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Article ; Online: The Ran-binding protein RanBPM can depress the NF-κB pathway by interacting with TRAF6.

Wang, Lan / Fu, Chengbo / Cui, Yingbin / Xie, Yunfei / Yuan, Yuhe / Wang, Xin / Chen, Hong / Huang, Bing-Ren

2011 Volume 359, Issue 1-2, Page(s) 83–94

Abstract: Ran-binding protein in microtubule-organizing center (RanBPM) has been reported to interact ...

Abstract	Ran-binding protein in microtubule-organizing center (RanBPM) has been reported to interact with the neurotrophin receptors p75NTR and TrkA, meanwhile p75NTR and TrkA can also interact with TRAF6. Whether RanBPM interacts directly with TRAF6 has not yet been established. In this study, using a yeast two-hybrid system and glutathione-S: -transferase pull-down assays, we determined that RanBPM binds to the TRAF6 C-terminus through its SPRY motif. Complex formation between overexpressed RanBPM and TRAF6 was also confirmed with a co-immunoprecipitation assay, laser scanning confocal and fluorescence resonance energy transfer. Additional co-immunoprecipitation experiments verified that endogenous RanBPM and TRAF6 interact in several mammalian cell lines. A series of experiments revealed that RanBPM influences TRAF6 ubiquitination and the TRAF6-triggered NF-κB signaling pathway through RanBPM's interaction with TRAF6. These data suggest that RanBPM participates in gene transcription by binding to TRAF6.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Cytoskeletal Proteins/metabolism ; Humans ; NF-kappa B/metabolism ; Nuclear Proteins/metabolism ; Protein Binding ; Protein Interaction Mapping ; Signal Transduction ; TNF Receptor-Associated Factor 6/metabolism ; Transcription, Genetic
Chemical Substances	Adaptor Proteins, Signal Transducing ; Cytoskeletal Proteins ; NF-kappa B ; Nuclear Proteins ; Ran binding protein 9 ; TNF Receptor-Associated Factor 6
Language	English
Publishing date	2011-07-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-011-1002-3
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Article ; Online: Molecular characterization of Ran gene up-regulated in large yellow croaker (Pseudosciaena crocea) immunity.

Han, Fang / Wang, Xiao-Qing / Yao, Cui-luan / Wang, Zhi-yong

Fish & shellfish immunology

2010 Volume 29, Issue 2, Page(s) 327–333

Abstract: ... remains limited. In this report, Ran gene (named LycRan) cDNA was cloned from the large yellow croaker ...

Abstract	RanGTPase, one family of small G protein superfamily, has been widely demonstrated to be involved in transport system between cytoplasm and nucleus. However the knowledge about the function of RanGTPase in immunity remains limited. In this report, Ran gene (named LycRan) cDNA was cloned from the large yellow croaker, Pseudosciaena crocea, a marine fish. The full-length cDNA of LycRan was of 1033 bp, including a 5'-terminal untranslated region (UTR) of 43 bp, 3'-terminal UTR of 338 bp and an open reading frame (ORF) of 648 bp encoding a polypeptide of 216 amino acids. The deduced protein is highly homologous, it shares 90.74%, 88.89%, 89.35% and 85.20% identities with those of salmon, frog, human and fruit fly respectively. RT-PCR analysis indicated that LycRan gene was constitutively expressed in 9 tissues examined, including kidney, liver, gill, muscle, spleen, skin, heart, intestine and blood. The result of quantitative Real-Time RT-PCR analysis revealed the highest expression in kidney and the weakest expression in skin. Time course analysis showed that LycRan expression was obviously up-regulated in kidney, blood and spleen after immunization with either poly I:C or formalin-inactive Gram-negative bacterium Vibrio parahaemolyticus. It indicated that the highest expression was 2.8 times (at 48 h) as much as that in the control in the kidney (p < 0.05) challenged by poly I:C and 3.2 times (at 24 h) in the blood (p < 0.05) challenged by bacteria. These results suggested that LycRan might play an important role in large yellow croaker defense against the pathogen infection. Our study, therefore, might provide a clue to elucidate the large yellow croaker innate immunity.
MeSH term(s)	Adjuvants, Immunologic/pharmacology ; Amino Acid Sequence ; Animals ; Base Sequence ; Fish Diseases/immunology ; Fish Proteins/genetics ; Fish Proteins/immunology ; Gene Expression Profiling ; Immunity, Innate/immunology ; Molecular Sequence Data ; Perciformes/classification ; Perciformes/genetics ; Perciformes/immunology ; Phylogeny ; Poly I-C/pharmacology ; Up-Regulation/drug effects ; Vibrio Infections/immunology ; Vibrio Infections/veterinary ; Vibrio parahaemolyticus/immunology ; ran GTP-Binding Protein/genetics ; ran GTP-Binding Protein/immunology
Chemical Substances	Adjuvants, Immunologic ; Fish Proteins ; ran GTP-Binding Protein (EC 3.6.5.2) ; Poly I-C (O84C90HH2L)
Language	English
Publishing date	2010-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2010.04.005
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Article ; Online: Osteitis in long bones of SAPHO syndrome mimicking osteosarcoma.

