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Article ; Online: The case of the eyelid silicone granulomas.

Wulu, Jacqueline A / Garcia-Rodriguez, Laura / Prilutskiy, Andrey / Spiegel, Jeffrey H

2019 Volume 40, Issue 5, Page(s) 776–778

Abstract: Foreign body granulomas can develop even several years after autologous fat or filler injection. In some instances the foreign body granulomas have been found at sites other than the original injection site. We present a case of a 48-year-old male with ... ...

Abstract	Foreign body granulomas can develop even several years after autologous fat or filler injection. In some instances the foreign body granulomas have been found at sites other than the original injection site. We present a case of a 48-year-old male with reported "hyaluronic acid fillers" injected into his upper and lower eyelids several years prior. He subsequently developed periorbital swelling with negative allergic and rheumatologic workup. The patient ultimately underwent a blepharoplasty for improvement of the swelling. Histopathology suggested silicone granulomas of the upper and lower eyelid. This case illustrates the importance of keeping foreign body granulomas on the differential for all patients with a history of facial dermal filler injections. Although hyaluronic acid is the most common dermal filler, providers should suspect the use of other dermal fillers including those not FDA approved particularly when common conservative treatment methods are not sufficient.
MeSH term(s)	Biopsy, Needle ; Blepharoplasty/adverse effects ; Blepharoplasty/methods ; Dermal Fillers/adverse effects ; Follow-Up Studies ; Granuloma, Foreign-Body/etiology ; Granuloma, Foreign-Body/pathology ; Granuloma, Foreign-Body/surgery ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Risk Assessment ; Silicones/adverse effects ; Treatment Outcome
Chemical Substances	Dermal Fillers ; Silicones
Language	English
Publishing date	2019-05-14
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2019.05.010
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Zs.A 1637: Show issues

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Article ; Online: Solitary intramuscular myofibroma in an adult: Case report and MR imaging findings.

Santo, Irene Dixe de Oliveira / Staziaki, Pedro V / Prilutskiy, Andrey / Sachs, Teviah E / Murakami, Akira M

Clinical imaging

2020 Volume 67, Page(s) 95–100

Abstract: Myofibroma is a benign, soft tissue neoplasm that predominantly affects infants and young children. Most occur in the skin or subcutaneous tissues, with a predilection for the head and neck regions. We describe the magnetic resonance (MR) imaging and ... ...

Abstract	Myofibroma is a benign, soft tissue neoplasm that predominantly affects infants and young children. Most occur in the skin or subcutaneous tissues, with a predilection for the head and neck regions. We describe the magnetic resonance (MR) imaging and histophathologic findings of a rare case of intramuscular myofibroma of the right deltoid in a healthy 30-year-old male. MR imaging revealed a well-circumscribed intramuscular mass, with isointense signal on T1-weighted images, hyperintense signal on T2-weighed images, and a "target-sign" with peripheral rim enhancement after gadolinium administration. The lesion was surgically excised with no complications, and the histopathologic analysis revealed the typical morphologic and histochemical markers of a myofibroma. We conclude that, although rare, myofibroma can be considered in the differential diagnosis of adults with lesions the above signal characteristics.
MeSH term(s)	Adult ; Diagnosis, Differential ; Gadolinium ; Head/pathology ; Humans ; Leiomyoma ; Magnetic Resonance Imaging ; Male ; Myofibroma/diagnostic imaging ; Myofibroma/pathology ; Myofibromatosis ; Neck/pathology ; Soft Tissue Neoplasms
Chemical Substances	Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2020-05-30
Publishing country	United States
Document type	Case Reports
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2020.05.027
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Zs.A 1469: Show issues

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Article ; Online: First Clinical Results of Fluorescence Lifetime-enhanced Tumor Imaging Using Receptor-targeted Fluorescent Probes.

Pal, Rahul / Hom, Marisa E / van den Berg, Nynke S / Lwin, Thinzar M / Lee, Yu-Jin / Prilutskiy, Andrey / Faquin, William / Yang, Eric / Saladi, Srinivas V / Varvares, Mark A / Rosenthal, Eben L / Kumar, Anand T N

Clinical cancer research : an official journal of the American Association for Cancer Research

2022 Volume 28, Issue 11, Page(s) 2373–2384

Abstract: Purpose: Fluorescence molecular imaging, using cancer-targeted near infrared (NIR) fluorescent probes, offers the promise of accurate tumor delineation during surgeries and the detection of cancer specific molecular expression in vivo. However, ... ...

