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  1. Book ; Online ; E-Book: CRISPR-Cas System in Translational Biotechnology

    Joshi, Swati / Verma, Digvijay / Gupta, Ravi Kr

    2024  

    Author's details Swati Joshi, Digvijay Verma, and Ravi Kr. Gupta, editors
    MeSH term(s) CRISPR-Cas Systems. ; Biotechnology. ; Genetic Therapy. ; Genetic Engineering.
    Keywords Molecular genetics ; Gene therapy ; Genetic engineering
    Subject code 660.65
    Language English
    Size 1 online resource (317 pages)
    Edition First edition.
    Publisher Elsevier Inc
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-97228-4 ; 9780323918084 ; 978-0-323-97228-4 ; 0323918085
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Direct-to-Consumer Pharmacies: Disruptive Innovation or More Complexity?

    Gupta, Ravi

    Journal of general internal medicine

    2024  

    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-024-08729-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Digital Privacy and Data Protection: From Ethical Principles to Action.

    Gupta, Ravi

    The American journal of bioethics : AJOB

    2023  Volume 23, Issue 11, Page(s) 24–26

    MeSH term(s) Humans ; Privacy ; Confidentiality/ethics ; Computer Security ; Moral Obligations
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2023.2256292
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  4. Article ; Online: Attenuation of brassinosteroid signaling enhances grain yield in semi-dwarf wheat varieties.

    Gupta, Ravi

    Plant cell reports

    2023  Volume 43, Issue 1, Page(s) 11

    Abstract: Key message: A recent study identified a natural deletion in the r-e-z haploblock which confers a semi-dwarf trait, higher nitrogen use efficiency, and improved yield in semi-dwarf wheat varieties by attenuating the brassinosteroid signaling. ...

    Abstract Key message: A recent study identified a natural deletion in the r-e-z haploblock which confers a semi-dwarf trait, higher nitrogen use efficiency, and improved yield in semi-dwarf wheat varieties by attenuating the brassinosteroid signaling.
    MeSH term(s) Triticum/genetics ; Brassinosteroids ; Edible Grain ; Phenotype ; Signal Transduction/genetics
    Chemical Substances Brassinosteroids
    Language English
    Publishing date 2023-12-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8397-5
    ISSN 1432-203X ; 0721-085X ; 0721-7714
    ISSN (online) 1432-203X
    ISSN 0721-085X ; 0721-7714
    DOI 10.1007/s00299-023-03113-7
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  5. Article ; Online: Melatonin: A promising candidate for maintaining food security under the threat of phytopathogens.

    Gupta, Ravi

    Plant physiology and biochemistry : PPB

    2023  Volume 198, Page(s) 107691

    Abstract: Plant immune response is tightly controlled by an interplay of various phytohormones and plant growth regulators. Among them, the role of salicylic acid, jasmonic acid, and ethylene is well established while some others such as nitric oxide, polyamines, ... ...

    Abstract Plant immune response is tightly controlled by an interplay of various phytohormones and plant growth regulators. Among them, the role of salicylic acid, jasmonic acid, and ethylene is well established while some others such as nitric oxide, polyamines, and hydrogen sulfide have appeared to be key regulators of plant immunity. In addition, some other chemicals, such as melatonin (N-acetyl-5-methoxytryptamine), are apparently turning out to be the novel regulators of plant defense responses. Melatonin has shown promising results in enhancing resistance of plants to a variety of pathogens including fungi, bacteria, and viruses, however, the molecular mechanism of melatonin-mediated plant immune regulation is currently elusive. Evidence gathered so far indicates that melatonin regulates plant immunity by (1) facilitating the maintenance of ROS homeostasis, (2) interacting with other phytohormones and growth regulators, and (3) inducing the accumulation of defense molecules. Therefore, engineering crops with improved melatonin production could enhance crop productivity under stress conditions. This review extends our understanding of the multifaceted role of melatonin in the regulation of plant defense response and presents a putative pathway of melatonin functioning and its interaction with phytohormones during biotic stress.
    MeSH term(s) Melatonin/pharmacology ; Plant Growth Regulators/metabolism ; Salicylic Acid/metabolism ; Plant Immunity ; Crops, Agricultural/metabolism
    Chemical Substances Melatonin (JL5DK93RCL) ; Plant Growth Regulators ; Salicylic Acid (O414PZ4LPZ)
    Language English
    Publishing date 2023-04-05
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2023.107691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; E-Book: Sleep and neuropsychiatric disorders

    Gupta, Ravi / Neubauer, David N. / Pandi-Perumal, Seithikurippu R.

