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  1. Article ; Online: 2019-nCoV-SARS-CoV-2 (COVID-19) infection: Crucıalıty of Furın and relevance wıth cancer.

    Usul Afsar, Cigdem

    Medical hypotheses

    2020  Volume 140, Page(s) 109770

    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109770
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1132: Show issues Location:
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  3. Article ; Online: 2019-nCoV-SARS-CoV-2 (COVID-19) infection

    Usul Afsar, Cigdem

    Medical Hypotheses

    Crucıalıty of Furın and relevance wıth cancer

    2020  Volume 140, Page(s) 109770

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109770
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: SARS-CoV-2 (Covid-19): Interferon-epsilon may be responsible of decreased mortality in females.

    Afsar, Cigdem Usul / Afsar, Selim

    Journal of reproductive immunology

    2020  Volume 141, Page(s) 103154

    MeSH term(s) Animals ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Disease Reservoirs/veterinary ; Disease Reservoirs/virology ; Eutheria/immunology ; Eutheria/virology ; Female ; Humans ; Immunity, Innate/immunology ; Interferons/genetics ; Interferons/immunology ; Male ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; SARS-CoV-2 ; Signal Transduction/immunology
    Chemical Substances IFNE protein, human ; Interferons (9008-11-1)
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country Ireland
    Document type Letter
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2020.103154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1483: Show issues Location:
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  5. Article: The Relationship between Furin and Chronic Inflammation in the Progression of Cervical Intraepithelial Neoplasia to Cancer: A Cross-Sectional Study.

    Afsar, Selim / Turan, Gulay / Guney, Gurhan / Sahin, Gozde / Talmac, Merve Aldıkactıoglu / Afsar, Cigdem Usul

    Cancers

    2023  Volume 15, Issue 19

    Abstract: Objective: The current study aimed to delineate the relationship between furin and chronic inflammation while cervical intraepithelial neoplasia progresses to cancer.: Study design: This cross-sectional study included 81 women who required ... ...

    Abstract Objective: The current study aimed to delineate the relationship between furin and chronic inflammation while cervical intraepithelial neoplasia progresses to cancer.
    Study design: This cross-sectional study included 81 women who required colposcopic examinations. The study groups were formed based on pathological results: Group I included women with cervical intraepithelial neoplasia (CIN) I (n = 30); Group II included women with CIN II-III (n = 28); and Group III included women with cervical cancer (CC) (n = 23). Furin, ki-67, and p16 levels were evaluated based on immunostaining intensity. The inflammatory indices were calculated in parallel with the literature from routine blood samples retrieved within one week before the procedure.
    Results: Furin expression gradually increased from CIN I to CIN II-III and from CIN II-III to CC, respectively (
    Conclusion: Furin expression increased gradually in parallel with the severity of cervical intraepithelial neoplasia. The inflammatory indices were higher in the presence of CC and denoted a good discrimination ability for predicting cervical cancer.
    Language English
    Publishing date 2023-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15194878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SARS-CoV-2 (Covid-19)

    Afsar, Cigdem Usul / Afsar, Selim

    Journal of Reproductive Immunology

    Interferon-epsilon may be responsible of decreased mortality in females

    2020  Volume 141, Page(s) 103154

    Keywords Obstetrics and Gynaecology ; Immunology ; Immunology and Allergy ; Reproductive Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2020.103154
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1483: Show issues Location:
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  8. Article ; Online: HIF-1α Levels in patients receiving chemoradiotherapy for locally advanced non-small cell lung carcinoma

    Cigdem Usul Afsar / Pelin Uysal

    Revista da Associação Médica Brasileira, Vol 65, Iss 10, Pp 1295-

    2019  Volume 1299

    Abstract: SUMMARY AIM To examine the relationship between treatment response and hypoxia-inducible factor-1 alpha (HIF-1α) levels in patients with locally advanced non-small cell lung cancer (NSCLC) who received chemoradiotherapy (CRT). METHODS Eighty patients ... ...

    Abstract SUMMARY AIM To examine the relationship between treatment response and hypoxia-inducible factor-1 alpha (HIF-1α) levels in patients with locally advanced non-small cell lung cancer (NSCLC) who received chemoradiotherapy (CRT). METHODS Eighty patients with NSCLC were included in the study and treated at Acibadem Mehmet Ali Aydınlar University Medical Faculty. HIF-1 α levels were measured before and after CRT by the enzyme-linked immunosorbent assay (ELISA) method. RESULTS Patients’ stages were as follows; stage IIIA (65%) and stage IIIB (35%). Squamous histology was 45%, adenocarcinoma was 44%, and others were 11%. Chemotherapy and radiotherapy were given concurrently to 80 patients. Forty-five (56%) patients received cisplatin-based chemotherapy, and 35 (44%) received carboplatin-based chemotherapy. Serum HIF-1α levels (42.90 ± 10.55 pg/mL) after CRT were significantly lower than the pretreatment levels (63.10 ± 10.22 pg/mL, p<0.001) in patients with locally advanced NSCLC. CONCLUSION The results of this study revealed that serum HIF-1α levels decreased after CRT. Decrease of HIF-1α levels after the initiation of CRT may be useful for predicting the efficacy of CRT.
    Keywords Carcinoma ; Non-Small-Cell Lung ; Chemoradiotherapy ; Hypoxia-Inducible Factor 1 ; alpha Subunit ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: HIF-1α Levels in patients receiving chemoradiotherapy for locally advanced non-small cell lung carcinoma.

