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  1. Article ; Online: Endothelial cells are major players in SARS-CoV-2-related acute respiratory distress syndrome.

    Caccuri, Francesca / Caruso, Arnaldo

    EBioMedicine

    2022  Volume 86, Page(s) 104328

    Language English
    Publishing date 2022-11-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  2. Article: Editorial: Cell cycle control as a new therapeutic approach for SARS-CoV-2 infection.

    Rizzo, Roberta / Caccuri, Francesca / Valacchi, Giuseppe / Zauli, Giorgio

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1136277

    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1136277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Virucidal efficacy of a novel silver-based disinfectant against SARS-CoV-2 Omicron BA.5.

    Zani, Alberto / Messali, Serena / Caccuri, Francesca

    The new microbiologica

    2023  Volume 46, Issue 1, Page(s) 60–64

    Abstract: In this study we evaluated the antiviral activity of the Silver Barrier® disinfectant against SARSCoV-2. Silver Barrier® showed time- and concentration-dependent antiviral activity against SARSCoV-2. After 5 min contact time, Silver Barrier® at 0.002% ... ...

    Abstract In this study we evaluated the antiviral activity of the Silver Barrier® disinfectant against SARSCoV-2. Silver Barrier® showed time- and concentration-dependent antiviral activity against SARSCoV-2. After 5 min contact time, Silver Barrier® at 0.002% showed a strong inhibitory effect (p<0.001), with a 2-fold reduction of viral genome copy numbers, and a robust suppression (94%) of SARS-CoV-2 infectivity. Considering the effects obtained in solution and within a very short time, Silver Barrier® stands as an excellent new candidate for the disinfection of work environments, especially at the healthcare level, where there are people at high risk of serious illnesses.
    MeSH term(s) Humans ; SARS-CoV-2 ; Disinfectants/pharmacology ; COVID-19/prevention & control ; Silver/pharmacology ; Antiviral Agents/pharmacology
    Chemical Substances Disinfectants ; Silver (3M4G523W1G) ; Antiviral Agents
    Language English
    Publishing date 2023-02-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 756168-4
    ISSN 1121-7138 ; 0391-5352
    ISSN 1121-7138 ; 0391-5352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endothelial cells are major players in SARS-CoV-2-related acute respiratory distress syndrome

    Francesca Caccuri / Arnaldo Caruso

    EBioMedicine, Vol 86, Iss , Pp 104328- (2022)

    2022  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: First detection of SARS-CoV-2 BA.2.86.1 in Italy.

    Caccuri, Francesca / Messali, Serena / Scarpa, Fabio / Giovanetti, Marta / Ciccozzi, Massimo / Caruso, Arnaldo

    Journal of medical virology

    2023  Volume 95, Issue 10, Page(s) e29175

    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Italy/epidemiology
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29175
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  6. Article ; Online: Emergence of S gene-based quasispecies explains an optimal adaptation of Omicron BA.5 subvariant in the immunocompetent vaccinated human host.

    Messali, Serena / Bugatti, Antonella / Filippini, Federica / Caruso, Arnaldo / Caccuri, Francesca

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28167

    MeSH term(s) Humans ; Quasispecies
    Language English
    Publishing date 2022-10-01
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28167
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  7. Article: SARS-CoV-2 Systemic Effects: New Clues.

    Beltrami, Silvia / Rizzo, Sabrina / Caccuri, Francesca / Rizzo, Roberta / Bortolotti, Daria / Schiuma, Giovanna

    Microorganisms

    2023  Volume 11, Issue 5

    Abstract: To date, much discussion has been had on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung infection associated with COVID-19 onset, of which the major manifestation is characterized by a "cytokine storm" [ ... ]. ...

    Abstract To date, much discussion has been had on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung infection associated with COVID-19 onset, of which the major manifestation is characterized by a "cytokine storm" [...].
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11051209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Detection of SARS-CoV-2 Alpha variant in a severely immunocompromised HIV-1-infected patient in the omicron era.

    Messali, Serena / Giovanetti, Marta / Ciccozzi, Massimo / Caruso, Arnaldo / Caccuri, Francesca

    The new microbiologica

    2022  Volume 45, Issue 4

    Abstract: Persistence of detectable viral RNA does not depend on the symptomatic status of the patients. Here we describe the case of a strongly immunocompromised patient living with a prolonged SARS-CoV-2 Alpha variant infection without showing any symptoms. The ... ...

