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  1. Article ; Online: SARS-CoV-2 Infection Among Community Health Workers in India Before and After Use of Face Shields.

    Bhaskar, M Emmanuel / Arun, Santhanam

    JAMA

    2020  Volume 324, Issue 13, Page(s) 1348–1349

    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Community Health Workers ; Contact Tracing ; Coronavirus Infections/diagnosis ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Decontamination/methods ; Female ; Humans ; India ; Male ; Masks ; Pandemics/prevention & control ; Personal Protective Equipment ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Transportation/methods
    Keywords covid19
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.15586
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  3. Article ; Online: SARS-CoV-2 Infection Among Community Health Workers in India Before and After Use of Face Shields

    Bhaskar, M. Emmanuel / Arun, Santhanam

    JAMA

    2020  Volume 324, Issue 13, Page(s) 1348

    Keywords General Medicine ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.15586
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  4. Article ; Online: Nail changes in a patient with leukaemia.

    Bhaskar, M Emmanuel

    BMJ (Clinical research ed.)

    2011  Volume 342, Page(s) c6439

    MeSH term(s) Antineoplastic Agents/adverse effects ; Humans ; Hydroxyurea/adverse effects ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Male ; Melanosis/chemically induced ; Melanosis/diagnosis ; Middle Aged ; Nail Diseases/chemically induced ; Nail Diseases/diagnosis
    Chemical Substances Antineoplastic Agents ; Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2011-01-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.c6439
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  5. Article ; Online: Direction of blood flow in a vein.

    Bhaskar, M Emmanuel

    Mayo Clinic proceedings

    2009  Volume 84, Issue 4, Page(s) 306

    MeSH term(s) Blood Circulation/physiology ; Humans ; Veins/physiology
    Language English
    Publishing date 2009-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.4065/84.4.306
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  6. Article: Comparison of Fasting Insulin Level, Homeostatic Model of Insulin Resistance, and Lipid Levels between Patients with Primary Hypertension and Normotensive Subjects.

    Ramesh, Rithvik / Pandurangan, Viswanathan / Madhavan, Sudha / Srinivasan, Devasena / Bhaskar, Emmanuel / Marappa, Lakshmi / Nair, Aiswarya M / Rajendran, Vaasanthi / Varadaraj, Priyadarshini

    Rambam Maimonides medical journal

    2022  Volume 13, Issue 2

    Abstract: Background: Hyperinsulinemia and insulin resistance occurs in obese patients with primary hypertension independent of diabetes and obesity. This study was aimed at assessing serum fasting insulin levels, the homeostatic model assessment for insulin ... ...

    Abstract Background: Hyperinsulinemia and insulin resistance occurs in obese patients with primary hypertension independent of diabetes and obesity. This study was aimed at assessing serum fasting insulin levels, the homeostatic model assessment for insulin resistance (HOMA-IR), and serum lipid levels in non-obese patients with primary hypertension when compared to normotensive subjects.
    Methods: This observational study comprised 100 patients over 18 years of age, divided into two groups. The hypertensive group comprised non-obese patients with primary hypertension (n=50); the normotensive group comprised normotensive age- and sex-matched individuals (n=50). Patients with diabetes, impaired fasting glucose, obesity, and other causative factors of insulin resistance were excluded from the study. Serum fasting insulin levels and fasting lipid profiles were measured, and insulin resistance was calculated using HOMA-IR. These data were compared between the two groups. Pearson's correlation coefficient was used to assess the extent of a linear relationship between HOMA-IR and to evaluate the association between HOMA-IR and systolic and diastolic blood pressures.
    Results: Mean serum fasting insulin levels (mIU/L), mean HOMA-IR values, and fasting triglyceride levels (mg/dL) were significantly higher in the hypertensive versus normotensive patients (10.32 versus 6.46, P<0.001; 1.35 versus 0.84, P<0.001; 113.70 versus 97.04, P=0.005, respectively). The HOMA-IR levels were associated with systolic blood pressure (r value 0.764, P=0.0005).
    Conclusion: We observed significantly higher fasting insulin levels, serum triglyceride levels, and HOMA-IR reflecting hyperinsulinemia and possibly an insulin-resistant state among primary hypertension patients with no other causally linked factors for insulin resistance. We observed a significant correlation between systolic blood pressure and HOMA-IR.
    Language English
    Publishing date 2022-04-26
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2573657-7
    ISSN 2076-9172
    ISSN 2076-9172
    DOI 10.5041/RMMJ.10468
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  7. Article: Role of secondary sepsis in COVID-19 mortality: Observations on patients with preexisting diabetes mellitus and newly diagnosed hyperglycemia.

