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Article ; Online: Hepatopathology of flaviviruses.

Bailey, Adam L / Diamond, Michael S

2022 Volume 77, Issue 6, Page(s) 1711–1713

Language	English
Publishing date	2022-08-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2022.05.024
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Article: Inactivation of Blood-Borne Enveloped Viruses with the Nonionic Detergent 2-[4-(2,4,4-Trimethylpentan-2-yl)Phenoxy]Ethanol Does Not Bias Clinical Chemistry Results.

Bailey, Adam L / Farnsworth, Christopher

The journal of applied laboratory medicine

2021 Volume 6, Issue 5, Page(s) 1123–1132

Abstract: ... of -0.78 mmol/L (95% CI, -2.41 to 0.85) was observed for CO2 and 5.79 U/L (95% CI, -0.05 to 11.63) was ...

Abstract	Background: Patients infected with virulent pathogens require the sophisticated diagnostic capabilities of a core laboratory for optimal care. This is especially true in outbreaks that strain healthcare system capacity. However, samples from such patients pose an infection risk for laboratory workers. We evaluated a strategy for mitigating this risk by preincubating specimens with 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol, a non-ionic detergent commonly calledTriton X-100. Methods: Lithium-heparinized plasma was mixed with the detergent Triton X-100 at 1%. Inactivation of Ebola virus (EBOV), yellow fever virus (YFV), and chikungunya virus (CHIKV) was assessed using a virus-outgrowth assay. The impact of 1% Triton X-100 dilution on the components of a complete metabolic panel (CMP) was assessed on a Roche Cobas analyzer with 15 specimens that spanned a large portion of the analytical measurement range. Results: Incubation with 1% Triton X-100 for 5 min was sufficient to completely inactivate EBOV and YFV spiked into plasma but did not completely inactivate CHIKV infectivity even after 60 min of incubation. This was true only for CHIKV when spiked into plasma; CHIKV was completely inactivated in cell culture medium. A bias of -0.78 mmol/L (95% CI, -2.41 to 0.85) was observed for CO2 and 5.79 U/L (95% CI, -0.05 to 11.63) was observed for aspartate aminotransferase after addition of Triton X-100. No other components of the CMP were affected by the addition of Triton X-100. Conclusions: Detergent-based inactivation of plasma specimens may be a viable approach to mitigating the risk that certain blood-borne pathogens pose to laboratory workers in an outbreak setting. However, the effectiveness of this method for inactivation may depend on the specimen type and pathogen in question.
MeSH term(s)	Chemistry, Clinical ; Detergents ; Ethanol/pharmacology ; Humans ; Virus Inactivation ; Viruses
Chemical Substances	Detergents ; Ethanol (3K9958V90M)
Language	English
Publishing date	2021-05-05
Publishing country	England
Document type	Journal Article
ISSN	2576-9456
ISSN	2576-9456
DOI	10.1093/jalm/jfab006
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Article ; Online: A Crisp(r) New Perspective on SARS-CoV-2 Biology.

Bailey, Adam L / Diamond, Michael S

Cell

2020 Volume 184, Issue 1, Page(s) 15–17

Abstract: Complementary genome-wide CRISPR-Cas9 screens performed by multiple groups reveal new insights into SARS-CoV-2 biology including aspects of viral entry, translation, replication, egress, and the genes regulating these processes. Comparisons with other ... ...

Abstract	Complementary genome-wide CRISPR-Cas9 screens performed by multiple groups reveal new insights into SARS-CoV-2 biology including aspects of viral entry, translation, replication, egress, and the genes regulating these processes. Comparisons with other coronaviruses enhances our understanding of the cellular life cycle of this medically important family of emerging viruses.
Language	English
Publishing date	2020-12-17
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2020.12.003
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Article ; Online: Risks of requiring a dedicated molecular specimen for HIV diagnosis and a potential strategy for mitigation.

Bailey, Adam L / Anderson, Neil

PloS one

2020 Volume 15, Issue 8, Page(s) e0237580

Abstract: Background: HIV screening (i.e. antigen/antibody) tests are followed by a supplemental (i.e. antibody-only) if the screen is positive. Discrepant results can result from two scenarios: a false-positive screening test or acute HIV infection. These ... ...

