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  1. Article ; Online: The global challenge of carbapenemases and the critical need for more data.

    Marimuthu, Kalisvar / Ng, Oon-Tek / Bagdasarian, Natasha / Tambyah, Paul A

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2019  Volume 84, Page(s) 141–142

    Language English
    Publishing date 2019-05-14
    Publishing country Canada
    Document type Editorial
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2019.05.018
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    Zs.A 4516: Show issues Location:
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  2. Article ; Online: HIV self-testing: money matters.

    Ng, Oon-Tek / Tan, Mei-Ting

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2013  Volume 57, Issue 5, Page(s) 771–772

    MeSH term(s) Clinical Laboratory Techniques/methods ; HIV Infections/diagnosis ; HIV Infections/prevention & control ; Humans ; Self Administration/methods
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Comment ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cit361
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  3. Article ; Online: Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies.

    Chakraborty, Nayanika / Jha, Diksha / Roy, Indrajit / Kumar, Pradeep / Gaurav, Shailendra Singh / Marimuthu, Kalisvar / Ng, Oon-Tek / Lakshminarayanan, Rajamani / Verma, Navin Kumar / Gautam, Hemant K

    Journal of nanobiotechnology

    2022  Volume 20, Issue 1, Page(s) 375

    Abstract: Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of "post-antibiotic era". It is anticipated that current SARS-CoV2 pandemic would worsen the situation in future, mainly due to the lack of new/next generation of ... ...

    Abstract Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of "post-antibiotic era". It is anticipated that current SARS-CoV2 pandemic would worsen the situation in future, mainly due to the lack of new/next generation of antimicrobials. In this context, nanoscale materials with antimicrobial potential have a great promise to treat deadly pathogens. These functional materials are uniquely positioned to effectively interfere with the bacterial systems and augment biofilm penetration. Most importantly, the core substance, surface chemistry, shape, and size of nanomaterials define their efficacy while avoiding the development of AMR. Here, we review the mechanisms of AMR and emerging applications of nanoscale functional materials as an excellent substitute for conventional antibiotics. We discuss the potential, promises, challenges and prospects of nanobiotics to combat AMR.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; Drug Resistance, Bacterial ; Humans ; RNA, Viral ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; RNA, Viral
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-022-01573-9
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  4. Article ; Online: Compliance with face mask use during the COVID-19 pandemic: a community observational study in Singapore.

    Xiang Ong, Sean Wei / Tang, Ying Wei / Linn, Kyaw Zaw / Huan, Xiao Wei / Lim, Allie / Poon, Chu Ying / Ru Tan, Danielle Hui / Binte Hamed, Nur Hafizah / Syed Husen, Sharifah Farhanah Binte / Hui Ong, Clara Chong / Chan, Monica / Vasoo, Shawn / Leo, Yee-Sin / Ng, Oon-Tek / Marimuthu, Kalisvar

    Singapore medical journal

    2023  

    Abstract: Introduction: Widespread mask use is an important intervention for control of the coronavirus disease 2019 pandemic. However, data on the factors affecting mask use are lacking. In this observational study, we evaluated the proportion of and factors ... ...

    Abstract Introduction: Widespread mask use is an important intervention for control of the coronavirus disease 2019 pandemic. However, data on the factors affecting mask use are lacking. In this observational study, we evaluated the proportion of and factors influencing face mask use and related hygiene practices.
    Methods: We observed randomly selected members from the public in 367 venues across Singapore, and recorded the proportion of individuals with full compliance with mask use and mask hygiene (hand hygiene before and after touching the mask or face). Logistic regression analyses were used to determine variables associated with mask and hand hygiene compliance.
    Results: We made 3,821 observations - 2,149 (56.2%) females, 3,569 (93.4%) adults (≥21 years), 212 (5.5%) children (6-20 years) and 40 (1.0%) children (2-5 years). The overall full compliance rate (correct mask use), poor compliance rate (incorrect mask use) and absent mask use were 84.5%, 12.9% and 2.6%, respectively. The factors - male gender, fabric mask usage and crowded indoor venues - were associated with lower mask compliance. Face or mask touching behaviour was observed in 10.7% and 13.7% of individuals observed, respectively. Only one individual performed hand hygiene before and after touching the mask.
    Conclusion: The rate of mask compliance was high, probably due to legislation mandating mask usage. However, specific factors and crowded indoor venues associated with lower mask compliance were identified. We also noted an issue with the absence of hand hygiene before and after face or mask touching. These issues may benefit from targeted public health messaging.
    Language English
    Publishing date 2023-04-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2021-010
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  5. Article ; Online: Myopic Shift in a Patient with Dengue Fever.

    Mi Fang, Helen / Ng, Oon Tek / Agrawal, Rupesh

    Ocular immunology and inflammation

    2021  Volume 31, Issue 1, Page(s) 191–193

    Abstract: Purpose: This report aims to present a case of dengue-related myopic shift.: Methods: This is a case report of a patient with dengue-related transient myopia, and demonstrates possible underlying pathophysiology.: Results: A 38-year-old gentleman ... ...

    Abstract Purpose: This report aims to present a case of dengue-related myopic shift.
    Methods: This is a case report of a patient with dengue-related transient myopia, and demonstrates possible underlying pathophysiology.
    Results: A 38-year-old gentleman presented with bilateral blurring of vision with an unaided visual acuity (VA) of 6/120 bilaterally. He had a refractive error of -2.50 dioptres in the right eye, and -3.50 dioptres in the left eye. Ultrasound biomicroscopy (UBM) revealed suprachoroidal effusion with anterior displacement of the lens-iris complex bilaterally. Biometry performed showed lens thickness (LT) of 4.47 mm in the right eye, and 4.65 mm in the left eye. His unaided VA was noted to be 6/6 bilaterally 4 days later.
    Conclusions: Dengue-related myopic shift was likely secondary to two mechanisms. Firstly, suprachoroidal effusion resulted in an anterior displacement of the lens-iris complex. Secondly, there was an increase in the antero-posterior diameter of the lens, resulting in index myopia.
    MeSH term(s) Male ; Humans ; Adult ; Myopia/complications ; Myopia/diagnosis ; Visual Acuity ; Lens, Crystalline ; Iris ; Dengue/complications ; Dengue/diagnosis
    Language English
    Publishing date 2021-10-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2021.1985523
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  6. Article ; Online: Monkeypox and ocular implications in humans.

