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Article ; Online: Evaluation of Adverse Effects in Nursing Mothers and Their Infants After COVID-19 mRNA Vaccination.

Romero Ramírez, Dolores Sabina / Suárez Hernández, María Isis / Fernández Vilar, Ana María / Rivero Falero, Mónica / Reyes Millán, Beatriz / González Carretero, Paloma / Pérez, María Magdalena Lara / Carretero Pérez, Mercedes / Martín Pulido, Saúl / Pera Villacampa, Lorena / García Bello, Miguel Ángel / Mesa Medina, Orlando Manuel / Roper, Sabine

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

2022 Volume 17, Issue 5, Page(s) 412–421

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	2019-nCoV Vaccine mRNA-1273/adverse effects ; Adult ; BNT162 Vaccine/adverse effects ; Breast Feeding ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Humans ; Infant ; Mothers ; Prospective Studies ; Vaccination/adverse effects
Chemical Substances	COVID-19 Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2234680-6
ISSN	1556-8342 ; 1556-8253
ISSN (online)	1556-8342
ISSN	1556-8253
DOI	10.1089/bfm.2021.0256
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Article ; Online: SARS-CoV-2 Antibodies in Breast Milk After Vaccination.

Romero Ramírez, Dolores Sabina / Lara Pérez, María Magdalena / Carretero Pérez, Mercedes / Suárez Hernández, María Isis / Martín Pulido, Saúl / Pera Villacampa, Lorena / Fernández Vilar, Ana María / Rivero Falero, Mónica / González Carretero, Paloma / Reyes Millán, Beatriz / Roper, Sabine / García Bello, Miguel Ángel

Pediatrics

2021 Volume 148, Issue 5

Abstract: Background and objectives: Passive and active immunity transfer through human milk (HM) constitutes a key element in the infant's developing immunity. Certain infectious diseases and vaccines have been described to induce changes in the immune ... ...

Abstract	Background and objectives: Passive and active immunity transfer through human milk (HM) constitutes a key element in the infant's developing immunity. Certain infectious diseases and vaccines have been described to induce changes in the immune components of HM. Methods: We conducted a prospective cohort single-institution study from February 2 to April 4, 2021. Women who reported to be breastfeeding at the time of their coronavirus disease 2019 (COVID-19) vaccination were invited to participate. Blood and milk samples were collected on day 14 after their second dose of the vaccine. Immunoglobulin G (IgG) antibodies against nucleocapsid protein as well as IgG, immunoglobulin M and immunoglobulin A (IgA) antibodies against the spike 1 protein receptor-binding domain against severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2 RBD-S1) were analyzed in both serum and HM samples. Results: Most of the participants (ie, 94%) received the BNT162b2 messenger RNA COVID-19 vaccine. The mean serum concentration of anti-SARS-CoV-2 RBD-S-IgG antibodies in vaccinated individuals was 3379.6 ± 1639.5 binding antibody units per mL. All vaccinated study participants had anti-SARS-CoV-2 RBD-S1-IgG, and 89% of them had anti-SARS-CoV-2 RBD-S-IgA in their milk. The antibody concentrations in the milk of mothers who were breastfeeding 24 months were significantly higher than in mothers with breastfeeding periods <24 months ( Conclusions: We found a clear association between COVID-19 vaccination and specific immunoglobulin concentrations in HM. This effect was more pronounced when lactation periods exceeded 23 months. The influence of the lactation period on immunoglobulins was specific and independent of other variables.
MeSH term(s)	Adult ; Antibodies, Viral/analysis ; COVID-19 Vaccines ; Female ; Humans ; Immunoglobulin A/analysis ; Immunoglobulin G/analysis ; Immunoglobulin M/analysis ; Infant ; Infant, Newborn ; Male ; Milk, Human/chemistry ; Milk, Human/immunology ; Prospective Studies ; SARS-CoV-2/immunology ; Vaccination
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2021-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2021-052286
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Article: Neonatal Infection Due to SARS-CoV-2: An Epidemiological Study in Spain.

