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Article ; Online: Malignant Histiocytic Neoplasm of the Mediastinum with Pericardial Involvement in a Child.

Huang, Jessie / Lorca, Maria Clara / Chen, Irene Y / Chaturvedi, Apeksha

Radiology. Imaging cancer

2024 Volume 6, Issue 2, Page(s) e230133

MeSH term(s)	Child ; Humans ; Mediastinum/diagnostic imaging ; Mediastinum/pathology ; Pericardium/diagnostic imaging ; Pericardium/pathology ; Lung Neoplasms ; Thorax/pathology
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Journal Article
ISSN	2638-616X
ISSN (online)	2638-616X
DOI	10.1148/rycan.230133
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of diagnostic guidelines on the diagnosis of hypersensitivity pneumonitis.

Huang, Yuh Chin / Gu, Jessie P

Frontiers in medicine

2023 Volume 10, Page(s) 1109525

Abstract: Introduction: Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease from exposure to environmental antigens. Diagnosing HP could be challenging. The American College of Chest Physicians (CHEST) and American Thoracic Society/ ... ...

Abstract	Introduction: Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease from exposure to environmental antigens. Diagnosing HP could be challenging. The American College of Chest Physicians (CHEST) and American Thoracic Society/Japanese Respiratory Society/and Asociación Latinoamericana del Tórax (ATS/JRS/ALAT) have published diagnostic guidelines in 2021 and 2020 respectively. The CHEST guideline uses four grades of confidence: confident (>90%), provisional high (70-89%), provisional low (51-69%), and unlikely (≤50%). The ATS/JRS/ALAT guideline uses five grades of confidence: definite (>90%), high (80-89%), moderate (70-79%), low (51-69%) and not excluded (≤50%). In this study, we determined how these two guidelines could have affected the diagnosis of HP made before the guidelines. Methods: Two hundred and fifty-nine adult patients from a previous cohort with HP (ICD-9:495) made between Jan. 1, 2008, and Dec. 31, 2013, at Duke University Medical Center were included. We simplified the diagnostic confidence into three categories so we could compare the guidelines: high (≥90%), intermediate (51-89%), and low (≤50%). Results: There were 156 female and 103 male. Mean age was 58 (range: 20-90). 68.8% of the patients had restrictive defects (FVC < 80% pred) and 48.6% had lung biopsy. The CHEST guideline classified 33.6% of the patients into high, 59.5% into intermediate and 6.9% into low confidence categories. The ATS/JRS/ALAT guideline classified 29.7% of the patients into high, 21.2% into intermediate and 49.0% into low confidence categories ( Discussion: In our HP cohort with two-thirds of the patients with restrictive defects, we found the two guidelines had fair agreement in diagnosing HP with or without identifiable IAs. They agreed more when the diagnostic confidence was high. When the diagnostic confidence was lower, however, the ATS/JRS/ALAT guideline was more stringent. Clinicians should be aware of the differences between the two guidelines when evaluating patients suspicious of HP.
Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1109525
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Article ; Online: Impact of diagnostic guidelines on the diagnosis of hypersensitivity pneumonitis

Yuh Chin Huang / Jessie P. Gu

Frontiers in Medicine, Vol

2023 Volume 10

Abstract: IntroductionHypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease from exposure to environmental antigens. Diagnosing HP could be challenging. The American College of Chest Physicians (CHEST) and American Thoracic Society/ ... ...

