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  1. Article ; Online: Cervical exenteration and its variants for locally advanced thyroid cancer: when, why, and how?

    Piazza, Cesare / Lancini, Davide / Paderno, Alberto

    Current opinion in otolaryngology & head and neck surgery

    2023  Volume 31, Issue 2, Page(s) 65–72

    Abstract: Purpose of review: To describe the modern surgical approach for management of advanced thyroid cancers infiltrating the cervicovisceral axis with special attention to well differentiated tumors not amenable to organ-sparing techniques. In particular, ... ...

    Abstract Purpose of review: To describe the modern surgical approach for management of advanced thyroid cancers infiltrating the cervicovisceral axis with special attention to well differentiated tumors not amenable to organ-sparing techniques. In particular, cervical exenteration, herein defined as the sum of total thyroidectomy, central compartment and lateral neck dissections, variously associated with total laryngectomy and possible partial or total pharyngoesophagectomy, represents an extreme surgical procedure that, in properly selected cases, allows for reasonable palliation of central compartment life-threatening signs/symptoms if not cure for an advanced oncologic condition.
    Recent findings: Cervical exenteration is not contraindicated by the presence of limited distant metastases at presentation. Even though it requires that the patient is in general good health as it can be associated with a number of complications and long in-hospital stay, when appropriately planned and performed according to the most recent reconstructive nuances, it allows good oncologic outcomes that are not inferior to those described for similarly advanced primaries of the upper aerodigestive tract. In addition, quality of life and functional results are not significantly different from those described after total laryngectomy for primary laryngeal squamous cell carcinomas.
    Summary: Cervical exenteration requires a tertiary, expert, multidisciplinary effort in terms of diagnosis, surgical performance, and postoperative care. A patient-centered decision process is strongly warranted taking into consideration alternative therapeutic and symptom-based palliative strategies.
    MeSH term(s) Humans ; Quality of Life ; Thyroid Neoplasms/pathology ; Thyroidectomy/methods ; Neck Dissection
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000873
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  2. Article ; Online: Is the exoscope ready to replace the operative microscope in transoral surgery?

    Paderno, Alberto / Deganello, Alberto / Lancini, Davide / Piazza, Cesare

    Current opinion in otolaryngology & head and neck surgery

    2022  Volume 30, Issue 2, Page(s) 79–86

    Abstract: Purpose of review: Exoscopes are external digital devices that provide enhanced and magnified visualization of the surgical field. They usually have dedicated digital controls and a more compact mechanical structure than operative microscopes and ... ...

    Abstract Purpose of review: Exoscopes are external digital devices that provide enhanced and magnified visualization of the surgical field. They usually have dedicated digital controls and a more compact mechanical structure than operative microscopes and current robotic surgical systems. This technology has significant potential in otolaryngology - head and neck surgery, especially concerning the field of transoral approaches. We herein analysed the overall technical characteristics of currently available exoscopic systems and contextualized their advantages and drawbacks in the setting of transoral surgery.
    Recent findings: The actual advantages of exoscopy are still indeterminate, as it has only been applied to limited surgical series. However, its specific properties are herein compared with conventional transoral microsurgery and transoral robotic surgery, discussing the available literature on such a topic, filtered on the basis of the authors' experience and its possible future evolutions. Finally, a summary of current experiences in the field of three-dimensional (3D) transoral exoscopic surgery is presented, highlighting differences compared with standard approaches.
    Summary: 3D-exoscopic transoral surgery will possibly play an essential role in future management of early laryngeal and oropharyngeal lesions, significantly shifting the paradigms of this type of procedures.
    MeSH term(s) Humans ; Microsurgery/methods ; Robotic Surgical Procedures
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000794
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  3. Article: Editorial: Advances in the Multidisciplinary Management of Oral Cancer.

    Paderno, Alberto / Bossi, Paolo / Piazza, Cesare

    Frontiers in oncology

    2021  Volume 11, Page(s) 817756

    Language English
    Publishing date 2021-12-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.817756
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  4. Article ; Online: Using Generative Artificial Intelligence in the Production and Dissemination of Innovation in Otolaryngology-Ethical Considerations.

    Khoury, Carolyn Jane / Enver, Necati / Paderno, Alberto / Ratti, Emanuele / Rameau, Anaïs

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  

    Language English
    Publishing date 2023-12-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Deep learning in endoscopy: the importance of standardisation.

    Paderno, Alberto / Villani, Francesca Pia / Sordi, Alessandra / Montenegro, Claudia / Moccia, Sara

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2023  Volume 43, Issue 6, Page(s) 430–432

    MeSH term(s) Humans ; Algorithms ; Deep Learning ; Endoscopy/standards ; Larynx
    Language English
    Publishing date 2023-10-10
    Publishing country Italy
    Document type Letter
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-N2580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Long-term Olfactory and Gustatory Dysfunction May Be Related to Neural Damage.

    Paderno, Alberto / Mattavelli, Davide / Piazza, Cesare

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2021  Volume 165, Issue 5, Page(s) 755

    MeSH term(s) Humans ; Smell ; Taste Disorders/diagnosis ; Taste Disorders/etiology
    Language English
    Publishing date 2021-02-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599821994845
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  7. Article ; Online: Classifying Vocal Folds Fixation from Endoscopic Videos with Machine Learning.

    Villani, Francesca Pia / Paderno, Alberto / Fiorentino, Maria Chiara / Casella, Alessandro / Piazza, Cesare / Moccia, Sara

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2023  Volume 2023, Page(s) 1–4

    Abstract: Vocal folds motility evaluation is paramount in both the assessment of functional deficits and in the accurate staging of neoplastic disease of the glottis. Diagnostic endoscopy, and in particular videoendoscopy, is nowadays the method through which the ... ...