Abstract	Purpose: Fluorescence molecular imaging, using cancer-targeted near infrared (NIR) fluorescent probes, offers the promise of accurate tumor delineation during surgeries and the detection of cancer specific molecular expression in vivo. However, nonspecific probe accumulation in normal tissue results in poor tumor fluorescence contrast, precluding widespread clinical adoption of novel imaging agents. Here we present the first clinical evidence that fluorescence lifetime (FLT) imaging can provide tumor specificity at the cellular level in patients systemically injected with panitumumab-IRDye800CW, an EGFR-targeted NIR fluorescent probe. Experimental design: We performed wide-field and microscopic FLT imaging of resection specimens from patients injected with panitumumab-IRDye800CW under an FDA directed clinical trial. Results: We show that the FLT within EGFR-overexpressing cancer cells is significantly longer than the FLT of normal tissue, providing high sensitivity (>98%) and specificity (>98%) for tumor versus normal tissue classification, despite the presence of significant nonspecific probe accumulation. We further show microscopic evidence that the mean tissue FLT is spatially correlated (r > 0.85) with tumor-specific EGFR expression in tissue and is consistent across multiple patients. These tumor cell-specific FLT changes can be detected through thick biological tissue, allowing highly specific tumor detection and noninvasive monitoring of tumor EFGR expression in vivo. Conclusions: Our data indicate that FLT imaging is a promising approach for enhancing tumor contrast using an antibody-targeted NIR probe with a proven safety profile in humans, suggesting a strong potential for clinical applications in image guided surgery, cancer diagnostics, and staging.
MeSH term(s)	Cell Line, Tumor ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Fluorescence ; Fluorescent Dyes/metabolism ; Humans ; Neoplasms/diagnostic imaging ; Neoplasms/metabolism ; Optical Imaging/methods ; Panitumumab
Chemical Substances	Fluorescent Dyes ; Panitumumab (6A901E312A) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-21-3429
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Zs.A 4223: Show issues

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Article ; Online: Acute promyelocytic leukaemia presenting as necrotising fasciitis of the perineum (Fournier gangrene).

Furtado, Vanessa Fiorini / Batalini, Felipe / Staziaki, Pedro V / Prilutskiy, Andrey / Sloan, John Mark

BMJ case reports

2018 Volume 11, Issue 1

Abstract: We present a case of an unusual presentation of acute promyelocytic leukaemia (APML), which presented with Fournier gangrene (FG). A 38-year-old man presented with malaise, groin swelling, anal bleeding, fever and was found to have FG. Initial workup ... ...

Abstract	We present a case of an unusual presentation of acute promyelocytic leukaemia (APML), which presented with Fournier gangrene (FG). A 38-year-old man presented with malaise, groin swelling, anal bleeding, fever and was found to have FG. Initial workup revealed pancytopaenia, borderline low fibrinogen, prolonged international normalized ratio (INR), which raised the suspicion for leukaemia. The peripheral blood differential revealed leucopaenia with absolute neutropaenia and a 5% abnormal promyelocytes but no blasts, suspicious for APML. Bone marrow biopsy was performed and fluorescence in situ hydridization (FISH), karyotype and PCR confirmed a t(15;17) translocation, establishing a diagnosis of APML. After 1 month of therapy for intermediate risk APML with All-trans retinoic acid (ATRA) and arsenic trioxide (ATO), repeat chromosomal analysis and repeat bone marrow biopsy revealed no evidence of residual APML. After the consolidation phase was started with ATRA and ATO regimen, the wound healed after 2 months and the patient achieved complete remission.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Arsenic Trioxide/therapeutic use ; Fasciitis, Necrotizing/drug therapy ; Fasciitis, Necrotizing/etiology ; Fasciitis, Necrotizing/microbiology ; Fournier Gangrene/drug therapy ; Fournier Gangrene/etiology ; Fournier Gangrene/microbiology ; Humans ; Leukemia, Promyelocytic, Acute/diagnosis ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/microbiology ; Leukemia, Promyelocytic, Acute/pathology ; Male ; Perineum/pathology ; Remission Induction ; Treatment Outcome ; Tretinoin/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Tretinoin (5688UTC01R) ; Arsenic Trioxide (S7V92P67HO)
Language	English
Publishing date	2018-12-07
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2018-226837
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Article ; Online: Distinctive pseudopalisaded histiocytic hyperplasia characterizes the transition of exudative to proliferative phase of diffuse alveolar damage in patients dying of COVID-19.

