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  1. Article: SARS-CoV-2 Laboratory Testing in India's Pandemic Response: A Public Health Perspective.

    Moorthy, Mahesh / Fletcher, John

    Indian journal of public health

    2020  Volume 64, Issue Supplement, Page(s) S128–S131

    Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted (at the time of writing) in over 3.3 million cases and 233,000 deaths globally and ~33,000 cases and ~1,100 deaths in India. The ... ...

    Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted (at the time of writing) in over 3.3 million cases and 233,000 deaths globally and ~33,000 cases and ~1,100 deaths in India. The mainstay of the diagnosis is a reverse-transcription polymerase chain reaction assay to detect SARS-CoV-2 RNA. The accurate diagnosis is contingent on appropriate specimen choice, time of collection, and assay employed. In this commentary, we highlight the role of laboratory diagnostic tests used in the different stages of India's COVID-19 pandemic response.
    MeSH term(s) Antibodies, Viral/metabolism ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; False Negative Reactions ; Humans ; Immunoassay ; India/epidemiology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Virus Cultivation
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.IJPH_491_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Three waves, three vaccines, three COVID-19 infections - Saga of a frontline health care worker during the pandemic.

    Hazra, Darpanarayan / Nekkanti, Ankita Chowdary / Moorthy, Mahesh / Prabhakar Abhilash, Kundavaram Paul

    Indian journal of medical microbiology

    2022  Volume 40, Issue 4, Page(s) 608–610

    Abstract: The COVID-19 pandemic affected millions around the globe, with front line healthcare workers (HCW) amongst the most vulnerable. The Emergency Department (ED) was the first line of care for all patients infected with the virus, making HCWs in the ED one ... ...

    Abstract The COVID-19 pandemic affected millions around the globe, with front line healthcare workers (HCW) amongst the most vulnerable. The Emergency Department (ED) was the first line of care for all patients infected with the virus, making HCWs in the ED one of the most exposed populations during the pandemic. We highlight the case of a 35-year-old ED physician who developed COVID-19 infections on three separate instances during the peaks of each wave despite the usage of personal protective equipment and being triple vaccinated.
    MeSH term(s) Adult ; COVID-19/prevention & control ; Health Personnel ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1038798-5
    ISSN 1998-3646 ; 0255-0857
    ISSN (online) 1998-3646
    ISSN 0255-0857
    DOI 10.1016/j.ijmmb.2022.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SARS-CoV-2 Laboratory Testing in India's Pandemic Response

    Mahesh Moorthy / John Fletcher

    Indian Journal of Public Health, Vol 64, Iss 6, Pp 128-

    A Public Health Perspective

    2020  Volume 131

    Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted (at the time of writing) in over 3.3 million cases and 233,000 deaths globally and ~33,000 cases and ~1,100 deaths in India. The ... ...

    Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted (at the time of writing) in over 3.3 million cases and 233,000 deaths globally and ~33,000 cases and ~1,100 deaths in India. The mainstay of the diagnosis is a reverse-transcription polymerase chain reaction assay to detect SARS-CoV-2 RNA. The accurate diagnosis is contingent on appropriate specimen choice, time of collection, and assay employed. In this commentary, we highlight the role of laboratory diagnostic tests used in the different stages of India's COVID-19 pandemic response.
    Keywords antibody ; covid-19 ; laboratory diagnosis ; real-time reverse transcription polymerase chain reaction ; severe acute respiratory syndrome coronavirus 2 ; Public aspects of medicine ; RA1-1270 ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: COVID-19 and international medical graduates: the frustrated and forgotten future NHS workforce.

    Kumaran, N K / Mahesh, A / Sankar, T K / Moorthy, A

    British journal of hospital medicine (London, England : 2005)

    2020  Volume 81, Issue 7, Page(s) 1

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Educational Measurement ; Foreign Medical Graduates ; Health Workforce ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Quarantine ; SARS-CoV-2 ; Specialty Boards ; State Medicine ; Travel/legislation & jurisprudence ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country England
    Document type Letter
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2020.0397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: SARS-CoV-2 Laboratory Testing in India's Pandemic Response

    Moorthy, Mahesh / Fletcher, John

    Indian Journal of Public Health

    A Public Health Perspective

    2020  Volume 64, Issue 6, Page(s) 128

    Keywords General Medicine ; covid19
    Language English
    Publisher Medknow
    Publishing country in
    Document type Article ; Online
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.ijph_491_20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: SARS-CoV-2 Laboratory Testing in India's Pandemic Response: A Public Health Perspective

    Moorthy, Mahesh / Fletcher, John

    Indian J Public Health

    Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted (at the time of writing) in over 3.3 million cases and 233,000 deaths globally and ~33,000 cases and ~1,100 deaths in India. The ... ...

    Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted (at the time of writing) in over 3.3 million cases and 233,000 deaths globally and ~33,000 cases and ~1,100 deaths in India. The mainstay of the diagnosis is a reverse-transcription polymerase chain reaction assay to detect SARS-CoV-2 RNA. The accurate diagnosis is contingent on appropriate specimen choice, time of collection, and assay employed. In this commentary, we highlight the role of laboratory diagnostic tests used in the different stages of India's COVID-19 pandemic response.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32496242
    Database COVID19

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  8. Article ; Online: SMART-lipid nanoparticles enabled mRNA vaccine elicits cross-reactive humoral responses against the omicron sub-variants.

    Mahalingam, Gokulnath / Rachamalla, Hari Krishnareddy / Arjunan, Porkizhi / Karuppusamy, Karthik V / Periyasami, Yogapriya / Mohan, Aruna / Subramaniyam, Kanimozhi / M, Salma / Rajendran, Vigneshwar / Moorthy, Mahesh / Varghese, George M / Mohankumar, Kumarasamypet M / Thangavel, Saravanabhavan / Srivastava, Alok / Marepally, Srujan

    Molecular therapy : the journal of the American Society of Gene Therapy

    2024  Volume 32, Issue 5, Page(s) 1284–1297

    Abstract: The continual emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has necessitated the development of broad cross-reactive vaccines. Recent findings suggest that enhanced antigen presentation could lead to cross-reactive ... ...

    Abstract The continual emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has necessitated the development of broad cross-reactive vaccines. Recent findings suggest that enhanced antigen presentation could lead to cross-reactive humoral responses against the emerging variants. Toward enhancing the antigen presentation to dendritic cells (DCs), we developed a novel shikimoylated mannose receptor targeting lipid nanoparticle (SMART-LNP) system that could effectively deliver mRNAs into DCs. To improve the translation of mRNA, we developed spike domain-based trimeric S1 (TS1) mRNA with optimized codon sequence, base modification, and engineered 5' and 3' UTRs. In a mouse model, SMART-LNP-TS1 vaccine could elicit robust broad cross-reactive IgGs against Omicron sub-variants, and induced interferon-γ-producing T cells against SARS-CoV-2 virus compared with non-targeted LNP-TS1 vaccine. Further, T cells analysis revealed that SMART-LNP-TS1 vaccine induced long-lived memory T cell subsets, T helper 1 (Th1)-dominant and cytotoxic T cells immune responses against the SARS-CoV-2 virus. Importantly, SMART-LNP-TS1 vaccine produced strong Th1-predominant humoral and cellular immune responses. Overall, SMART-LNPs can be explored for precise antigenic mRNA delivery and robust immune responses. This platform technology can be explored further as a next-generation delivery system for mRNA-based immune therapies.
    MeSH term(s) Animals ; Nanoparticles/chemistry ; Mice ; SARS-CoV-2/immunology ; COVID-19/prevention & control ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/administration & dosage ; Immunity, Humoral ; Humans ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Spike Glycoprotein, Coronavirus/immunology ; mRNA Vaccines/immunology ; Cross Reactions/immunology ; Antibodies, Viral/immunology ; Lipids/chemistry ; Lipids/immunology ; Female ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Liposomes
    Chemical Substances COVID-19 Vaccines ; Lipid Nanoparticles ; Spike Glycoprotein, Coronavirus ; mRNA Vaccines ; Antibodies, Viral ; Lipids ; spike protein, SARS-CoV-2 ; RNA, Messenger ; Liposomes
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2024.02.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A clinico-epidemiological profile, coinfections and outcome of patients with Influenza Like Illnesses (ILI) presenting to the emergency department during the COVID-19 pandemic.

