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  1. Article ; Online: Synthesis, LC-MS/MS analysis, and biological evaluation of two vaccine candidates against ticks based on the antigenic P0 peptide from R. sanguineus linked to the p64K carrier protein from Neisseria meningitidis.

    González, Luis Javier / Encinosa Guzmán, Pedro E / Machado, Wendy / Pousa, Satomy / Leyva, Alejandro / Arguelles, Ana Laura Cano / Cabrera, Gleysin / Espinosa, Luis Ariel / Parra, Rubén / Hernández, Rachel / Soto, Yamil Bello / Ledesma, Frank L / Joglar, Marisdania / Guirola, Osmany / Kurt, Louise Ulrich / Carvalho, Paulo C / Cabrales, Ania / Garay, Hilda / Besada, Vladimir /
    Durán, Rosario / Takao, Toshifumi / Estrada, Mario Pablo / Rodríguez-Mallon, Alina

    Analytical and bioanalytical chemistry

    2021  Volume 413, Issue 23, Page(s) 5885–5900

    Abstract: A peptide from the P0 acidic ribosomal protein (pP0) of ticks conjugated to keyhole limpet hemocyanin from Megathura crenulata has shown to be effective against different tick species when used in host vaccination. Turning this peptide into a commercial ... ...

    Abstract A peptide from the P0 acidic ribosomal protein (pP0) of ticks conjugated to keyhole limpet hemocyanin from Megathura crenulata has shown to be effective against different tick species when used in host vaccination. Turning this peptide into a commercial anti-tick vaccine will depend on finding the appropriate, technically and economically feasible way to present it to the host immune system. Two conjugates (p64K-Cys
    MeSH term(s) Animals ; Bacterial Outer Membrane Proteins/immunology ; Chromatography, Liquid/methods ; Electrophoresis, Polyacrylamide Gel ; Hemocyanins/immunology ; Neisseria meningitidis/immunology ; Rabbits ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Tandem Mass Spectrometry/methods ; Ticks/immunology ; Vaccines/immunology
    Chemical Substances Bacterial Outer Membrane Proteins ; Vaccines ; lpdA protein, Neisseria meningitidis ; Hemocyanins (9013-72-3) ; keyhole-limpet hemocyanin (FV4Y0JO2CX)
    Language English
    Publishing date 2021-08-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-021-03569-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The distribution of amphibian species richness in protected areas of Chiapas, Mexico

    Cabrera-Hernández, Rodolfo / Köhler, Gunther / Tejeda-Cruz, César / Peralta-Meixueiro, Miguel A. / López, Sergio

    Journal for Nature Conservation. 2023 Aug., v. 74 p.126444-

    2023  

    Abstract: Due to the current environmental crisis, many animal species face extinction problems. Amphibian populations have been affected by this crisis. Our goal is to study amphibian species diversity in Chiapas, which has 7.6% of the endemic amphibians in ... ...

    Abstract Due to the current environmental crisis, many animal species face extinction problems. Amphibian populations have been affected by this crisis. Our goal is to study amphibian species diversity in Chiapas, which has 7.6% of the endemic amphibians in Mexico and 53 protected areas. Only 58% of the protected areas have management plans or information on their resident amphibians. We aim to determine the extent of protection provided by the network of natural areas for the conservation of amphibian species in the state and to discuss the effectiveness of this protection. Therefore, we compiled a georeferenced database of 112 amphibian species in Chiapas to create each distribution model. In addition, we carried out representativeness, beta diversity, and species richness analyses. As a result, we obtained a high degree of representativeness for the records and species distribution models. However, we found a decrease in the richness of amphibians involving 20% of total species, 13% of endemics, 18% threatened according to NOM-059, and 31% threatened according to IUCN between 1800 and 2020 and 1980–2020. We also identified two biodiversity hotspots in the Sierra Madre de Chiapas and the Northern Highlands physiographic regions. Finally, based on potential distributions, we found more endemic and threatened species outside protected natural areas than inside them. Our results give a broader picture of how amphibian richness is distributed in Chiapas. This information can help to prioritize conservation efforts toward those areas rich in threatened or endemic species, such as the Northern Mountains Hotspot we identified in northern Chiapas.
    Keywords amphibians ; databases ; extinction ; geographical distribution ; georeferencing ; indigenous species ; models ; natural resources conservation ; species richness ; threatened species ; Mexico ; Chiapas ; Protected natural areas ; Species distribution model ; Endemic species ; Richness analysis
    Language English
    Dates of publication 2023-08
    Publishing place Elsevier GmbH
    Document type Article ; Online
    ZDB-ID 2077553-2
    ISSN 1618-1093 ; 1617-1381
    ISSN (online) 1618-1093
    ISSN 1617-1381
    DOI 10.1016/j.jnc.2023.126444
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  3. Article: The distribution of amphibian species richness in protected areas of Chiapas, Mexico

