections/virology ; Circovirus/immunology ; Enzyme-Linked Immunosorbent Assay/veterinary ; Interferon-gamma/blood ; Random Allocation ; Recombinant Proteins ; Swine ; Swine Diseases/prevention & control ; Swine Diseases/virology ; Vaccination/veterinary ; Vaccines, Inactivated/immunology ; Viral Load/veterinary ; Viral Vaccines/immunology ; Viremia/prevention & control ; Viremia/veterinary
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; Recombinant Proteins ; Vaccines, Inactivated ; Viral Vaccines ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2020-10-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2020.108887
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pre-Existing Diabetes and COVID-Associated Hyperglycaemia in Patients with COVID-19 Pneumonia.

Laurenzi, Andrea / Caretto, Amelia / Molinari, Chiara / Bazzigaluppi, Elena / Brigatti, Cristina / Marzinotto, Ilaria / Mercalli, Alessia / Melzi, Raffaella / Nano, Rita / Tresoldi, Cristina / Landoni, Giovanni / Ciceri, Fabio / Lampasona, Vito / Scavini, Marina / Piemonti, Lorenzo

Biology

2021 Volume 10, Issue 8

Abstract: Aim: The aim of the current study was to compare clinical characteristics, laboratory findings, and major outcomes of patients hospitalized for COVID-19 pneumonia with COVID-associated hyperglycaemia or pre-existing diabetes.: Methods: A cohort of ... ...

Abstract	Aim: The aim of the current study was to compare clinical characteristics, laboratory findings, and major outcomes of patients hospitalized for COVID-19 pneumonia with COVID-associated hyperglycaemia or pre-existing diabetes. Methods: A cohort of 176 adult patients with a diagnosis of pre-existing diabetes ( Results: Patients with COVID-associated hyperglycaemia had lower BMI, significantly less comorbidities, and higher levels of inflammatory markers and indicators of multi-organ injury than those with pre-existing diabetes. No differences between pre-existing diabetes and COVID-associated hyperglycaemia were evident for symptoms at admission, the humoral response against SARS-CoV-2, or autoantibodies to glutamic acid decarboxylase or interferon alpha-4. COVID-associated hyperglycaemia was independently associated with the risk of adverse clinical outcome, which was defined as ICU admission or death (HR 2.11, 95% CI 1.34-3.31; Conclusions: Recognizing hyperglycaemia as a specific clinical entity associated with COVID-19 pneumonia is relevant for early and appropriate patient management and close monitoring for the progression of disease severity.
Language	English
Publishing date	2021-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology10080754
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Treatment of spasticity in children and adolescents with cerebral palsy in Northern Europe: a CP-North registry study.

Hägglund, Gunnar / Hollung, Sandra Julsen / Ahonen, Matti / Andersen, Guro L / Eggertsdóttir, Guðbjörg / Gaston, Mark S / Jahnsen, Reidun / Jeglinsky-Kankainen, Ira / Nordbye-Nielsen, Kirsten / Tresoldi, Ilaria / Alriksson-Schmidt, Ann I

BMC neurology

2021 Volume 21, Issue 1, Page(s) 276

Abstract: Background: Spasticity is present in more than 80% of the population with cerebral palsy (CP). The aim of this study was to describe and compare the use of three spasticity reducing methods; Botulinum toxin-A therapy (BTX-A), Selective dorsal rhizotomy ( ...

Abstract	Background: Spasticity is present in more than 80% of the population with cerebral palsy (CP). The aim of this study was to describe and compare the use of three spasticity reducing methods; Botulinum toxin-A therapy (BTX-A), Selective dorsal rhizotomy (SDR) and Intrathecal baclofen therapy (ITB) among children and adolescents with CP in six northern European countries. Methods: This registry-based study included population-based data in children and adolescents with CP born 2002 to 2017 and recorded in the follow-up programs for CP in Sweden, Norway, Denmark, Iceland and Scotland, and a defined cohort in Finland. Results: A total of 8,817 individuals were included. The proportion of individuals treated with SDR and ITB was significantly different between the countries. SDR treatment ranged from 0% ( Finland and Iceland) to 3.4% (Scotland) and ITB treatment from 2.2% (Sweden) to 3.7% (Denmark and Scotland). BTX-A treatment in the lower extremities reported 2017-2018 ranged from 8.6% in Denmark to 20% in Norway (p < 0.01). Mean age for undergoing SDR ranged from 4.5 years in Norway to 7.3 years in Denmark (p < 0.01). Mean age at ITB surgery ranged from 6.3 years in Norway to 10.1 years in Finland (p < 0.01). Mean age for BTX-A treatment ranged from 7.1 years in Denmark to 10.3 years in Iceland (p < 0.01). Treatment with SDR was most common in Gross Motor Function Classification System (GMFCS) level III, ITB in level V, and BTX-A in level I. The most common muscle treated with BTX-A was the calf muscle, with the highest proportion in GMFCS level I. BTX-A treatment of hamstring and hip muscles was most common in GMFCS levels IV-V in all countries. Conclusion: There were statistically significant differences between countries regarding the proportion of children and adolescents with CP treated with the three spasticity reducing methods, mean age for treatment and treatment related to GMFCS level. This is likely due to differences in the availability of these treatment methods and/or differences in preferences of treatment methods among professionals and possibly patients across countries.
MeSH term(s)	Adolescent ; Baclofen/administration & dosage ; Botulinum Toxins, Type A/administration & dosage ; Cerebral Palsy/diagnosis ; Cerebral Palsy/epidemiology ; Cerebral Palsy/therapy ; Child ; Child, Preschool ; Cohort Studies ; Europe/epidemiology ; Humans ; Injections, Spinal/methods ; Male ; Muscle Relaxants, Central/administration & dosage ; Muscle Spasticity/diagnosis ; Muscle Spasticity/epidemiology ; Muscle Spasticity/therapy ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/pathology ; Registries ; Rhizotomy/methods
Chemical Substances	Muscle Relaxants, Central ; Botulinum Toxins, Type A (EC 3.4.24.69) ; Baclofen (H789N3FKE8)
Language	English
Publishing date	2021-07-12
Publishing country	England
Document type	Journal Article
ISSN	1471-2377
ISSN (online)	1471-2377
DOI	10.1186/s12883-021-02289-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dataset of immune responses induced in swine by an inactivated Porcine Circovirus 2b vaccine

