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  1. Article ; Online: Properties of co-gel between Tenebrio Molitor larvae protein and myofibrillar protein induced by transglutaminase.

    Sun, Hailei / Zhao, Yaqi / Li, Xiaolong / Huang, Ming / Qiao, Changming / Sun, Jingxin

    Food chemistry

    2024  Volume 443, Page(s) 138609

    Abstract: This study explored the effect of adding transglutaminase (TGase) to a co-gel of Tenebrio Molitor larvae protein (TMLP) and myofibrillar protein (MP). Different concentrations of TGase (0-90 U/g) were added to the co-gel. The results showed that 60 U/g ... ...

    Abstract This study explored the effect of adding transglutaminase (TGase) to a co-gel of Tenebrio Molitor larvae protein (TMLP) and myofibrillar protein (MP). Different concentrations of TGase (0-90 U/g) were added to the co-gel. The results showed that 60 U/g TGase treatment significantly improved the gel strength and water holding capacity (WHC) by 26.51 g and 9.2 %, respectively. TGase promoted the rheological properties and accelerated the three-dimensional network structure of the co-gel. Moreover, TGase significantly increased (P < 0.05) the tyrosine residues, tryptophan residues content and hydrophobic interactions of the aliphatic groups. The chemical forces between the protein molecules changed. TGase promoted the transition of α-helix to β-sheet and free water to immobilized water, thereby improving the WHC of co-gel. The principal component analysis reflected the links among indicators. This study illustrated that TGase might be an effective strategy to improve the co-gel of TMLP and MP and emulsified meat products with insects.
    MeSH term(s) Animals ; Tenebrio/metabolism ; Larva/metabolism ; Transglutaminases/metabolism ; Muscle Proteins/chemistry ; Gels/chemistry ; Water
    Chemical Substances Transglutaminases (EC 2.3.2.13) ; Muscle Proteins ; Gels ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.138609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  2. Article ; Online: Clinical and genetic analysis of a case of Gitelman syndrome accompanied with Graves disease and adrenocortical adenoma: A case report.

    Qiao, Yan / Zhao, Jinghong / Wu, Ji / Cao, Lewei / Song, Guiqin / Mao, Jingxin

    Medicine

    2024  Volume 103, Issue 15, Page(s) e37770

    Abstract: Rationale: Gitelman syndrome (GS), also known as familial hypokalemia and hypomagnesemia, is a rare autosomal recessive inherited disease caused by primary renal desalinization caused by impaired reabsorption of sodium and chloride ions in the distal ... ...

    Abstract Rationale: Gitelman syndrome (GS), also known as familial hypokalemia and hypomagnesemia, is a rare autosomal recessive inherited disease caused by primary renal desalinization caused by impaired reabsorption of sodium and chloride ions in the distal renal tubules. We report a case of clinical and genetic characteristics of GS accompanied with Graves disease and adrenocorticotrophic hormone (ACTH)-independent adrenocortical adenoma.
    Patient concerns: The patient is a 45 year old female, was admitted to our hospital, due to a left adrenal gland occupying lesion as the chief complaint.
    Diagnosis: The patient was finally diagnosed as GS with Graves disease and adrenocortical adenoma.
    Interventions: Potassium magnesium aspartate (1788 mg/d, taken orally 3 times a day (supplement a few times a day, intake method, treatment duration). Contains 217.2 mg of potassium and 70.8 mg of magnesium, and potassium chloride (4.5 g/d, taken orally 3 times a day (supplement a few times a day, intake method, and treatment duration); Potassium 2356 mg), spironolactone (20 mg/d, taken orally once a day (supplement a few times a day, intake method, treatment duration). After 3 months of treatment, the patient's blood potassium fluctuated between 3.3-3.6 mmol/L, and blood magnesium fluctuated between 0.5-0.7 mmol/L, indicating a relief of fatigue symptoms.
    Outcomes: On the day 6 of hospitalization, the symptoms of dizziness, limb fatigue, fatigue and pain were completely relieved on patient. In the follow-up of the following year, no recurrence of the condition was found.
    Lessons: The novel c.1444-10(IVS11)G > A variation may be a splicing mutation. The compound heterozygous mutations of the SLC12A3 gene may be the pathogenic cause of this GS pedigree.
    MeSH term(s) Female ; Humans ; Middle Aged ; Gitelman Syndrome/complications ; Gitelman Syndrome/diagnosis ; Gitelman Syndrome/genetics ; Adrenocortical Adenoma ; Magnesium ; Graves Disease/complications ; Graves Disease/genetics ; Fatigue ; Potassium ; Solute Carrier Family 12, Member 3
    Chemical Substances Magnesium (I38ZP9992A) ; Potassium (RWP5GA015D) ; SLC12A3 protein, human ; Solute Carrier Family 12, Member 3
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037770
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Ba

    Song, Fangyuan / Liu, Andi / Chen, Qiao / Zhou, Jin / Li, Jingxin / Tong, Wei / Wang, Shun / Wang, Yanhong / Lu, Hongcheng / Yuan, Songliu / Guo, Hanjie / Tian, Zhaoming

    Inorganic chemistry

    2024  Volume 63, Issue 13, Page(s) 5831–5841

    Abstract: The exploration of new rare-earth (RE)-based triangular-lattice materials plays a significant role in motivating the discovery of exotic magnetic states. Herein, we report a family of hexagonal perovskite compounds ... ...