    2022  

    Author's details Ravi Gupta, David N. Neubauer, S. R. Pandi-Perumal editors
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xv, 845 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021250693
    ISBN 978-981-16-0123-1 ; 9789811601224 ; 981-16-0123-2 ; 9811601224
    DOI 10.1007/978-981-16-0123-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: An update on antifungal resistance in dermatophytosis.

    Gupta, Aditya K / Mann, Avantika / Polla Ravi, Shruthi / Wang, Tong

    Expert opinion on pharmacotherapy

    2024  , Page(s) 1–9

    Abstract: Introduction: The reports of resistance to antifungal agents used for treating onychomycosis and other superficial fungal infections are increasing. This rise in antifungal resistance poses a public health challenge that requires attention.: Areas ... ...

    Abstract Introduction: The reports of resistance to antifungal agents used for treating onychomycosis and other superficial fungal infections are increasing. This rise in antifungal resistance poses a public health challenge that requires attention.
    Areas covered: This review explores the prevalence of dermatophytes and the current relationship between dermatophyte species, their minimum inhibitory concentrations (MICs) for terbinafine (an allylamine) and itraconazole (an azole), and various mutations prevalent in these species. The most frequently isolated dermatophyte associated with resistance in patients with onychomycosis and dermatophytosis was
    Expert opinion: Managing dermatophyte infections requires a personalized approach. A detailed history should be obtained including details of travel, home and occupational exposure, and clinical examination of the skin, nails and other body systems. Relevant testing includes mycological examination (traditional and molecular). Additional testing, where available, includes MIC evaluation and detection of
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2024.2343079
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  8. Article ; Online: Effectiveness and safety of oral terbinafine for dermatophyte distal subungual onychomycosis.

    Gupta, Aditya K / Polla Ravi, Shruthi / Talukder, Mesbah / Mann, Avantika

    Expert opinion on pharmacotherapy

    2024  Volume 25, Issue 1, Page(s) 15–23

    Abstract: Introduction: Terbinafine has been a cornerstone in dermatophyte infection treatment. Despite its global efficacy, the emergence of terbinafine resistance raises concerns, requiring ongoing vigilance.: Areas covered: This paper focuses on evaluating ... ...

    Abstract Introduction: Terbinafine has been a cornerstone in dermatophyte infection treatment. Despite its global efficacy, the emergence of terbinafine resistance raises concerns, requiring ongoing vigilance.
    Areas covered: This paper focuses on evaluating the efficacy and safety of terbinafine in treating dermatophyte toenail infections. Continuous and pulse therapies, with a 24-week continuous regimen and a higher dosage of 500 mg/day have demonstrated superior efficacy to the FDA approved regimen of 250 mg/day x 12 weeks. Pulse therapies, though showing comparable effectiveness, present debates with regards to their efficacy as conflicting findings have been reported. Safety concerns encompass hepatotoxicity, gastrointestinal, cutaneous, neurologic, hematologic and immune adverse-effects, and possible drug interactions, suggesting the need for ongoing monitoring.
    Expert opinion: Terbinafine efficacy depends on dosage, duration, and resistance patterns. Continuous therapy for 24 weeks and a dosage of 500 mg/day may enhance outcomes, but safety considerations and resistance necessitate individualized approaches. Alternatives, including topical agents and alternative antifungals, are to be considered for resistant cases. Understanding the interplay between treatment parameters, adverse effects, and resistance mechanisms is critical for optimizing therapeutic efficacy while mitigating resistance risks. Patient education and adherence are vital for early detection and management of adverse effects and resistance, contributing to tailored and effective treatments.
    MeSH term(s) Humans ; Terbinafine/adverse effects ; Onychomycosis/drug therapy ; Arthrodermataceae ; Itraconazole/adverse effects ; Naphthalenes/adverse effects ; Foot Dermatoses/chemically induced ; Foot Dermatoses/drug therapy ; Antifungal Agents/adverse effects ; Nail Diseases/chemically induced ; Nail Diseases/drug therapy ; Treatment Outcome ; Drug-Related Side Effects and Adverse Reactions
    Chemical Substances Terbinafine (G7RIW8S0XP) ; Itraconazole (304NUG5GF4) ; Naphthalenes ; Antifungal Agents
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2024.2305304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Alopecia areata and pattern hair loss (androgenetic alopecia) on social media - Current public interest trends and cross-sectional analysis of YouTube and TikTok contents.