    Abstract Persistence of detectable viral RNA does not depend on the symptomatic status of the patients. Here we describe the case of a strongly immunocompromised patient living with a prolonged SARS-CoV-2 Alpha variant infection without showing any symptoms. The importance of our findings is that the persistence of infection with an old SARS-CoV-2 strain, in an immunocompromised host, may allow recombination events generating new viral variants whose pathogenicity cannot be predicted. Our observation calls for the urgent need for continuous monitoring of SARS-CoV-2 genomic evolution in immunocompromised patients.
    Language English
    Publishing date 2022-05-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 756168-4
    ISSN 1121-7138 ; 0391-5352
    ISSN 1121-7138 ; 0391-5352
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  9. Article ; Online: Detection of HIV-1 matrix protein p17 in sera of viremic and aviremic patients.

    Zani, Alberto / Messali, Serena / Uggeri, Matteo / Bonfanti, Carlo / Caruso, Arnaldo / Caccuri, Francesca

    Journal of virological methods

    2023  Volume 324, Page(s) 114858

    Abstract: People living with human immunodeficiency virus type 1 (HIV-1), even if successfully treated with a combined antiretroviral therapy, display a persistent inflammation and chronic immune activation, and an increasing risk of developing cardiovascular and ... ...

    Abstract People living with human immunodeficiency virus type 1 (HIV-1), even if successfully treated with a combined antiretroviral therapy, display a persistent inflammation and chronic immune activation, and an increasing risk of developing cardiovascular and thrombotic events, cancers, and neurologic disorders. Accumulating evidence reveals that biologically active HIV-1 proteins may play a role in the development of these HIV-1-associated conditions. The HIV-1 matrix protein p17 (p17) is released and accumulates in different organs and tissue where it may exert multiple biological activities on different target cells. To assess a role of p17 in different HIV-1-related pathological processes, it is central to definitively ascertain and quantitate its expression in a large number of sera obtained from HIV-1-infected (HIV-1
    MeSH term(s) Humans ; HIV-1 ; gag Gene Products, Human Immunodeficiency Virus/metabolism ; HIV Antigens/metabolism ; Viremia ; HIV Infections
    Chemical Substances gag Gene Products, Human Immunodeficiency Virus ; HIV Antigens
    Language English
    Publishing date 2023-11-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2023.114858
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    Zs.A 1565: Show issues Location:
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  10. Article ; Online: Traceability of SARS-CoV-2 transmission through quasispecies analysis.

    Messali, Serena / Rondina, Alessandro / Giovanetti, Marta / Bonfanti, Carlo / Ciccozzi, Massimo / Caruso, Arnaldo / Caccuri, Francesca

    Journal of medical virology

    2023  Volume 95, Issue 6, Page(s) e28848

    Abstract: During COVID-19 pandemic, consensus genomic sequences were used for rapidly monitor the spread of the virus worldwide. However, less attention was paid to intrahost genetic diversity. In fact, in the infected host, SARS-CoV-2 consists in an ensemble of ... ...

    Abstract During COVID-19 pandemic, consensus genomic sequences were used for rapidly monitor the spread of the virus worldwide. However, less attention was paid to intrahost genetic diversity. In fact, in the infected host, SARS-CoV-2 consists in an ensemble of replicating and closely related viral variants so-called quasispecies. Here we show that intrahost single nucleotide variants (iSNVs) represent a target for contact tracing analysis. Our data indicate that in the acute phase of infection, in highly likely transmission links, the number of viral particles transmitted from one host to another (bottleneck size) is large enough to propagate iSNVs among individuals. Furthermore, we demonstrate that, during SARS-CoV-2 outbreaks when the consensus sequences are identical, it is possible to reconstruct the transmission chains by genomic investigations of iSNVs. Specifically, we found that it is possible to identify transmission chains by limiting the analysis of iSNVs to only three well-conserved genes, namely nsp2, ORF3, and ORF7.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Quasispecies ; Pandemics ; Genome, Viral
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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