Abstract	IntroductionHypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease from exposure to environmental antigens. Diagnosing HP could be challenging. The American College of Chest Physicians (CHEST) and American Thoracic Society/Japanese Respiratory Society/and Asociación Latinoamericana del Tórax (ATS/JRS/ALAT) have published diagnostic guidelines in 2021 and 2020 respectively. The CHEST guideline uses four grades of confidence: confident (>90%), provisional high (70–89%), provisional low (51–69%), and unlikely (≤50%). The ATS/JRS/ALAT guideline uses five grades of confidence: definite (>90%), high (80–89%), moderate (70–79%), low (51–69%) and not excluded (≤50%). In this study, we determined how these two guidelines could have affected the diagnosis of HP made before the guidelines.MethodsTwo hundred and fifty-nine adult patients from a previous cohort with HP (ICD-9:495) made between Jan. 1, 2008, and Dec. 31, 2013, at Duke University Medical Center were included. We simplified the diagnostic confidence into three categories so we could compare the guidelines: high (≥90%), intermediate (51–89%), and low (≤50%).ResultsThere were 156 female and 103 male. Mean age was 58 (range: 20–90). 68.8% of the patients had restrictive defects (FVC < 80% pred) and 48.6% had lung biopsy. The CHEST guideline classified 33.6% of the patients into high, 59.5% into intermediate and 6.9% into low confidence categories. The ATS/JRS/ALAT guideline classified 29.7% of the patients into high, 21.2% into intermediate and 49.0% into low confidence categories (p < 0.0001 vs. CHEST). Cohen's kappa was 0.331. In patients with identifiable inciting agents (IAs) (N = 168), the CHEST guideline classified 32.1% of the patients into high, 64.3% into intermediate and 3.6% into low confidence categories. The ATS/JRS/ALAT guideline classified 29.2% of the patients into high, 20.8% into intermediate, and 50.0% into low confidence categories. Cohen's kappa was 0.314.DiscussionIn our HP cohort with two-thirds of the ...
Keywords	hypersensitivity pneumonitis ; inciting agent ; environmental exposure ; pulmonary function test ; guidelines and recommendations ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Review of Ambient Air Pollution as a Risk Factor for Posterior Segment Ocular Diseases.

Markeviciute, Agne / Huang-Lung, Jessie / Zemaitiene, Reda / Grzybowski, Andrzej

Journal of clinical medicine

2023 Volume 12, Issue 11

Abstract: Purpose: To review the most recent evidence on the association of ambient air pollution with posterior segment ocular diseases.: Methods: A search of the most recently published medical literature was performed in PubMed and Google Scholar on 10 ... ...

Abstract	Purpose: To review the most recent evidence on the association of ambient air pollution with posterior segment ocular diseases. Methods: A search of the most recently published medical literature was performed in PubMed and Google Scholar on 10 December 2022. Articles published between 2018 and December 2022 were included in this rapid review. Studies that evaluated the association between ambient air pollutants (nitrogen dioxide (NO Results: Nineteen research articles met the inclusion criteria. Significant associations were found between PM Conclusions: There is increasing evidence that toxic air pollutants have an impact on posterior segment ocular diseases, hence determining it as a potential modifiable risk factor for visual impairment.
Language	English
Publishing date	2023-06-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12113842
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Article ; Online: A Review of Ambient Air Pollution as a Risk Factor for Posterior Segment Ocular Diseases

Agne Markeviciute / Jessie Huang-Lung / Reda Zemaitiene / Andrzej Grzybowski

Journal of Clinical Medicine, Vol 12, Iss 3842, p

2023 Volume 3842

Abstract: Purpose. To review the most recent evidence on the association of ambient air pollution with posterior segment ocular diseases. Methods. A search of the most recently published medical literature was performed in PubMed and Google Scholar on 10 December ... ...

Abstract	Purpose. To review the most recent evidence on the association of ambient air pollution with posterior segment ocular diseases. Methods. A search of the most recently published medical literature was performed in PubMed and Google Scholar on 10 December 2022. Articles published between 2018 and December 2022 were included in this rapid review. Studies that evaluated the association between ambient air pollutants (nitrogen dioxide (NO 2 ), carbon monoxide (CO), sulfur dioxide (SO 2 ), ozone (O 3 ), particulate matters (PM s ), total hydrocarbons (THC), nonmethane hydrocarbons (NMHC), benzene), and ocular posterior segment diseases (glaucoma, age-related macular degeneration (AMD), and retinal vascular diseases) were included. Results. Nineteen research articles met the inclusion criteria. Significant associations were found between PM 2.5 and glaucoma, including primary open angle, primary angle closure, and normal tension glaucoma. An increased risk of AMD was linked to increased exposure to PM 2.5 , NO 2 , and CO. Single studies suggested that increased exposure to PM 2.5 and PM 10 is associated with diabetic retinopathy; THC and NMHC increased the risk of retinal vein occlusion; and CO, NO 2 , and PM 10 are linked to an increased risk of central retinal artery occlusion. Conclusions. There is increasing evidence that toxic air pollutants have an impact on posterior segment ocular diseases, hence determining it as a potential modifiable risk factor for visual impairment.
Keywords	ambient air pollutants ; air pollution ; eye disorders ; eye diseases ; glaucoma ; age related macular degeneration ; Medicine ; R
Subject code	333
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Discovery of P450-Modified Sesquiterpenoids Levinoids A-D through Global Genome Mining.