    Abstract The exploration of new rare-earth (RE)-based triangular-lattice materials plays a significant role in motivating the discovery of exotic magnetic states. Herein, we report a family of hexagonal perovskite compounds Ba
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c04162
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  4. Article ; Online: Preheating and high-intensity ultrasound synergistically affect the physicochemical, structural, and gelling properties of chicken wooden breast myofibrillar protein.

    Wang, Ke / Li, Yan / Zhang, Yimin / Sun, Jingxin / Qiao, Changming

    Food research international (Ottawa, Ont.)

    2022  Volume 162, Issue Pt A, Page(s) 111975

    Abstract: The effect of different preheating temperatures (PT, 30, 40, 50, and 60 °C) cooperate with high-intensity ultrasound (HIU) treatment on the physicochemical, structural, and gelling properties of wooden breast myofibrillar protein (WBMP) was studied. The ... ...

    Abstract The effect of different preheating temperatures (PT, 30, 40, 50, and 60 °C) cooperate with high-intensity ultrasound (HIU) treatment on the physicochemical, structural, and gelling properties of wooden breast myofibrillar protein (WBMP) was studied. The results show that G' of WBMP was the highest with preheating to 50 °C (PT50) (P < 0.05). Notably, the PT50 gel had the best hardness (9.38 ± 0.31 N) and springiness (0.51 ± 0.11), and water-holding capacity (89.95 ± 4.03 %). An analysis of the Raman spectra showed that the β-fold content of PT50 was the highest (33.85 ± 0.03 %, P < 0.05). Low-field NMR data showed that the immobilized-water content of PT50 was also the highest (91.04 ± 1.36 %, P < 0.05). Scanning electron microscopy images showed that the PT50 gel was uniform and dense. Therefore, preheating to 50 °C enhances the HIU effect to produce an improved WBMP gel.
    MeSH term(s) Animals ; Chickens ; Gels ; Colloids ; Ultrasonography ; Water
    Chemical Substances Gels ; Colloids ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-10-02
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2022.111975
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    In stock of ZB MED Bonn / Germany

    Z 2972: Show issues

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  5. Article ; Online: Discovery of 3-phenyl-1,2,4-oxadiazole derivatives as a new class of SARS-CoV-2 main protease inhibitors.

    Guo, Nihong / Huang, Chong / Qiao, Jingxin / Li, Yueyue / Wang, Yifei / Xia, Anjie / Zhang, Guo / Fang, Zhen / You, Jing / Li, Linli

    Bioorganic & medicinal chemistry letters

    2023  Volume 86, Page(s) 129238

    Abstract: The ongoing COVID-19 pandemic has led to massive infections and deaths and caused tremendous grief among the people. Although vaccines have played an important role in fighting COVID-19, the situation that the protective effect of current vaccines ... ...

    Abstract The ongoing COVID-19 pandemic has led to massive infections and deaths and caused tremendous grief among the people. Although vaccines have played an important role in fighting COVID-19, the situation that the protective effect of current vaccines significantly decreases against mutated strains reminds us of the pressing need for developing effective antiviral therapeutics. The main protease (M
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Pandemics ; Protease Inhibitors/pharmacology ; Antiviral Agents/pharmacology ; Molecular Docking Simulation
    Chemical Substances 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Protease Inhibitors ; Antiviral Agents
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2023.129238
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: Rehmannia glutinosa

    Ren, Heng / Li, Kejie / Min, Yan / Qiu, Binhang / Huang, Xiaolu / Luo, Jingxin / Qi, Liwen / Kang, Maoli / Xia, Peng / Qiao, Hanzhen / Chen, Jun / Cui, Yaoming / Gan, Liping / Wang, Peng / Wang, Jinrong

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Polysaccharide decolorization has a major effect on polysaccharide function. In the present study, the decolorization ... ...

    Abstract Polysaccharide decolorization has a major effect on polysaccharide function. In the present study, the decolorization of
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12040914
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  7. Article ; Online: Identification of a new class of activators of the Hippo pathway with antitumor activity in vitro and in vivo.

