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  1. Article: Putting leaders on the couch. A conversation with Manfred F. R. Kets de Vries. Interview by Diane L. Coutu.

    Kets de Vries, Manfred F

    Harvard business review

    2004  Volume 82, Issue 1, Page(s) 64–71, 113

    Abstract: ... Kets de Vries has made the analysis of CEOs his life's work. In this article, Kets de Vries ... leaders are talented in self-observation and self-analysis, Kets de Vries says. The best are highly ... to succeed. Although a number of business scholars have explored the psychology of executives, Manfred F.R ...

    Abstract Much of the business literature on leadership starts with the assumption that leaders are rational beings. But irrationality is integral to human nature, and inner conflict often contributes to the drive to succeed. Although a number of business scholars have explored the psychology of executives, Manfred F.R Kets de Vries has made the analysis of CEOs his life's work. In this article, Kets de Vries, a psychoanalyst, author, and instead professor, draws on three decades of study to describe the psychological profile of successful CEOs. He explores senior executives' vulnerabilities, which are often intensified by followers' attempts to manipulate their leaders. Leaders, he says, have an uncanny ability to awaken transferential processes--in which people transfer the dynamics of past relationships onto present interactions--among their employees and even in themselves. These processes can present themselves in a number of ways, sometimes negatively. What's more, many top executives, being middle-aged, suffer from depression. Mid-life prompts a reappraisal of career identity, and by the time a leader is a CEO, an existential crisis is often imminent. This can happen with anyone, but the probability is higher with CEOs, and senior executives because so many have devoted themselves exclusively to work. Not all CEOs are psychologically unhealthy, of course. Healthy leaders are talented in self-observation and self-analysis, Kets de Vries says. The best are highly motivated to spend time on self-reflection. Their lives are in balance, they can play, they are creative and inventive, and they have the capacity to be nonconformist. "Those who accept the madness in themselves may be the healthiest leaders of all," he concludes.
    MeSH term(s) Administrative Personnel/psychology ; Anxiety ; Culture ; Humans ; Leadership ; Narcissism ; Parent-Child Relations ; Personality Assessment ; Power (Psychology) ; Professional Competence ; Psychological Theory ; Self Concept
    Language English
    Publishing date 2004-01
    Publishing country United States
    Document type Interview
    ZDB-ID 2066391-2
    ISSN 0017-8012
    ISSN 0017-8012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: F. de Vries, leermeester van economisten

    Dullaart, M. H. J / Vries, F. de

    Economisch statistische berichten : ESB Vol. 64 , p. 1276-1277

    1979  Volume 64, Page(s) 1276–1277

    Author's details M. H. J. Dullaart
    Publisher Sdu Uitgevers
    Publishing place Den Haag
    Document type Article
    ZDB-ID 864090-7
    Database ECONomics Information System

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  3. Book ; Online ; E-Book: PET and SPECT of neurobiological systems

    Dierckx, Rudi A.J.O. / Otte, Andreas / de Vries, Erik F.J. / van Waarde, Aren / Lammertsma, Adriaan A.

    2021  

    Author's details Rudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, Adriaan A. Lammertsma editors
    Keywords Nuclear medicine ; Radiology ; Neurology
    Subject code 616.07548
    Language English
    Size 1 Online-Ressource (xii, 1132 Seiten), Illustrationen
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020614560
    ISBN 978-3-030-53176-8 ; 9783030531751 ; 3-030-53176-7 ; 3030531759
    DOI 10.1007/978-3-030-53176-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online ; E-Book: PET and SPECT in psychiatry

    Dierckx, Rudi A. J. O. / Otte, Andreas / de Vries, Erik F. J. / van Waarde, Aren / Sommer, Iris E.

    2021  

    Author's details Rudi A. J. O. Dierckx, Andreas Otte, Erik F. J. de Vries, Aren van Waarde editors ; Iris E. Sommer guest editor
    Keywords Nuclear medicine ; Radiology ; Psychiatry
    Subject code 616.07548
    Language English
    Size 1 Online-Ressource (xii, 1084 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020699720
    ISBN 978-3-030-57231-0 ; 9783030572303 ; 3-030-57231-5 ; 3030572307
    DOI 10.1007/978-3-030-57231-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article: In memoriam Prof. Dr. F. de Vries

    Ven, F. J. H. M van der / Vries, F. de

    Maandschrift economie : tijdschrift voor algemeen economische en social-economische vraagstukken Vol. 22, No. 10 , p. 497-501

    1958  Volume 22, Issue 10, Page(s) 497–501

    Author's details F. J. H. M van der Ven
    Publisher Wolters-Noordhoff
    Publishing place Groningen
    Document type Article
    ZDB-ID 412653-1
    Database ECONomics Information System

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  6. Article ; Online: Prediction model for lower limb amputation in hospitalized diabetic foot patients using classification and regression trees.