    Ci Ng, Faye Yu / Yeh, Steven / Smit, Derrick / Ng, Oon Tek / Vasoo, Shawn / Land Curi, Andre Luiz / Agrawal, Rupesh

    The ocular surface

    2022  Volume 27, Page(s) 13–15

    MeSH term(s) Humans ; Mpox (monkeypox) ; Eye
    Language English
    Publishing date 2022-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2208578-6
    ISSN 1937-5913 ; 1542-0124
    ISSN (online) 1937-5913
    ISSN 1542-0124
    DOI 10.1016/j.jtos.2022.10.005
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  7. Article ; Online: Effect of extended use N95 respirators and eye protection on personal protective equipment (PPE) utilization during SARS-CoV-2 outbreak in Singapore

    Glorijoy Shi En Tan / Kyaw Zaw Linn / Margaret Mei Ling Soon / Shawn Vasoo / Monica Chan / Bee Fong Poh / Oon-Tek Ng / Brenda Sze-Peng Ang / Yee-Sin Leo / Kalisvar Marimuthu

    Antimicrobial Resistance and Infection Control, Vol 9, Iss 1, Pp 1-

    2020  Volume 3

    Keywords SARS-CoV-2 ; Personal protective equipment ; Extended use N95 respirator ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Lack of viable severe acute respiratory coronavirus virus 2 (SARS-CoV-2) among PCR-positive air samples from hospital rooms and community isolation facilities.

    Ong, Sean Wei Xiang / Tan, Yian Kim / Coleman, Kristen Kelli / Tan, Boon Huan / Leo, Yee-Sin / Wang, Dong Ling / Ng, Ching Ging / Ng, Oon-Tek / Wong, Michelle Su Yen / Marimuthu, Kalisvar

    Infection control and hospital epidemiology

    2021  Volume 42, Issue 11, Page(s) 1327–1332

    Abstract: Background: Understanding the extent of aerosol-based transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is important for tailoring interventions for control of the coronavirus disease 2019 (COVID-19) pandemic. Multiple studies ...

    Abstract Background: Understanding the extent of aerosol-based transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is important for tailoring interventions for control of the coronavirus disease 2019 (COVID-19) pandemic. Multiple studies have reported the detection of SARS-CoV-2 nucleic acid in air samples, but only one study has successfully recovered viable virus, although it is limited by its small sample size.
    Objective: We aimed to determine the extent of shedding of viable SARS-CoV-2 in respiratory aerosols from COVID-19 patients.
    Methods: In this observational air sampling study, air samples from airborne-infection isolation rooms (AIIRs) and a community isolation facility (CIF) housing COVID-19 patients were collected using a water vapor condensation method into liquid collection media. Samples were tested for presence of SARS-CoV-2 nucleic acid using quantitative real-time polymerase chain reaction (qRT-PCR), and qRT-PCR-positive samples were tested for viability using viral culture.
    Results: Samples from 6 (50%) of the 12 sampling cycles in hospital rooms were positive for SARS-CoV-2 RNA, including aerosols ranging from <1 µm to >4 µm in diameter. Of 9 samples from the CIF, 1 was positive via qRT-PCR. Viral RNA concentrations ranged from 179 to 2,738 ORF1ab gene copies per cubic meter of air. Virus cultures were negative after 4 blind passages.
    Conclusion: Although SARS-CoV-2 is readily captured in aerosols, virus culture remains challenging despite optimized sampling methodologies to preserve virus viability. Further studies on aerosol-based transmission and control of SARS-CoV-2 are needed.
    MeSH term(s) COVID-19 ; Hospitals ; Humans ; Polymerase Chain Reaction ; RNA, Viral/genetics ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2021.8
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  9. Article ; Online: Prevalence and Distribution of

    Teo, Jeanette W P / Octavia, Sophie / Rama Sridatta Prakki, Sai / Venkatachalam, Indumathi / Marimuthu, Kalisvar / Ng, Oon Tek

    Antimicrobial agents and chemotherapy

    2022  Volume 66, Issue 9, Page(s) e0101922

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Genotype ; Prevalence ; Retrospective Studies ; Singapore/epidemiology ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01019-22
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  10. Article ; Online: Dissemination of

    Prakki, Sai Rama Sridatta / Hon, Pei Yun / Lim, Ze Qin / Thevasagayam, Natascha May / Loy, Song Qi Dennis / De, Partha Pratim / Marimuthu, Kalisvar / Vasoo, Shawn / Ng, Oon Tek

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0403322

    Abstract: Pseudomonas aeruginosa ST308 clone has been reported to carry carbapenemase genes such ... ...

    Abstract Pseudomonas aeruginosa ST308 clone has been reported to carry carbapenemase genes such as
    MeSH term(s) Humans ; Pseudomonas aeruginosa/genetics ; Singapore/epidemiology ; Phylogeny ; Pseudomonas Infections/epidemiology ; Anti-Bacterial Agents/pharmacology ; beta-Lactamases/genetics ; Microbial Sensitivity Tests
    Chemical Substances beta-lactamase NDM-1 (EC 3.5.2.6) ; Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04033-22
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