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  1. Book ; Online: Application of Remote Sensing and GIS in Droughts and Floods Assessment and Monitoring

    Huang, Yaohuan / Liu, Yesen / Shi, Runhe / Ren, Hongyan / Ren, Hongyan

    2023  

    Keywords Technology: general issues ; History of engineering & technology ; Environmental science, engineering & technology ; GRACE ; drought ; mainland China ; extreme climate ; climatic conditions ; urban floods ; rainfall movement direction (RMD) ; rainfall intensity (RI) ; peak runoff ; Linear Directional Mean (LDM) ; Shenzhen ; flood forecasting ; error correction ; residual property ; ridge coefficient criterion ; rainstorm mode ; high dimension ; dimension reduction ; cluster ; surface water ; monitoring history ; change trends in surface water quality ; water quality protection ; "Thirteenth Five-Year Plan" period ; water environment quality ; Heilongjiang Province ; correlation analysis ; manifold learning ; machine learning ; spatial-temporal distribution of rainstorms ; feature extraction ; Beijing ; n/a
    Language English
    Size 1 electronic resource (128 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030378056
    ISBN 9783036571478 ; 3036571477
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Progress and perspective of organoid technology in breast cancer research.

    Huang, Changsheng / Jin, Hongyan

    Chinese medical journal

    2024  

    Abstract: Abstract: Breast cancer, a malignant tumor with a high incidence in women, lacks in vitro research models that can represent the biological functions of breast tumors in vivo. As a new biological tool, the organoid model has unique advantages over ... ...

    Abstract Abstract: Breast cancer, a malignant tumor with a high incidence in women, lacks in vitro research models that can represent the biological functions of breast tumors in vivo. As a new biological tool, the organoid model has unique advantages over traditional methods, such as cell culture and patient-derived xenografts. Combining organoids with other emerging technologies, such as gene engineering and microfluidic chip technology, provides an effective method to compensate for the deficiencies in organoid models of breast cancer in vivo. The emergence of breast cancer organoids has provided new tools and research directions in precision medicine, personality therapy, and drug research. In this review, we summarized the merits and demerits of organoids compared to traditional biological models, explored the latest developments in the combination of new technologies and organoid models, and discussed the construction methods and application prospects of different breast organoid models.
    Language English
    Publishing date 2024-01-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1207: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Ua VI Zs.425: Show issues Location:
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  3. Article: Parasitic leiomyoma of the greater omentum: a case report and literature review.

    Huang, Zhiman / Wang, Yongzhou / Lei, Hongyan

    Journal of surgical case reports

    2024  Volume 2024, Issue 1, Page(s) rjad733

    Abstract: Parasitic leiomyomas (PL), also known as free leiomyomas, which occur outside the uterus and rarely happen in clinical practice. They are usually reported in women of reproductive age who underwent hysterectomy or myomectomy and frequently present with ... ...

    Abstract Parasitic leiomyomas (PL), also known as free leiomyomas, which occur outside the uterus and rarely happen in clinical practice. They are usually reported in women of reproductive age who underwent hysterectomy or myomectomy and frequently present with symptoms such as abdominal pain and distention. In fact, it is hard to determine the nature of the mass according to the imaging examination and clinical manifestation. At present, the most common treatment involves an abdominal or laparoscopic surgery in order to remove the mass and perform the next step of treatment based on the histological diagnosis. In this case report, we describe a 35-year-old woman with a 12.4 × 9.3 × 9.8 cm
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjad733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Photoredox Catalytic Phosphine-Mediated Deoxygenative Hydroacylation of Azobenzenes with Carboxylic Acids.

    Yang, Jingya / Wang, Cunhui / Huang, Bao / Zhou, Hongyan / Li, Jiangjiang / Liu, Xiaojun

    Organic letters

    2024  Volume 26, Issue 2, Page(s) 498–502

    Abstract: The convenient and precise preparation ... ...

    Abstract The convenient and precise preparation of
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Advances in the role of the GADD45 family in neurodevelopmental, neurodegenerative, and neuropsychiatric disorders.

