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  1. Article ; Online: Assessment of the Effectiveness of Ticagrelor Preloading in Mitigating Periprocedural Myocardial Injury Among Non-ST Elevation Myocardial Infarction Patients Opting for an Early Invasive Approach.

    Caturano, Alfredo / Nilo, Davide / Russo, Vincenzo / Galiero, Raffaele / Monda, Marcellino / Marfella, Raffaele / Sasso, Ferdinando Carlo

    Journal of cardiovascular pharmacology

    2024  Volume 83, Issue 4, Page(s) 308–310

    MeSH term(s) Humans ; Ticagrelor/adverse effects ; Platelet Aggregation Inhibitors/adverse effects ; Purinergic P2Y Receptor Antagonists/adverse effects ; Non-ST Elevated Myocardial Infarction ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
    Chemical Substances Ticagrelor (GLH0314RVC) ; Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1471: Show issues Location:
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  2. Article: Editorial: Hyperglycemia and Coronary Artery Diseases: Physio-Pathological Findings and Therapeutic Implications.

    Marfella, Raffaele / Federici, Massimo / Paolisso, Giuseppe

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 901815

    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.901815
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  3. Article ; Online: Impact of Sex Differences in Incident and Recurrent Coronary Events and All-Cause Mortality.

    Sardu, Celestino / Paolisso, Giuseppe / Marfella, Raffaele

    Journal of the American College of Cardiology

    2021  Volume 77, Issue 6, Page(s) 829–830

    MeSH term(s) Cause of Death ; Female ; Humans ; Male ; Myocardial Infarction ; Sex Characteristics
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.10.059
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 196: Show issues

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  4. Article: Advances in Pharmacological Approaches for Managing Hypercholesterolemia: A Comprehensive Overview of Novel Treatments.

    Mormone, Andrea / Tortorella, Giovanni / Esposito, Francesca / Caturano, Alfredo / Marrone, Aldo / Cozzolino, Domenico / Galiero, Raffaele / Marfella, Raffaele / Sasso, Ferdinando Carlo / Rinaldi, Luca

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Hypercholesterolemia plays a crucial role in the formation of lipid plaques, particularly with elevated low-density lipoprotein (LDL-C) levels, which are linked to increased risks of cardiovascular disease, cerebrovascular disease, and peripheral ... ...

    Abstract Hypercholesterolemia plays a crucial role in the formation of lipid plaques, particularly with elevated low-density lipoprotein (LDL-C) levels, which are linked to increased risks of cardiovascular disease, cerebrovascular disease, and peripheral arterial disease. Controlling blood cholesterol values, specifically reducing LDL-C, is widely recognized as a key modifiable risk factor for decreasing the morbidity and mortality associated with cardiovascular diseases. Historically, statins, by inhibiting the enzyme β-hydroxy β-methylglutaryl-coenzyme A (HMG)-CoA reductase, have been among the most effective drugs. However, newer non-statin agents have since been introduced into hypercholesterolemia therapy, providing a viable alternative with a favorable cost-benefit ratio. This paper aims to delve into the latest therapies, shedding light on their mechanisms of action and therapeutic benefits.
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020432
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  5. Article ; Online: Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease.

    Martino, Elisa / D'Onofrio, Nunzia / Balestrieri, Anna / Colloca, Antonino / Anastasio, Camilla / Sardu, Celestino / Marfella, Raffaele / Campanile, Giuseppe / Balestrieri, Maria Luisa

    Nutrients

    2024  Volume 16, Issue 1

    Abstract: In the context of nutrient-driven epigenetic alterations, food-derived miRNAs can be absorbed into the circulatory system and organs of recipients, especially humans, and potentially contribute to modulating health and diseases. Evidence suggests that ... ...