    Nair, Aiswarya M / Gopalan, Sowmya / Rajendran, Vaasanthi / Varadaraj, Priyadarshini / Marappa, Lakshmi / Pandurangan, Viswanathan / Madhavan, Sudha / Mani, Rajkumar / Bhaskar, Emmanuel

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2022  Volume 92, Issue 4

    Abstract: Diabetics who develop severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) are more likely to have severe disease, higher odds of intensive care requirement and mortality. Fifteen percent of patients have new onset hyperglycemia. We studied the ... ...

    Abstract Diabetics who develop severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) are more likely to have severe disease, higher odds of intensive care requirement and mortality. Fifteen percent of patients have new onset hyperglycemia. We studied the comparative outcomes between prior DM, newly detected hyperglycemia and assessed role of secondary sepsis on mortality. RWe performed a r etrospective study of confirmed SARS-CoV-2 patients at a tertiary care hospital in Chennai, India. Patients were divided as 2 groups (Group 1: With preexisting diabetes mellitus, Group 2: With newly diagnosed hyperglycemia due to newly detected diabetes mellitus or non-diabetic hyperglycemia. Clinical and laboratory data was analysed. Two hundred and thirty eight patients had prior-diabetes mellitus (Group 1) and 40 had newly diagnosed hyperglycemia (Group 2). Thirty four of group 1 and 7 of group 2 patients required intensive care. Mean capillary blood glucose (MCBG) during hospital stay was 207 mg/dl (Group 1) and 192 mg/dl (Group 2). Twentysix patients (9.3%) had secondary sepsis of which sixteen died. Logistic regression identified secondary sepsis(p<0.0001), elevated D-dimer >6 fold (p= 0.0001), elderly p=0.0045), male (p=0.0006), NLR >5 (p=0.01),serum creatinine ≥2 mg/dl (p=0.0004), FiO2 requirement >0.6 in first 48 hours (p=0.001) as mortality predictors.Our study observed a 14.38 % prevalence of newly diagnosed DM or non-diabetic hyperglycemia. Secondary sepsis and >6 fold elevation in D-dimer were strong predictors of mortality. Steroid use possibly contributed to secondary sepsis. Early identification and aggressive management of secondary sepsis are necessary for diabetics.
    MeSH term(s) Humans ; Male ; Aged ; COVID-19/complications ; SARS-CoV-2 ; India/epidemiology ; Hyperglycemia/epidemiology ; Diabetes Mellitus/epidemiology ; Sepsis/complications ; Blood Glucose
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2022-04-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2022.2037
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  8. Article ; Online: Role of secondary sepsis in COVID-19 mortality

    Aiswarya M Nair / Sowmya Gopalan / Vaasanthi Rajendran / Priyadarshini Varadaraj / Lakshmi Marappa / Viswanathan Pandurangan / Sudha Madhavan / Rajkumar Mani / Emmanuel Bhaskar

    Monaldi Archives for Chest Disease (2022)

    Observations on patients with preexisting diabetes mellitus and newly diagnosed hyperglycemia

    2022  

    Abstract: Diabetics who develop severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) are more likely to have severe disease, higher odds of intensive care requirement and mortality. Fifteen percent of patients have new onset hyperglycemia. We studied the ... ...

    Abstract Diabetics who develop severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) are more likely to have severe disease, higher odds of intensive care requirement and mortality. Fifteen percent of patients have new onset hyperglycemia. We studied the comparative outcomes between prior DM, newly detected hyperglycemia and assessed role of secondary sepsis on mortality. RWe performed a r etrospective study of confirmed SARS-CoV-2 patients at a tertiary care hospital in Chennai, India. Patients were divided as 2 groups (Group 1: With preexisting diabetes mellitus, Group 2: With newly diagnosed hyperglycemia due to newly detected diabetes mellitus or non-diabetic hyperglycemia. Clinical and laboratory data was analysed. Two hundred and thirty eight patients had prior-diabetes mellitus (Group 1) and 40 had newly diagnosed hyperglycemia (Group 2). Thirty four of group 1 and 7 of group 2 patients required intensive care. Mean capillary blood glucose (MCBG) during hospital stay was 207 mg/dl (Group 1) and 192 mg/dl (Group 2). Twentysix patients (9.3%) had secondary sepsis of which sixteen died. Logistic regression identified secondary sepsis(p<0.0001), elevated D-dimer >6 fold (p= 0.0001), elderly p=0.0045), male (p=0.0006), NLR >5 (p=0.01),serum creatinine ≥2 mg/dl (p=0.0004), FiO2 requirement >0.6 in first 48 hours (p=0.001) as mortality predictors.Our study observed a 14.38 % prevalence of newly diagnosed DM or non-diabetic hyperglycemia. Secondary sepsis and >6 fold elevation in D-dimer were strong predictors of mortality. Steroid use possibly contributed to secondary sepsis. Early identification and aggressive management of secondary sepsis are necessary for diabetics.
    Keywords secondary sepsis ; mortality ; newly diagnosed hyperglycemia ; steroid therapy ; covid 19 infection ; Medicine ; R
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
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  9. Article ; Online: Comparison of Fasting Insulin Level, Homeostatic Model of Insulin Resistance, and Lipid Levels between Patients with Primary Hypertension and Normotensive Subjects