Fernández Colomer, Belén / Sánchez-Luna, Manuel / de Alba Romero, Concepción / Alarcón, Ana / Baña Souto, Ana / Camba Longueira, Fátima / Cernada, María / Galve Pradell, Zenaida / González López, María / López Herrera, M Cruz / Ribes Bautista, Carmen / Sánchez García, Laura / Zamora Flores, Elena / Pellicer, Adelina / Alonso Díaz, Clara / Herraiz Perea, Cristina / Romero Ramírez, Dolores Sabina / de Las Cuevas Terán, Isabel / Pescador Chamorro, Isabel /

Fernández Trisac, José Luis / Arruza Gómez, Luis / Cardo Fernández, Luis Miguel / García García, Mª Jesús / Nicolás López, Marta / Hortelano López, Miryam / Riaza Gómez, Mónica / Hernández González, Natalio / González Sánchez, Raquel / Zambudio Sert, Sílvia / Larrosa Capacés, Susana / Matías Del Pozo, Vanesa

Frontiers in pediatrics

2020 Volume 8, Page(s) 580584

Abstract: Objective: ...

Abstract	Objective:
Keywords	covid19
Language	English
Publishing date	2020-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2020.580584
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Article ; Online: Neonatal Infection Due to SARS-CoV-2

Fernández Colomer, Belén / Sánchez-Luna, Manuel / de Alba Romero, Concepción / Alarcón, Ana / Baña Souto, Ana / Camba Longueira, Fátima / Cernada, María / Galve Pradell, Zenaida / González López, María / López Herrera, M. Cruz / Ribes Bautista, Carmen / Sánchez García, Laura / Zamora Flores, Elena / Pellicer, Adelina / Alonso Díaz, Clara / Herraiz Perea, Cristina / Romero Ramírez, Dolores Sabina / de las Cuevas Terán, Isabel / Pescador Chamorro, Isabel /

Fernández Trisac, José Luis / Arruza Gómez, Luis / Cardo Fernández, Luis Miguel / García García, M� Jesús / Nicolás López, Marta / Hortelano López, Miryam / Riaza Gómez, Mónica / Hernández González, Natalio / González Sánchez, Raquel / Zambudio Sert, Sílvia / Larrosa Capacés, Susana / Matías del Pozo, Vanesa

Frontiers in Pediatrics

An Epidemiological Study in Spain

2020 Volume 8

Keywords	covid19
Publisher	Frontiers Media SA
Publishing country	ch
Document type	Article ; Online
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2020.580584
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An Epidemiological Study in Spain.docx

2020

Abstract: Objective: Coronavirus disease 2019 (COVID-19) cases caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to increase worldwide. Although some data from pediatric series are available, more evidence is required, especially ... ...