Abstract	Background: HIV screening (i.e. antigen/antibody) tests are followed by a supplemental (i.e. antibody-only) if the screen is positive. Discrepant results can result from two scenarios: a false-positive screening test or acute HIV infection. These scenarios can be distinguished by a molecular HIV test, but due to contamination concerns, our laboratory recently implemented a policy requiring a second specimen dedicated for molecular HIV testing. Our objective was to (1) characterize the effect of this policy on the time-to-diagnosis for patients with discrepant screening and supplemental test results, and (2) explore "strength of positivity" as an interim predictor of screening test accuracy while awaiting confirmatory test results. Methods: Data from our laboratory information system, electronic health record, and instrument logs were used to collate data for all HIV testing performed at Barnes-Jewish Hospital (BJH) between January 1, 2014 and October 18, 2017. Results: Requiring a dedicated specimen for molecular testing significantly increased the time-to-diagnosis for patients with discrepant screening and supplemental HIV tests (p = 0.0084). This policy also contributed to loss-to-followup, with 0/35 discrepant cases lost-to-followup prior to policy implementation compared to 2/10 after implementation. However, by optimizing the signal-to-cutoff (S/CO) ratio of the screening test, we were able to more accurately distinguish false-positives from acute-HIV prior to molecular testing (sensitivity of 100%, specificity of 89%). Conclusions: We propose utilizing quantitative fourth-generation assay results (S/CO) ratios as a predictor of infection true positivity in situations where the screening assay is reactive but the supplemental test is negative and confirmatory molecular results are not immediately available.
MeSH term(s)	AIDS Serodiagnosis/standards ; Algorithms ; False Positive Reactions ; HIV Antibodies/blood ; HIV Antibodies/immunology ; HIV Antigens/immunology ; HIV Infections/blood ; HIV Infections/diagnosis ; HIV Infections/prevention & control ; HIV Infections/virology ; HIV-1/immunology ; Humans ; Mass Screening/methods
Chemical Substances	HIV Antibodies ; HIV Antigens
Language	English
Publishing date	2020-08-13
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0237580
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Article ; Online: Snack frequency, size, and energy density are associated with diet quality among US adolescents.

Tripicchio, Gina L / Bailey, Regan L / Davey, Adam / Croce, Christina M / Fisher, Jennifer Orlet

Public health nutrition

2023 Volume 26, Issue 11, Page(s) 2374–2382

Abstract: Objective: To evaluate snacking and diet quality among US adolescents.: Design: Cross-sectional analysis examined snack frequency (snacks/day), size (kcal/snack) and energy density (kcal/g/snack) as predictors of diet quality using the mean of two 24- ...

Abstract	Objective: To evaluate snacking and diet quality among US adolescents. Design: Cross-sectional analysis examined snack frequency (snacks/day), size (kcal/snack) and energy density (kcal/g/snack) as predictors of diet quality using the mean of two 24-h dietary recalls. Diet quality was assessed using the Healthy Eating Index (HEI-2015, 0-100), a mean adequacy ratio (MAR, 0-100) for under-consumed nutrients (potassium, fibre, Ca, vitamin D) and mean percentage of recommended limits for over-consumed nutrients (added sugar, saturated fat, Na). Linear regression models examined total snacks, food only snacks and beverage only snacks, as predictors of diet quality adjusting for demographic characteristics and estimated energy reporting accuracy. Setting: 2007-2018 National Health and Nutrition Examination Survey. Participants: Adolescents 12-19 years ( Results: Snack frequency was associated with higher HEI-2015 ( Conclusions: Smaller, frequent, less energy-dense food only snacks are associated with higher diet quality in adolescents; beverages consumed as snacks are associated with greater intake of over-consumed nutrients.
MeSH term(s)	Humans ; Adolescent ; Snacks ; Feeding Behavior ; Nutrition Surveys ; Cross-Sectional Studies ; Diet ; Energy Intake
Language	English
Publishing date	2023-08-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1436024-x
ISSN	1475-2727 ; 1368-9800
ISSN (online)	1475-2727
ISSN	1368-9800
DOI	10.1017/S1368980023001635
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Article ; Online: Risks of requiring a dedicated molecular specimen for HIV diagnosis and a potential strategy for mitigation.

