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Article: Mechanism of Jingfang Granule in treatment of coronavirus infection by biological information technology

Chen, W. L. / Zhang, Y. P. / Mu, Y. F. / Li, S. S. / Ye, S. L. / Zhi, Y. X. / Zhang, G. M.

Chinese Traditional and Herbal Drugs

Abstract: Objective: To explore the mechanism of Jingfang Granule in treatment of corona virus infection ... of TCMIP and TCMSP were used to summarize the flavor and meridian tropism and active compounds of Jingfang ... and key targets were screened for molecular docking Results: Totally 139 active components of Jingfang ...

Abstract	Objective: To explore the mechanism of Jingfang Granule in treatment of corona virus infection through biological information technology based on network pharmacology and molecular docking Methods: The databases of TCMIP and TCMSP were used to summarize the flavor and meridian tropism and active compounds of Jingfang Granule, and the potential targets of active compounds were searched by PubChem and SwissTargetPrediction The corona virus targets were collected from the GeneCards database And common targets were enriched and analyzed by DAVID database after the intersection of the compounds targets and the disease targets Then the network of "TCM-Ingredients-Common targets" was established by Cytoscape 3 7 2, the main active components and key targets were screened for molecular docking Results: Totally 139 active components of Jingfang Granule and 27 common targets were obtained GO enrichment analysis and KEGG enrichment analysis found that the pathways in cancer, MAPK signaling pathway, PI3K-Akt signaling pathway, TNF signaling pathway were the main pathways of Jingfang Granule in treatment of corona virus infection The network of "TCM-Ingredients-Common targets" was successfully constructed, and results of molecular docking showed that the main components in this network such as β-sitosterol, cerevisterol, isorhamnetin, hesperetin, and luteolin etc , have good affinity with key targets of VEGFA, IL6, TNF, PPARγ, APP, ACE2, and SARS-CoV-2 3CL hydrolase Conclusion: Jingfang Granule treats corona virus infectious diseases through the compatibility of multiple traditional Chinese medicine Its resistance to corona virus infection may be through the β-sitosterol, cerevisterol, isorhamnetin, hesperetin, and luteolin act on the VEGFA, IL6, TNF, PPARγ, APP and other targets, and then affects the pathways in cancer, MAPK signal pathway, PI3K-Akt signal pathway, TNF signal pathways to achieve
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #769798
Database	COVID19

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Article ; Online: The 3A protein of coxsackievirus B3 acts as a viral suppressor of RNA interference.

Mu, Jingfang / Zhang, Haobo / Li, Tao / Shu, Ting / Qiu, Yang / Zhou, Xi

The Journal of general virology

2020 Volume 101, Issue 10, Page(s) 1069–1078

Abstract: RNA interference (RNAi) is a potent antiviral defence mechanism in eukaryotes, and numerous viruses have been found to encode viral suppressors of RNAi (VSRs). Coxsackievirus B3 (CVB3) belongs to the ... ...

Abstract	RNA interference (RNAi) is a potent antiviral defence mechanism in eukaryotes, and numerous viruses have been found to encode viral suppressors of RNAi (VSRs). Coxsackievirus B3 (CVB3) belongs to the genus
MeSH term(s)	Enterovirus B, Human/genetics ; Enterovirus B, Human/pathogenicity ; Enterovirus B, Human/physiology ; HEK293 Cells ; Humans ; Point Mutation ; Protein Multimerization ; RNA Interference ; RNA, Double-Stranded/metabolism ; RNA, Small Interfering/genetics ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism
Chemical Substances	3A protein, coxsackievirus B ; RNA, Double-Stranded ; RNA, Small Interfering ; Viral Proteins
Language	English
Publishing date	2020-07-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219316-4
ISSN	1465-2099 ; 0022-1317
ISSN (online)	1465-2099
ISSN	0022-1317
DOI	10.1099/jgv.0.001434
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2.

Mu, Jingfang / Fang, Yaohui / Yang, Qi / Shu, Ting / Wang, An / Huang, Muhan / Jin, Liang / Deng, Fei / Qiu, Yang / Zhou, Xi

Cell discovery

2020 Volume 6, Page(s) 65

Keywords	covid19
Language	English
Publishing date	2020-09-15
Publishing country	England
Document type	Journal Article ; Letter
ISSN	2056-5968
ISSN	2056-5968
DOI	10.1038/s41421-020-00208-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: KNK437 Inhibits Replication and Transcription of the Hepatitis B Virus.

