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  1. Article: Gastro-Resistant Microparticles Produced by Spray-Drying as Controlled Release Systems for Liposoluble Vitamins.

    Terracina, Francesca / Caruana, Roberto / Bonomo, Francesco Paolo / Montalbano, Francesco / Licciardi, Mariano

    Pharmaceutics

    2022  Volume 14, Issue 7

    Abstract: In the present study, gastro-resistant microparticles (MPs) were produced using the spray-drying technique as controlled-release systems for some model liposoluble vitamins, including retinyl-palmitate, retinyl-acetate, β-carotene, cholecalciferol and α- ... ...

    Abstract In the present study, gastro-resistant microparticles (MPs) were produced using the spray-drying technique as controlled-release systems for some model liposoluble vitamins, including retinyl-palmitate, retinyl-acetate, β-carotene, cholecalciferol and α-tocopherol. The gastroprotective action of three different gastro-resistant excipients, the anionic methacrylic copolymer (Eudraguard
    Language English
    Publishing date 2022-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14071480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System.

    Fallarini, Silvia / Papi, Francesco / Licciardi, Federico / Natali, Francesca / Lombardi, Grazia / Maestrelli, Francesca / Nativi, Cristina

    Bioconjugate chemistry

    2022  Volume 34, Issue 1, Page(s) 181–192

    Abstract: Fully synthetic tumor-associated carbohydrate antigen (TACA)-based vaccines are a promising strategy to treat cancer. To overcome the intrinsic low immunogenicity of TACAs, the choice of the antigens' analogues and multivalent presentation have been ... ...

    Abstract Fully synthetic tumor-associated carbohydrate antigen (TACA)-based vaccines are a promising strategy to treat cancer. To overcome the intrinsic low immunogenicity of TACAs, the choice of the antigens' analogues and multivalent presentation have been proved to be successful. Here, we present the preparation, characterization, and
    MeSH term(s) Humans ; Antigens, Tumor-Associated, Carbohydrate ; Liposomes ; Neoplasms/therapy ; Carbohydrates/chemistry ; Vaccines, Synthetic ; Immune System ; Cancer Vaccines
    Chemical Substances Antigens, Tumor-Associated, Carbohydrate ; Liposomes ; Carbohydrates ; Vaccines, Synthetic ; Cancer Vaccines
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.2c00383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Anionic Methacrylate Copolymer Microparticles for the Delivery of Myo-Inositol Produced by Spray-Drying: In Vitro and In Vivo Bioavailability.

    Caruana, Roberto / Zizzo, Maria Grazia / Caldara, Gaetano Felice / Montalbano, Francesco / Fasciano, Silvia / Arena, Dora / Salamone, Marida / Di Fazio, Gaetano / Bottino, Alessandro / Licciardi, Mariano

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: In this study, a new micro delivery system based on an anionic methacrylate copolymer, able to improve the biological response of myo-inositol by daily oral administration, was manufactured by spray-drying. It has an ideal dose form for oral ... ...

    Abstract In this study, a new micro delivery system based on an anionic methacrylate copolymer, able to improve the biological response of myo-inositol by daily oral administration, was manufactured by spray-drying. It has an ideal dose form for oral administration, with an experimental drug loading (DL)% of 14% and a regulated particle size of less than 15 µm. The new formulation features an improvement on traditional formulations used as a chronic therapy for the treatment of polycystic ovary syndrome. The microparticles' release profile was studied and ex vivo porcine intestinal mucosa permeation experiments were performed to predict potential improvements in oral absorption. Batch n. 3, with the higher Eudragit/MI weight ratio (ratio = 6), showed the best-modified release profiles of the active ingredient, ensuring the lowest myo-inositol loss in an acidic environment. The in vivo evaluation of the myo-inositol micro delivery system was carried out in a rat animal model to demonstrate that the bioavailability of myo-inositol was increased when compared to the administration of the same dosage of the pure active ingredient. The AUC and Cmax of the loaded active molecule in the micro delivery system was improved by a minimum of 1.5 times when compared with the pure substance, administered with same dosage and route. Finally, the increase of myo-inositol levels in the ovary follicles was assessed to confirm that a daily administration of the new formulation improves myo-inositol concentration at the site of action, resulting in an improvement of about 1.25 times for the single administration and 1.66 times after 7 days of repeated administration when compared to pure MI.
    MeSH term(s) Female ; Animals ; Rats ; Swine ; Methacrylates ; Biological Availability ; Administration, Oral ; Cell-Derived Microparticles ; Commerce ; Polymers
    Chemical Substances Methacrylates ; Polymers
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073852
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  4. Article ; Online: Polybutylene Succinate Processing and Evaluation as a Micro Fibrous Graft for Tissue Engineering Applications.