    Gupta, Aditya K / Polla Ravi, Shruthi / Wang, Tong

    Journal of cosmetic dermatology

    2023  Volume 22, Issue 2, Page(s) 586–592

    Abstract: Background: With an ever-growing influence of social media in healthcare, concurrent with increased emphasis on patient autonomy and shared decision-making, dermatologists treating hair loss need to be cognizant of online interest trends and the types ... ...

    Abstract Background: With an ever-growing influence of social media in healthcare, concurrent with increased emphasis on patient autonomy and shared decision-making, dermatologists treating hair loss need to be cognizant of online interest trends and the types of information disseminated across popular platforms.
    Objectives: To evaluate recent health-related interest trends and assess engagement, quality, and accuracy of alopecia areata (AA) and pattern hair loss (PHL, androgenetic alopecia) contents on social media.
    Methods: Relative search volumes (RSVs) were extracted from Google Trends using the search category 'alopecia areata' and 'pattern hair loss'. Eighty matching videos on TikTok and YouTube were also extracted and characterized. Viewer engagement was estimated using the engagement ratio, and quality and accuracy were assessed using DISCERN and Dy et al. Accuracy Scale (DAS).
    Conclusions: AA-related contents on TikTok discussing personal experiences of female subjects were significantly more engaging. DISCERN and DAS scoring showed significantly higher quality and accuracy in videos created by healthcare providers on YouTube, but not TikTok, which could in part be related to YouTube videos being longer. RSV fluctuations corresponding to news in popular culture had high impact. Sponsorship disclosures were generally not reported in product promotional videos.
    MeSH term(s) Humans ; Female ; Social Media ; Cross-Sectional Studies ; Alopecia Areata/therapy ; Alopecia/diagnosis
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15605
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  10. Article ; Online: Biodegradation of Naphthalene Using Biosurfactant Producing Fusarium proliferatum WC416 Isolated from Refinery Effluent.

    Gupta, Shalini / Pathak, Bhawana / Ravi, Raman Kumar

    Applied biochemistry and biotechnology

    2023  

    Abstract: Naphthalene is one of the priority pollutants in the environment which can effectively managed through bioremediation approach. Here fungal remediation of PAHs may be cost-effective technology. In present research study, biodegradation of naphthalene at ... ...

    Abstract Naphthalene is one of the priority pollutants in the environment which can effectively managed through bioremediation approach. Here fungal remediation of PAHs may be cost-effective technology. In present research study, biodegradation of naphthalene at varying concentrations in laboratory scale was investigated using Fusarium proliferatum WC416 isolated from refinery effluent. Degradation of naphthalene was computed by high-performance liquid chromatography (HPLC) and gas chromatography -mass spectroscopy (GC-MS). The results show that Fusarium proliferatum WC416 has effectively degraded the naphthalene to salicylamide and salicylic acid. The highest degradation achieved was 83% for the concentration of 100 ppm followed 74% and 63% for the concentration of 250 ppm and 500 ppm respectively. The intermediates confirmed by GC-MS were salicylic acid (m/z identification 138) and salicylamide (m/z identification 137). During the study, fungal growth, COD, pH, and surface tension have been monitored, which show the continuous variation that indicates progressive biodegradation of naphthalene. The qualitative assessment of extracellular enzymes shows positive activity for lipase, manganese peroxidase, and laccase. The present study also assessed the biosurfactant production by fungus which was characterized as sophorolipid in nature. The study suggests that Fusarium proliferatum WC416 would be an efficient degrader of naphthalene for environmental clean-up.
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04364-6
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