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  1. Article: Editorial: Oxidative stress link associated with mitochondrial bioenergetics: relevance in cell aging and age-related pathologies.

    Kalra, Rajkumar Singh / Kumar, Subodh / Tomar, Dhanendra

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1273420

    Language English
    Publishing date 2023-09-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1273420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Non-coding RNA in Alzheimer's pathology and diagnosis.

    Kalra, Rajkumar Singh / Vijayan, Murali / Ghosal, Suman

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 1030742

    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.1030742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Genomic alteration landscapes of aging, metabolic disorders, and cancer: Emerging overlaps and clinical importance.

    Dhanjal, Jaspreet Kaur / Kalra, Rajkumar Singh / Tomar, Dhanendra / Ajay, Amrendra K

    Frontiers in genetics

    2023  Volume 13, Page(s) 1102953

    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.1102953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Apoptosis, autophagy, and mitophagy dysfunction in Alzheimer's disease: Evolving emergence and mechanisms.

    Kalra, Rajkumar Singh / Kandimalla, Ramesh / Bk, Binukumar

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 1049914

    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.1049914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Protein Structure Readouts of Cancer Drivers for Precision Medicine.

    Dhanjal, Jaspreet Kaur / Kalra, Rajkumar Singh

    Current protein & peptide science

    2022  Volume 23, Issue 3, Page(s) 158–165

    Abstract: Cancer is fundamentally a disease of perturbed genes. Although many mutations can be marked in the genome of cancer or a transformed cell, the initiation and progression are driven by only a few mutational events, viz., driver mutations that ... ...

    Abstract Cancer is fundamentally a disease of perturbed genes. Although many mutations can be marked in the genome of cancer or a transformed cell, the initiation and progression are driven by only a few mutational events, viz., driver mutations that progressively govern and execute the functional impacts. The driver mutations are thus believed to dictate and dysregulate the subsequent cellular proliferative function/decisions, thereby producing a cancerous state. Therefore, identifying the driver events from the genomic alterations in a patient's cancer cell gained enormous attention recently for designing better targeting therapies and paving the way for precision cancer medicine. With rolling advancements in high-throughput omic technologies, analysis of genetic variations and gene expression profiles for cancer patients has become a routine clinical practice. However, it is anticipated that protein structural alterations resulting from such driver mutations can provide more direct and clinically relevant evidence of disease states than genetic signatures alone. This review comprehensively discusses various aspects and approaches that have been developed for the prediction of cancer drivers using genetic signatures and protein structures and their potential application in developing precision cancer therapies.
    MeSH term(s) Genomics/methods ; Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/therapy ; Precision Medicine/methods ; Proteins/genetics
    Chemical Substances Proteins
    Language English
    Publishing date 2022-03-21
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2045662-1
    ISSN 1875-5550 ; 1389-2037
    ISSN (online) 1875-5550
    ISSN 1389-2037
    DOI 10.2174/1389203723666220324141754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5884: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection.

    Kalra, Rajkumar Singh / Kandimalla, Ramesh

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 39

    MeSH term(s) COVID-19 ; Heparitin Sulfate ; Humans ; Peptidyl-Dipeptidase A/metabolism ; Protein Binding ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Heparitin Sulfate (9050-30-0) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00470-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Engaging the spikes

    Rajkumar Singh Kalra / Ramesh Kandimalla

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection

    2021  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Stress-induced changes in CARF expression serve as a quantitative predictive measure of cell proliferation fate.

    Kalra, Rajkumar Singh / Chaudhary, Anupama / Omar, Amr / Li, Xiaoshuai / Khurana, Mallika / Kaul, Sunil C / Wadhwa, Renu

    Experimental cell research

    2023  Volume 429, Issue 2, Page(s) 113669

    Abstract: Discovery of CARF (Collaborator of ARF)/CDKN2AIP as an ARF-interacting protein that promotes ARF-p53- ... ...

    Abstract Discovery of CARF (Collaborator of ARF)/CDKN2AIP as an ARF-interacting protein that promotes ARF-p53-p21
    MeSH term(s) Humans ; Tumor Suppressor Protein p53/genetics ; Apoptosis ; Cellular Senescence/physiology ; Cell Proliferation ; Apoptosis Regulatory Proteins/genetics ; Cell Transformation, Neoplastic ; Cyclin-Dependent Kinase Inhibitor p21/metabolism
    Chemical Substances Tumor Suppressor Protein p53 ; Apoptosis Regulatory Proteins ; Cyclin-Dependent Kinase Inhibitor p21
    Language English
    Publishing date 2023-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1016/j.yexcr.2023.113669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Clinical Strategies and Therapeutics for Human Monkeypox Virus: A Revised Perspective on Recent Outbreaks.

