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  1. Article ; Online: Modulating the afterglow time of Mn

    Wang, Peng / Wang, Ying / Guan, Wei / Dong, Hongzhou / Sui, Lina / Gan, Zhixing / Dong, Lifeng / Yu, Liyan

    Optics express

    2023  Volume 31, Issue 6, Page(s) 10191–10200

    Abstract: ... ...

    Abstract Mn
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.484244
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  2. Article ; Online: HDAC6 decreases H4K16 and α-tubulin acetylation during porcine oocyte maturation.

    Zhang, Sheng / Sui, Liyan / Kong, Xiangjie / Huang, Rong / Li, Ziyi

    Cell cycle (Georgetown, Tex.)

    2023  Volume 22, Issue 18, Page(s) 2057–2069

    Abstract: HDAC6 is an essential factor in mouse oocyte maturation. However, the roles of HDAC6 in porcine oocyte maturation are still unclear. Therefore, we analyzed the roles of HDAC6 in porcine oocyte maturation by treatment with Tubastatin A (TubA) which is an ... ...

    Abstract HDAC6 is an essential factor in mouse oocyte maturation. However, the roles of HDAC6 in porcine oocyte maturation are still unclear. Therefore, we analyzed the roles of HDAC6 in porcine oocyte maturation by treatment with Tubastatin A (TubA) which is an HDAC6 inhibitor. Our results showed that treatment with 10 μg/ml TubA significantly decreased the rate of porcine oocyte maturation, but it did not influence the rate of germinal vesicle breakdown (GVBD). Then, we found that TubA treatment disrupted spindle organization by increasing the α-tubulin acetylation level during porcine oocyte maturation. Moreover, TubA treatment significantly increased H4K16 acetylation, which may compromise kinetochore and microtubule (K-MT) attachment during meiosis in porcine oocytes. We also analyzed the effects of TubA on meiosis-related (H3T3pho and H3S10pho) and transcription-related histone modifications (H3K4me3, H3K9me3 and H3K4ac) during porcine oocyte maturation. The results showed that TubA treatment increased H3S10pho and H3K4ac levels, but no influence was seen in H3T3pho, H3K4me3 and H3K9me3 levels in porcine oocytes. TubA treated oocytes also showed a compromised ability to develop after parthenogenetic activation. Finally, we found that
    MeSH term(s) Mice ; Swine ; Animals ; Tubulin/metabolism ; Acetylation ; Oogenesis ; Oocytes/metabolism ; Meiosis ; Spindle Apparatus/metabolism ; Mammals/metabolism
    Chemical Substances Tubulin
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2023.2275907
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses.

    Sui, Liyan / Li, Letian / Zhao, Yinghua / Zhao, Yicheng / Hao, Pengfei / Guo, Xuerui / Wang, Wenfang / Wang, Guoqing / Li, Chang / Liu, Quan

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 21

    MeSH term(s) Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Transcriptome/genetics ; COVID-19/genetics ; Proteome/genetics ; Proteome/metabolism ; Antiviral Agents/pharmacology
    Chemical Substances Proteome ; Antiviral Agents
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01296-1
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  4. Article ; Online: Carbon-Restricted Anoxic Zone as an Overlooked Anammox Hotspot in Municipal Wastewater Treatment Plants.

    Zhao, Qi / Zhang, Liang / Li, Jianwei / Jia, Tipei / Deng, Liyan / Liu, Qiyu / Sui, Jun / Zhang, Qiong / Peng, Yongzhen

    Environmental science & technology

    2023  Volume 57, Issue 51, Page(s) 21767–21778

    Abstract: The anoxic zone serves as the core functional unit in municipal wastewater treatment plants (MWWTPs). Unfortunately, in most cases, the downstream range of the anoxic zone is severely lacking in available organic carbon and thus contributes little to the ...

    Abstract The anoxic zone serves as the core functional unit in municipal wastewater treatment plants (MWWTPs). Unfortunately, in most cases, the downstream range of the anoxic zone is severely lacking in available organic carbon and thus contributes little to the removal of nutrients. This undesirable range is termed the "carbon-restricted anoxic zone", representing an insurmountable drawback for traditional MWWTPs. This study uncovers a previously overlooked role for the carbon-restricted anoxic zone: a hotspot for anaerobic ammonium oxidation (anammox). In a continuous-flow pilot-scale plant treating municipal wastewater (55 m
    MeSH term(s) Carbon ; Anaerobic Ammonia Oxidation ; Bioreactors/microbiology ; Oxidation-Reduction ; Water Purification ; Nitrogen/metabolism
    Chemical Substances Carbon (7440-44-0) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c07017
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  5. Article ; Online: Construction of PdSe

    Guan, Wei / Jia, Ruiming / Zhang, Lin / Meng, Ming / Wang, Peng / Wang, Ying / Wang, Haoyu / Dong, Xingchen / Sui, Lina / Gan, Zhixing / Dong, Lifeng / Yu, Liyan

    Journal of colloid and interface science

    2023  Volume 649, Page(s) 685–693

    Abstract: Constructing semiconductor heterojunctions can enable novel schemes for highly efficient photocatalytic activity. However, introducing strong covalent bonding at the interface remains an open challenge. Herein, ... ...