    Abstract In the context of nutrient-driven epigenetic alterations, food-derived miRNAs can be absorbed into the circulatory system and organs of recipients, especially humans, and potentially contribute to modulating health and diseases. Evidence suggests that food uptake, by carrying exogenous miRNAs (xenomiRNAs), regulates the individual miRNA profile, modifying the redox homeostasis and inflammatory conditions underlying pathological processes, such as type 2 diabetes mellitus, insulin resistance, metabolic syndrome, and cancer. The capacity of diet to control miRNA levels and the comprehension of the unique characteristics of dietary miRNAs in terms of gene expression regulation show important perspectives as a strategy to control disease susceptibility via epigenetic modifications and refine the clinical outcomes. However, the absorption, stability, availability, and epigenetic roles of dietary miRNAs are intriguing and currently the subject of intense debate; additionally, there is restricted knowledge of their physiological and potential side effects. Within this framework, we provided up-to-date and comprehensive knowledge on dietary miRNAs' potential, discussing the latest advances and controversial issues related to the role of miRNAs in human health and disease as modulators of chronic syndromes.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/genetics ; Nutritional Status ; Diet ; Epigenesis, Genetic ; MicroRNAs/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16010160
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  6. Article: Precision Medicine in Type 2 Diabetes Mellitus: Utility and Limitations.

    Galiero, Raffaele / Caturano, Alfredo / Vetrano, Erica / Monda, Marcellino / Marfella, Raffaele / Sardu, Celestino / Salvatore, Teresa / Rinaldi, Luca / Sasso, Ferdinando Carlo

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2023  Volume 16, Page(s) 3669–3689

    Abstract: Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases in Western countries, and its incidence is constantly increasing. Epidemiological studies have shown that in the next 20 years. The number of subjects affected by T2DM will double. In ...

    Abstract Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases in Western countries, and its incidence is constantly increasing. Epidemiological studies have shown that in the next 20 years. The number of subjects affected by T2DM will double. In recent years, owing to the development and improvement in methods for studying the genome, several authors have evaluated the association between monogenic or polygenic genetic alterations and the development of metabolic diseases and complications. In addition, sedentary lifestyle and socio-economic and pandemic factors have a great impact on the habits of the population and have significantly contributed to the increase in the incidence of metabolic disorders, obesity, T2DM, metabolic syndrome, and liver steatosis. Moreover, patients with type 2 diabetes appear to respond to antihyperglycemic drugs. Only a minority of patients could be considered true non-responders. Thus, it appears clear that the main aim of precision medicine in T2DM is to identify patients who can benefit most from a specific drug class more than from the others. Precision medicine is a discipline that evaluates the applicability of genetic, lifestyle, and environmental factors to disease development. In particular, it evaluated whether these factors could affect the development of diseases and their complications, response to diet, lifestyle, and use of drugs. Thus, the objective is to find prevention models aimed at reducing the incidence of pathology and mortality and therapeutic personalized approaches, to obtain a greater probability of response and efficacy. This review aims to evaluate the applicability of precision medicine for T2DM, a healthcare burden in many countries.
    Language English
    Publishing date 2023-11-16
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S390752
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  7. Article ; Online: GLP-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: Current Evidence and Future Perspectives.

    Nevola, Riccardo / Epifani, Raffaella / Imbriani, Simona / Tortorella, Giovanni / Aprea, Concetta / Galiero, Raffaele / Rinaldi, Luca / Marfella, Raffaele / Sasso, Ferdinando Carlo

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease, affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available for its treatment. Beyond their anti-hyperglycemic effect and the ... ...

    Abstract To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease, affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available for its treatment. Beyond their anti-hyperglycemic effect and the surprising role of cardio- and nephroprotection, GLP-1 receptor agonists (GLP-1 RAs) have shown a significant impact on body weight and clinical, biochemical and histological markers of fatty liver and fibrosis in patients with NAFLD. Therefore, GLP-1 RAs could be a weapon for the treatment of both diabetes mellitus and NAFLD. The aim of this review is to summarize the evidence currently available on the role of GLP-1 RAs in the treatment of NAFLD and to hypothesize potential future scenarios.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/pathology ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/genetics ; Glucagon-Like Peptide-1 Receptor/metabolism ; Liver/metabolism ; Liver/pathology ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology
    Chemical Substances Glucagon-Like Peptide 1 (89750-14-1) ; Glucagon-Like Peptide-1 Receptor
    Language English
    Publishing date 2023-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021703
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  8. Article: Non-alcoholic Fatty Liver Disease (NAFLD), Type 2 Diabetes, and Non-viral Hepatocarcinoma: Pathophysiological Mechanisms and New Therapeutic Strategies.