    Lin, Guifeng / Xia, Anjie / Qiao, Jingxin / Zhang, Hailin / Chen, Pei / Zhou, Pei / Hu, Qian / Xiang, Zhiyu / Zhang, Shiyu / Li, Linli / Yang, Shengyong

    Biochemical pharmacology

    2024  Volume 224, Page(s) 116217

    Abstract: The Hippo pathway is a key regulator of tissue growth, organ size, and tumorigenesis. Activating the Hippo pathway by gene editing or pharmaceutical intervention has been proven to be a new therapeutic strategy for treatment of the Hippo pathway- ... ...

    Abstract The Hippo pathway is a key regulator of tissue growth, organ size, and tumorigenesis. Activating the Hippo pathway by gene editing or pharmaceutical intervention has been proven to be a new therapeutic strategy for treatment of the Hippo pathway-dependent cancers. To now, a number of compounds that directly target the downstream effector proteins of Hippo pathway, including YAP and TEADs, have been disclosed, but very few Hippo pathway activators are reported. Here, we discovered a new class of Hippo pathway activator, YL-602, which inhibited CTGF expression in cells irrespective of cell density and the presence of serum. Mechanistically, YL-602 activates the Hippo pathway via MST1/2, which is different from known activators of Hippo pathway. In vitro, YL-602 significantly induced tumor cell apoptosis and inhibited colony formation of tumor cells. In vivo, oral administration of YL-602 substantially suppressed the growth of cancer cells by activation of Hippo pathway. Overall, YL-602 could be a promising lead compound, and deserves further investigation for its mechanism of action and therapeutic applications.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116217
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Ultrasound-Assisted Hydrothermal Synthesis of Highly Fluorescent Sulfur Quantum Dots for Fe

    Fu, Wei / Ma, Jingxin / Qiao, Zirui / Xu, Li / Wang, Liangying / Ling, Min / Fu, Xingqin / Li, Gang / Han, Chen / Zhang, Jian / Jin, Juncheng

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 46, Page(s) 16349–16357

    Abstract: In this work, the ultrasound-assisted hydrothermal synthesis method offers a facile method to synthesize highly efficient photoluminescence sulfur quantum dots (SQDs). Impressively, a switchable fluorescent "on-off-on" sensor was developed using the ... ...

    Abstract In this work, the ultrasound-assisted hydrothermal synthesis method offers a facile method to synthesize highly efficient photoluminescence sulfur quantum dots (SQDs). Impressively, a switchable fluorescent "on-off-on" sensor was developed using the acquired SQDs, which are capable of sequentially detecting iron ions (Fe
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c02079
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  9. Article: Discovery of [1,2,3]Triazolo[4,5-

    Zhang, Shiyu / Zhou, Pei / Liu, Jingming / Xia, Anjie / Lin, Guifeng / Xiang, Zhiyu / Fang, Zhen / Yang, Xin / Qiao, Jingxin / Hu, Qian / Zhang, Jiahao / Zhao, Jinlong / Li, Linli

    ACS medicinal chemistry letters

    2023  Volume 14, Issue 6, Page(s) 746–756

    Abstract: Ataxia-telangiectasia mutated (ATM) is an atypical serine/threonine protein kinase which is implicated in the repair of DNA double-strand breaks. Numerous reports have shown that ATM inhibition is an attractive target for radiotherapy and chemotherapy ... ...

    Abstract Ataxia-telangiectasia mutated (ATM) is an atypical serine/threonine protein kinase which is implicated in the repair of DNA double-strand breaks. Numerous reports have shown that ATM inhibition is an attractive target for radiotherapy and chemotherapy sensitization. Herein we report a new series of ATM kinase inhibitors containing the 1
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.3c00034
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  10. Article ; Online: Fabrication and Characterization of Chicken- and Bovine-Derived Chondroitin Sulfate/Sodium Alginate Hybrid Hydrogels.

    Zhao, Yaqi / Li, Yan / Lan, Tianchan / Wang, Baowei / Huang, Ming / Huang, He / Qiao, Changming / Sun, Jingxin

    Gels (Basel, Switzerland)

    2022  Volume 8, Issue 10

    Abstract: The physicochemical properties and microstructure of hybrid hydrogels prepared using sodium alginate (SA) and chondroitin sulfate (CS) extracted from two animal sources were investigated. SA-based hybrid hydrogels were prepared by mixing chicken- and ... ...

    Abstract The physicochemical properties and microstructure of hybrid hydrogels prepared using sodium alginate (SA) and chondroitin sulfate (CS) extracted from two animal sources were investigated. SA-based hybrid hydrogels were prepared by mixing chicken- and bovine-derived CS (CCS and BCS, respectively) with SA at 1/3 and 2/3 (
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels8100620
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