    Abstract Constructing semiconductor heterojunctions can enable novel schemes for highly efficient photocatalytic activity. However, introducing strong covalent bonding at the interface remains an open challenge. Herein, ZnIn
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.06.130
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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  6. Article ; Online: HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation.

    Sui, Liyan / Zhang, Sheng / Huang, Rong / Li, Ziyi

    Cell cycle (Georgetown, Tex.)

    2020  Volume 19, Issue 3, Page(s) 354–362

    Abstract: The smallest histone deacetylase (HDAC) and the solely member of class IV, HDAC11, is reported to regulate mitosis process and tumorigenesis, yet its roles in meiosis process remain unknown. In the present study, we first analyzed the expression of ... ...

    Abstract The smallest histone deacetylase (HDAC) and the solely member of class IV, HDAC11, is reported to regulate mitosis process and tumorigenesis, yet its roles in meiosis process remain unknown. In the present study, we first analyzed the expression of HDAC11 in mouse oocytes. HDAC11 showed gradual lower expression from GV (Germinal Vesicle) to MII (Metaphase II) stage oocytes. Then, the specific inhibitor of HDAC11, JB3-22 was used to explore the role of HDAC11 during mouse oocytes maturation. We found that inhibition of HDAC11 significantly interrupted mouse oocytes meiosis progress, caused abnormal spindle organization and misaligned chromosomes, impaired kinetochore-microtubule attachment and spindle assembly checkpoint (SAC) function. Moreover, HDAC11 inhibition significantly increased the acetylation level of α-tubulin that is associated with microtubule stability, and increased acetylation level of H4K16 that is important for kinetochore function. In conclusion, our study indicates that HDAC11 is an essential factor for oocytes maturation and it promotes meiotic process most likely though decreasing acetylation status of α-tubulin and H4K16.
    MeSH term(s) Acetylation ; Animals ; Chromosome Segregation/genetics ; Female ; Gene Expression Regulation/genetics ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Histones/metabolism ; Kinetochores/metabolism ; Kinetochores/pathology ; Lysine/metabolism ; M Phase Cell Cycle Checkpoints/genetics ; Meiosis/genetics ; Metaphase ; Mice ; Microtubules/metabolism ; Oocytes/enzymology ; Oocytes/growth & development ; Oocytes/metabolism ; Oogenesis/genetics ; Protein Processing, Post-Translational ; Spindle Apparatus/drug effects ; Spindle Apparatus/metabolism ; Spindle Apparatus/pathology ; Tubulin/metabolism
    Chemical Substances Histone Deacetylase Inhibitors ; Histones ; Tubulin ; Hdac11 protein, mouse (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98) ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2019.1711315
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Characterization and subcellular localization of Alongshan virus proteins.

    Zhao, Yinghua / Wu, Ping / Liu, Li / Ma, Baohua / Pan, Mingming / Huang, Yuan / Du, Nianyan / Yu, Hongyan / Sui, Liyan / Wang, Ze-Dong / Hou, Zhijun / Liu, Quan

    Frontiers in microbiology

    2022  Volume 13, Page(s) 1000322

    Abstract: Alongshan virus (ALSV) in the Jingmenvirus group within the ... ...

    Abstract Alongshan virus (ALSV) in the Jingmenvirus group within the family
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1000322
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  8. Article ; Online: Yezo Virus Infection in Tick-Bitten Patient and Ticks, Northeastern China.

    Lv, Xiaolong / Liu, Ziyan / Li, Liang / Xu, Wenbo / Yuan, Yongxu / Liang, Xiaojie / Zhang, Li / Wei, Zhengkai / Sui, Liyan / Zhao, Yinghua / Hou, Zhijun / Wei, Feng / Han, Shuzhen / Liu, Quan / Wang, Zedong

    Emerging infectious diseases

    2023  Volume 29, Issue 4, Page(s) 797–800

    Abstract: We identified Yezo virus infection in a febrile patient who had a tick bite in northeastern China, where 0.5% of Ixodes persulcatus ticks were positive for viral RNA. Clinicians should be aware of this potential health threat and include this emerging ... ...

    Abstract We identified Yezo virus infection in a febrile patient who had a tick bite in northeastern China, where 0.5% of Ixodes persulcatus ticks were positive for viral RNA. Clinicians should be aware of this potential health threat and include this emerging virus in the differential diagnosis for tick-bitten patients in this region.
    MeSH term(s) Animals ; Humans ; Tick Bites ; Ixodes ; Virus Diseases ; Viruses ; China/epidemiology
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2904.220885
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: HDAC11 inhibition disrupts porcine oocyte meiosis via regulating α-tubulin acetylation and histone modifications.

    Huang, Rong / Sui, Liyan / Fu, Cong / Zhai, Yanhui / Dai, Xiangpeng / Zhang, Sheng / Li, Ziyi

    Aging

    2021  Volume 13, Issue 6, Page(s) 8849–8864

    Abstract: HDAC11, the sole member of HDAC class IV family, plays vital roles in activating mitosis and apoptosis of tumor cells, but its functions in meiosis are rarely investigated. In the present study, the effect of HDAC11 on meiosis during porcine oocytes ... ...