    Cabrera-Hernández, Rodolfo / Köhler, Gunther / Tejeda-Cruz, César / Peralta-Meixueiro, Miguel A. / López, Sergio

    Journal for nature conservation

    2023  Volume 74, Issue -, Page(s) 126444

    Language English
    Document type Article
    ZDB-ID 2077553-2
    ISSN 1617-1381
    Database Current Contents Nutrition, Environment, Agriculture

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  4. Article: Synthesis, LC-MS/MS analysis, and biological evaluation of two vaccine candidates against ticks based on the antigenic P0 peptide from R. sanguineus linked to the p64K carrier protein from Neisseria meningitidis

    González, Luis Javier / Encinosa Guzmán, Pedro E. / Machado, Wendy / Pousa, Satomy / Leyva, Alejandro / Arguelles, Ana Laura Cano / Cabrera, Gleysin / Espinosa, Luis Ariel / Parra, Rubén / Hernández, Rachel / Soto, Yamil Bello / Ledesma, Frank L. / Joglar, Marisdania / Guirola, Osmany / Kurt, Louise Ulrich / Carvalho, Paulo C. / Cabrales, Ania / Garay, Hilda / Besada, Vladimir /
    Durán, Rosario / Takao, Toshifumi / Estrada, Mario Pablo / Rodríguez-Mallon, Alina

    Analytical and bioanalytical chemistry. 2021 Sept., v. 413, no. 23

    2021  

    Abstract: A peptide from the P0 acidic ribosomal protein (pP0) of ticks conjugated to keyhole limpet hemocyanin from Megathura crenulata has shown to be effective against different tick species when used in host vaccination. Turning this peptide into a commercial ... ...

    Abstract A peptide from the P0 acidic ribosomal protein (pP0) of ticks conjugated to keyhole limpet hemocyanin from Megathura crenulata has shown to be effective against different tick species when used in host vaccination. Turning this peptide into a commercial anti-tick vaccine will depend on finding the appropriate, technically and economically feasible way to present it to the host immune system. Two conjugates (p64K-Cys¹pP0 and p64K-βAla¹pP0) were synthesized using the p64K carrier protein from Neisseria meningitidis produced in Escherichia coli, the same cross-linking reagent, and two analogues of pP0. The SDS-PAGE analysis of p64K-Cys¹pP0 showed a heterogeneous conjugate compared to p64K-βAla¹pP0 that was detected as a protein band at 91kDa. The pP0/p64K ratio determined by MALDI-MS for p64K-Cys¹pP0 ranged from 1 to 8, being 3-5 the predominant ratio, while in the case of p64K-βAla¹pP0 this ratio was 5-7. Cys¹pP0 was partially linked to 35 out of 39 Lys residues and the N-terminal end, while βAla¹pP0 was mostly linked to the six free cysteine residues, to the N-terminal end, and, in a lesser extent, to Lys residues. The assignment of the conjugation sites and side reactions were based on the identification of type 2 peptides. Rabbit immunizations showed the best anti-pP0 titers and the highest efficacy against Rhipicephalus sanguineus ticks when the p64K-Cys¹pP0 was used as vaccine antigen. The presence of high molecular mass aggregates observed in the SDS-PAGE analysis of p64K-Cys¹pP0 could be responsible for a better immune response against pP0 and consequently for its better efficacy as an anti-tick vaccine. Graphical abstract
    Keywords Escherichia coli ; Megathura crenulata ; Neisseria meningitidis ; Rhipicephalus sanguineus ; analytical chemistry ; biological assessment ; cross-linking reagents ; cysteine ; economic feasibility ; immune response ; immune system ; keyhole limpet hemocyanin ; molecular weight ; peptides ; polyacrylamide gel electrophoresis ; ribosomal proteins ; ticks ; vaccination ; vaccines
    Language English
    Dates of publication 2021-09
    Size p. 5885-5900.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ISSN 1618-2642
    DOI 10.1007/s00216-021-03569-0
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Searching for a Clue to Characterize a Crystalline Dinosaur's Eggshell of Baja California, Mexico.

