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Book ; Online ; E-Book: Percutaneous and Non-fluoroscopical (PAN) Procedure for Structural Heart Disease

Pan, Xiangbin / Hijazi, Ziyad M. / Sievert, Horst

2020

Abstract: This book provides an extensive discussion of echocardiography-guided percutaneous interventional techniques for clinical practitioners, including cardiologists, interventional physicians, surgeons and specialist training candidates. It allows readers to ...

Author's details	by Xiangbin Pan, Ziyad M. Hijazi, Horst Sievert
Abstract	This book provides an extensive discussion of echocardiography-guided percutaneous interventional techniques for clinical practitioners, including cardiologists, interventional physicians, surgeons and specialist training candidates. It allows readers to gain a thorough understanding of interpreting echocardiography-guided procedures, which not only protect patients from pain and other complications associated with conventional surgery, but also obviate the use of fluoroscopy or contrast agents and so avoid radiation damage and the risks of allergy or renal function impairment. Further, these procedures could help to save patients in areas lacking medical resources. The book first demonstrates the substitution of transesophageal for transthoracic echocardiography to avoid intubation under general anesthesia, and then presents key technical and practical aspects of echo-guided percutaneous interventions for structural heart diseases, such as ASD, VSD, PDA, PS, MS, AS and CoA. Lastly, it explores the lessons learned in echocardiography, anesthesia and postprocedural management of echo-guided percutaneous interventions.
Keywords	Cardiology ; Radiology ; Ultrasound ; Ecocardiografia ; Cirurgia cardíaca ; Anestèsia en cardiologia
Subject code	616.12
Language	English
Size	1 online resource (XIX, 117 p. 80 illus. in color.)
Edition	1st ed. 2020.
Publisher	Springer Singapore ; Imprint: Springer
Publishing place	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	981-15-2055-0 ; 981-15-2054-2 ; 978-981-15-2055-6 ; 978-981-15-2054-9
DOI	10.1007/978-981-15-2055-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Reply by Pan

Pan, Chun / Chen, Lu / Lu, Cong / Du, Bin / Brochard, Laurent / Qiu, Haibo

American journal of respiratory and critical care medicine

2020 Volume 202, Issue 4, Page(s) 630–631

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Lung ; Pandemics ; Pneumonia, Viral ; Respiratory Distress Syndrome ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202005-2045LE
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Article: Complete Genome Sequence and Pan-Genome Analysis of

Zhang, Ying / Pan, Mengjie / Wang, Qiaoyun / Wang, Lan / Liao, Li

Microorganisms

2023 Volume 11, Issue 12

Abstract: In this study, we reported the complete genome sequence ... ...

Abstract	In this study, we reported the complete genome sequence of
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11122961
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Article ; Online: An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironment.

Song, Xiaoyi / Wei, Jiaxing / Li, Yang / Zhu, Wen / Cai, Zhiyuan / Li, Kunwei / Wei, Jingyue / Lu, Jieyu / Pan, Wanping / Li, Man

EBioMedicine

2024 Volume 102, Page(s) 105078

Abstract: ... of these activities at the pan-cancer level is still lacking.: Methods: We proposed a computational approach ...

Abstract	Background: Dietary restriction (DR), a general term for dieting, has been demonstrated as an effective intervention in reducing the occurrence of cancers. Molecular activities associated with DR are crucial in mediating its anti-cancer effects, yet a comprehensive exploration of the landscape of these activities at the pan-cancer level is still lacking. Methods: We proposed a computational approach for quantifying DR-related molecular activities and delineating the landscape of these activities across 33 cancer types and 30 normal tissues within 27,320 samples. We thoroughly examined the associations between DR-related molecular activities and various factors, including the tumour microenvironment, immunological phenotypes, genomic features, and clinical prognosis. Meanwhile, we identified two DR genes that show potential as prognostic predictors in hepatocellular carcinoma and verified them by immunohistochemical assays in 90 patients. Findings: We found that DR-related molecular activities showed a close association with tumour immunity and hold potential for predicting immunotherapy responses in various cancers. Importantly, a higher level of DR-related molecular activities is associated with improved overall survival and cancer-specific survival. FZD1 and G6PD are two DR genes that serve as biomarkers for predicting the prognosis of patients with hepatocellular carcinoma. Interpretation: This study presents a robust link between DR-related molecular activities and tumour immunity across multiple cancer types. Our research could open the path for further investigation of DR-related molecular processes in cancer treatment. Funding: National Natural Science Foundation of China (Grant No. 82000628) and the Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine Foundation of Guangdong Province (Grant No. 2023LSYS001).
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/genetics ; Transcriptome ; Gene Expression Profiling ; Tumor Microenvironment/genetics ; Prognosis ; Liver Neoplasms/genetics
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2024.105078
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Article ; Online: Potential prognosis and immunotherapy predictor TFAP2A in pan-cancer.

