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  1. Article: Self-reported side effects of COVID-19 vaccines among the public.

    Karuppannan, Mahmathi / Ming, Long Chiau / Abdul Wahab, Mohd Shahezwan / Mohd Noordin, Zakiah / Yee, Shermaine / Hermansyah, Andi

    Journal of pharmaceutical policy and practice

    2024  Volume 17, Issue 1, Page(s) 2308617

    Abstract: Background: The safety, side effects and efficacy profile of COVID-19 vaccines remain subjects of ongoing concern among the public in Malaysia. The aim of this study was to determine the types of adverse effects following immunisation with COVID-19 ... ...

    Abstract Background: The safety, side effects and efficacy profile of COVID-19 vaccines remain subjects of ongoing concern among the public in Malaysia. The aim of this study was to determine the types of adverse effects following immunisation with COVID-19 vaccines and the differences based on various types of COVID-19 vaccines to raise public awareness and reduce vaccine hesitancy among the public.
    Methods: A total of
    Results: A total of
    Conclusion: This study demonstrated the types of self-reported adverse effects following immunisation with single and mixed COVID-19 vaccines. These findings may provide the side effects of different COVID-19 vaccines with the hope of educating the public on the safety profiles of these vaccines and reducing vaccine hesitancy among the public.
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2734772-2
    ISSN 2052-3211
    ISSN 2052-3211
    DOI 10.1080/20523211.2024.2308617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-COV-2 as an artificial creation: scientific arguments and counterarguments.

    Yee, Shermaine / Tan, Ching Siang / Khan, Abdullah / Lee, Kah Seng / Goh, Bey Hing / Ming, Long Chiau

    Journal of medicine and life

    2021  Volume 14, Issue 1, Page(s) 118–120

    Language English
    Publishing date 2021-03-02
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2559353-5
    ISSN 1844-3117 ; 1844-3117 ; 1844-3109
    ISSN (online) 1844-3117
    ISSN 1844-3117 ; 1844-3109
    DOI 10.25122/jml-2020-0175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Predicting chemotherapeutic drug combinations through gene network profiling.

    Nguyen, Thi Thuy Trang / Chua, Jacqueline Kia Kee / Seah, Kwi Shan / Koo, Seok Hwee / Yee, Jie Yin / Yang, Eugene Guorong / Lim, Kim Kiat / Pang, Shermaine Yu Wen / Yuen, Audrey / Zhang, Louxin / Ang, Wee Han / Dymock, Brian / Lee, Edmund Jon Deoon / Chen, Ee Sin

    Scientific reports

    2016  Volume 6, Page(s) 18658

    Abstract: Contemporary chemotherapeutic treatments incorporate the use of several agents in combination. However, selecting the most appropriate drugs for such therapy is not necessarily an easy or straightforward task. Here, we describe a targeted approach that ... ...

    Abstract Contemporary chemotherapeutic treatments incorporate the use of several agents in combination. However, selecting the most appropriate drugs for such therapy is not necessarily an easy or straightforward task. Here, we describe a targeted approach that can facilitate the reliable selection of chemotherapeutic drug combinations through the interrogation of drug-resistance gene networks. Our method employed single-cell eukaryote fission yeast (Schizosaccharomyces pombe) as a model of proliferating cells to delineate a drug resistance gene network using a synthetic lethality workflow. Using the results of a previous unbiased screen, we assessed the genetic overlap of doxorubicin with six other drugs harboring varied mechanisms of action. Using this fission yeast model, drug-specific ontological sub-classifications were identified through the computation of relative hypersensitivities. We found that human gastric adenocarcinoma cells can be sensitized to doxorubicin by concomitant treatment with cisplatin, an intra-DNA strand crosslinking agent, and suberoylanilide hydroxamic acid, a histone deacetylase inhibitor. Our findings point to the utility of fission yeast as a model and the differential targeting of a conserved gene interaction network when screening for successful chemotherapeutic drug combinations for human cells.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Doxorubicin/pharmacology ; Drug Combinations ; Drug Resistance, Multiple/genetics ; Drug Resistance, Neoplasm/genetics ; Drug Screening Assays, Antitumor ; Gene Expression Profiling ; Gene Expression Regulation, Fungal/drug effects ; Gene Regulatory Networks/drug effects ; Humans ; Mutation ; Schizosaccharomyces/drug effects ; Schizosaccharomyces/genetics
    Chemical Substances Antineoplastic Agents ; Drug Combinations ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2016-01-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep18658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluating the association of COVID-19 restrictions on discharge planning and post-discharge outcomes in the community hospital and Singapore regional health system.

    Chia, Shermain / Xia, Jiawen / Kwan, Yu Heng / Lim, Zhui Ying / Tan, Chuen Seng / Low, Sher Guan / Xu, Bangyu / Loo, Yu Xian / Kong, Lai Yee / Koh, Chee Wai / Towle, Rachel Marie / Lim, Su Fee / Yoon, Sungwon / Seah, Sharna Si Ying / Low, Lian Leng

    Frontiers in health services

    2023  Volume 3, Page(s) 1147698

    Abstract: Objectives: The COVID-19 is a global health issue with widespread impact around the world, and many countries initiated lockdowns as part of their preventive measures. We aim to quantify the duration of delay in discharge to community from Community ... ...

    Abstract Objectives: The COVID-19 is a global health issue with widespread impact around the world, and many countries initiated lockdowns as part of their preventive measures. We aim to quantify the duration of delay in discharge to community from Community Hospitals, as well as quantify adverse patient outcomes post discharge pre and during lockdown period.
    Design and methods: We conducted a before-after study comparing the length of stay in Community Hospitals, unscheduled readmissions or Emergency Department attendance, patients' quality of life using EQ5D-5l, number and severity of falls, in patients admitted and discharged before and during lockdown period.
    Results: The average length of stay in the lockdown group (27.77 days) were significantly longer than that of the pre-lockdown group (23.76 days),
    Conclusion: Our study would help in developing a future systematic preparedness guideline and contingency plans in times of disease outbreak and other similar public health emergencies.
    Language English
    Publishing date 2023-09-05
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2813-0146
    ISSN (online) 2813-0146
    DOI 10.3389/frhs.2023.1147698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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