Adam L Bailey / Neil Anderson

PLoS ONE, Vol 15, Iss 8, p e

2020 Volume 0237580

Abstract: BACKGROUND:HIV screening (i.e. antigen/antibody) tests are followed by a supplemental (i.e. antibody-only) if the screen is positive. Discrepant results can result from two scenarios: a false-positive screening test or acute HIV infection. These ... ...

Abstract	BACKGROUND:HIV screening (i.e. antigen/antibody) tests are followed by a supplemental (i.e. antibody-only) if the screen is positive. Discrepant results can result from two scenarios: a false-positive screening test or acute HIV infection. These scenarios can be distinguished by a molecular HIV test, but due to contamination concerns, our laboratory recently implemented a policy requiring a second specimen dedicated for molecular HIV testing. Our objective was to (1) characterize the effect of this policy on the time-to-diagnosis for patients with discrepant screening and supplemental test results, and (2) explore "strength of positivity" as an interim predictor of screening test accuracy while awaiting confirmatory test results. METHODS:Data from our laboratory information system, electronic health record, and instrument logs were used to collate data for all HIV testing performed at Barnes-Jewish Hospital (BJH) between January 1, 2014 and October 18, 2017. RESULTS:Requiring a dedicated specimen for molecular testing significantly increased the time-to-diagnosis for patients with discrepant screening and supplemental HIV tests (p = 0.0084). This policy also contributed to loss-to-followup, with 0/35 discrepant cases lost-to-followup prior to policy implementation compared to 2/10 after implementation. However, by optimizing the signal-to-cutoff (S/CO) ratio of the screening test, we were able to more accurately distinguish false-positives from acute-HIV prior to molecular testing (sensitivity of 100%, specificity of 89%). CONCLUSIONS:We propose utilizing quantitative fourth-generation assay results (S/CO) ratios as a predictor of infection true positivity in situations where the screening assay is reactive but the supplemental test is negative and confirmatory molecular results are not immediately available.
Keywords	Medicine ; R ; Science ; Q
Subject code	310
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Snack frequency, size, and energy density are associated with diet quality among US adolescents

Gina L Tripicchio / Regan L Bailey / Adam Davey / Christina M Croce / Jennifer Orlet Fisher

Public Health Nutrition, Vol 26, Pp 2374-

2023 Volume 2382

Abstract: Abstract Objective: To evaluate snacking and diet quality among US adolescents. Design: Cross-sectional analysis examined snack frequency (snacks/day), size (kcal/snack) and energy density (kcal/g/snack) as predictors of diet quality using the mean of ... ...

Abstract	Abstract Objective: To evaluate snacking and diet quality among US adolescents. Design: Cross-sectional analysis examined snack frequency (snacks/day), size (kcal/snack) and energy density (kcal/g/snack) as predictors of diet quality using the mean of two 24-h dietary recalls. Diet quality was assessed using the Healthy Eating Index (HEI-2015, 0–100), a mean adequacy ratio (MAR, 0–100) for under-consumed nutrients (potassium, fibre, Ca, vitamin D) and mean percentage of recommended limits for over-consumed nutrients (added sugar, saturated fat, Na). Linear regression models examined total snacks, food only snacks and beverage only snacks, as predictors of diet quality adjusting for demographic characteristics and estimated energy reporting accuracy. Setting: 2007–2018 National Health and Nutrition Examination Survey. Participants: Adolescents 12–19 years (n 4985). Results: Snack frequency was associated with higher HEI-2015 (β = 0·7 (0·3), P < 0·05) but also with higher intake of over-consumed nutrients (β = 3·0 (0·8), P ≤ 0·001). Snack size was associated with lower HEI (β = –0·005 (0·001), P ≤ 0·001) and MAR (β = –0·005 (0·002), P < 0·05) and higher intake of over-consumed nutrients (β = 0·03 (0·005), P ≤ 0·001). Associations differed for food only and beverage only snacks. Food only snack frequency was associated with higher HEI-2015 (β = 1·7 (0·03), P ≤ 0·001), while food only snack size (β = –0·006 (0·0009), P ≤ 0·001) and food only snack energy density (β = –1·1 (0·2), P ≤ 0·001) were associated with lower HEI-2015. Conversely, beverage only snack frequency (β = 4·4 (2·1) P < 0·05) and beverage only snack size (β = 0·03 (0·01), P ≤ 0·001) were associated with higher intake of over-consumed nutrients. Conclusions: Smaller, frequent, less energy-dense food only snacks are associated with higher diet quality in adolescents; beverages consumed as snacks are associated with greater intake of over-consumed nutrients.
Keywords	Diet ; Snacking ; Adolescents ; Behavioural health ; Public aspects of medicine ; RA1-1270 ; Nutritional diseases. Deficiency diseases ; RC620-627
Subject code	590
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Interferon Gamma on Ebola Virus Infection of Primary Kupffer Cells and a Kupffer Cell Line.