Cui, Ran / Dai, Sheng-Ming

Rheumatology (Oxford, England)

2024

Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keae241
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Article ; Online: TITAN: Combining a bidirectional forwarding graph and GCN to detect saturation attack targeted at SDN.

Ran, Longyan / Cui, Yunhe / Zhao, Jianpeng / Yang, Hongzhen

PloS one

2024 Volume 19, Issue 4, Page(s) e0299846

Abstract: The decoupling of control and forwarding layers brings Software-Defined Networking (SDN) the network programmability and global control capability, but it also poses SDN security risks. The adversaries can use the forwarding and control decoupling ... ...

Abstract	The decoupling of control and forwarding layers brings Software-Defined Networking (SDN) the network programmability and global control capability, but it also poses SDN security risks. The adversaries can use the forwarding and control decoupling character of SDN to forge legitimate traffic, launching saturation attacks targeted at SDN switches. These attacks can cause the overflow of switch flow tables, thus making the switch cannot forward benign network traffic. How to effectively detect saturation attack is a research hotspot. There are only a few graph-based saturation attack detection methods. Meanwhile, the current graph generation methods may take useless or misleading information to the attack detection, thus decreasing the attack detection accuracy. To solve the above problems, this paper proposes TITAN, a bidirecTional forwardIng graph-based saturaTion Attack detectioN method. TITAN defines flow forwarding rules and topology information, and designs flow statistical features. Based on these definitions, TITAN generates nodes of the bi-forwarding graph based on the flow statistics features and edges of the bi-forwarding graph based on the network traffic routing paths. In this way, each traffic flow in the network is transformed into a bi-directional forwarding graph. Then TITAN feeds the above bidirectional forwarding graph into a Graph Convolutional Network (GCN) to detect whether the flow is a saturation attack flow. The experimental results show that TITAN can effectively detect saturation attacks in SDNs with a detection accuracy of more than 97%.
MeSH term(s)	Software ; Algorithms ; Computer Security ; Computer Communication Networks
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299846
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Article: Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer.

Zhao, Andi / Yang, Jin / Ran, Ran / Zhao, Shidi / Cui, Yuxin / Hu, Fang / Zhou, Yan

Translational oncology

2024 Volume 44, Page(s) 101960

Abstract: The interaction between tumor fatty acid metabolism and immune microenvironment is a novel topic in oncology research, and the relationship of lipid-derived factors with immune editing in tumor is unclear. The breast cancer samples from the TCGA database ...