Abstract	Objective: Coronavirus disease 2019 (COVID-19) cases caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to increase worldwide. Although some data from pediatric series are available, more evidence is required, especially in neonates, a group with specific characteristics that deserve special attention. This study aimed to describe general and clinical characteristics, management, and treatment of postnatal-acquired (community and nosocomial/hospital-acquired) COVID-19 neonatal cases in Spain. Methods: This was a national prospective epidemiological study that included cases from a National Registry supported by the Spanish Society of Neonatology. Neonates with postnatal SARS-CoV-2 infection were included in this study. General data and infection-related information (mode and source of transmission, age at diagnosis, clinical manifestations, need for hospitalization, admission unit, treatment administered, and complementary studies performed, hospital stay associated with the infection) were collected. Results: A total of 40 cases, 26 community-acquired and 14 nosocomial were registered. Ten were preterm newborns (2 community-acquired and 8 nosocomial COVID-19 cases). Mothers (in both groups) and healthcare workers (in nosocomial cases) were the main source of infection. Hospital admission was required in 22 community-acquired cases [18 admitted to the neonatal intermediate care unit (NIMCU) and 4 to the neonatal intensive care unit (NICU)]. Among nosocomial COVID-19 cases (n = 14), previously admitted for other reasons, 4 were admitted to the NIMCU and 10 to the NICU. Ten asymptomatic patients were registered (5 in each group). In the remaining cases, clinical manifestations were generally mild in both groups, including upper respiratory airways infection, febrile syndrome or acute gastroenteritis with good overall health. In both groups, most severe cases occurred in preterm neonates or neonates with concomitant pathologies. Most of the cases did not require respiratory support. Hydroxychloroquine was administered to 4 patients in the community-acquired group and to 2 patients in the nosocomial group. Follow-up after hospital discharge was performed in most patients. Conclusions: This is the largest series of COVID-19 neonatal cases in Spain published to date. Although clinical manifestations were generally mild, prevention, treatment, and management in this group are essential.
Keywords	Foetal Development and Medicine ; Obstetrics and Gynaecology ; Paediatrics ; Paediatrics and Reproductive Medicine not elsewhere classified ; coronavirus disease 2019 ; SARS-CoV-2 infection ; neonates ; epidemiology–descriptive ; hospital-acquired infection ; community-acquired infection ; covid19
Subject code	610
Publishing date	2020-10-23T04:36:32Z
Publishing country	uk
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neonatal Infection Due to SARS-CoV-2

Frontiers in Pediatrics, Vol

An Epidemiological Study in Spain

2020 Volume 8

Abstract	Objective: Coronavirus disease 2019 (COVID-19) cases caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to increase worldwide. Although some data from pediatric series are available, more evidence is required, especially in neonates, a group with specific characteristics that deserve special attention. This study aimed to describe general and clinical characteristics, management, and treatment of postnatal-acquired (community and nosocomial/hospital-acquired) COVID-19 neonatal cases in Spain.Methods: This was a national prospective epidemiological study that included cases from a National Registry supported by the Spanish Society of Neonatology. Neonates with postnatal SARS-CoV-2 infection were included in this study. General data and infection-related information (mode and source of transmission, age at diagnosis, clinical manifestations, need for hospitalization, admission unit, treatment administered, and complementary studies performed, hospital stay associated with the infection) were collected.Results: A total of 40 cases, 26 community-acquired and 14 nosocomial were registered. Ten were preterm newborns (2 community-acquired and 8 nosocomial COVID-19 cases). Mothers (in both groups) and healthcare workers (in nosocomial cases) were the main source of infection. Hospital admission was required in 22 community-acquired cases [18 admitted to the neonatal intermediate care unit (NIMCU) and 4 to the neonatal intensive care unit (NICU)]. Among nosocomial COVID-19 cases (n = 14), previously admitted for other reasons, 4 were admitted to the NIMCU and 10 to the NICU. Ten asymptomatic patients were registered (5 in each group). In the remaining cases, clinical manifestations were generally mild in both groups, including upper respiratory airways infection, febrile syndrome or acute gastroenteritis with good overall health. In both groups, most severe cases occurred in preterm neonates or neonates with concomitant pathologies. Most of the cases did not require respiratory support. Hydroxychloroquine was administered to 4 patients in the community-acquired group and to 2 patients in the nosocomial group. Follow-up after hospital discharge was performed in most patients.Conclusions: This is the largest series of COVID-19 neonatal cases in Spain published to date. Although clinical manifestations were generally mild, prevention, treatment, and management in this group are essential.
Keywords	coronavirus disease 2019 ; SARS-CoV-2 infection ; neonates ; epidemiology–descriptive ; hospital-acquired infection ; community-acquired infection ; Pediatrics ; RJ1-570 ; covid19
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article: Correction: Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study.