    Huang, Mengbing / Wang, Ji / Liu, Wei / Zhou, Hongyan

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1349409

    Abstract: The growth arrest and DNA damage inducible protein 45 (GADD45) family comprises stress-induced nuclear proteins that interact with DNA demethylases to facilitate DNA demethylation, thereby regulating diverse cellular processes including oxidative stress, ...

    Abstract The growth arrest and DNA damage inducible protein 45 (GADD45) family comprises stress-induced nuclear proteins that interact with DNA demethylases to facilitate DNA demethylation, thereby regulating diverse cellular processes including oxidative stress, DNA damage repair, apoptosis, proliferation, differentiation, inflammation, and neuroplasticity by modulating the expression patterns of specific genes. Widely expressed in the central nervous system, the GADD45 family plays a pivotal role in various neurological disorders, rendering it a potential therapeutic target for central nervous system diseases. This review presented a comprehensive overview of the expression patterns and potential mechanisms of action associated with each member of GADD45 family (GADD45α, GADD45β, and GADD45γ) in neurodevelopmental, neurodegenerative, and neuropsychiatric disorders, while also explored strategies to harness these mechanisms for intervention and treatment. Future research should prioritize the development of effective modulators targeting the GADD45 family for clinical trials aimed at treating central nervous system diseases.
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1349409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Public knowledge, perception of and willingness-to-accept nuclear energy in China: Evidence from a representative national survey.

    Su, Hongyan / Huang, Ying / Guo, Xiaodan

    Journal of environmental management

    2024  Volume 359, Page(s) 120937

    Abstract: The Chinese government promotes nuclear energy development in the context of mitigating climate change. However, the large-scale development is still facing challenges related to the knowledge gap among the general public and the potential "not-in-my- ... ...

    Abstract The Chinese government promotes nuclear energy development in the context of mitigating climate change. However, the large-scale development is still facing challenges related to the knowledge gap among the general public and the potential "not-in-my-back-yard" objection. Based on a representative national survey, we analyze Chinese people's knowledge and perceptions of nuclear energy and estimate their willingness-to-accept the potential risks of new nuclear programs in neighborhoods via the Contingent Valuation Method. Generally, more than half of people do not know anything about nuclear energy. The main factors influencing public knowledge are identified, such as the residential distance to existing nuclear power stations and the frequency of internet use. Moreover, approximately 12% of individuals with some knowledge seem to be willing to accept new nuclear power plants in their neighborhoods with no compensation needed. Specifically, the perceptions of nuclear risks and pollution from fossil fuels are significant factors influencing people's acceptance of nuclear energy. Although public knowledge does not directly influence acceptance, more knowledge seems to reduce risk perception and increase benefit perception. The residential distance to exiting nuclear stations has limited effects on people's acceptance of newly planned nuclear programs for those living in the same county with some knowledge. In general, a typical Chinese household is willing to accept USD $5.66 every month or USD $67.97 every year to bear the potential risks of the new nuclear program in neighborhoods. Significant practical implications that can be transferable to other new energy technologies and countries or regions are provided.
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  7. Article ; Online: A Highly Selective and Sensitive Sequential Recognition Probe Zn

    Yang, Shan / Huang, Yichuan / Lu, Aidang / Wang, Ziwen / Li, Hongyan

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 10

    Abstract: A series of novel chiral thiourea fluorescent ... ...

    Abstract A series of novel chiral thiourea fluorescent probes
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28104166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article: Evaluation of

    He, Ye / Yin, Lu / Zhou, Wei / Wan, Hongyan / Lei, Chang / Li, Shunxiang / Huang, Dan

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 13

    Abstract: ... ...

    Abstract 60
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12132489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Regulatory mechanism of GPER in the invasion and migration of ectopic endometrial stromal cells in endometriosis.

