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  1. Article ; Online: Thermochemical Expansion and Protonic and Electronic Hole Conductivity of Grain Interior and Grain Boundaries in 10 Mole% Y-Substituted SrZrO

    Jiang, Lulu / Norby, Truls / Han, Donglin

    ChemSusChem

    2023  Volume 16, Issue 14, Page(s) e202300661

    Abstract: Proton conducting acceptor-doped ... ...

    Abstract Proton conducting acceptor-doped SrZrO
    Language English
    Publishing date 2023-06-28
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202300661
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  2. Article ; Online: (La

    Zhang, Xiaorong / Jiang, Lulu / Guo, Shihang / Han, Donglin

    ChemSusChem

    2022  , Page(s) e202201879

    Abstract: In this work, a class of ionic conductor ( ... ...

    Abstract In this work, a class of ionic conductor (La
    Language English
    Publishing date 2022-10-18
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202201879
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  3. Article ; Online: Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ROCK pathway.

    Han, Lulu / Wang, Shenghai / Li, Juan / Zhao, Lulu / Zhou, Hong

    Experimental and molecular pathology

    2023  Volume 134, Page(s) 104877

    Abstract: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease without early diagnostic and specific therapeutic approaches. Podocyte apoptosis and loss play important roles in the pathological process of DKD. This study aimed to explore ... ...

    Abstract Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease without early diagnostic and specific therapeutic approaches. Podocyte apoptosis and loss play important roles in the pathological process of DKD. This study aimed to explore whether urinary exosomes from type 2 diabetes patients with DKD could induce podocyte apoptosis and the underlying pathological mechanisms. The exosomes were isolated from the urine samples of patients with DKD (DKD-Exo). Later, they were taken up and internalized by MPC5 cells. MPC5 cells were co-cultured with DKD-Exo (45 μg/ml) for 24 h in the presence or absence of microRNA-145-5p (miR-145-5p) inhibitor, fasudil and pcDNA-Srgap2 transfection. MiR-145-5p and Srgap2 expression was evaluated using real-time quantitative PCR. The protein levels of Srgap2, Bcl-2, Bax, and cleaved caspase-3, as well as ROCK activity were determined using Western blotting. Cell apoptosis was measured using flow cytometry and the TUNEL assay. miR-145-5p expression in MPC5 cells exposed to DKD-Exo was markedly upregulated. miR-145-5p negatively regulated Srgap2 levels. Exposure of MPC5 cells to DKD-Exo reduced Srgap2 expression and activated ROCK, which was partly reversed by the presence of the miR-145-5p inhibitor or Srgap2 overexpression. The apoptosis of MPC5 cells exposed to DKD-Exo increased significantly, which was counteracted by the addition of the miR-145-5p inhibitor and fasudil. The results showed that urinary exosomal miR-145-5p from patients with DKD induced podocyte apoptosis by inhibiting Srgap2 and activating the RhoA/ROCK pathway, suggesting that urinary exosomal miR-145-5p is involved in the pathological process of DKD and could become a noninvasive diagnostic biomarker for DKD.
    MeSH term(s) Humans ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/pathology ; MicroRNAs/metabolism ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Podocytes/pathology ; Exosomes/metabolism ; Apoptosis/genetics
    Chemical Substances MicroRNAs ; fasudil (Q0CH43PGXS) ; MIRN145 microRNA, human
    Language English
    Publishing date 2023-11-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 207655-x
    ISSN 1096-0945 ; 0014-4800
    ISSN (online) 1096-0945
    ISSN 0014-4800
    DOI 10.1016/j.yexmp.2023.104877
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    Zs.A 183: Show issues Location:
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  4. Article ; Online: [Determination of 15 preservative allergens in cosmetics by gas chromatography-tandem mass spectrometry].

    Han, Weina / Liu, Tongtong / Wang, Lulu / Hou, Xiaoyu / Cao, Jin

    Se pu = Chinese journal of chromatography

    2024  Volume 42, Issue 1, Page(s) 75–83

    Abstract: Most preservatives are irritating and can easily induce skin sensitivities. Therefore, both domestic and international regulations impose clear restrictions on the use of preservatives in cosmetics. Herein, gas chromatography-tandem mass spectrometry (GC- ...