    Abstract HDAC11, the sole member of HDAC class IV family, plays vital roles in activating mitosis and apoptosis of tumor cells, but its functions in meiosis are rarely investigated. In the present study, the effect of HDAC11 on meiosis during porcine oocytes maturation was fully studied. The results showed that HDAC11 inhibition by its specific inhibitor JB-3-22 dramatically decreased the porcine oocyte maturation rate by disturbing spindle organization and chromosomes alignment without affecting the cytoplasmic maturation. Further study indicated that HDAC11 inhibition significantly elevated the acetylation levels of α-tubulin and H4K16, which are crucial for spindle organization and chromosomes alignment. Moreover, immunofluorescence staining results showed that HDAC11 inhibition also disturbed other meiosis-related histone modifications, such as increased H3S10pho, H4K5ac and H4K12ac levels and reduced H3T3pho level. Furthermore, RNA-seq analysis results indicated that HDAC11 inhibition disturbed porcine oocytes transcriptome (157 up-regulation, 106 down-regulation). In addition, HDAC11 inhibition compromised oocytes quality and subsequent development after parthenogenetic activation, which may be caused by the aberrant nuclear maturation and transcriptome expression profile during oocytes maturation. Therefore, our results elucidate the function of HDAC11 in porcine oocytes maturation and embryos development through regulating α-tubulin acetylation, meiosis-related histone modifications and transcriptome.
    MeSH term(s) Animals ; Female ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylases/metabolism ; Histones/metabolism ; Meiosis/drug effects ; Oocytes/drug effects ; Oocytes/metabolism ; Swine ; Transcriptome ; Tubulin/metabolism ; Up-Regulation/drug effects
    Chemical Substances Histone Deacetylase Inhibitors ; Histones ; Tubulin ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.202697
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  10. Article ; Online: Inhibition of HDAC6 by tubastatin A disrupts mouse oocyte meiosis via regulating histone modifications and mRNA expression.

    Sui, Liyan / Huang, Rong / Yu, Hao / Zhang, Sheng / Li, Ziyi

    Journal of cellular physiology

    2020  Volume 235, Issue 10, Page(s) 7030–7042

    Abstract: Histone deacetylase 6 (HDAC6) participates in mouse oocyte maturation by deacetylating α-tubulin. However, how HDAC6 expression is regulated in oocytes remains unknown. In the present study, we discovered that mouse oocytes had a high level of HDAC6 ... ...

    Abstract Histone deacetylase 6 (HDAC6) participates in mouse oocyte maturation by deacetylating α-tubulin. However, how HDAC6 expression is regulated in oocytes remains unknown. In the present study, we discovered that mouse oocytes had a high level of HDAC6 expression and a low level of DNA methylation status in their promoter region. Then, a selective HDAC6 inhibitor, tubastatin A (Tub-A) was chosen to investigate the role of HDAC6 in oocyte maturation. Our results revealed that inhibition of HDAC6 caused meiotic progression arrest, disturbed spindle/chromosome organization, and kinetochore-microtubule attachments without impairing spindle assembly checkpoint function. Moreover, inhibition of HDAC6 not only increased the acetylation of α-tubulin but also elevated the acetylation status of H4K16 and decreased the phosphorylation level of H3T3 and H3S10. Conversely, depressed H3T3 phosphorylation by its kinase inhibitor increased the acetylation level of H4K16. Finally, single cell RNA-seq analysis revealed that the cell cycle-related genes CCNB1, CDK2, SMAD3, YWHAZ and the methylation-related genes DNMT1 and DNMT3B were strongly repressed in Tub-A treated oocytes. Taken together, our results indicate that HDAC6 plays important roles in chromosome condensation and kinetochore function via regulating several key histone modifications and messenger RNA transcription during oocyte meiosis.
    MeSH term(s) Acetylation/drug effects ; Animals ; Chromosome Segregation/drug effects ; Female ; Histone Deacetylase 6/antagonists & inhibitors ; Histone Deacetylase Inhibitors/pharmacology ; Histones/metabolism ; Hydroxamic Acids/pharmacology ; Indoles/pharmacology ; Kinetochores/drug effects ; Kinetochores/metabolism ; Meiosis/drug effects ; Mice ; Mice, Inbred ICR ; Microtubules/drug effects ; Oocytes/drug effects ; Oocytes/metabolism ; RNA, Messenger/metabolism ; Spindle Apparatus/drug effects ; Spindle Apparatus/metabolism ; Tubulin/metabolism
    Chemical Substances Histone Deacetylase Inhibitors ; Histones ; Hydroxamic Acids ; Indoles ; RNA, Messenger ; Tubulin ; tubastatin A (2XTSOX1NF8) ; Hdac6 protein, mouse (EC 3.5.1.98) ; Histone Deacetylase 6 (EC 3.5.1.98)
    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.29599
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.212: Show issues Location:
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