    Miceli, Giovanni Carlo / Palumbo, Fabio Salvatore / Bonomo, Francesco Paolo / Zingales, Massimiliano / Licciardi, Mariano

    Polymers

    2022  Volume 14, Issue 21

    Abstract: A microfibrous tubular scaffold has been designed and fabricated by electrospinning using poly (1,4-butylene succinate) as biocompatible and biodegradable material. The scaffold morphology was optimized as a small diameter and micro-porous conduit, able ... ...

    Abstract A microfibrous tubular scaffold has been designed and fabricated by electrospinning using poly (1,4-butylene succinate) as biocompatible and biodegradable material. The scaffold morphology was optimized as a small diameter and micro-porous conduit, able to foster cell integration, adhesion, and growth while avoiding cell infiltration through the graft's wall. Scaffold morphology and mechanical properties were explored and compared to those of native conduits. Scaffolds were then seeded with adult normal human dermal fibroblasts to evaluate cytocompatibility in vitro. Haemolytic effect was evaluated upon incubation with diluted whole blood. The scaffold showed no delamination, and mechanical properties were in the physiological range for tubular conduits: elastic modulus (17.5 ± 1.6 MPa), ultimate tensile stress (3.95 ± 0.17 MPa), strain to failure (57 ± 4.5%) and suture retention force (2.65 ± 0.32 N). The shown degradation profile allows the graft to provide initial mechanical support and functionality while being colonized and then replaced by the host cells. This combination of features might represent a step toward future research on PBS as a biomaterial to produce scaffolds that provide structure and function over time and support host cell remodelling.
    Language English
    Publishing date 2022-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14214486
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  5. Article ; Online: Peculiar immunophenotypic signature in MIS-C-affected children.

    Licciardi, Francesco / Baldini, Letizia / Denina, Marco / Ricotti, Emanuela / Covizzi, Carlotta / Dellepiane, Marta / Mignone, Federica / Zoppo, Marisa / Felici, Enrico / Montin, Davide

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2021  Volume 32, Issue 4, Page(s) 801–804

    MeSH term(s) COVID-19 ; Child ; Humans ; Immunophenotyping ; SARS-CoV-2
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Letter
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13434
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3096: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Corrigendum: MIS-C Treatment: Is IVIG Always Necessary?

    Licciardi, Francesco / Baldini, Letizia / Dellepiane, Marta / Covizzi, Carlotta / Mogni, Roberta / Pruccoli, Giulia / Orsi, Cecilia / Rabbone, Ivana / Parodi, Emilia / Mignone, Federica / Montin, Davide

    Frontiers in pediatrics

    2022  Volume 9, Page(s) 826518

    Abstract: This corrects the article DOI: 10.3389/fped.2021.753123.]. ...

    Abstract [This corrects the article DOI: 10.3389/fped.2021.753123.].
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.826518
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  7. Article ; Online: Polybutylene Succinate Processing and Evaluation as a Micro Fibrous Graft for Tissue Engineering Applications

    Giovanni Carlo Miceli / Fabio Salvatore Palumbo / Francesco Paolo Bonomo / Massimiliano Zingales / Mariano Licciardi

    Polymers, Vol 14, Iss 4486, p

    2022  Volume 4486

    Abstract: A microfibrous tubular scaffold has been designed and fabricated by electrospinning using poly (1,4-butylene succinate) as biocompatible and biodegradable material. The scaffold morphology was optimized as a small diameter and micro-porous conduit, able ... ...

    Abstract A microfibrous tubular scaffold has been designed and fabricated by electrospinning using poly (1,4-butylene succinate) as biocompatible and biodegradable material. The scaffold morphology was optimized as a small diameter and micro-porous conduit, able to foster cell integration, adhesion, and growth while avoiding cell infiltration through the graft’s wall. Scaffold morphology and mechanical properties were explored and compared to those of native conduits. Scaffolds were then seeded with adult normal human dermal fibroblasts to evaluate cytocompatibility in vitro. Haemolytic effect was evaluated upon incubation with diluted whole blood. The scaffold showed no delamination, and mechanical properties were in the physiological range for tubular conduits: elastic modulus (17.5 ± 1.6 MPa), ultimate tensile stress (3.95 ± 0.17 MPa), strain to failure (57 ± 4.5%) and suture retention force (2.65 ± 0.32 N). The shown degradation profile allows the graft to provide initial mechanical support and functionality while being colonized and then replaced by the host cells. This combination of features might represent a step toward future research on PBS as a biomaterial to produce scaffolds that provide structure and function over time and support host cell remodelling.
    Keywords poly (1,4-butylene succinate) ; electrospinning ; biomaterials ; vascular grafts ; bile ducts ; tissue engineering ; Organic chemistry ; QD241-441
    Subject code 571
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy in Two Siblings: Same Mutations but Very Different Phenotypes.