Kritselis, Michael / Yambayev, Ilyas / Prilutskiy, Andrey / Shevtsov, Artem / Vadlamudi, Charitha / Zheng, Hanqiao / Elsadwai, Murad / Ma, Lina / Aniskovich, Emily / Kataria, Yachana / Higgins, Sara / Sarita-Reyes, Carmen / Zuo, Tao / Zhao, Qing / Quillen, Karen / Burks, Eric J

Human pathology

2021 Volume 116, Page(s) 49–62

Abstract: Severe COVID-19 results in a glucocorticoid responsive form of acute respiratory distress (ARDS)/diffuse alveolar damage (DAD). Herein we compare the immunopathology of lung tissue procured at autopsy in patients dying of SARS-CoV-2 with those dying of ... ...

Abstract	Severe COVID-19 results in a glucocorticoid responsive form of acute respiratory distress (ARDS)/diffuse alveolar damage (DAD). Herein we compare the immunopathology of lung tissue procured at autopsy in patients dying of SARS-CoV-2 with those dying of DAD prior to the COVID-19 pandemic. Autopsy gross and microscopic features stratified by duration of illness in twelve patients who tested positive for SARS-CoV-2 viral RNA, as well as seven patients dying of DAD prior to the COVID-19 pandemic were evaluated with multiplex (5-plex: CD4, CD8, CD68, CD20, AE1/AE3) and SARS-CoV immunohistochemistry to characterize the immunopathologic stages of DAD. We observed a distinctive pseudopalisaded histiocytic hyperplasia interposed between the exudative and proliferative phase of COVID-19 associated DAD, which was most pronounced at the fourth week from symptom onset. Pulmonary macrothrombi were seen predominantly in cases with pseudopalisaded histiocytic hyperplasia and/or proliferative phase DAD. Neither pseudopalisaded histiocytic hyperplasia nor pulmonary macrothrombi was seen in non-COVID-19 DAD cases, whereas microthrombi were common in DAD regardless of etiology. The inflammatory pattern of pseudopalisaded histiocytic hyperplasia may represent the distinctive immunopathology associated with the dexamethasone responsive form of DAD seen in severe COVID-19.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/pathology ; Cell Proliferation/physiology ; Female ; Histiocytes/pathology ; Humans ; Hyperplasia/pathology ; Lung/pathology ; Male ; Middle Aged ; Pulmonary Alveoli/pathology
Language	English
Publishing date	2021-07-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2021.06.008
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Zs.A 722: Show issues

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Article ; Online: Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients.

Pal, Rahul / Lwin, Thinzar M / Krishnamoorthy, Murali / Collins, Hannah R / Chan, Corey D / Prilutskiy, Andrey / Nasrallah, MacLean P / Dijkhuis, Tom H / Shukla, Shriya / Kendall, Amy L / Marshall, Michael S / Carp, Stefan A / Hung, Yin P / Shih, Angela R / Martinez-Lage, Maria / Zukerberg, Lawrence / Sadow, Peter M / Faquin, William C / Nahed, Brian V /

Feng, Allen L / Emerick, Kevin S / Mieog, J Sven D / Vahrmeijer, Alexander L / Rajasekaran, Karthik / Lee, John Y K / Rankin, Kenneth S / Lozano-Calderon, Santiago / Varvares, Mark A / Tanabe, Kenneth K / Kumar, Anand T N

Nature biomedical engineering

2023 Volume 7, Issue 12, Page(s) 1649–1666

Abstract: The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging. However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the accuracy of distinguishing tumour from normal tissue via conventional ... ...