Chaparro, María / Garre, Ana / Núñez Ortiz, Andrea / Diz-Lois Palomares, María Teresa / Rodríguez, Cristina / Riestra, Sabino / Vela, Milagros / Benítez, José Manuel / Fernández Salgado, Estela / Sánchez Rodríguez, Eugenia / Hernández, Vicent / Ferreiro-Iglesias, Rocío / Ponferrada Díaz, Ángel / Barrio, Jesús / Huguet, José María / Sicilia, Beatriz / Martín-Arranz, María Dolores / Calvet, Xavier / Ginard, Daniel /

Alonso-Abreu, Inmaculada / Fernández-Salazar, Luis / Varela Trastoy, Pilar / Rivero, Montserrat / Vera-Mendoza, Isabel / Vega, Pablo / Navarro, Pablo / Sierra, Mónica / Cabriada, José Luis / Aguas, Mariam / Vicente, Raquel / Navarro-Llavat, Mercè / Echarri, Ana / Gomollón, Fernando / Guerra Del Río, Elena / Piñero, Concepción / Casanova, María José / Spicakova, Katerina / Ortiz de Zarate, Jone / Torrella Cortés, Emilio / Gutiérrez, Ana / Alonso-Galán, Horacio / Hernández-Martínez, Álvaro / Marrero, José Miguel / Lorente Poyatos, Rufo / Calafat, Margalida / Martí Romero, Lidia / Robledo, Pilar / Bosch, Orencio / Jiménez, Nuria / Esteve Comas, María / Duque, José María / Fuentes Coronel, Ana María / Josefa Sampedro, Manuela / Sesé Abizanda, Eva / Herreros Martínez, Belén / Pozzati, Liliana / Fernández Rosáenz, Hipólito / Crespo Suarez, Belén / López Serrano, Pilar / Lucendo, Alfredo J / Muñoz Vicente, Margarita / Bermejo, Fernando / Ramírez Palanca, José Joaquín / Menacho, Margarita / Carmona, Amalia / Camargo, Raquel / Torra Alsina, Sandra / Maroto, Nuria / Nerín de la Puerta, Juan / Castro, Elena / Marín-Jiménez, Ignacio / Botella, Belén / Sapiña, Amparo / Cruz, Noelia / Forcelledo, José Luis F / Bouhmidi, Abdel / Castaño-Milla, Carlos / Opio, Verónica / Nicolás, Isabel / Kutz, Marcos / Abraldes Bechiarelli, Alfredo / Gordillo, Jordi / Ber, Yolanda / Torres Domínguez, Yolanda / Novella Durán, María Teresa / Rodríguez Mondéjar, Silvia / Martínez-Cerezo, Francisco J / Kolle, Lilyan / Sabat, Miriam / Ledezma, Cesar / Iyo, Eduardo / Roncero, Óscar / Irisarri, Rebeca / Lluis, Laia / Blázquez Gómez, Isabel / Zapata, Eva María / José Alcalá, María / Martínez Pascual, Cristina / Montealegre, María / Mata, Laura / Monrobel, Ana / Hernández Camba, Alejandro / Hernández, Luis / Tejada, María / Mir, Alberto / Galve, María Luisa / Soler, Marta / Hervías, Daniel / Gómez-Valero, José Antonio / Barreiro-de Acosta, Manuel / Rodríguez-Artalejo, Fernando / García-Esquinas, Esther / Gisbert, Javier P / On Behalf Of The EpidemIBD Study Group Of Geteccu

Journal of clinical medicine

2022 Volume 11, Issue 19

Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [...].
Language	English
Publishing date	2022-09-30
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11195816
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Article ; Online: Effectiveness and Safety of the Sequential Use of a Second and Third Anti-TNF Agent in Patients With Inflammatory Bowel Disease: Results From the Eneida Registry.