    Shi, Hongyan / Xu, Kejun / Huang, Mengna / Mao, Meiya / Ou, Jilan

    Women & health

    2024  Volume 64, Issue 2, Page(s) 109–120

    Abstract: Endometriosis (EMS) is a chronic inflammatory disorder of high incidence that causes serious reproductive consequences. High estrogen production is a consistently observed endocrine feature of EMS. The present study aims to probe the molecular mechanism ... ...

    Abstract Endometriosis (EMS) is a chronic inflammatory disorder of high incidence that causes serious reproductive consequences. High estrogen production is a consistently observed endocrine feature of EMS. The present study aims to probe the molecular mechanism of G protein-coupled estrogen receptor 1 (GPER) in the invasion and migration of ectopic endometrial stromal cells (Ect-ESCs) and provides a new rationale for EMS treatment. Eutopic and ectopic endometrial tissues were collected from 41 EMS patients, and primary ESCs were separated. GPER, miR-16-5p, and miR-103a-3p levels in cells and tissues were determined by qRT-PCR or Western blot assay. Cell viability, proliferation, invasion, and migration were evaluated by CCK-8, colony formation, and Transwell assays. The upstream miRNAs of GPER were predicted by databases, and dual-luciferase assay was performed to validate the binding of miR-16-5p and miR-103a-3p to GPER 3'UTR. GPER was highly expressed in EMS tissues and Ect-ESCs. Inhibition of GPER mitigated the proliferation, invasion, and migration of Ect-ESCs. GPER was regulated by miR-16-5p and miR-103a-3p. Overexpression of miR-16-5p and miR-103a-3p negatively regulated GPER expression and inhibited the invasion and migration of Ect-ESC. In conclusion, GPER promoted the invasion and migration of Ect-ESCs, which can be reversed by upstream miR-16-5p and miR-103a-3p.
    MeSH term(s) Female ; Humans ; Cell Movement/genetics ; Endometriosis ; Estrogens ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Stromal Cells/metabolism
    Chemical Substances Estrogens ; MicroRNAs ; GPER1 protein, human
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603396-9
    ISSN 1541-0331 ; 0363-0242
    ISSN (online) 1541-0331
    ISSN 0363-0242
    DOI 10.1080/03630242.2023.2296522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2265: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Catalytic hairpin assembly triggering amplified DNAzyme-feedback for sensitive detection of hepatitis C virus genotype 1b.

    Xu, Yuting / Li, Lili / Yang, Yumeng / Huang, Chengzhi / Zou, Hongyan

    Talanta

    2024  Volume 271, Page(s) 125754

    Abstract: Developing a simple, reliable, and sensitive hepatitis C virus (HCV) genetic sensing platform is of great significance for diagnosing diseases and selecting appropriate antiviral treatments. Herein, a tandem nucleic acid amplification strategy for ... ...

    Abstract Developing a simple, reliable, and sensitive hepatitis C virus (HCV) genetic sensing platform is of great significance for diagnosing diseases and selecting appropriate antiviral treatments. Herein, a tandem nucleic acid amplification strategy for sensitive detection of HCV genotype 1b (HCV-1b) was developed by stringing the catalytic hairpin assembly (CHA) and the triggered DNAzyme amplifier. The hairpin reactants were initiated by the target to produce lots of triggering double-stranded DNA sequences which can efficiently activate the subsequent blocked DNAzyme. Thereby, the continuous cleavage of substrate was realized, resulting in the fluorescence signal amplification. The DNA-based isothermal CHA-DNAzyme (CDz) sensing platform was successfully applied for sensitive detection of HCV-1b with the limit of detection (84 pM) and showed good selectivity. Moreover, the practical detection of target DNA in the complex biologic matrix indicated that the developing strategy had good potential for early HCV infection diagnosis.
    MeSH term(s) Humans ; DNA, Catalytic/genetics ; Hepacivirus/genetics ; Feedback ; Biosensing Techniques/methods ; DNA/genetics ; Hepatitis C/diagnosis ; Genotype ; Limit of Detection
    Chemical Substances DNA, Catalytic ; DNA (9007-49-2)
    Language English
    Publishing date 2024-02-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.125754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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