    Abstract Most preservatives are irritating and can easily induce skin sensitivities. Therefore, both domestic and international regulations impose clear restrictions on the use of preservatives in cosmetics. Herein, gas chromatography-tandem mass spectrometry (GC-MS/MS) was employed to simultaneously analyze the levels of 15 preservative allergens in cosmetics. Further, a precise identification approach based on a two-column retention index and mass spectrometry matching degree was developed. Cosmetic samples were extracted via acetonitrile vortex ultrasound extraction and then dehydrated with anhydrous MgSO
    MeSH term(s) Allergens ; Tandem Mass Spectrometry ; Gas Chromatography-Mass Spectrometry ; Alkanes ; Cosmetics ; Preservatives, Pharmaceutical
    Chemical Substances Allergens ; Alkanes ; Cosmetics ; Preservatives, Pharmaceutical
    Language Chinese
    Publishing date 2024-01-10
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1872-2059
    ISSN (online) 1872-2059
    DOI 10.3724/SP.J.1123.2023.04010
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  5. Article: Comparative Analysis between

    Shi, Wenjian / Tang, Wenli / Li, Yafei / Han, Yu / Cui, Lulu / Sun, Shuhong

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: Salmonella ... ...

    Abstract Salmonella enterica
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020390
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  6. Article ; Online: Constructing Sequential Type II Heterojunction CQDs/Bi

    Pan, Yanjie / Dong, Zhenbiao / Qin, Dongmei / Liu, Baopeng / Cui, Lulu / Han, Sheng / Lin, Hualin

    ACS applied materials & interfaces

    2024  Volume 16, Issue 13, Page(s) 16062–16074

    Abstract: Efficient charge transfer and light-trapping units are pivotal prerequisites in the realm of Ti-based photoanode photoelectrochemical (PEC) water splitting. In this work, we successfully synthesized a ternary carbon quantum dots/ ... ...

    Abstract Efficient charge transfer and light-trapping units are pivotal prerequisites in the realm of Ti-based photoanode photoelectrochemical (PEC) water splitting. In this work, we successfully synthesized a ternary carbon quantum dots/Bi
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c17726
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  7. Article: Aquaporins and CO

    Chen, Junyu / Yue, Ke / Shen, Lulu / Zheng, Chuncui / Zhu, Yiyong / Han, Kun / Kai, Lei

    Frontiers in physiology

    2023  Volume 14, Page(s) 1205290

    Abstract: Despite the physiological significance of effective ... ...

    Abstract Despite the physiological significance of effective CO
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1205290
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  8. Article ; Online: Exosomal microRNAs: potential nanotherapeutic targets for diabetic kidney disease.

    Han, Lulu / Cai, Xiaoning / Zhou, Hong

    Nanomedicine (London, England)

    2023  Volume 18, Issue 23, Page(s) 1669–1680

    Abstract: Diabetic kidney disease (DKD) is a primary cause for end-stage renal disease, but no specific therapeutic approaches exist. Exosomal miRNAs, a key functional cargo of nanovesicles, play crucial roles in the pathophysiological processes of DKD. Exosomal ... ...

    Abstract Diabetic kidney disease (DKD) is a primary cause for end-stage renal disease, but no specific therapeutic approaches exist. Exosomal miRNAs, a key functional cargo of nanovesicles, play crucial roles in the pathophysiological processes of DKD. Exosomal miRNAs are involved in cell-to-cell transfer of biological information, mediating nephritic inflammation, oxidative stress, apoptosis, autophagy, epithelial-mesenchymal transition and fibrosis. Circulating exosomal miRNAs derived from urine or serum might function as noninvasive prognostic biomarkers for DKD. Exosomal miRNAs from stem cells have been reported to exert beneficial effects on diabetic kidneys, which suggests that these exosomes might function as potential nanotherapy tools for treating DKD. In this review, we have summarized recent studies based on the association between exosomal miRNAs and DKD.
    MeSH term(s) Humans ; MicroRNAs/genetics ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/genetics ; Kidney ; Epithelial-Mesenchymal Transition ; Exosomes/genetics ; Diabetes Mellitus
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2023-0023
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6617: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Macroscopic and Microscopic Characteristics of Strength Degradation of Silty Soil Improved by Regenerated Polyester Fibers under Dry-Wet Cycling.