Abstract	The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging. However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the accuracy of distinguishing tumour from normal tissue via conventional fluorescence intensity-based imaging. Here we show that, after systemic injection of the near-infrared dye indocyanine green in patients with various types of solid tumour, the fluorescence lifetime (FLT) of tumour tissue is longer than the FLT of non-cancerous tissue. This tumour-specific shift in FLT can be used to distinguish tumours from normal tissue with an accuracy of over 97% across tumour types, and can be visualized at the cellular level using microscopy and in larger specimens through wide-field imaging. Unlike fluorescence intensity, which depends on imaging-system parameters, tissue depth and the amount of dye taken up by tumours, FLT is a photophysical property that is largely independent of these factors. FLT imaging with indocyanine green may improve the accuracy of cancer surgeries.
MeSH term(s)	Humans ; Indocyanine Green ; Fluorescence ; Neoplasms/diagnostic imaging ; Fluorescent Dyes
Chemical Substances	Indocyanine Green (IX6J1063HV) ; Fluorescent Dyes
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article
ISSN	2157-846X
ISSN (online)	2157-846X
DOI	10.1038/s41551-023-01105-2
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Article ; Online: SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis.

Prilutskiy, Andrey / Kritselis, Michael / Shevtsov, Artem / Yambayev, Ilyas / Vadlamudi, Charitha / Zhao, Qing / Kataria, Yachana / Sarosiek, Shayna R / Lerner, Adam / Sloan, J Mark / Quillen, Karen / Burks, Eric J

American journal of clinical pathology

2020 Volume 154, Issue 4, Page(s) 466–474

Abstract: Objectives: A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the ... ...

Abstract	Objectives: A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the reticuloendothelial organs of 4 consecutive patients who died of COVID-19 and correlated with clinical and laboratory parameters to detect HLH. Methods: Autopsies were performed on 4 patients who died of COVID-19. Routine H&E staining and immunohistochemical staining for CD163 were performed to detect hemophagocytosis. Clinical and laboratory results from premortem blood samples were used to calculate H-scores. Results: All 4 cases demonstrated diffuse alveolar damage within the lungs. Three of the 4 cases had histologic evidence of hemophagocytosis within pulmonary lymph nodes. One case showed hemophagocytosis in the spleen but none showed hemophagocytosis in liver or bone marrow. Lymphophagocytosis was the predominant form of hemophagocytosis observed. One patient showed diagnostic features of HLH with an H-score of 217, while a second patient likely had HLH with a partial H-score of 145 due to a missing triglyceride level. The remaining 2 patients had H-scores of 131 and 96. Conclusions: This is the first report of severe acute respiratory syndrome coronavirus 2-associated HLH. Identification of HLH in a subset of patients with severe COVID-19 will inform clinical trials of therapeutic strategies.
MeSH term(s)	Aged ; Aged, 80 and over ; Autopsy ; Betacoronavirus ; Bone Marrow/pathology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/pathology ; Fatal Outcome ; Female ; Humans ; Liver/pathology ; Lung/pathology ; Lymph Nodes/pathology ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/pathology ; Lymphohistiocytosis, Hemophagocytic/virology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; Spleen/pathology
Keywords	covid19
Language	English
Publishing date	2020-07-17
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqaa124
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Ud II Zs.91: Show issues

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Article: SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis

Am J Clin Pathol

Abstract: OBJECTIVES: A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the ... ...

Abstract	OBJECTIVES: A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the reticuloendothelial organs of 4 consecutive patients who died of COVID-19 and correlated with clinical and laboratory parameters to detect HLH. METHODS: Autopsies were performed on 4 patients who died of COVID-19. Routine H&E staining and immunohistochemical staining for CD163 were performed to detect hemophagocytosis. Clinical and laboratory results from premortem blood samples were used to calculate H-scores. RESULTS: All 4 cases demonstrated diffuse alveolar damage within the lungs. Three of the 4 cases had histologic evidence of hemophagocytosis within pulmonary lymph nodes. One case showed hemophagocytosis in the spleen but none showed hemophagocytosis in liver or bone marrow. Lymphophagocytosis was the predominant form of hemophagocytosis observed. One patient showed diagnostic features of HLH with an H-score of 217, while a second patient likely had HLH with a partial H-score of 145 due to a missing triglyceride level. The remaining 2 patients had H-scores of 131 and 96. CONCLUSIONS: This is the first report of severe acute respiratory syndrome coronavirus 2-associated HLH. Identification of HLH in a subset of patients with severe COVID-19 will inform clinical trials of therapeutic strategies.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #654222
Database	COVID19

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Article ; Online: SARS-CoV-2 Infection Associated Hemophagocytic Lymphohistiocytosis: An autopsy series with clinical and laboratory correlation.