    Vetrano, Erica / Rinaldi, Luca / Mormone, Andrea / Giorgione, Chiara / Galiero, Raffaele / Caturano, Alfredo / Nevola, Riccardo / Marfella, Raffaele / Sasso, Ferdinando Carlo

    Biomedicines

    2023  Volume 11, Issue 2

    Abstract: In recent years, the incidence of non-viral hepatocellular carcinoma (HCC) has increased dramatically, which is probably related to the increased prevalence of metabolic syndrome, together with obesity and type 2 diabetes mellitus (T2DM). Several ... ...

    Abstract In recent years, the incidence of non-viral hepatocellular carcinoma (HCC) has increased dramatically, which is probably related to the increased prevalence of metabolic syndrome, together with obesity and type 2 diabetes mellitus (T2DM). Several epidemiological studies have established the association between T2DM and the incidence of HCC and have demonstrated the role of diabetes mellitus as an independent risk factor for the development of HCC. The pathophysiological mechanisms underlying the development of Non-alcoholic fatty liver disease (NAFLD) and its progression to Non-alcoholic steatohepatitis (NASH) and cirrhosis are various and involve pro-inflammatory agents, oxidative stress, apoptosis, adipokines, JNK-1 activation, increased IGF-1 activity, immunomodulation, and alteration of the gut microbiota. Moreover, these mechanisms are thought to play a significant role in the development of NAFLD-related hepatocellular carcinoma. Early diagnosis and the timely correction of risk factors are essential to prevent the onset of liver fibrosis and HCC. The purpose of this review is to summarize the current evidence on the association among obesity, NASH/NAFLD, T2DM, and HCC, with an emphasis on clinical impact. In addition, we will examine the main mechanisms underlying this complex relationship, and the promising strategies that have recently emerged for these diseases' treatments.
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020468
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  9. Article: Update on prevention of diabetic foot ulcer.

    Miranda, Cesare / Da Ros, Roberto / Marfella, Raffaele

    Archives of medical sciences. Atherosclerotic diseases

    2021  Volume 6, Page(s) e123–e131

    Abstract: The diabetic foot ulcer is the most important reason for non-traumatic limb amputation. Based on recent data, it has been estimated that up to 34% of type 2 diabetes patients may develop diabetic foot ulcers once in their lifetime. Risk factors for ... ...

    Abstract The diabetic foot ulcer is the most important reason for non-traumatic limb amputation. Based on recent data, it has been estimated that up to 34% of type 2 diabetes patients may develop diabetic foot ulcers once in their lifetime. Risk factors for developing foot ulcers are distal sensorimotor peripheral neuropathy, peripheral arterial disease, previous ulcers, and/or amputations. Understanding the factors that place patients with diabetes mellitus at high ulceration risk and the early treatment of risk factors, and continuous education of the patient (and/or caregivers) are essential for the prevention and management of diabetic foot complications. Implementing strategies to prevent these complications is a key aspect of diabetes care, but the most effective strategy in prevention has to be investigated. More evidence from well-designed studies is needed on this topic.
    Language English
    Publishing date 2021-06-30
    Publishing country Poland
    Document type Journal Article ; Review
    ISSN 2451-0629
    ISSN 2451-0629
    DOI 10.5114/amsad.2021.107817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Corrigendum: miR-21 in Human Cardiomyopathies.

    Surina / Fontanella, Rosaria Anna / Scisciola, Lucia / Marfella, Raffaele / Paolisso, Giuseppe / Barbieri, Michelangela

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 913429

    Abstract: This corrects the article DOI: 10.3389/fcvm.2021.767064.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcvm.2021.767064.].
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.913429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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