    Elejalde-Cadena, Nerith R / Cabrera-Hernández, Jonathan S / Hernández-Rivera, René / Moreno, Abel

    ACS omega

    2020  Volume 5, Issue 40, Page(s) 25936–25946

    Abstract: This work presents a detailed structural and morphological analysis of different dinosaur eggshells such ... ...

    Abstract This work presents a detailed structural and morphological analysis of different dinosaur eggshells such as
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c03334
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  6. Article ; Online: Reacciones adversas asociadas al interferón alfa 2b recombinante en pacientes sospechosos y confirmados de COVID-19

    Lisvan Yassel Cala-Rosabal / Katia Peña-Infante / Yisell Urquiza-Yero / Irlenis Cabrera-Hernández / Rosa María Cala-Peña

    Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, Vol 47, Iss 1, Pp e2996-e

    2022  Volume 2996

    Abstract: ... con el Heberon® Alfa R 3 M en el tratamiento de pacientes sospechosos y confirmados de COVID-19, ingresados ... de tiempo antes definidos. De un universo de 1570 pacientes que recibieron tratamiento con Heberon® Alfa R 3 M, se definió ... Conclusiones: el Heberon® Alfa R 3 M es un medicamento seguro en el tratamiento de pacientes sospechosos y ...

    Abstract Fundamento: los interferones se han incorporado al tratamiento de pacientes sospechosos y confirmados de COVID-19. Existen reportes de reacciones adversas asociadas a este medicamento en el tratamiento de pacientes con otras enfermedades. Objetivo: describir las reacciones adversas asociadas con el Heberon® Alfa R 3 M en el tratamiento de pacientes sospechosos y confirmados de COVID-19, ingresados en el centro de atención “Motel Los Cocos”, en Las Tunas, entre el 6 de enero y el 30 de octubre de 2021. Métodos: se realizó un estudio descriptivo, retrospectivo, de corte transversal, en el centro y periodo de tiempo antes definidos. De un universo de 1570 pacientes que recibieron tratamiento con Heberon® Alfa R 3 M, se definió como muestra a los 730 que reportaron reacciones adversas. Resultados: el sexo no influyó en las reacciones adversas. Al grupo de edades entre los 50-59 años correspondió el 24,38 % de las reacciones, seguido por los grupos de 30-39 años (17,26 %), 40-49 años (16,30 %) y 20-29 años (13,15 %). Se notificaron 1102 reacciones adversas; las más frecuentes fueron: cefalea (41,23 % de los eventos), fiebre (28,08 %), malestar general (18,49 %) y escalofrío (15,75). Los pacientes tuvieron reacciones adversas de intensidad moderada (62,87 %) y leve (37,13 %), con las primeras dosis y no requirieron la suspensión del tratamiento. Conclusiones: el Heberon® Alfa R 3 M es un medicamento seguro en el tratamiento de pacientes sospechosos y confirmados de COVID-19.
    Keywords interferón alfa-2 ; antivirales ; infecciones por coronavirus ; covid-19 ; farmacovigilancia ; Medicine ; R ; Medicine (General) ; R5-920
    Language Spanish
    Publishing date 2022-01-01T00:00:00Z
    Publisher Universidad de Ciencias Médicas de Las Tunas
    Document type Article ; Online
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  7. Article ; Online: [Translated article] Combined Therapies for Locally Advanced Basal Cell Carcinoma: From Theory to Clinical Practice.