Abstract	The interaction between tumor fatty acid metabolism and immune microenvironment is a novel topic in oncology research, and the relationship of lipid-derived factors with immune editing in tumor is unclear. The breast cancer samples from the TCGA database were used as the training set, and samples from GSE42568 were employed as the validation set for constructing a model to identify a signature associated with fatty acid metabolism through Lasso Cox regression. And the changes in immune related signatures and risk score before and after anti-PD-1 monotherapy were caught by the differential analysis in GSE225078. A 14-gene prognostic risk scoring model identifying by fatty acid metabolism relevant signature was conducted, and the high risk group had shorter overall survival and progression free survival than low risk group. Many metabolism-related pathways were enriched in the high risk group, and many immune-related pathways were enriched in low risk group. The crucial differentially expressed genes between the high/low risk groups, CYP4F8 and CD52, were found to be strongly associated with SUCLA2 and ACOT4 of 14-gene model, and strongly related to immune infiltration. Immune related signatures, fatty acid metabolism-risk score and the expression level of ALDH1A1 (in 14-gene-model) changed after anti-PD-1 monotherapy. And the mice model results also showed anti-PD-1 mAb could significantly reduce the expression level of ALDH1A1 (p < 0.01). These results brought up the crosstalk between immune components and fatty acid metabolism in breast cancer microenvironment, which provided a new possibility of targeting fatty acid metabolism for combination therapy in breast cancer immunotherapy.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2443840-6
ISSN	1936-5233
ISSN	1936-5233
DOI	10.1016/j.tranon.2024.101960
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Article: Bupleurum

Ran, Shuzhen / Peng, Rui / Guo, Qingwan / Cui, Jinshuai / Chen, Gang / Wang, Ziying

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 4

Abstract: The incidence of depression has been steadily rising in recent years, making it one of the most prevalent mental illnesses. As the pursuit of novel antidepressant drugs captivates the pharmaceutical field, the therapeutic efficacy of Traditional Chinese ... ...

Abstract	The incidence of depression has been steadily rising in recent years, making it one of the most prevalent mental illnesses. As the pursuit of novel antidepressant drugs captivates the pharmaceutical field, the therapeutic efficacy of Traditional Chinese Medicine (TCM) has been widely explored. Chaihu (
Language	English
Publishing date	2024-04-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17040512
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Article: Corrigendum: Screening and identification of hub genes in the development of early diabetic kidney disease based on weighted gene co-expression network analysis.

Wei, Ran / Qiao, Jingtao / Cui, Di / Pan, Qi / Guo, Lixin

Frontiers in endocrinology

2024 Volume 15, Page(s) 1367390

Abstract: This corrects the article DOI: 10.3389/fendo.2022.883658.]. ...

Abstract	[This corrects the article DOI: 10.3389/fendo.2022.883658.].
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1367390
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Article: Intensive care unit readmission and unexpected death after emergency general surgery.

Guo, Ran / Cui, Na

Heliyon

2023 Volume 9, Issue 3, Page(s) e14278

Abstract: Background: Intensive care unit (ICU) readmission and unexpected death are closely associated with increased length of hospitalization and total mortality. However, data about readmission or unexpected death after discharge from ICU in patients who have ...

Abstract	Background: Intensive care unit (ICU) readmission and unexpected death are closely associated with increased length of hospitalization and total mortality. However, data about readmission or unexpected death after discharge from ICU in patients who have undergone emergency general surgery (EGS) is very limited. Methods: In total, 1133 patients who underwent EGS were identified in the Multiparameter Intelligent Monitoring in Intensive Care IV (MIMIC-IV) database. Of these 1133 patients, 124 underwent readmission into the ICU or death unexpectedly after their initial discharge. The clinical characteristics of the patients were investigated. A logistic regression model was implemented for the analysis of the independent risk factors associated with ICU readmission or unexpected death. A nomogram model was established to predict the risk of ICU readmission or unexpected death within 72 h after EGS. Results: Peripheral vascular disease and atrial fibrillation, vasopressor requirement, a higher respiratory rate or heart rate, a lower pulse oxygen saturation or a platelet count of <150 K/μL and a relatively low Glasgow coma scale score in the last 24 h before ICU discharge were independent risk factors for ICU readmission or death within 72 h. The nomogram had moderate accuracy with an area under the curve of 0.852, which had a stronger prediction power than the Stability and Workload Index for Transfer (SWIFT) score, a classic prediction model for ICU readmission risk. Conclusions: In critically ill patients who undergo EGS, ICU readmission or unexpected death within 72 h can be predicted using a nomogram model based on eight parameters including physiological and laboratory test values in the last 24 h before discharge and comorbidities. ICU physicians should prudently assess patients to make effective discharge decisions.
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14278
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Article ; Online: Intensive care unit readmission and unexpected death after emergency general surgery