    Hazra, Darpanarayan / Chandy, Gina Maryann / Thanjavurkar, Abirahmi / Gunasekaran, Karthik / Nekkanti, Ankita Chowdary / Pal, Rathijit / Moorthy, Mahesh / Abhilash, Kundavaram Paul Prabhakar

    Journal of family medicine and primary care

    2023  Volume 12, Issue 4, Page(s) 672–678

    Abstract: Background: During the COVID-19 pandemic, many patients presented to the emergency department (ED) with features of Influenza-like illnesses (ILI) and with other atypical presentations. This study was done to determine the etiology, co-infections, and ... ...

    Abstract Background: During the COVID-19 pandemic, many patients presented to the emergency department (ED) with features of Influenza-like illnesses (ILI) and with other atypical presentations. This study was done to determine the etiology, co-infections, and clinical profile of patients with ILI.
    Methods: This prospective observational study included all patients presenting to the ED with fever and/or cough, breathing difficulty, sore throat, myalgia, gastrointestinal complaints (abdominal pain/vomiting/diarrhea), loss of taste and altered sensorium or asymptomatic patients who resided in or travelled from containment zones, or those who had contact with COVID-19 positive patients during the first wave of the pandemic between April and August 2020. Respiratory virus screening was done on a subset of COVID-19 patients to determine co-infection.
    Results: During the study period, we recruited 1462 patients with ILI and 857 patients with the non-ILI presentation of confirmed COVID-19 infection. The mean age group of our patient population was 51.4 (SD: 14.9) years with a male predominance (n-1593; 68.7%). The average duration of symptoms was 4.1 (SD: 2.9) days. A sub-analysis to determine an alternate viral etiology was done in 293 (16.4%) ILI patients, where 54 (19.4%) patients had COVID 19 and co-infection with other viruses, of which Adenovirus (n-39; 14.0%) was the most common. The most common symptoms in the ILI-COVID-19 positive group (other than fever and/or cough and/or breathing difficulty) were loss of taste (n-385; 26.3%) and diarrhea (n- 123; 8.4%). Respiratory rate (27.5 (SD: 8.1)/minute: p-value < 0.001) and oxygen saturation (92.1% (SD: 11.2) on room air; p-value < 0.001) in the ILI group were statistically significant. Age more than 60 years (adjusted odds ratio (OR): 4.826 (3.348-6.956); p-value: <0.001), sequential organ function assessment score more than or equal to four (adjusted OR: 5.619 (3.526-8.957); p-value: <0.001), and WHO critical severity score (Adjusted OR: 13.812 (9.656-19.756); p-value: <0.001) were independent predictors of mortality.
    Conclusion: COVID-19 patients were more likely to present with ILI than atypical features. Co-infection with Adenovirus was most common. Age more than 60 years, SOFA score more than or equal to four and WHO critical severity score were independent predictors of mortality.
    Language English
    Publishing date 2023-04-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_1705_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Recurrent COVID-19 infection in a case of rituximab-induced hypogammaglobulinaemia.

    Daniel, Jefferson / Thangakunam, Balamugesh / Isaac, Barney Thomas Jesudason / Moorthy, Mahesh / Christopher, Devasahayam Jesudas

    Respirology case reports

    2021  Volume 10, Issue 1, Page(s) e0891

    Abstract: Patients with immunodeficiency are at an increased risk of recurrent COVID-19 infection. They may lack the natural immune response that usually confers long-lasting immunity. Here, we present our experience managing one such patient, who had a COVID-19 ... ...

    Abstract Patients with immunodeficiency are at an increased risk of recurrent COVID-19 infection. They may lack the natural immune response that usually confers long-lasting immunity. Here, we present our experience managing one such patient, who had a COVID-19 infection twice, 5 months apart. He had a positive SARS-CoV-2 real-time reverse transcription polymerase chain reaction (RT-PCR) and computed tomography (CT) thorax with classical findings of COVID-19 on both occasions. He had multiple negative RT-PCR tests and two CT scans without COVID-19 features between these two infections. While the antibody response to the first infection was not detectable, the response to the second infection was robust. Live attenuated vaccines are contraindicated in patients with immunodeficiency, and other vaccines may not elicit an adequate immune response. A high index of suspicion for recurrent COVID-19 is warranted in this group of patients.
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.891
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