Aguilar-Briseño, José A / Elliff, Jonah M / Patten, Justin J / Wilson, Lindsay R / Davey, Robert A / Bailey, Adam L / Maury, Wendy J

Viruses

2023 Volume 15, Issue 10

Abstract: Ebola virus disease (EVD) represents a global health threat. The etiological agents of EVD are six species of Orthoebolaviruses, ... ...

Abstract	Ebola virus disease (EVD) represents a global health threat. The etiological agents of EVD are six species of Orthoebolaviruses, with
MeSH term(s)	Animals ; Mice ; Hemorrhagic Fever, Ebola ; Interferon-gamma/pharmacology ; Kupffer Cells ; Ebolavirus/genetics ; Interferons/pharmacology ; Antiviral Agents/pharmacology
Chemical Substances	Interferon-gamma (82115-62-6) ; Interferons (9008-11-1) ; Antiviral Agents
Language	English
Publishing date	2023-10-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15102077
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Article ; Online: Antibody surface mobility amplifies FcγR signaling via Arp2/3 during phagocytosis.

Jo, Seongwan / Fischer, Brady R / Cronin, Nicholas M / Nurmalasari, Ni Putu Dewi / Loyd, Yoseph M / Kerkvliet, Jason G / Bailey, Elizabeth M / Anderson, Robert B / Scott, Brandon L / Hoppe, Adam D

Biophysical journal

2024

Abstract: We report herein that the anti-CD20 therapeutic antibody, rituximab, is rearranged into microclusters within the phagocytic synapse by macrophage Fcγ receptors (FcγR) during antibody-dependent cellular phagocytosis. These microclusters were observed to ... ...

Abstract	We report herein that the anti-CD20 therapeutic antibody, rituximab, is rearranged into microclusters within the phagocytic synapse by macrophage Fcγ receptors (FcγR) during antibody-dependent cellular phagocytosis. These microclusters were observed to potently recruit Syk and to undergo rearrangements that were limited by the cytoskeleton of the target cell, with depolymerization of target-cell actin filaments leading to modest increases in phagocytic efficiency. Total internal reflection fluorescence analysis revealed that FcγR total phosphorylation, Syk phosphorylation, and Syk recruitment were enhanced when IgG-FcγR microclustering was enabled on fluid bilayers relative to immobile bilayers in a process that required Arp2/3. We conclude that on fluid surfaces, IgG-FcγR microclustering promotes signaling through Syk that is amplified by Arp2/3-driven actin rearrangements. Thus, the surface mobility of antigens bound by IgG shapes the signaling of FcγR with an unrecognized complexity beyond the zipper and trigger models of phagocytosis.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2024.01.036
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Article ; Online: Correction: Using Bayesian Population Viability Analysis to Define Relevant Conservation Objectives.

Green, Adam W / Bailey, Larissa L

PloS one

2016 Volume 11, Issue 1, Page(s) e0147163

Language	English
Publishing date	2016
Publishing country	United States
Document type	Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0147163
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