Casanova, María José / Chaparro, María / Mínguez, Miguel / Ricart, Elena / Taxonera, Carlos / García-López, Santiago / Guardiola, Jordi / López-San Román, Antonio / Iglesias, Eva / Beltrán, Belén / Sicilia, Beatriz / Vera, María Isabel / Hinojosa, Joaquín / Riestra, Sabino / Domènech, Eugeni / Calvet, Xavier / Pérez-Calle, José Lázaro / Martín-Arranz, María Dolores / Aldeguer, Xavier /

Rivero, Montserrat / Monfort, David / Barrio, Jesús / Esteve, María / Márquez, Lucía / Lorente, Rufo / García-Planella, Esther / de Castro, Luisa / Bermejo, Fernando / Merino, Olga / Rodríguez-Pérez, Antonio / Martínez-Montiel, Pilar / Van Domselaar, Manuel / Alcaín, Guillermo / Domínguez-Cajal, Manuel / Muñoz, Carmen / Gomollón, Fernando / Fernández-Salazar, Luis / García-Sepulcre, Mariana Fe / Rodríguez-Lago, Iago / Gutiérrez, Ana / Argüelles-Arias, Federico / Rodriguez, Cristina / Rodríguez, Gloria Esther / Bujanda, Luis / Llaó, Jordina / Varela, Pilar / Ramos, Laura / Huguet, José María / Almela, Pedro / Romero, Patricia / Navarro-Llavat, Mercè / Abad, Águeda / Ramírez-de la Piscina, Patricia / Lucendo, Alfredo J / Sesé, Eva / Madrigal, Rosa Eva / Charro, Mara / García-Herola, Antonio / Pajares, Ramón / Khorrami, Sam / Gisbert, Javier P

Inflammatory bowel diseases

2019 Volume 26, Issue 4, Page(s) 606–616

Abstract: Background: The effectiveness of the switch to another anti-tumor necrosis factor (anti-TNF) agent is not known. The aim of this study was to analyze the effectiveness and safety of treatment with a second and third anti-TNF drug after intolerance to or ...

Abstract	Background: The effectiveness of the switch to another anti-tumor necrosis factor (anti-TNF) agent is not known. The aim of this study was to analyze the effectiveness and safety of treatment with a second and third anti-TNF drug after intolerance to or failure of a previous anti-TNF agent in inflammatory bowel disease (IBD) patients. Methods: We included patients diagnosed with IBD from the ENEIDA registry who received another anti-TNF after intolerance to or failure of a prior anti-TNF agent. Results: A total of 1122 patients were included. In the short term, remission was achieved in 55% of the patients with the second anti-TNF. The incidence of loss of response was 19% per patient-year with the second anti-TNF. Combination therapy (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.8-3; P < 0.0001) and ulcerative colitis vs Crohn's disease (HR, 1.6; 95% CI, 1.1-2.1; P = 0.005) were associated with a higher probability of loss of response. Fifteen percent of the patients had adverse events, and 10% had to discontinue the second anti-TNF. Of the 71 patients who received a third anti-TNF, 55% achieved remission. The incidence of loss of response was 22% per patient-year with a third anti-TNF. Adverse events occurred in 7 patients (11%), but only 1 stopped the drug. Conclusions: Approximately half of the patients who received a second anti-TNF achieved remission; nevertheless, a significant proportion of them subsequently lost response. Combination therapy and type of IBD were associated with loss of response. Remission was achieved in almost 50% of patients who received a third anti-TNF; nevertheless, a significant proportion of them subsequently lost response.
MeSH term(s)	Adalimumab/administration & dosage ; Adalimumab/therapeutic use ; Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Colitis, Ulcerative/drug therapy ; Crohn Disease/drug therapy ; Female ; Humans ; Infliximab/administration & dosage ; Infliximab/therapeutic use ; Kaplan-Meier Estimate ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Prospective Studies ; Registries ; Remission Induction ; Spain ; Tumor Necrosis Factor Inhibitors/adverse effects ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Young Adult
Chemical Substances	Tumor Necrosis Factor Inhibitors ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842)
Language	English
Publishing date	2019-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izz192
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Article: Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study.

