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  1. Article ; Online: TYK2 signaling promotes the development of autoreactive CD8

    Mine, Keiichiro / Nagafuchi, Seiho / Akazawa, Satoru / Abiru, Norio / Mori, Hitoe / Kurisaki, Hironori / Shimoda, Kazuya / Yoshikai, Yasunobu / Takahashi, Hirokazu / Anzai, Keizo

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1337

    Abstract: Tyrosine kinase 2 (TYK2), a member of the JAK family, has attracted attention as a potential therapeutic target for autoimmune diseases. However, the role of TYK2 in ... ...

    Abstract Tyrosine kinase 2 (TYK2), a member of the JAK family, has attracted attention as a potential therapeutic target for autoimmune diseases. However, the role of TYK2 in CD8
    MeSH term(s) Mice ; Animals ; CD8-Positive T-Lymphocytes ; T-Lymphocytes, Cytotoxic ; Diabetes Mellitus, Type 1/genetics ; TYK2 Kinase/genetics ; Mice, Knockout ; Mice, Inbred NOD ; Antineoplastic Agents
    Chemical Substances TYK2 Kinase (EC 2.7.10.2) ; Antineoplastic Agents
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45573-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: MHC class II inhibits the generation of IL-17A

    Hatano, Shinya / Mine, Keiichiro / Noguchi, Naoto / Matsumoto, Mitsuru / Baba, Yoshihiro / Yoshikai, Yasunobu

    European journal of immunology

    2022  Volume 52, Issue 8, Page(s) 1366–1368

    Abstract: ... ...

    Abstract Vγ6
    MeSH term(s) Animals ; Genes, MHC Class II ; Interleukin-17 ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Antigen, T-Cell, gamma-delta ; T-Lymphocyte Subsets ; Thymus Gland/cytology
    Chemical Substances Interleukin-17 ; Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2022-05-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149542
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  3. Article ; Online: SARS-CoV-2 Infection and Pancreatic β Cell Failure

    Keiichiro Mine / Seiho Nagafuchi / Hitoe Mori / Hirokazu Takahashi / Keizo Anzai

    Biology, Vol 11, Iss 22, p

    2022  Volume 22

    Abstract: SARS-CoV-2 infection primarily causes pulmonary symptoms; however, accumulating reports indicate that some patients with COVID-19 have multiple organ dysfunction or failure. Although diabetes is considered a risk factor for severe COVID-19, SARS-CoV-2 ... ...

    Abstract SARS-CoV-2 infection primarily causes pulmonary symptoms; however, accumulating reports indicate that some patients with COVID-19 have multiple organ dysfunction or failure. Although diabetes is considered a risk factor for severe COVID-19, SARS-CoV-2 infection may also be a causal factor for diabetes mellitus in patients with COVID-19. According to the research reviewed in this paper, the pancreas and pancreatic β cells appear to be targets of SARS-CoV-2 and are damaged by direct or indirect effects of the infection. However, controversial results have been reported between study groups, mainly due to the limited number of cases with diabetes precipitated by COVID-19. In this review, we comprehensively discuss the published findings on the potential association between SARS-CoV-2 infection or COVID-19 and pancreatic β-cell damage leading to diabetes onset. These findings will further contribute to our understanding of the pathogenesis of diabetes mellitus.
    Keywords virus ; diabetes ; COVID-19 ; SARS-CoV-2 ; pancreas ; β cell ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: SARS-CoV-2 Infection and Pancreatic β Cell Failure.

    Mine, Keiichiro / Nagafuchi, Seiho / Mori, Hitoe / Takahashi, Hirokazu / Anzai, Keizo

    Biology

    2021  Volume 11, Issue 1

    Abstract: SARS-CoV-2 infection primarily causes pulmonary symptoms; however, accumulating reports indicate that some patients with COVID-19 have multiple organ dysfunction or failure. Although diabetes is considered a risk factor for severe COVID-19, SARS-CoV-2 ... ...

    Abstract SARS-CoV-2 infection primarily causes pulmonary symptoms; however, accumulating reports indicate that some patients with COVID-19 have multiple organ dysfunction or failure. Although diabetes is considered a risk factor for severe COVID-19, SARS-CoV-2 infection may also be a causal factor for diabetes mellitus in patients with COVID-19. According to the research reviewed in this paper, the pancreas and pancreatic β cells appear to be targets of SARS-CoV-2 and are damaged by direct or indirect effects of the infection. However, controversial results have been reported between study groups, mainly due to the limited number of cases with diabetes precipitated by COVID-19. In this review, we comprehensively discuss the published findings on the potential association between SARS-CoV-2 infection or COVID-19 and pancreatic β-cell damage leading to diabetes onset. These findings will further contribute to our understanding of the pathogenesis of diabetes mellitus.
    Language English
    Publishing date 2021-12-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11010022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dermal Vγ6

    Mine, Keiichiro / Tun, Xin / Hatano, Shinya / Noguchi, Naoto / Iwakura, Yoichiro / Sawa, Shinichiro / Nagafuchi, Seiho / Yoshikai, Yasunobu

    The Journal of investigative dermatology

    2022  Volume 142, Issue 8, Page(s) 2294–2297.e5

    MeSH term(s) Animals ; Interleukin-17 ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Pressure Ulcer ; Receptors, Antigen, T-Cell, gamma-delta ; Skin ; T-Lymphocyte Subsets
    Chemical Substances Interleukin-17 ; Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.12.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Vγ6

    Tun, Xin / Hatano, Shinya / Mine, Keiichiro / Noguchi, Naoto / Iwakura, Yoichiro / Sun, Xun / Yoshikai, Yasunobu

    European journal of immunology

    2021  Volume 51, Issue 8, Page(s) 2093–2096

    Abstract: γδ T cells producing IL-17A (γδTh17 cells) are known to be involved in peritonitis induced by Escherichia coli infection in mice. In vivo treatment with Vγ6-specific mAb (1C10-1F7) significantly hampered resolution of E. coli infection. Thus, ... ...