Hu, Kanghong / Huang, Yayun / Mu, Jingfang / Cheng, Zhikui / Zhu, Xiang

Bing du xue bao = Chinese journal of virology

2019 Volume 33, Issue 1, Page(s) 24–35

Abstract: During replication of the hepatitis B virus (HBV) in liver cells, the reverse transcription of pre-genomic RNA (pgRNA) is initiated by protein priming at an RNA packaging signal ε located near the 5' end of pgRNA. Heat-shock proteins (Hsps) such as Hsc70, ...

Abstract	During replication of the hepatitis B virus (HBV) in liver cells, the reverse transcription of pre-genomic RNA (pgRNA) is initiated by protein priming at an RNA packaging signal ε located near the 5' end of pgRNA. Heat-shock proteins (Hsps) such as Hsc70, Hsp40, and Hsp90 have been reported to be involved in the reconstitution of HBV polymerase (P protein) and E. The P - E complex initiates the reverse transcription and assembly of nucleocapsids. Hence, blockade of P - ε interactions is an attractive target for drug intervention. We explored the influence of the Hsp inhibitor KNK437 on replication and transcription of the HBV. Three working models were applied: HepG2. 2. 15 cell line; Huh7 cells transfected transiently with the 1. 05 X HBV (pCH9-3091) plasmid; Huh7 cells transfected transiently with the 1. 3 X HBV (pGEM-1. 3 X HBV) plasmid. Cytotoxic effects of KNK437 were detected by the CCK-8 method. Levels of hepatitis B surface antigen (HBsAg) and hepatitis B viral protein (HBeAg) in the media secreted from cells were measured using an ELISA. Intracellular HBV DNAs within nucleocapsids were measured by quantitative polymerase chain reaction (qPCR), and intracellular HBV RNAs by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Transcription of Hsps in cells was determined by qRT-PCR. Data suggested that KNK437 reduced the extracellular secretion of HBsAg and HBeAg in most cases; it downregulated expression of intracellular HBV DNAs within nucleocapsids and RNA transcripts. The lowest rate of viral DNAs in KNK437-treated hepatocytes for all experimental groups was ~1. 5%o (control, 100%), whereas that for RNAs was ~30%. Western blotting revealed KNK437 to inhibit intracellular core expression in HepG2. 2. 15. As a general inhibitor, KNK437 suppressed transcription of hsp70, hsp90b, and hsp4o. These data suggest that KNK437 may be a potent anti-HBV inhibitor for future therapy against chronic hepatitis.
MeSH term(s)	Antiviral Agents/pharmacology ; Benzhydryl Compounds/pharmacology ; DNA Replication/drug effects ; Gene Expression Regulation, Viral ; Hepatitis B/drug therapy ; Hepatitis B/virology ; Hepatitis B Surface Antigens/genetics ; Hepatitis B Surface Antigens/metabolism ; Hepatitis B e Antigens/genetics ; Hepatitis B e Antigens/metabolism ; Hepatitis B virus/drug effects ; Hepatitis B virus/genetics ; Hepatitis B virus/physiology ; Humans ; Pyrrolidinones/pharmacology ; RNA, Viral/genetics ; Reverse Transcription/drug effects ; Transcription, Genetic ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; Benzhydryl Compounds ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; KNK 437 ; Pyrrolidinones ; RNA, Viral
Language	Chinese
Publishing date	2019-01-31
Publishing country	China
Document type	Journal Article
ZDB-ID	1158410-5
ISSN	1000-8721
ISSN	1000-8721
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

Jingfang Mu / Yaohui Fang / Qi Yang / Ting Shu / An Wang / Muhan Huang / Liang Jin / Fei Deng / Yang Qiu / Xi Zhou

Cell Discovery, Vol 6, Iss 1, Pp 1-

2020 Volume 4

Keywords	Cytology ; QH573-671 ; covid19
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of CRM1-dependent nuclear export inhibition on viral structural protein nuclear accumulation during Autographa californica multiple nucleopolyhedrovirus infection.

Hu, Xue / Tian, Lingqian / Li, Jingqi / Zhou, Yuan / Chen, Xinwen / Mu, Jingfang / Bai, Huimin / Zhang, Yongli / Wang, Yun

Virus research

2021 Volume 303, Page(s) 198504

Abstract: Autographa californica multiple nucleopolyhedrovirus (AcMNPV) assembles its nucleocapsids and occlusion-derived virions (ODVs) in the nucleus, which requires AcMNPV regulation for viral structural proteins to accumulate in the nucleus during its ... ...