    Afsar, Cigdem Usul / Uysal, Pelin

    Revista da Associacao Medica Brasileira (1992)

    2019  Volume 65, Issue 10, Page(s) 1295–1299

    Abstract: Aim: To examine the relationship between treatment response and hypoxia-inducible factor-1 alpha (HIF-1α) levels in patients with locally advanced non-small cell lung cancer (NSCLC) who received chemoradiotherapy (CRT).: Methods: Eighty patients with ...

    Abstract Aim: To examine the relationship between treatment response and hypoxia-inducible factor-1 alpha (HIF-1α) levels in patients with locally advanced non-small cell lung cancer (NSCLC) who received chemoradiotherapy (CRT).
    Methods: Eighty patients with NSCLC were included in the study and treated at Acibadem Mehmet Ali Aydınlar University Medical Faculty. HIF-1 α levels were measured before and after CRT by the enzyme-linked immunosorbent assay (ELISA) method.
    Results: Patients' stages were as follows; stage IIIA (65%) and stage IIIB (35%). Squamous histology was 45%, adenocarcinoma was 44%, and others were 11%. Chemotherapy and radiotherapy were given concurrently to 80 patients. Forty-five (56%) patients received cisplatin-based chemotherapy, and 35 (44%) received carboplatin-based chemotherapy. Serum HIF-1α levels (42.90 ± 10.55 pg/mL) after CRT were significantly lower than the pretreatment levels (63.10 ± 10.22 pg/mL, p<0.001) in patients with locally advanced NSCLC.
    Conclusion: The results of this study revealed that serum HIF-1α levels decreased after CRT. Decrease of HIF-1α levels after the initiation of CRT may be useful for predicting the efficacy of CRT.
    MeSH term(s) Adenocarcinoma/blood ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/blood ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/therapy ; Chemoradiotherapy ; Female ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/blood ; Lung Neoplasms/blood ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Middle Aged
    Chemical Substances Biomarkers, Tumor ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit
    Language English
    Publishing date 2019-11-07
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2027973-5
    ISSN 1806-9282 ; 0104-4230
    ISSN (online) 1806-9282
    ISSN 0104-4230
    DOI 10.1590/1806-9282.65.10.1295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Serum fetuin-A and RANKL levels in patients with early stage breast cancer.

    Afsar, Cigdem Usul / Aral, Hale / Can, Orçun / Can, Trabulus Didem / Karacetin, Didem / Ali, Nazlı Mehmet / Umar, Gursu Rıza / Karabulut, Senem

    Journal of medical biochemistry

    2023  Volume 42, Issue 2, Page(s) 249–257

    Abstract: Background: Breast cancer (BC) is the primary cause of mortality due to cancer in females around the world. Fetuin-A is known to increase metastases over signals and peroxisomes related with growing. Receptor activator of nuclear factor-kB ligand (RANKL) ...

    Abstract Background: Breast cancer (BC) is the primary cause of mortality due to cancer in females around the world. Fetuin-A is known to increase metastases over signals and peroxisomes related with growing. Receptor activator of nuclear factor-kB ligand (RANKL) takes part in cell adhesion, and RANKL inhibition is used in the management of cancer. We aimed to examine the relationship between serum fetuin-A, RANKL levels, other laboratory parameters and clinical findings in women diagnosed with early stage BC, in our population.
    Methods: Women having early stage BC (n=117) met our study inclusion criteria as they had no any anti-cancer therapy before. Thirty-seven healthy women controls were also confirmed with breast examination and ultrasonography and/or mammography according to their ages. Serum samples were stored at -80°C and analysed via ELISA.
    Results: Median age of the patients was 53 (range: 57-86) while it was 47 (range: 23-74) in the healthy group. Patients had lower high-density lipoprotein levels (p=0.002) and higher neutrophil counts (p=0.014). Fetuin-A and RANKL levels did not differ between the groups (p=0.116 and p=0.439, respectively) but RANKL leves were found to be lower in the favorable histological subtypes (p=0.04).
    Conclusions: In this study, we found no correlation between serum fetuin-A levels and clinical findings in patients diagnosed with early stage BC. However, RANKL levels are found to be lower in subgroups with favorable histopathologic subtypes such as tubular, papillary and mucinous BC and there was statistically significant difference.
    Language English
    Publishing date 2023-03-07
    Publishing country Serbia
    Document type Journal Article
    ZDB-ID 2387367-X
    ISSN 1452-8258
    ISSN 1452-8258
    DOI 10.5937/jomb0-37386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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