    Loizate Sarrionandia, I / Hernández González, R / Suárez Hernández, J / Fernández-de-Misa Cabrera, R

    Actas dermo-sifiliograficas

    2024  

    Language Spanish
    Publishing date 2024-03-11
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2024.03.002
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  8. Article ; Online: Neuropsychiatric disorders in patients with HIV/AIDS

    Yordany Arias-Molina / Yuleimy Cabrera-Hernández / Yosvany Herrero-Solano / Yolaine Tamayo-González

    Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, Vol 44, Iss

    2019  Volume 4

    Abstract: Background : antiretroviral therapy has been an effective response to HIV infection; however, as it is a chronic disease, some psychological variables can interfere with the adaptation to treatment and the quality of life of the patients. Objective : to ... ...

    Abstract Background : antiretroviral therapy has been an effective response to HIV infection; however, as it is a chronic disease, some psychological variables can interfere with the adaptation to treatment and the quality of life of the patients. Objective : to identify neuropsychiatric disorders in patients with HIV/AIDS of two health districts of the municipality of Bayamo, Granma, Cuba. Methods : a descriptive cross-sectional observational study was carried out with 68 patients diagnosed with HIV/AIDS treated at the "13 de Marzo" and "René Vallejo" polyclinics, between January 2018 and March 2019. Conventional and psychiatric tests were set to determine anxiety disorders, psychotic disorders, personality disorders and suicidal ideation. The results were analyzed according to descriptive statistics. Results : the studied patients showed anxiety as a trait and state with low (16,17 %) and high (42,64 %) levels respectively; 92,64 % did not show psychotic disorders; of the mental disorders studied, histrionic personality disorder (41,17 %) and paranoid personality disorder (30,88 %) were described as of major significance; 26,47 % presented suicidal ideation. Conclusions : the studied patients with HIV/AIDS had neuropsychiatric disorders with high state anxiety, personality disorders, without psychotic disorders.
    Keywords vih ; síndrome de inmunodeficiencia adquirida ; ideación suicida ; ansiedad ; trastornos psicóticos ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 150 ; 616
    Language Spanish
    Publishing date 2019-07-01T00:00:00Z
    Publisher Universidad de Ciencias Médicas de Las Tunas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Role of Drug Hypersensitivity in the Cutaneous Manifestations of SARS-CoV-2 Infection.

    Solano-Solares, E / Chica-Guzmán, V / Pérez-Allegue, I / Cabrera-Hernández, R / Fernández-Guarino, M / Fernández-Nieto, D / Moreno-García-Del-Real, C / de-Andres-Martin, A / García-Bermejo, L / González-de-Olano, D / de-la-Hoz-Caballer, B

    Journal of investigational allergology & clinical immunology

    2021  Volume 32, Issue 3, Page(s) 218–220

    MeSH term(s) Antiviral Agents ; COVID-19 ; Drug Hypersensitivity/diagnosis ; Humans ; SARS-CoV-2 ; Skin Diseases
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-09-07
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Combined Therapies for Locally Advanced Basal Cell Carcinoma: From Theory to Clinical Practice.

    Loizate Sarrionandia, I / Hernández González, R / Suárez Hernández, J / Fernández-de-Misa Cabrera, R

    Actas dermo-sifiliograficas

    2023  

    Title translation Combinación de terapias en el carcinoma basocelular localmente avanzado. De la teoría a la práctica clínica.
    Language Spanish
    Publishing date 2023-02-04
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2022.11.012
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