Abstract	Autographa californica multiple nucleopolyhedrovirus (AcMNPV) assembles its nucleocapsids and occlusion-derived virions (ODVs) in the nucleus, which requires AcMNPV regulation for viral structural proteins to accumulate in the nucleus during its replication in cells. It is generally accepted that the nuclear import receptor plays a predominant role in this process. CRM1 is a nuclear export receptor that forms an export complex with its cargo protein to exit the nucleus. We previously discovered that AcMNPV inhibited CRM1-dependent nuclear export by the viral protein Ac34. This finding suggested that Ac34 could sequester CRM1-dependent proteins in the nucleus and play a novel role in the nuclear accumulation of viral structural proteins. Using the CRM1 inhibitor leptomycin B (LMB), we demonstrated that CRM1 inhibition promoted AcMNPV replication, as LMB treatment readily increased the virus titer, and even functionally surrogate Ac34 to rescue the infectivity of an ac34-knockout virus. To elucidate whether CRM1 inhibition contributes to the nuclear accumulation of viral structural proteins, we systematically analyzed the impact of CRM1 inhibition on viral protein spatial distribution patterns. We found that the nucleocapsid protein Ac102 and ODV envelope protein E26 were retained in the nucleus in response to CRM1 inhibition by Ac34. This finding indicates that AcMNPV is evolving to simultaneously exploit bidirectional nucleocytoplasmic trafficking to assist in viral replication.
MeSH term(s)	Active Transport, Cell Nucleus ; Animals ; Nucleopolyhedroviruses ; Sf9 Cells ; Spodoptera ; Viral Proteins/metabolism ; Viral Structural Proteins/metabolism ; Virus Replication/physiology
Chemical Substances	Viral Proteins ; Viral Structural Proteins
Language	English
Publishing date	2021-07-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2021.198504
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of CRM1-dependent nuclear export inhibition on viral structural protein nuclear accumulation during Autographa californica multiple nucleopolyhedrovirus infection

Hu, Xue / Tian, Lingqian / Li, Jingqi / Zhou, Yuan / Chen, Xinwen / Mu, Jingfang / Bai, Huimin / Zhang, Yongli / Wang, Yun

Virus research. 2021 Oct. 02, v. 303

2021

Abstract	Autographa californica multiple nucleopolyhedrovirus (AcMNPV) assembles its nucleocapsids and occlusion-derived virions (ODVs) in the nucleus, which requires AcMNPV regulation for viral structural proteins to accumulate in the nucleus during its replication in cells. It is generally accepted that the nuclear import receptor plays a predominant role in this process. CRM1 is a nuclear export receptor that forms an export complex with its cargo protein to exit the nucleus. We previously discovered that AcMNPV inhibited CRM1-dependent nuclear export by the viral protein Ac34. This finding suggested that Ac34 could sequester CRM1-dependent proteins in the nucleus and play a novel role in the nuclear accumulation of viral structural proteins. Using the CRM1 inhibitor leptomycin B (LMB), we demonstrated that CRM1 inhibition promoted AcMNPV replication, as LMB treatment readily increased the virus titer, and even functionally surrogate Ac34 to rescue the infectivity of an ac34-knockout virus. To elucidate whether CRM1 inhibition contributes to the nuclear accumulation of viral structural proteins, we systematically analyzed the impact of CRM1 inhibition on viral protein spatial distribution patterns. We found that the nucleocapsid protein Ac102 and ODV envelope protein E26 were retained in the nucleus in response to CRM1 inhibition by Ac34. This finding indicates that AcMNPV is evolving to simultaneously exploit bidirectional nucleocytoplasmic trafficking to assist in viral replication.
Keywords	Autographa californica multiple nucleopolyhedrovirus ; nucleocapsid ; nucleocapsid proteins ; pathogenicity ; research ; structural proteins ; viral load ; virus replication ; viruses
Language	English
Dates of publication	2021-1002
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2021.198504
Database	NAL-Catalogue (AGRICOLA)

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Article: Heterogeneous Nitrogen Supply With High Frequency and Ramet Damage Increases the Benefits of Clonal Integration in Invasive

Sun, Kai / Cai, Jing-Fang / Zhang, Yu / Mu, Ya-Nan / A, Si-Ha / Shen, Yi-Luan / Yang, Li-Juan / Li, Hong-Li

Frontiers in plant science

2022 Volume 13, Page(s) 825492

Abstract: Nitrogen (N) deposition significantly affects the growth and the function of invasive clonal plants. However, the effects of heterogeneous N supply with different frequencies on the growth and the potential contribution of clonal integration in invasion ... ...