    Rithvik Ramesh / Viswanathan Pandurangan / Sudha Madhavan / Devasena Srinivasan / Emmanuel Bhaskar / Lakshmi Marappa / Aiswarya M. Nair / Vaasanthi Rajendran / Priyadarshini Varadaraj

    Rambam Maimonides Medical Journal, Vol 13, Iss 2, p e

    2022  Volume 0009

    Abstract: Background: Hyperinsulinemia and insulin resistance occurs in obese patients with primary hypertension independent of diabetes and obesity. This study was aimed at assessing serum fasting insulin levels, the homeostatic model assessment for insulin ... ...

    Abstract Background: Hyperinsulinemia and insulin resistance occurs in obese patients with primary hypertension independent of diabetes and obesity. This study was aimed at assessing serum fasting insulin levels, the homeostatic model assessment for insulin resistance (HOMA-IR), and serum lipid levels in non-obese patients with primary hypertension when compared to normotensive subjects. Methods: This observational study comprised 100 patients over 18 years of age, divided into two groups. The hypertensive group comprised non-obese patients with primary hypertension (n=50); the normotensive group comprised normotensive age- and sex-matched individuals (n=50). Patients with diabetes, impaired fasting glucose, obesity, and other causative factors of insulin resistance were excluded from the study. Serum fasting insulin levels and fasting lipid profiles were measured, and insulin resistance was calculated using HOMA-IR. These data were compared between the two groups. Pearson’s correlation coefficient was used to assess the extent of a linear relationship between HOMA-IR and to evaluate the association between HOMA-IR and systolic and diastolic blood pressures. Results: Mean serum fasting insulin levels (mIU/L), mean HOMA-IR values, and fasting triglyceride levels (mg/dL) were significantly higher in the hypertensive versus normotensive patients (10.32 versus 6.46, P<0.001; 1.35 versus 0.84, P<0.001; 113.70 versus 97.04, P=0.005, respectively). The HOMA-IR levels were associated with systolic blood pressure (r value 0.764, P=0.0005). Conclusion: We observed significantly higher fasting insulin levels, serum triglyceride levels, and HOMA-IR reflecting hyperinsulinemia and possibly an insulin-resistant state among primary hypertension patients with no other causally linked factors for insulin resistance. We observed a significant correlation between systolic blood pressure and HOMA-IR.
    Keywords fasting insulin level ; homa-ir ; hyperinsulinemia ; insulin resistance ; lipids ; primary hypertension ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 571
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Rambam Health Care Campus
    Document type Article ; Online
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  10. Article ; Online: Association of Oral Lichen Planus and Electrocardiographic P-Wave Dispersion - An Original Research.

    Aditi, R / Sathasivasubramanian, S / Bhaskar, M Emmanuel

    Brazilian dental journal

    2017  Volume 28, Issue 6, Page(s) 699–703

    Abstract: Lichen planus (LP) is considered to be a T-cell-mediated inflammatory disorder. Inflammation is considered to produce disturbances of lipid metabolism which may affect the myocardium. Increased P-Wave Dispersion (PWD) is demonstrated as an independent ... ...

    Abstract Lichen planus (LP) is considered to be a T-cell-mediated inflammatory disorder. Inflammation is considered to produce disturbances of lipid metabolism which may affect the myocardium. Increased P-Wave Dispersion (PWD) is demonstrated as an independent risk factor for developing atrial fibrillation (AF). Hence the present study has been conducted to explore the possible relationship of oral lichen planus (OLP) with AF by the evaluation of PWD. Twelve-lead electrocardiographs (ECG) were obtained from 45 OLP patients and 45 age and gender-matched healthy controls. The P-wave durations (Pmax and Pmin) were calculated in all 12 leads. The difference between Pmax and Pmin was defined as P-Wave Dispersion (PWD). After the PWD was recorded, the results were statistically analyzed. The study showed that PWD increased on surface ECG measurements in OLP patients who were otherwise asymptomatic in relation to cardiac conditions. The p value obtained was <0.001 which was highly significant. The present study suggests a highly statistically significant association of OLP with increased P-wave dispersion. Hence the patients with OLP should undergo cardiac evaluation and follow up for early detection of atrial fibrillation.
    MeSH term(s) Electrocardiography/methods ; Female ; Humans ; Lichen Planus, Oral/physiopathology ; Male ; Middle Aged
    Language English
    Publishing date 2017-11
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1089484-6
    ISSN 1806-4760 ; 0103-6440
    ISSN (online) 1806-4760
    ISSN 0103-6440
    DOI 10.1590/0103-6440201701570
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