Liu, Wenchao / Tian, Xueying / Huang, Xin / Malit, Jessie James Limlingan / Wu, Chuanhai / Guo, Zhihong / Tang, Jian-Wei / Qian, Pei-Yuan

Journal of natural products

2024 Volume 87, Issue 4, Page(s) 876–883

Abstract: Cytochrome P450-modified bacterial terpenoids remain in a vast chemical space to be explored. In the present study, we conducted global genome mining of 223,829 bacterial genomes and identified 2892 bacterial terpenoid biosynthetic gene clusters (BGCs) ... ...

Abstract	Cytochrome P450-modified bacterial terpenoids remain in a vast chemical space to be explored. In the present study, we conducted global genome mining of 223,829 bacterial genomes and identified 2892 bacterial terpenoid biosynthetic gene clusters (BGCs) with cytochrome P450 genes. Among these, we selected 562 with multiple P450 enzymes, which were further clustered as 355 gene cluster families by sequence similarity analysis. We then chose
MeSH term(s)	Sesquiterpenes/chemistry ; Sesquiterpenes/pharmacology ; Cytochrome P-450 Enzyme System/metabolism ; Streptomyces/chemistry ; Streptomyces/genetics ; Molecular Structure ; Genome, Bacterial ; Multigene Family ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/chemistry
Chemical Substances	Sesquiterpenes ; Cytochrome P-450 Enzyme System (9035-51-2) ; Neuroprotective Agents
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.3c01136
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Article ; Online: Decoding the role of platelets in tumour metastasis: enigmatic accomplices and intricate targets for anticancer treatments.

Zhao, Jessie / Huang, Angela / Zeller, Johannes / Peter, Karlheinz / McFadyen, James D

Frontiers in immunology

2023 Volume 14, Page(s) 1256129

Abstract: The canonical role of platelets as central players in cardiovascular disease by way of their fundamental role in mediating thrombosis and haemostasis is well appreciated. However, there is now a large body of experimental evidence demonstrating that ... ...

Abstract	The canonical role of platelets as central players in cardiovascular disease by way of their fundamental role in mediating thrombosis and haemostasis is well appreciated. However, there is now a large body of experimental evidence demonstrating that platelets are also pivotal in various physiological and pathophysiological processes other than maintaining haemostasis. Foremost amongst these is the emerging data highlighting the key role of platelets in driving cancer growth, metastasis and modulating the tumour microenvironment. As such, there is significant interest in targeting platelets therapeutically for the treatment of cancer. Therefore, the purpose of this review is to provide an overview of how platelets contribute to the cancer landscape and why platelets present as valuable targets for the development of novel cancer diagnosis tools and therapeutics.
MeSH term(s)	Humans ; Blood Platelets/physiology ; Hemostasis ; Neoplasms/drug therapy ; Thrombosis/etiology ; Tumor Microenvironment
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1256129
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Article: A retrospective review of the rate of sexually transmitted infections in adolescents after universal screening protocol implementation in an urban United States clinic.

Tirone, Anthony / Maule, Laura / Huang, Jessie / Higgins, Jenna / Walsh, Tanner / Filingeri, Domenic / Songveera, Alyssa / Poh, Christina / Henderson, Ashley N

Preventive medicine reports

2024 Volume 40, Page(s) 102672

Abstract: Objective: Despite expanded guidelines, adolescent gonorrhea and chlamydia (GC/CT) screening rates remain low due to multiple psychosocial barriers and biases. This intervention aimed to improve screening and diagnosis rates at adolescent well visits by ...

Abstract	Objective: Despite expanded guidelines, adolescent gonorrhea and chlamydia (GC/CT) screening rates remain low due to multiple psychosocial barriers and biases. This intervention aimed to improve screening and diagnosis rates at adolescent well visits by establishing a streamlined universal screening protocol for all patients ages 13-18 years old. Methods: A universal sexually transmitted infection (STI) screening approach was introduced at an urban clinic affiliated with an academic medical center near Philadelphia, Pennsylvania (PA) in September 2018 for all adolescent well-visits. GC/CT screening and diagnosis rates were compared two years prior to and two years after implementation, deemed the baseline and intervention groups, respectively. Results: In total, 1,168 encounters were included for analysis. The patient cohort consisted of 47% females, with an average age of 15, and were predominantly publicly insured (79%). STI screening rates increased significantly from 16.7% (89/534) to 83.6% (530/634) of adolescents with implementation of the universal screening protocol. Furthermore, there was a 1.6-fold increase in total positive cases detected after implementation of ok universal screening. Conclusion: This study demonstrates improved adolescent GC/CT capture rates by establishing a universal screening protocol and highlights a streamlined means of implementation in virtually any pediatric clinic. Limitations include sample size, as this is a single academic practice, as well as any issues with lab collection and results reporting.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785569-7
ISSN	2211-3355
ISSN	2211-3355
DOI	10.1016/j.pmedr.2024.102672
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Article: Nuclear size-regulated emergence of topological packing order on growing human lung alveolospheres.