    Sánchez, C A / De Vries, E / Gil, F / Niño, M E

    Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

    2024  

    Abstract: Background: The decision to perform amputation of a limb in a patient with diabetic foot ulcer (DFU) is not an easy task. Prediction models aim to help the surgeon in decision making scenarios. Currently there are no prediction model to determine lower ... ...

    Abstract Background: The decision to perform amputation of a limb in a patient with diabetic foot ulcer (DFU) is not an easy task. Prediction models aim to help the surgeon in decision making scenarios. Currently there are no prediction model to determine lower limb amputation during the first 30 days of hospitalization for patients with DFU.
    Methods: Classification And Regression Tree analysis was applied on data from a retrospective cohort of patients hospitalized for the management of diabetic foot ulcer, using an existing database from two Orthopaedics and Traumatology departments. The secondary analysis identified independent variables that can predict lower limb amputation (mayor or minor) during the first 30 days of hospitalization.
    Results: Of the 573 patients in the database, 290 feet underwent a lower limb amputation during the first 30 days of hospitalization. Six different models were developed using a loss matrix to evaluate the error of not detecting false negatives. The selected tree produced 13 terminal nodes and after the pruning process, only one division remained in the optimal tree (Sensitivity: 69%, Specificity: 75%, Area Under the Curve: 0.76, Complexity Parameter: 0.01, Error: 0.85). Among the studied variables, the Wagner classification with a cut-off grade of 3 exceeded others in its predicting capacity.
    Conclusions: Wagner classification was the variable with the best capacity for predicting amputation within 30 days. Infectious state and vascular occlusion described indirectly by this classification reflects the importance of taking quick decisions in those patients with a higher compromise of these two conditions. Finally, an external validation of the model is still required.
    Level of evidence: III.
    Language English
    Publishing date 2024-03-21
    Publishing country France
    Document type Journal Article
    ZDB-ID 1424533-4
    ISSN 1460-9584 ; 1268-7731
    ISSN (online) 1460-9584
    ISSN 1268-7731
    DOI 10.1016/j.fas.2024.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fast creation of data-driven low-order predictive cardiac tissue excitation models from recorded activation patterns.

    Kabus, Desmond / De Coster, Tim / de Vries, Antoine A F / Pijnappels, Daniël A / Dierckx, Hans

    Computers in biology and medicine

    2024  Volume 169, Page(s) 107949

    Abstract: Excitable systems give rise to important phenomena such as heat waves, epidemics and cardiac arrhythmias. Understanding, forecasting and controlling such systems requires reliable mathematical representations. For cardiac tissue, computational models are ...

    Abstract Excitable systems give rise to important phenomena such as heat waves, epidemics and cardiac arrhythmias. Understanding, forecasting and controlling such systems requires reliable mathematical representations. For cardiac tissue, computational models are commonly generated in a reaction-diffusion framework based on detailed measurements of ionic currents in dedicated single-cell experiments. Here, we show that recorded movies at the tissue-level of stochastic pacing in a single variable are sufficient to generate a mathematical model. Via exponentially weighed moving averages, we create additional state variables, and use simple polynomial regression in the augmented state space to quantify excitation wave dynamics. A spatial gradient-sensing term replaces the classical diffusion as it is more robust to noise. Our pipeline for model creation is demonstrated for an in-silico model and optical voltage mapping recordings of cultured human atrial myocytes and only takes a few minutes. Our findings have the potential for widespread generation, use and on-the-fly refinement of personalised computer models for non-linear phenomena in biology and medicine, such as predictive cardiac digital twins.
    MeSH term(s) Humans ; Arrhythmias, Cardiac ; Myocytes, Cardiac/physiology ; Models, Cardiovascular ; Computer Simulation ; Medicine
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.107949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Conditional immortalization of human cardiomyocytes for translational in vitro modelling of cardiovascular disease.