Abstract	Nitrogen (N) deposition significantly affects the growth and the function of invasive clonal plants. However, the effects of heterogeneous N supply with different frequencies on the growth and the potential contribution of clonal integration in invasion plants are still unclear, especially in the complex environment considering ramet damage. To address this question, apical and basal ramets of the clonal invader
Language	English
Publishing date	2022-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.825492
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reviving chloroquine for anti-SARS-CoV-2 treatment with cucurbit[7]uril-based supramolecular formulation.

Kwong, Cheryl H T / Mu, Jingfang / Li, Shengke / Fang, Yaohui / Liu, Qianyun / Zhang, Xiangjun / Kam, Hiotong / Lee, Simon M Y / Chen, Yu / Deng, Fei / Zhou, Xi / Wang, Ruibing

Chinese chemical letters = Zhongguo hua xue kuai bao

2021 Volume 32, Issue 10, Page(s) 3019–3022

Abstract: The wide-spreading SARS-CoV-2 virus has put the world into boiling water for more than a year, however pharmacological therapies to act effectively against coronavirus disease 2019 (COVID-19) remain elusive. Chloroquine (CQ), an antimalarial drug, was ... ...

Abstract	The wide-spreading SARS-CoV-2 virus has put the world into boiling water for more than a year, however pharmacological therapies to act effectively against coronavirus disease 2019 (COVID-19) remain elusive. Chloroquine (CQ), an antimalarial drug, was found to exhibit promising antiviral activity
Language	English
Publishing date	2021-04-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2096242-3
ISSN	1001-8417
ISSN	1001-8417
DOI	10.1016/j.cclet.2021.04.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Independent Variables for Determining the Cumulative Live Birth Rates of Aged Patients with Polycystic Ovary Syndrome or Tubal Factor Infertility: A Retrospective Cohort Study.

Guan, Yichun / Kong, Pingping / Xiao, Zhiying / Zhang, Junyan / He, Jingfang / Geng, Wenjun / Yan, Junfang / Sun, Simin / Mu, Mingkun / Du, Xiaofang / Wang, Xingling

Frontiers in endocrinology

2022 Volume 12, Page(s) 728051

Abstract: Objective: To assess whether women of advanced age (≥35 years) with polycystic ovary syndrome (PCOS) have the same cumulative live birth rate (CLBR) as their age-matched controls with tubal factor infertility and to determine the influencing factors on ... ...

Abstract	Objective: To assess whether women of advanced age (≥35 years) with polycystic ovary syndrome (PCOS) have the same cumulative live birth rate (CLBR) as their age-matched controls with tubal factor infertility and to determine the influencing factors on the CLBRs of aged women. Design: A retrospective cohort study. Setting and population: A total of 160 women of advanced age (≥35 years) with PCOS and 1073 women with tubal factor infertility were included in our study. All patients underwent their first fresh cycles and subsequent frozen cycles within in one year in our centre from 2015 to 2020. Methods: To determine independent influencing factors on the CLBRs of these aged patients, a multivariable Cox regression model of CLBR according to the transfer cycle type was constructed. Result: The Cox regression model of the CLBRs indicated that there was no significant difference between the PCOS group and the tubal infertility group in terms of advanced age (HR, 0.95; 95% CI, 0.71-1.27, Conclusion: Despite the higher number of oocytes retrieved in PCOS patients, the reproductive window is not extended for PCOS patients compared with tubal factor infertility patients. Age, AMH and the number of oocytes retrieved play crucial roles in the CLBRs of patients of advanced age (≥35 years).
MeSH term(s)	Adult ; Anti-Mullerian Hormone/metabolism ; Case-Control Studies ; Cohort Studies ; Embryo Transfer ; Fallopian Tube Diseases/complications ; Female ; Fertilization in Vitro ; Humans ; Infertility, Female/etiology ; Infertility, Female/metabolism ; Infertility, Female/therapy ; Live Birth/epidemiology ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/metabolism ; Polycystic Ovary Syndrome/therapy ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Sperm Injections, Intracytoplasmic ; Treatment Outcome
Chemical Substances	Anti-Mullerian Hormone (80497-65-0)
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.728051
Database	MEDical Literature Analysis and Retrieval System OnLINE

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