Niu, Chenxi / Wen, Haixuan / Wang, Shutong / Shu, Guang / Wang, Maonan / Yi, Hanxi / Guo, Ke / Pan, Qiong / Yin, Gang

Aging

2024 Volume 16, Issue 2, Page(s) 1021–1048

Abstract: Background: TFAP2A is critical in regulating the expression of various genes, affecting various biological processes and driving tumorigenesis and tumor development. However, the significance of TFAP2A in carcinogenesis processes remains obscure.: ... ...

Abstract	Background: TFAP2A is critical in regulating the expression of various genes, affecting various biological processes and driving tumorigenesis and tumor development. However, the significance of TFAP2A in carcinogenesis processes remains obscure. Methods: In our study, we explored multiple databases including TCGA, GTEx, HPA, cBioPortal, TCIA, and other well-established databases for further analysis to expound TFAP2A expression, genetic alternations, and their relationship with the prognosis and cellular signaling network alternations. GO term and KEGG pathway enrichment analysis as well as GSEA were conducted to examine the common functions of TFAP2A. RT-qPCR, Western Blot and Dual Luciferase Reporter assay were employed to perform experimental validation. Results: TFAP2A mRNA expression level was upregulated and its genetic alternations were frequently present in most cancer types. The enrichment analysis results prompted us to investigate the changes in the tumor immune microenvironment further. We discovered that the expression of TFAP2A was significantly associated with the expression of immune checkpoint genes, immune subtypes, ESTIMATE scores, tumor-infiltrating immune cells, and the possible role of TFAP2A in predicting immunotherapy efficacy. In addition, high TFAP2A expression significantly correlated with several ICP genes, and promoted the expression of PD-L1 on mRNA and protein levels through regulating its expression at the transcriptional level. TFAP2A protein level was upregulated in fresh colon tumor tissue samples compared to that in the adjacent normal tissues, which essentially positively correlated with the expression of PD-L1. Conclusions: Our study suggests that targeting TFAP2A may provide a novel and effective strategy for cancer treatment.
MeSH term(s)	Humans ; B7-H1 Antigen ; Carcinogenesis ; Colonic Neoplasms ; Immunotherapy ; Prognosis ; RNA, Messenger/genetics ; Transcription Factor AP-2/genetics ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen ; RNA, Messenger ; TFAP2A protein, human ; Transcription Factor AP-2
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205225
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Article: Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody.

Johnson, Nicole V / Wall, Steven C / Kramer, Kevin J / Holt, Clinton M / Periasamy, Sivakumar / Richardson, Simone / Suryadevara, Naveenchandra / Andreano, Emanuele / Paciello, Ida / Pierleoni, Giulio / Piccini, Giulia / Huang, Ying / Ge, Pan / Allen, James D / Uno, Naoko / Shiakolas, Andrea R / Pilewski, Kelsey A / Nargi, Rachel S / Sutton, Rachel E /

Abu-Shmais, Alexandria A / Parks, Robert / Haynes, Barton F / Carnahan, Robert H / Crowe, James E / Montomoli, Emanuele / Rappuoli, Rino / Bukreyev, Alexander / Ross, Ted M / Sautto, Giuseppe A / McLellan, Jason S / Georgiev, Ivelin S

bioRxiv : the preprint server for biology

2024

Abstract: ... deadly epidemics or pandemics. The continued emergence of coronaviruses highlights the need for pan ...