Journal of clinical medicine

2021 Volume 10, Issue 13

Abstract: 1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: ... ...

Abstract	(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients,
Language	English
Publishing date	2021-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10132885
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Article ; Online: Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain

María Chaparro / Ana Garre / Andrea Núñez Ortiz / María Teresa Diz-Lois Palomares / Cristina Rodríguez / Sabino Riestra / Milagros Vela / José Manuel Benítez / Estela Fernández Salgado / Eugenia Sánchez Rodríguez / Vicent Hernández / Rocío Ferreiro-Iglesias / Ángel Ponferrada Díaz / Jesús Barrio / José María Huguet / Beatriz Sicilia / María Dolores Martín-Arranz / Xavier Calvet / Daniel Ginard /

Inmaculada Alonso-Abreu / Luis Fernández-Salazar / Pilar Varela Trastoy / Montserrat Rivero / Isabel Vera-Mendoza / Pablo Vega / Pablo Navarro / Mónica Sierra / José Luis Cabriada / Mariam Aguas / Raquel Vicente / Mercè Navarro-Llavat / Ana Echarri / Fernando Gomollón / Elena Guerra del Río / Concepción Piñero / María José Casanova / Katerina Spicakova / Jone Ortiz de Zarate / Emilio Torrella Cortés / Ana Gutiérrez / Horacio Alonso-Galán / Álvaro Hernández-Martínez / José Miguel Marrero / Rufo Lorente Poyatos / Margalida Calafat / Lidia Martí Romero / Pilar Robledo / Orencio Bosch / Nuria Jiménez / María Esteve Comas / José María Duque / Ana María Fuentes Coronel / Manuela Josefa Sampedro / Eva Sesé Abizanda / Belén Herreros Martínez / Liliana Pozzati / Hipólito Fernández Rosáenz / Belén Crespo Suarez / Pilar López Serrano / Alfredo J. Lucendo / Margarita Muñoz Vicente / Fernando Bermejo / José Joaquín Ramírez Palanca / Margarita Menacho / Amalia Carmona / Raquel Camargo / Sandra Torra Alsina / Nuria Maroto / Juan Nerín de la Puerta / Elena Castro / Ignacio Marín-Jiménez / Belén Botella / Amparo Sapiña / Noelia Cruz / José Luis F. Forcelledo / Abdel Bouhmidi / Carlos Castaño-Milla / Verónica Opio / Isabel Nicolás / Marcos Kutz / Alfredo Abraldes Bechiarelli / Jordi Gordillo / Yolanda Ber / Yolanda Torres Domínguez / María Teresa Novella Durán / Silvia Rodríguez Mondéjar / Francisco J. Martínez-Cerezo / Lilyan Kolle / Miriam Sabat / Cesar Ledezma / Eduardo Iyo / Óscar Roncero / Rebeca Irisarri / Laia Lluis / Isabel Blázquez Gómez / Eva María Zapata / María José Alcalá / Cristina Martínez Pascual / María Montealegre / Laura Mata / Ana Monrobel / Alejandro Hernández Camba / Luis Hernández / María Tejada / Alberto Mir / María Luisa Galve / Marta Soler / Daniel Hervías / José Antonio Gómez-Valero / Manuel Barreiro-de Acosta / Fernando Rodríguez-Artalejo / Esther García-Esquinas / Javier P. Gisbert / on behalf of the EpidemIBD study group of GETECCU

Journal of Clinical Medicine, Vol 10, Iss 2885, p

Large-Scale Epidemiological Study

2021 Volume 2885

Abstract	(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD—Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)—during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31–56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.
Keywords	epidemiology ; incidence ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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In stock of ZB MED Cologne/Königswinter

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Order via subito

Full text online

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Inter-library loan at ZB MED