    Abstract Vocal folds motility evaluation is paramount in both the assessment of functional deficits and in the accurate staging of neoplastic disease of the glottis. Diagnostic endoscopy, and in particular videoendoscopy, is nowadays the method through which the motility is estimated. The clinical diagnosis, however, relies on the examination of the videoendoscopic frames, which is a subjective and professional-dependent task. Hence, a more rigorous, objective, reliable, and repeatable method is needed. To support clinicians, this paper proposes a machine learning (ML) approach for vocal cords motility classification. From the endoscopic videos of 186 patients with both vocal cords preserved motility and fixation, a dataset of 558 images relative to the two classes was extracted. Successively, a number of features was retrieved from the images and used to train and test four well-grounded ML classifiers. From test results, the best performance was achieved using XGBoost, with precision = 0.82, recall = 0.82, F1 score = 0.82, and accuracy = 0.82. After comparing the most relevant ML models, we believe that this approach could provide precise and reliable support to clinical evaluation.Clinical Relevance- This research represents an important advancement in the state-of-the-art of computer-assisted otolaryngology, to develop an effective tool for motility assessment in the clinical practice.
    MeSH term(s) Humans ; Vocal Cords/diagnostic imaging ; Endoscopy ; Glottis ; Videotape Recording ; Machine Learning
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC40787.2023.10340017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Videomics: bringing deep learning to diagnostic endoscopy.

    Paderno, Alberto / Holsinger, F Christopher / Piazza, Cesare

    Current opinion in otolaryngology & head and neck surgery

    2021  Volume 29, Issue 2, Page(s) 143–148

    Abstract: Purpose of review: Machine learning (ML) algorithms have augmented human judgment in various fields of clinical medicine. However, little progress has been made in applying these tools to video-endoscopy. We reviewed the field of video-analysis (herein ... ...

    Abstract Purpose of review: Machine learning (ML) algorithms have augmented human judgment in various fields of clinical medicine. However, little progress has been made in applying these tools to video-endoscopy. We reviewed the field of video-analysis (herein termed 'Videomics' for the first time) as applied to diagnostic endoscopy, assessing its preliminary findings, potential, as well as limitations, and consider future developments.
    Recent findings: ML has been applied to diagnostic endoscopy with different aims: blind-spot detection, automatic quality control, lesion detection, classification, and characterization. The early experience in gastrointestinal endoscopy has recently been expanded to the upper aerodigestive tract, demonstrating promising results in both clinical fields. From top to bottom, multispectral imaging (such as Narrow Band Imaging) appeared to provide significant information drawn from endoscopic images.
    Summary: Videomics is an emerging discipline that has the potential to significantly improve human detection and characterization of clinically significant lesions during endoscopy across medical and surgical disciplines. Research teams should focus on the standardization of data collection, identification of common targets, and optimal reporting. With such a collaborative stepwise approach, Videomics is likely to soon augment clinical endoscopy, significantly impacting cancer patient outcomes.
    MeSH term(s) Algorithms ; Deep Learning ; Endoscopy ; Humans ; Narrow Band Imaging
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A roadmap of six different pathways to improve survival in laryngeal cancer patients.

    Bradley, Patrick J / Piazza, Cesare / Paderno, Alberto

    Current opinion in otolaryngology & head and neck surgery

    2021  Volume 29, Issue 2, Page(s) 65–78

    Abstract: Purpose of review: Laryngeal cancer continues to require improvement in earlier stage diagnosis and better imaging delineation of disease, and hence 'more evidence-based' selection of treatment, as recent evidence suggests that related mortality, in the ...

    Abstract Purpose of review: Laryngeal cancer continues to require improvement in earlier stage diagnosis and better imaging delineation of disease, and hence 'more evidence-based' selection of treatment, as recent evidence suggests that related mortality, in the last decades, has not significantly decreased worldwide. Even though the reasons are not fully understood, there persists an urgency for a review and development of future strategies to embrace such clinical and diagnostic challenges from a political, societal, as well as scientific and clinical points of view.
    Recent findings: This review of the published literature suggests that survival improvement in laryngeal cancer may be achieved by fuelling and combining at least some or all of six targeted agendas: documentation of disease global incidence and national burden monitoring; development and implementation of high-quality cancer registries; education on risk factors and hazardous habits associated with laryngeal cancer for the general population; active modification of proven at-risk population lifestyles; centralization of treatment; and use of machine learning of gathered 'big data' and their integration into approaches for the optimization of prevention and treatments strategies.
    Summary: Laryngeal cancer should be tackled on several fronts, commencing with disease monitoring and prevention, up to treatment optimisation. Available modern resources offer the possibility to generate significant advances in laryngeal cancer management. However, each nation needs to develop a comprehensive approach, which is an essential prerequisite to obtain meaningful improvement on results.
    MeSH term(s) Forecasting ; Humans ; Laryngeal Neoplasms/diagnosis ; Laryngeal Neoplasms/therapy ; Registries ; Risk Factors
    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Best Practice in Surgical Treatment of Malignant Head and Neck Tumors.

    Simon, Christian / Nicolai, Piero / Paderno, Alberto / Dietz, Andreas

    Frontiers in oncology

    2020  Volume 10, Page(s) 140

    Abstract: Purpose of review: ...

    Abstract Purpose of review:
    Language English
    Publishing date 2020-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.00140
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