Tang, Wenhui / Huang, Jessie / Pegoraro, Adrian F / Zhang, James H / Tang, Yiwen / Bi, Dapeng / Kotton, Darrell N / Guo, Ming

bioRxiv : the preprint server for biology

2024

Abstract: Within multicellular living systems, cells coordinate their positions with spatiotemporal accuracy to form various structures, setting the clock to control developmental processes and trigger maturation. These arrangements can be regulated by tissue ... ...

Abstract	Within multicellular living systems, cells coordinate their positions with spatiotemporal accuracy to form various structures, setting the clock to control developmental processes and trigger maturation. These arrangements can be regulated by tissue topology, biochemical cues, as well as mechanical perturbations. However, the fundamental rules of how local cell packing order is regulated in forming three-dimensional (3D) multicellular architectures remain unclear. Furthermore, how cellular coordination evolves during developmental processes, and whether this cell patterning behavior is indicative of more complex biological functions, is largely unknown. Here, using human lung alveolospheres as a model system, by combining experiments and numerical simulations, we find that, surprisingly, cell packing behavior on alveolospheres resembles hard-disk packing but with increased randomness; the stiffer cell nuclei act as the hard disks surrounded by deformable cell bodies. Interestingly, we observe the emergence of topological packing order during alveolosphere growth, as a result of increasing nucleus-to-cell size ratio. Specifically, we find more hexagon-concentrated cellular packing with increasing bond orientational order, indicating a topological gas-to-liquid transition. Additionally, by osmotically changing the compactness of cells on alveolospheres, we observe that the variations in packing order align with the change of nucleus-to-cell size ratio. Together, our findings reveal the underlying rules of cell coordination and topological phases during human lung alveolosphere growth. These static packing characteristics are consistent with cell dynamics, together suggesting that better cellular packing stabilizes local cell neighborhoods and may regulate more complex biological functions such as organ development and cellular maturation.
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.17.589951
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Article ; Online: On a sugar high: Role of O-GlcNAcylation in cancer.

Le Minh, Giang / Esquea, Emily M / Young, Riley G / Huang, Jessie / Reginato, Mauricio J

The Journal of biological chemistry

2023 Volume 299, Issue 11, Page(s) 105344

Abstract: Recent advances in the understanding of the molecular mechanisms underlying cancer progression have led to the development of novel therapeutic targeting strategies. Aberrant glycosylation patterns and their implication in cancer have gained increasing ... ...

Abstract	Recent advances in the understanding of the molecular mechanisms underlying cancer progression have led to the development of novel therapeutic targeting strategies. Aberrant glycosylation patterns and their implication in cancer have gained increasing attention as potential targets due to the critical role of glycosylation in regulating tumor-specific pathways that contribute to cancer cell survival, proliferation, and progression. A special type of glycosylation that has been gaining momentum in cancer research is the modification of nuclear, cytoplasmic, and mitochondrial proteins, termed O-GlcNAcylation. This protein modification is catalyzed by an enzyme called O-GlcNAc transferase (OGT), which uses the final product of the Hexosamine Biosynthetic Pathway (HBP) to connect altered nutrient availability to changes in cellular signaling that contribute to multiple aspects of tumor progression. Both O-GlcNAc and its enzyme OGT are highly elevated in cancer and fulfill the crucial role in regulating many hallmarks of cancer. In this review, we present and discuss the latest findings elucidating the involvement of OGT and O-GlcNAc in cancer.
MeSH term(s)	Humans ; Acetylglucosamine/metabolism ; Biosynthetic Pathways ; Glycosylation ; N-Acetylglucosaminyltransferases/metabolism ; Neoplasms/metabolism ; Protein Processing, Post-Translational
Chemical Substances	Acetylglucosamine (V956696549) ; N-Acetylglucosaminyltransferases (EC 2.4.1.-)
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.105344
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