Guarneri, Flavia / Tresoldi, Enrico Tommaso / Sarli, Giuseppe / Boniotti, Maria Beatrice / Lelli, Davide / Barbieri, Ilaria / Bacci, Barbara / D'Annunzio, Giulia / Amadori, Massimo

Data in Brief. 2021 Apr., v. 35

2021

Abstract	A whole virus, inactivated, Porcine Circovirus 2b (PCV2b) vaccine was submitted to a quantal assay of potency, as explained in detail in our companion paper [1]. To this purpose, twenty, 45-day old piglets, checked for maternally-derived antibody (MDA), were allocated to four groups of 5 animals each; these were vaccinated with 800/266/88/0 nanograms, respectively, of an inactivated PCV2b strain, consisting of two distinct virion populations. Twenty-six days later, all the pigs were challenged intranasally with the homologous PCV2b strain. In the presence of a clear dose-dependent protection in terms of viremia, no such effect was observed in terms of weight gain after challenge. The 800 and 266-ng payloads were associated with neutralizing antibody titers above the MDA levels in oral fluids. Higher levels of viremia in control and 88-ng groups [1] coincided with a higher Natural Killer activity of tracheobronchial lymph node cells from PCV2-infected pigs. The PCV2 ORF2-specific ELISPOT assay for IFN-g– secreting cells showed very few (2–4) ORF2-specific cells/10⁵ peripheral blood mononuclear cells beyond the basal levels under our experimental conditions (non-significant differences among groups). Also, no significant differences were observed in the degree of lymphoid tissue hyperplasia among the different groups.
Keywords	Porcine circovirus ; data collection ; dose response ; hyperplasia ; lymph nodes ; vaccines ; viremia ; virion ; viruses ; weight gain
Language	English
Dates of publication	2021-04
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2021.106906
Database	NAL-Catalogue (AGRICOLA)

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Article: Protective immunity in swine induced by Porcine Circovirus 2b inactivated vaccines with different antigen payload

Guarneri, Flavia / Tresoldi, Enrico Tommaso / Sarli, Giuseppe / Boniotti, Maria Beatrice / Lelli, Davide / Barbieri, Ilaria / Bacci, Barbara / D’Annunzio, Giulia / Amadori, Massimo

Veterinary microbiology. 2021 Jan., v. 252

2021

Abstract	Porcine Circovirus 2 (PCV2) vaccines are poorly standardized in terms of antigen payload and correlates of protection. Therefore, twenty, 45-day old piglets were divided into four groups of 5 animals each and vaccinated with 800 / 266 / 88 / 0 nanograms, respectively, of an inactivated PCV2b strain formulated in the same oil adjuvant. Twenty-six days later, all the pigs were challenged intranasally with the homologous PCV2b strain. No clinical signs were observed in the pigs under study. Viremia was observed after challenge in all the control pigs, as well as in 3 pigs of the 266 and 88-ng groups (one and two, respectively). No pigs of the 800-ng group developed viremia. On the basis of post challenge viremia, the PCV2b vaccine under study had a titer of 11 Protective Doses (PD) 50 %, and 1 PD₅₀ amounted to 74 ng of PCV2b Ag. Neutralizing and ELISA Ab titers showed no obvious correlation with protection in the single animals, even though the 800-ng group developed a significantly higher mean Ab response. All the pigs with a PCV2-specific, IFN-gamma response at 3 weeks after vaccination in whole blood samples were protected against viremia. In lymphoid tissues (mainly tonsils and ileum) the presence of sparse reactive histiocytes and multinucleated giant cells was the only PCV2-associated feature and, by immunohistochemistry, only 3 out of 20 subjects showed a low viral load.
Keywords	Porcine circovirus ; Porcine circovirus-2 ; adjuvants ; antigens ; blood ; histiocytes ; ileum ; immunity ; immunohistochemistry ; microbiology ; oils ; vaccination ; viral load ; viremia
Language	English
Dates of publication	2021-01
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2020.108887
Database	NAL-Catalogue (AGRICOLA)

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