Abstract	Three coronaviruses have spilled over from animal reservoirs into the human population and caused deadly epidemics or pandemics. The continued emergence of coronaviruses highlights the need for pan-coronavirus interventions for effective pandemic preparedness. Here, using LIBRA-seq, we report a panel of 50 coronavirus antibodies isolated from human B cells. Of these antibodies, 54043-5 was shown to bind the S2 subunit of spike proteins from alpha-, beta-, and deltacoronaviruses. A cryo-EM structure of 54043-5 bound to the pre-fusion S2 subunit of the SARS-CoV-2 spike defined an epitope at the apex of S2 that is highly conserved among betacoronaviruses. Although non-neutralizing, 54043-5 induced Fc-dependent antiviral responses, including ADCC and ADCP. In murine SARS-CoV-2 challenge studies, protection against disease was observed after introduction of Leu234Ala, Leu235Ala, and Pro329Gly (LALA-PG) substitutions in the Fc region of 54043-5. Together, these data provide new insights into the protective mechanisms of non-neutralizing antibodies and define a broadly conserved epitope within the S2 subunit.
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.15.575741
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Conference proceedings ; Online: Pan Canadian Narratives and Numbers

Van Zijll De Jong, S. / Pan, Y. / Graveline, M. / Dolphin, G.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

A Knowledge to Action Initiative in the Earthquake Early Warning Education (E3) Project

2023

Abstract: ... of Earth Sciences and others have been critical for reaching the target audience of the Pan Canadian bilingual E3 ...

Abstract	Partnerships with Earth Science for Society, the Canadian Risk and Hazards Network, the Assembly of First Nations, the International Association of Emergency Managers, the Canadian Federation of Earth Sciences and others have been critical for reaching the target audience of the Pan Canadian bilingual E3 Survey. Research partners also circulated our 2022 article entitled A new earthquake warning system will prepare Canada for dangerous shaking and its key message: “About 10 million people live in Canada’s earthquake-prone zones. Yet few have practical knowledge of what to do with new early warning system alerts which aim to save lives and protect livelihoods”. Importantly, such partnerships also provide the structure for the distribution of the E3 Survey final report. The primary aim of this presentation is to outline how our partners have helped us to research and report on three questions of national interest: What connects Canadian science education, earthquake literacy and time/space specific skills required to succeed in earthquake prone locations ? How do Canadians build their earthquake literacy? Why does Canada needs earthquake literacy taught in disaster risk management activities and programs? We showcase how the Knowledge to Action Framework analysis of E3 Survey results reveals multiple aspects of E3 delivery that need to change. We suggest that with evidence based recommendations, our partners can identify resource needs and pinpoint future interventions. Overall, we conclude that investment in future E3 products – via digital delivery - may revolutionize E3 geoliteracy levels and close the E3 Knowledge to Action gap.
Subject code	300
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
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Article ; Online: Facile preparation of UiO-66-Lys/PAN nanofiber membrane by electrospinning for the removal of Co(II) from simulated radioactive wastewater.

Li, Yanqiu / Pan, Ting / Feng, Jian / Yu, Bo / Xiong, Wei / Yuan, Guoyuan

The Science of the total environment

2024 Volume 914, Page(s) 169725

Abstract: In this study, metal-organic framework (MOF) nanofiber membranes (NFMs) UiO-66-Lys/PAN were ... prepared by electrospinning using polyacrylonitrile (PAN) as the matrix, UiO-66-NH ...

Abstract	In this study, metal-organic framework (MOF) nanofiber membranes (NFMs) UiO-66-Lys/PAN were prepared by electrospinning using polyacrylonitrile (PAN) as the matrix, UiO-66-NH
Language	English
Publishing date	2024-01-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.169725
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Article: Prognostic Implications of RAB35 and its Relationship With Immune Microenvironment in Pan-cancer.