Ran Guo / Na Cui

Heliyon, Vol 9, Iss 3, Pp e14278- (2023)

2023

Abstract	Background: Intensive care unit (ICU) readmission and unexpected death are closely associated with increased length of hospitalization and total mortality. However, data about readmission or unexpected death after discharge from ICU in patients who have undergone emergency general surgery (EGS) is very limited. Methods: In total, 1133 patients who underwent EGS were identified in the Multiparameter Intelligent Monitoring in Intensive Care IV (MIMIC-IV) database. Of these 1133 patients, 124 underwent readmission into the ICU or death unexpectedly after their initial discharge. The clinical characteristics of the patients were investigated. A logistic regression model was implemented for the analysis of the independent risk factors associated with ICU readmission or unexpected death. A nomogram model was established to predict the risk of ICU readmission or unexpected death within 72 h after EGS. Results: Peripheral vascular disease and atrial fibrillation, vasopressor requirement, a higher respiratory rate or heart rate, a lower pulse oxygen saturation or a platelet count of <150 K/μL and a relatively low Glasgow coma scale score in the last 24 h before ICU discharge were independent risk factors for ICU readmission or death within 72 h. The nomogram had moderate accuracy with an area under the curve of 0.852, which had a stronger prediction power than the Stability and Workload Index for Transfer (SWIFT) score, a classic prediction model for ICU readmission risk. Conclusions: In critically ill patients who undergo EGS, ICU readmission or unexpected death within 72 h can be predicted using a nomogram model based on eight parameters including physiological and laboratory test values in the last 24 h before discharge and comorbidities. ICU physicians should prudently assess patients to make effective discharge decisions.
Keywords	Emergency general surgery ; ICU Readmission ; MIMIC-IV Database ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Insomnia is related to long-term atrial fibrillation recurrence following radiofrequency ablation.

Li, Rui-Bin / Zhang, Ji-Dong / Cui, Xiao-Ran / Cui, Wei

Annals of medicine

2024 Volume 56, Issue 1, Page(s) 2323089

Abstract: Objective: Atrial fibrillation (AF), the most common cardiac arrhythmia, presents significant health challenges, and the intricate connection between insomnia and AF has garnered substantial attention. This cohort study aims to investigate the ... ...

Abstract	Objective: Atrial fibrillation (AF), the most common cardiac arrhythmia, presents significant health challenges, and the intricate connection between insomnia and AF has garnered substantial attention. This cohort study aims to investigate the relationship between insomnia and AF recurrences following radiofrequency ablation. Materials and methods: Data were retrieved from an electronic database of patients who underwent radiofrequency ablation for AF. The primary endpoint was AF recurrence. We utilized a multivariable Cox model, coupled with three propensity score methods, for analysis. Results: Between January 1, 2017, and June 1, 2022, 541 patients who underwent radiofrequency ablation for AF were recorded in the database. After excluding 185 patients, the final cohort comprised 356 patients. Among them, 68 were afflicted by insomnia, while 288 were not. Over a median follow-up of 755 days, one patient died, and 130 (36.5%) experienced AF recurrence. Multivariate Cox regression analysis revealed that the insomnia group had a higher risk of AF recurrence compared to the non-insomnia group (HR: 1.83, 95% CI: 1.16-2.89). Further landmark analysis showed no significant difference in AF recurrence rates during the initial 1-year follow-up. However, beyond 1 year, the insomnia group demonstrated a significantly higher AF recurrence rate. As the number of insomnia symptoms increased, the risk of AF recurrence also rose significantly, indicating a dose-response relationship. Conclusion: This study establishes a significant link between insomnia and long-term AF recurrence following radiofrequency ablation. It underscores the importance of identifying and addressing insomnia in patients with AF undergoing radiofrequency ablation.
MeSH term(s)	Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/surgery ; Cohort Studies ; Sleep Initiation and Maintenance Disorders/epidemiology ; Sleep Initiation and Maintenance Disorders/etiology ; Cluster Analysis ; Radiofrequency Ablation
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2024.2323089
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