    Abstract γδ T cells producing IL-17A (γδTh17 cells) are known to be involved in peritonitis induced by Escherichia coli infection in mice. In vivo treatment with Vγ6-specific mAb (1C10-1F7) significantly hampered resolution of E. coli infection. Thus, Vγ6
    MeSH term(s) Animals ; Escherichia coli Infections/immunology ; Immunity, Innate/immunology ; Mice ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Th17 Cells/immunology
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2021-04-01
    Publishing country Germany
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202049010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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  7. Article ; Online: Viruses with masked pathogenicity and genetically susceptible hosts-How to discover potentially pathogenic viruses.

    Nagafuchi, Seiho / Mine, Keiichiro / Takahashi, Hirokazu / Anzai, Keizo / Yoshikai, Yasunobu

    Journal of medical virology

    2019  Volume 91, Issue 8, Page(s) 1365–1367

    MeSH term(s) Animals ; Disease Susceptibility ; Host-Pathogen Interactions ; Humans ; Viruses/isolation & purification ; Viruses/pathogenicity
    Language English
    Publishing date 2019-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25472
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  8. Article: SARS-CoV-2 Infection and Pancreatic β Cell Failure

    Mine, Keiichiro / Nagafuchi, Seiho / Mori, Hitoe / Takahashi, Hirokazu / Anzai, Keizo

    Biology. 2021 Dec. 24, v. 11, no. 1

    2021  

    Abstract: SARS-CoV-2 infection primarily causes pulmonary symptoms; however, accumulating reports indicate that some patients with COVID-19 have multiple organ dysfunction or failure. Although diabetes is considered a risk factor for severe COVID-19, SARS-CoV-2 ... ...

    Abstract SARS-CoV-2 infection primarily causes pulmonary symptoms; however, accumulating reports indicate that some patients with COVID-19 have multiple organ dysfunction or failure. Although diabetes is considered a risk factor for severe COVID-19, SARS-CoV-2 infection may also be a causal factor for diabetes mellitus in patients with COVID-19. According to the research reviewed in this paper, the pancreas and pancreatic β cells appear to be targets of SARS-CoV-2 and are damaged by direct or indirect effects of the infection. However, controversial results have been reported between study groups, mainly due to the limited number of cases with diabetes precipitated by COVID-19. In this review, we comprehensively discuss the published findings on the potential association between SARS-CoV-2 infection or COVID-19 and pancreatic β-cell damage leading to diabetes onset. These findings will further contribute to our understanding of the pathogenesis of diabetes mellitus.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; diabetes mellitus ; pathogenesis ; risk factors
    Language English
    Dates of publication 2021-1224
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11010022
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Model Animal Mimicking Human Virus-induced Diabetes.

    Mine, Keiichiro / Takahashi, Hirokazu / Nagafuchi, Seiho

    EBioMedicine

    2018  Volume 32, Page(s) 8

    MeSH term(s) Animals ; Diabetes Mellitus, Type 1/etiology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/prevention & control ; Disease Models, Animal ; Genetic Predisposition to Disease ; Humans ; Vaccination ; Virus Diseases/complications ; Virus Diseases/genetics ; Virus Diseases/prevention & control
    Language English
    Publishing date 2018-05-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2018.05.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  10. Article ; Online: Immunohistochemical detection of enteroviruses in pancreatic tissues of patients with type 1 diabetes using a polyclonal antibody against 2A protease of Coxsackievirus.

    Jimbo, Erika / Kobayashi, Tetsuro / Takeshita, Akira / Mine, Keiichiro / Nagafuchi, Seiho / Fukui, Tomoyasu / Yagihashi, Soroku

    Journal of diabetes investigation

    2021  Volume 13, Issue 3, Page(s) 435–442

    Abstract: Aims/introduction: The need for antiserum for immunohistochemical (IHC) detection of enterovirus (EV) in formaldehyde-fixed and paraffin-embedded samples is increasing. The gold standard monoclonal antibody (clone 5D8/1) against EV-envelope protein (VP1) ...

    Abstract Aims/introduction: The need for antiserum for immunohistochemical (IHC) detection of enterovirus (EV) in formaldehyde-fixed and paraffin-embedded samples is increasing. The gold standard monoclonal antibody (clone 5D8/1) against EV-envelope protein (VP1) was proven to cross-react with other proteins. Another candidate marker of EV proteins is 2A protease (2A
    Materials and methods: We raised polyclonal antiserum by immunizing a rabbit with an 18-mer peptide of Coxsackievirus B1 (CVB1)-2A
    Results: Enzyme-linked immunosorbent assay study showed a high titer of antibody for 18-mer peptide of CVB1-2A
    Conclusions: Our study provides a new polyclonal antiserum against CVB1-2A
    MeSH term(s) Animals ; Chlorocebus aethiops ; Diabetes Mellitus, Type 1 ; Enterovirus/metabolism ; Humans ; Pancreas/metabolism ; Peptide Hydrolases/metabolism ; Rabbits ; Vero Cells
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2021-12-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13700
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