Pan, Dongdong / Chen, Xueting / Zong, Yujie / Lei, Deru

Alternative therapies in health and medicine

2023 Volume 29, Issue 8, Page(s) 452–460

Abstract: ... microenvironment, and drug sensitivity in pan-cancer.: Results: RAB35 exhibited significant differential ...

Abstract	Context: Ras-associated binding 35 (RAB35) is an oncogenic, guanosine triphosphate (GTP)ase that plays a role in cancer invasion, metastasis, and immune evasion. However, systematic and comprehensive research to identify the importance of RAB35 in various cancer types is still absent. Objective: The study intended to explore the potential value of RAB35 as a molecular biomarker. Design: The research team performed a genetic evaluation of RAB35. Setting: The study took place at the Second Affiliated Hospital of Wenzhou Medical University in Wenzhou, China. Outcome measures: The research team assessed the expression of RAB35 in various tumor tissues and performed correlation analyses between RAB35 expression and prognosis, molecular subtypes, immunological subtypes, immune-associated cell infiltration, the tumor immune microenvironment, and drug sensitivity in pan-cancer. Results: RAB35 exhibited significant differential expression for 21 cancer types. It demonstrated high sensitivity and specificity in diagnosing eight cancer types, showed distinct expression patterns in various molecular subtypes for six cancer types, and found different immune subtypes for eight cancer types. The abnormal expression of RAB35 was significantly related to overall survival (OS) for nine cancer types, progress free interval (PFI) for five cancer types, and disease-specific survival (DSS) for five cancer types. Its abnormal expression was closely associated with the immune microenvironment and multiple immune cells. Furthermore, it was related to the drug sensitivity for various drugs and might be associated with chemotherapy resistance. Conclusions: RAB35 showed significant differential expression in various cancers and was significantly related to the prognosis of cancer patients, the immune microenvironment, multiple immune cells, drug sensitivity to various drugs, and chemotherapy resistance. It may serve as a potential biomarker and therapeutic target for cancer treatment.
MeSH term(s)	Humans ; Prognosis ; Neoplasms/diagnosis ; China ; Biomarkers ; Tumor Microenvironment ; rab GTP-Binding Proteins/genetics
Chemical Substances	rasagiline (003N66TS6T) ; Biomarkers ; RAB35 protein, human (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Comprehensive pan-carcinoma analysis of ITGB1 distortion and its potential clinical significance for cancer immunity.

Fei, Yuchang / Wu, Yulun / Chen, Luting / Yu, Huan / Pan, Lei

Discover. Oncology

2024 Volume 15, Issue 1, Page(s) 47

Abstract: ... in colon cancer, according to an investigation of immune infiltration in pan-cancer. In the gene co-expression ... Our pan-cancer analysis of ITGB1 gives evidence in favor of a further investigation into its oncogenic ...

Abstract	The human protein-coding gene ITGB1 (Integrin 1), also known as CD29, has a length of 58048 base pairs. The Integrin family's most prevalent subunit, it participates in the transmission of numerous intracellular signaling pathways. A thorough examination of ITGB1's functions in human malignancies, however, is inadequate and many of their relationships to the onset and development of human cancers remain unknown. In this work, we examined ITGB1's role in 33 human cancers. Finally, a multi-platform analysis revealed that three of the 33 malignancies had significantly altered ITGB1 expression in tumor tissues in comparison to normal tissues. In addition, it was discovered through survival analysis that ITGB1 was a stand-alone prognostic factor in a number of cancers. ITGB1 expression was linked to immune cell infiltration in colon cancer, according to an investigation of immune infiltration in pan-cancer. In the gene co-expression research, ITGB1 showed a positive connection with the majority of the cell proliferation and EMT indicators, indicating that ITGB1 may have an essential function in controlling cancer metastasis and proliferation. Our pan-cancer analysis of ITGB1 gives evidence in favor of a further investigation into its oncogenic function in various cancer types.
Language	English
Publishing date	2024-02-24
Publishing country	United States
Document type	Journal Article
ISSN	2730-6011
ISSN (online)	2730-6011
DOI	10.1007/s12672-024-00901-9
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