Prilutskiy, Andrey / Kritselis, Michael / Shevtsov, Artem / Yambayev, Ilyas / Vadlamudi, Charitha / Zhao, Qing / Kataria, Yachana / Sarosiek, Shayna / Lerner, Adam / Sloan, John Mark / Quillen, Karen / Burks, Eric

medRxiv

Abstract: Background: A subset of COVID-19 patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. Pathologic studies to date have largely focused on ... ...

Abstract	Background: A subset of COVID-19 patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. Pathologic studies to date have largely focused on the pulmonary finding of diffuse alveolar damage (DAD). To this aim, we study the reticuloendothelial organs of four consecutive patients dying of COVID-19 and correlate with clinical and laboratory parameters to detect HLH. Methods: Autopsies restricted to chest and abdomen were performed on four patients who succumbed to COVID-19. Spleen, liver, and multiple pulmonary hilar/mediastinal lymph nodes were sampled in all cases. Bone marrow was obtained by rib squeeze in a subset of cases. Routine H&E staining as well as immunohistochemical staining for CD163 was performed to detect hemophagocytosis. Clinical and laboratory results from pre-mortem blood samples were used to calculate H-scores. Findings: All four cases demonstrated DAD within the lungs. Three of the four cases had histologic evidence of hemophagocytosis within pulmonary hilar/mediastinal lymph nodes. One case showed hemophagocytosis in the spleen but none showed hemophagocytosis in liver or bone marrow. Lymphophagocytosis was the predominant form of hemophagocytosis observed. One patient showed diagnostic features of HLH with an H-score of 217 while a second patient was likely HLH with a partial H-score of 145 due to missing triglyceride level. Both patients exhibited high fever and early onset rise in serum ferritin; however, neither bicytopenia, pancytopenia, nor hypofibrinogenemia were observed in either. The remaining two patients had H-scores of 131 and 96. Interpretation: This is the first report of SARS-CoV-2 associated HLH. Identification of HLH in a subset of patients with severe COVID-19 will inform clinical trials of therapeutic strategies.
Keywords	covid19
Language	English
Publishing date	2020-05-12
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.05.07.20094888
Database	COVID19

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Article ; Online: SARS-CoV-2 Infection–Associated Hemophagocytic Lymphohistiocytosis

American Journal of Clinical Pathology

2020 Volume 154, Issue 4, Page(s) 466–474

Abstract: Abstract Objectives A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the ... ...

Abstract	Abstract Objectives A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the reticuloendothelial organs of 4 consecutive patients who died of COVID-19 and correlated with clinical and laboratory parameters to detect HLH. Methods Autopsies were performed on 4 patients who died of COVID-19. Routine H&E staining and immunohistochemical staining for CD163 were performed to detect hemophagocytosis. Clinical and laboratory results from premortem blood samples were used to calculate H-scores. Results All 4 cases demonstrated diffuse alveolar damage within the lungs. Three of the 4 cases had histologic evidence of hemophagocytosis within pulmonary lymph nodes. One case showed hemophagocytosis in the spleen but none showed hemophagocytosis in liver or bone marrow. Lymphophagocytosis was the predominant form of hemophagocytosis observed. One patient showed diagnostic features of HLH with an H-score of 217, while a second patient likely had HLH with a partial H-score of 145 due to a missing triglyceride level. The remaining 2 patients had H-scores of 131 and 96. Conclusions This is the first report of severe acute respiratory syndrome coronavirus 2–associated HLH. Identification of HLH in a subset of patients with severe COVID-19 will inform clinical trials of therapeutic strategies.
Keywords	General Medicine ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqaa124
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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