    Carpino, Andrea / Buganza, Raffaele / Matarazzo, Patrizia / Tuli, Gerdi / Pinon, Michele / Calvo, Pier Luigi / Montin, Davide / Licciardi, Francesco / De Sanctis, Luisa

    Genes

    2021  Volume 12, Issue 2

    Abstract: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), caused by mutations in ... ...

    Abstract Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), caused by mutations in the
    MeSH term(s) Adolescent ; COVID-19/complications ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Mutation/genetics ; Phenotype ; Polyendocrinopathies, Autoimmune/complications ; Polyendocrinopathies, Autoimmune/genetics ; Polyendocrinopathies, Autoimmune/pathology ; Siblings
    Language English
    Publishing date 2021-01-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12020169
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  9. Article: MIS-C Treatment: Is IVIG Always Necessary?

    Licciardi, Francesco / Baldini, Letizia / Dellepiane, Marta / Covizzi, Carlotta / Mogni, Roberta / Pruccoli, Giulia / Orsi, Cecilia / Rabbone, Ivana / Parodi, Emilia / Mignone, Federica / Montin, Davide

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 753123

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.753123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mulibrey nanism and immunological complications: a comprehensive case report and literature review.

    Gazzin, Andrea / Pala, Francesca / Bosticardo, Marita / Niemela, Julie / Stoddard, Jennifer / Biasin, Eleonora / Quarello, Paola / Carli, Diana / Ferroni, Francesca / Delmonte, Ottavia M / Montin, Davide / Rosenzweig, Sergio D / Licciardi, Francesco / Notarangelo, Luigi D

    Frontiers in immunology

    2023  Volume 14, Page(s) 1303251

    Abstract: Introduction: Mulibrey nanism (MUL) is a rare disorder caused by : Methods: We present a case of MUL with progressive lymphopenia and review similar cases from the literature.: Results: Our patient presented with prenatal onset growth restriction, ...

    Abstract Introduction: Mulibrey nanism (MUL) is a rare disorder caused by
    Methods: We present a case of MUL with progressive lymphopenia and review similar cases from the literature.
    Results: Our patient presented with prenatal onset growth restriction, characteristic dysmorphic features, and Wilms' tumor. She developed progressive lymphopenia starting at 10 years of age, leading to the initiation of intravenous immunoglobulin (IVIG) replacement therapy and infection prophylaxis. Genetic analysis detected a likely pathogenic variant on the maternal allele and copy number loss on the paternal allele in
    Discussion: The immunological profile of MUL patients reported so far shares similarities with that described in protein-losing enteropathy secondary to CHF in Fontan circulation and primary intestinal lymphangiectasia. These similarities include hypogammaglobulinemia, significant T-cell deficiency with decreased CD4+ and CD8+ counts, altered CD4+/CD8+ ratios, and significantly modified CD4+ and CD8+ T-cell phenotypes toward effector and terminal differentiated T cells, accompanied by a loss of naïve CD45RA+ T lymphocytes. In MUL, CHF is a cardinal feature, occurring in a significant proportion of patients and influencing prognosis. Signs of CHF or constrictive pericarditis have been evident in the case reported here and in all cases of MUL with documented immune dysfunction reported so far. These observations raise intriguing connections between these conditions. However, further investigation is warranted to in-depth define the immunological defect, providing valuable insights into the pathophysiology and treatment strategies for this condition.
    MeSH term(s) Female ; Humans ; Agammaglobulinemia/complications ; Heart Failure/etiology ; Heart Failure/therapy ; Immunoglobulins, Intravenous/therapeutic use ; Kidney Neoplasms/genetics ; Lymphopenia/complications ; Mulibrey Nanism/genetics ; Mutation ; Nuclear Proteins/genetics ; Tripartite Motif Proteins/genetics ; Ubiquitin-Protein Ligases/genetics ; Wilms Tumor/complications
    Chemical Substances Immunoglobulins, Intravenous ; Nuclear Proteins ; TRIM37 protein, human (EC 2.3.2.27) ; Tripartite Motif Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1303251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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