    Liu, Xiaoyan / Han, Meng / Liu, Tong / Liu, Lulu

    Polymers

    2023  Volume 15, Issue 22

    Abstract: The structural stability of silt foundations, particularly sensitive to moisture content, can be severely compromised by recurring wetting and drying processes. This not only threatens the foundational integrity but also raises grave concerns about the ... ...

    Abstract The structural stability of silt foundations, particularly sensitive to moisture content, can be severely compromised by recurring wetting and drying processes. This not only threatens the foundational integrity but also raises grave concerns about the long-term safety of major civil engineering endeavors. Addressing this critical issue, our study delves into the transformative effects of reclaimed polyester fiber on subgrade silt exposed to such environmental stressors. Through rigorous wet-dry cycle tests on this enhanced soil, we evaluate shifts in shear strength across varying confining pressures. We also dissect the interplay between average pore diameter, particle distribution, and morphology in influencing the soil's microstructural responses to these cycles. A detailed analysis traces the structural damage timeline in the treated soil, elucidating the intertwined micro-macro dynamics driving strength reduction. Key discoveries indicate a notably non-linear trajectory of shear strength degradation, marked by distinct phases of rapid, subdued, and stabilized strength attrition. Alterations within the micropores induce a rise in both their count and size, ultimately diminishing the total volume proportion of the reinforced soil. Intriguingly, particle distribution is directly tied to the wet-dry cycle frequency, while the fractal dimension of soil particles consistently wanes. This research identifies cement hydrolysis and pore expansion as the dominant culprits behind the observed macroscopic strength degradation due to incessant wet-dry cycles. These revelations hold profound implications for risk management and infrastructural strategizing in areas dominated by silt foundations.
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15224367
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  10. Article ; Online: Allicin Protects Renal Function, Improves Oxidative Stress and Lipid Peroxidation in Rats with Chronic Renal Failure.

    Xu, Ningning / Han, Weinan / Yun, Guoping / Shi, Lulu

    Iranian journal of kidney diseases

    2023  Volume 17, Issue 3, Page(s) 135–140

    Abstract: Introduction: The research was an attempt to explore the potential impact of allicin on lipid peroxidation and oxidative stress in rats diagnosed with chronic kidney disease (CKD), and to determine its underlying mechanism.: Methods: Sixty rats were ... ...

    Abstract Introduction: The research was an attempt to explore the potential impact of allicin on lipid peroxidation and oxidative stress in rats diagnosed with chronic kidney disease (CKD), and to determine its underlying mechanism.
    Methods: Sixty rats were randomly divided into sham-operated, modelling, and allicin low, medium, and high dose groups. The histopathological structure of the kidney was observed in each group. Biochemical measurements were conducted to assess kidney function, including serum creatinine (Scr) and blood urea nitrogen (BUN), and 24-hour urine protein quantification. Levels of malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxidative species (ROS), and reduced glutathione (GSH) in kidney tissue were measured, and mitogen-activated protein kinase (MAPK) and NF (nuclear factor) -κB protein levels were detected by western blotting.
    Results: They showed that allicin improved the pathological structure of renal tissue and protected renal function by reducing oxidative stress and lipid peroxidation via targeting the ROS/ MAPK/NF-κB pathway. Allicin increased SOD and GSH levels, while decreasing Scr, MDA, ROS, BUN, and the amount of protein excreted in urine over a 24-hour in medium and high dose groups. MAPK and NF-κB protein levels in medium and high dose allicin groups were lower than the modelling group.
    Conclusion: Based on the results, it can be inferred that allicin may safeguard renal function in rats with CKD and has the potential to serve as a treatment for kidney ailments.  DOI: 10.52547/ijkd.7496.
    MeSH term(s) Rats ; Animals ; Reactive Oxygen Species/metabolism ; NF-kappa B/metabolism ; NF-kappa B/therapeutic use ; Lipid Peroxidation ; Kidney/pathology ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/metabolism ; Kidney Failure, Chronic ; Oxidative Stress ; Glutathione ; Superoxide Dismutase/metabolism
    Chemical Substances allicin (3C39BY17Y6) ; Reactive Oxygen Species ; NF-kappa B ; Glutathione (GAN16C9B8O) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2023-07-10
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2388271-2
    ISSN 1735-8604 ; 1735-8582
    ISSN (online) 1735-8604
    ISSN 1735-8582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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