    Harlaar, Niels / Pijnappels, Daniël A / de Vries, Antoine A F

    Cardiovascular research

    2022  Volume 118, Issue 15, Page(s) e105–e107

    MeSH term(s) Humans ; Cardiovascular Diseases/therapy ; Protein Processing, Post-Translational ; Proteomics ; Myocytes, Cardiac
    Language English
    Publishing date 2022-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Case report: Pharmacokinetics of pembrolizumab in a patient with stage IV non-small cell lung cancer after a single 200 mg administration.

    de Vries, Fenna / Smit, Adrianus A J / Wolbink, Gertjan / de Vries, Annick / Loeff, Floris C / Franssen, Eric J F

    Frontiers in oncology

    2023  Volume 12, Page(s) 960116

    Abstract: Background: Pembrolizumab is a well-tolerated biologic agent with a potentially stable and durable anti-tumor response. Unfortunately, discontinuation of therapy can occur as a consequence of immune-related adverse effects (irAEs). These irAEs appear ... ...

    Abstract Background: Pembrolizumab is a well-tolerated biologic agent with a potentially stable and durable anti-tumor response. Unfortunately, discontinuation of therapy can occur as a consequence of immune-related adverse effects (irAEs). These irAEs appear independent of dose and exposure. However, such irAEs might also result from pembrolizumab's highly specific mechanism of action and current dosing regimens. However, the currently available pharmacokinetic (PK) and pharmacodynamic (PD) data to reassess dosing strategies are insufficient.To highlight the importance of additional PK/PD studies, we present a case describing the complexity of pembrolizumab's PK/PD after a single 200 mg pembrolizumab dose in a treatment-naive patient with non-small cell lung cancer (NSCLC).
    Case description: A 72-year-old man with stage IV NSCLC presented hepatotoxic symptoms 19 days after receiving the first 200 mg pembrolizumab dose. Hence, pembrolizumab therapy was paused, and prednisolone therapy was initiated, which successfully inhibited the toxic effect of pembrolizumab. However, repeated flare-ups due to prednisolone tapering suggest that the toxic effect of pembrolizumab outlasts the presence of pembrolizumab in the bloodstream. This further suggests that the T-cell-mediated immune response outlasts the programmed cell death protein 1 (PD-1) receptor occupancy by pembrolizumab, which challenges the need for the current fixed-interval strategies and their stop criteria.Furthermore, a validated ELISA quantified pembrolizumab levels in 15 samples within 123 days after administration. A shift in the pembrolizumab clearance rate was evident ensuing day 77 (0.6 µg/mL) after administration. Pembrolizumab levels up to day 77 (9.1-0.6 µg/mL) strongly exhibited a linear, first-order clearance (R
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.960116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Arm-support exoskeleton reduces shoulder muscle activity in ceiling construction.

    Baltrusch, S J / Krause, F / de Vries, A W / de Looze, M P

    Ergonomics

    2023  , Page(s) 1–13

    Abstract: The objective of this study was to assess the efficacy and user's impression of an arm-support exoskeleton in complex and realistic ceiling construction tasks. 11 construction workers performed 9 tasks. We determined objective and subjective efficacy of ... ...

    Abstract The objective of this study was to assess the efficacy and user's impression of an arm-support exoskeleton in complex and realistic ceiling construction tasks. 11 construction workers performed 9 tasks. We determined objective and subjective efficacy of the exoskeleton by measuring shoulder muscle activity and perceived exertion. User's impression was assessed by questionnaires on expected support, perceived support, perceived hindrance and future intention to use the exoskeleton. Wearing the exoskeleton yielded persistent reductions in shoulder muscle activity of up to 58% and decreased perceived exertion. Participants reported limited perceived hindrance by the exoskeleton, as also indicated by no increase in antagonistic muscle activity. The findings demonstrate the high potential of an arm-support exoskeleton for unloading the shoulder muscles when used in the dynamic and versatile working environment of a ceiling construction worker, which is in line with the consistent intention of the workers to use the exoskeleton in the future.
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1920-3
    ISSN 1366-5847 ; 0014-0139
    ISSN (online) 1366-5847
    ISSN 0014-0139
    DOI 10.1080/00140139.2023.2280443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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