    Ghosh, Nilanjan / Chacko, Leena / Vallamkondu, Jayalakshmi / Banerjee, Tanmoy / Sarkar, Chandrima / Singh, Birbal / Kalra, Rajkumar Singh / Bhatti, Jasvinder Singh / Kandimalla, Ramesh / Dewanjee, Saikat

    Viruses

    2023  Volume 15, Issue 7

    Abstract: An enveloped double-stranded DNA monkeypox virus (MPXV) is a causative agent of the zoonotic viral disease, human monkeypox (HMPX). MPXV belongs to the genus Orthopoxviridae, a family of notorious smallpox viruses, and so it shares similar clinical ... ...

    Abstract An enveloped double-stranded DNA monkeypox virus (MPXV) is a causative agent of the zoonotic viral disease, human monkeypox (HMPX). MPXV belongs to the genus Orthopoxviridae, a family of notorious smallpox viruses, and so it shares similar clinical pathophysiological features. The recent multicountry HMPX outbreak (May 2022 onwards) is recognized as an emerging global public health emergency by the World Health Organization, shunting its endemic status as opined over the past few decades. Re-emergence of HMPX raises concern to reassess the present clinical strategy and therapeutics as its outbreak evolves further. Keeping a check on these developments, here we provide insights into the HMPX epidemiology, pathophysiology, and clinical representation. Weighing on its early prevention, we reviewed the strategies that are being enrolled for HMPX diagnosis. In the line of expanded MPXV prevalence, we further reviewed its clinical management and the diverse employed preventive/therapeutic strategies, including vaccines (JYNNEOS, ACAM2000, VIGIV) and antiviral drugs/inhibitors (Tecovirimat, Cidofovir, Brincidofovir). Taken together, with a revised perspective of HMPX re-emergence, the present report summarizes new knowledge on its prevalence, pathology, and prevention strategies.
    MeSH term(s) Humans ; Animals ; Mpox (monkeypox)/drug therapy ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/prevention & control ; Monkeypox virus ; Disease Outbreaks ; Zoonoses
    Chemical Substances human intravenous vaccinia immune globulin (7UB4J759TD)
    Language English
    Publishing date 2023-07-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15071533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cell Transdifferentiation and Reprogramming in Disease Modeling: Insights into the Neuronal and Cardiac Disease Models and Current Translational Strategies.

    Kalra, Rajkumar Singh / Dhanjal, Jaspreet Kaur / Das, Mriganko / Singh, Birbal / Naithani, Rajesh

    Cells

    2021  Volume 10, Issue 10

    Abstract: Cell transdifferentiation and reprogramming approaches in recent times have enabled the manipulation of cell fate by enrolling exogenous/artificial controls. The chemical/small molecule and regulatory components of transcription machinery serve as ... ...

    Abstract Cell transdifferentiation and reprogramming approaches in recent times have enabled the manipulation of cell fate by enrolling exogenous/artificial controls. The chemical/small molecule and regulatory components of transcription machinery serve as potential tools to execute cell transdifferentiation and have thereby uncovered new avenues for disease modeling and drug discovery. At the advanced stage, one can believe these methods can pave the way to develop efficient and sensitive gene therapy and regenerative medicine approaches. As we are beginning to learn about the utility of cell transdifferentiation and reprogramming, speculations about its applications in translational therapeutics are being largely anticipated. Although clinicians and researchers are endeavoring to scale these processes, we lack a comprehensive understanding of their mechanism(s), and the promises these offer for targeted and personalized therapeutics are scarce. In the present report, we endeavored to provide a detailed review of the original concept, methods and modalities enrolled in the field of cellular transdifferentiation and reprogramming. A special focus is given to the neuronal and cardiac systems/diseases towards scaling their utility in disease modeling and drug discovery.
    MeSH term(s) Animals ; Cell Transdifferentiation ; Cellular Reprogramming/genetics ; Disease Models, Animal ; Heart Diseases/genetics ; Humans ; Mice
    Language English
    Publishing date 2021-09-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10102558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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