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  1. Article ; Online: An insight into the burden of drug-resistant tuberculosis in children.

    Dias, Joana Valente / Varandas, Luís / Gonçalves, Luzia / Kagina, Benjamin M

    Acta paediatrica (Oslo, Norway : 1992)

    2024  Volume 113, Issue 4, Page(s) 781–782

    MeSH term(s) Child ; Humans ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology ; Global Health
    Language English
    Publishing date 2024-01-20
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.17120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Congenital ichthyosis: a multidisciplinary approach in a neonatal care unit.

    Dias, Joana Valente / Cardoso, Kátia / Prado, Sara Noéme / Cavaco, Hugo

    BMJ case reports

    2023  Volume 16, Issue 2

    Abstract: Congenital ichthyoses are a rare group of genetic disorders caused by defects in the two outermost skin layers, resulting in an abnormal barrier function. We report the case of a male preterm neonate presenting at delivery with thickened and scaling skin, ...

    Abstract Congenital ichthyoses are a rare group of genetic disorders caused by defects in the two outermost skin layers, resulting in an abnormal barrier function. We report the case of a male preterm neonate presenting at delivery with thickened and scaling skin, ectropium and eclabium. Supportive care aiming at improving skin condition and handling possible complications was provided. Following gradual clinical improvement, he was discharged after 27 days. Molecular testing identified mutations in a gene encoding lipoxygenase (
    MeSH term(s) Infant, Newborn ; Male ; Humans ; Ichthyosis, Lamellar/diagnosis ; Ichthyosis, Lamellar/genetics ; Ichthyosis, Lamellar/therapy ; Ichthyosiform Erythroderma, Congenital ; Genetic Counseling ; Mutation ; Patient Discharge
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-250077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multiple myeloma in dogs: Use of the cell block technique as a new diagnostic tool.

    Valente, Pâmela Cristina Lopes Gurgel / Peleteiro, Maria Conceição / Dias, Maria Joana / Vicente, Gonçalo / Pomba, Constança / Duarte, António / Correia, Jorge

    Veterinary clinical pathology

    2024  Volume 53, Issue 1, Page(s) 93–98

    Abstract: Background: The diagnosis of multiple myeloma (MM) in dogs may be challenging and complex. The cell blocks are a diagnostic technique that allows the characterization of neoplastic cells and, therefore, might help in the diagnosis of atypical MM.: ... ...

    Abstract Background: The diagnosis of multiple myeloma (MM) in dogs may be challenging and complex. The cell blocks are a diagnostic technique that allows the characterization of neoplastic cells and, therefore, might help in the diagnosis of atypical MM.
    Objective: The objective of the present work is to describe three clinical cases in which the cell blocks and immunohistochemistry contributed to the definitive diagnosis of canine MM.
    Methods: Three dogs, one female and two males, with different clinical signs, were presented for consultation with anemia, hyperproteinemia with monoclonal gammopathy, and the presence of plasmacytosis in the bone marrow. Cytologic analysis of the spleen was performed in two dogs and was suggestive of the presence of lymphocytes or plasma cells of a neoplastic nature in one of the cases and plasma cell hyperplasia associated with extramedullary hematopoiesis in the other. Given the hypotheses of lymphoid neoplasms with a plasma cell phenotype, cell blocks from aspiration punctures were performed for immunohistochemical analysis with anti-CD3, CD20, CD79αcy, PAX5, and MUM1 antibodies.
    Results: The results revealed positive staining for MUM1 in 80% of the cells in the spleen cell block and for CD20 and MUM1 in 70% of the cells in the bone marrow cell blocks, with negative staining for the other antibodies. The immunophenotyping results allowed the diagnosis of MM in the three cases and excluded other lymphoid neoplasms.
    Conclusions: This work reinforces the importance of using cell blocks in the diagnosis of neoplasms by demonstrating their potential to aid the diagnosis of MM.
    MeSH term(s) Male ; Dogs ; Animals ; Female ; Multiple Myeloma/veterinary ; Plasma Cells ; Paraproteinemias/veterinary ; Lymphoma/veterinary ; Immunohistochemistry ; Dog Diseases/diagnosis
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2114702-4
    ISSN 1939-165X ; 0275-6382
    ISSN (online) 1939-165X
    ISSN 0275-6382
    DOI 10.1111/vcp.13320
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  4. Article: Arginine-Modified 3D-Printed Chromatographic Supports.

    Valente, Joana F A / Carreira, Tiago Soares / Dias, Juliana R / Sousa, Fani / Alves, Nuno

    Pharmaceutics

    2022  Volume 14, Issue 11

    Abstract: The increasing progression of biopharmaceutical-based therapies highlights the demand for efficient chromatographic methods that can be used to purify the desired biomolecules (e.g., nucleic acids, enzymes, or monoclonal antibodies) which are presently ... ...

    Abstract The increasing progression of biopharmaceutical-based therapies highlights the demand for efficient chromatographic methods that can be used to purify the desired biomolecules (e.g., nucleic acids, enzymes, or monoclonal antibodies) which are presently under consideration in clinical trials or approved by the Food and Drug Administration. These molecules present distinct chemical and structural properties, which are critical cues for the development and production of adequate chromatographic supports. Until now, it has not been possible to fully control the characteristics of the chromatographic matrices to assure the total reproducibility of their structure and packing. Meanwhile, three-dimensional printing (3DP) is in the early stage of its use in the production of chromatographic supports as a fast, very precise, and reproducible methodology. Although 3DP can provide excellent performance properties to the chromatographic structures, it cannot, per se, lead to high-quality pharmaceutical products. However, the association of affinity ligands, such as amino acids, which is possible in 3DP, could enable the attainment of high-purity yields of the desired molecules. Beyond the amino acids most widely studied as chromatographic ligands, arginine has been successfully immobilized on different chromatographic supports (namely, agarose bead matrices, macroporous matrices, and monoliths) to achieve extra-pure gene therapy products. In this research, we studied the immobilization of arginine on 3DP chromatographic supports, evaluating the stability of the ligand/chromatographic support linkage under different chromatographic conditions to determine the robustness of these new prototypes. Moreover, we also applied plasmid DNA samples to these supports to observe the practical behaviour of the developed arginine 3DP chromatographic structures.
    Language English
    Publishing date 2022-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14112266
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  5. Article ; Online: SARS-CoV-2 Pandemic

    Joana Valente Dias / Marta Contreiras / Paulo Oom

    Acta Médica Portuguesa, Vol 33, Iss 10, Pp 711-

    Should Children Wear Masks?

    2020  Volume 711

    Abstract: N/a. ...

    Abstract N/a.
    Keywords child ; covid-19 ; masks ; sars-cov-2 ; Medicine ; R ; Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Ordem dos Médicos
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: SARS-CoV-2 Pandemic: Should Children Wear Masks?

    Dias, Joana Valente / Contreiras, Marta / Oom, Paulo

    Acta medica portuguesa

    2020  Volume 33, Issue 10, Page(s) 711

    MeSH term(s) Age Factors ; Betacoronavirus ; COVID-19 ; Child, Preschool ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Equipment Design ; Humans ; Infant ; Masks ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Portugal ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-03
    Publishing country Portugal
    Document type Letter
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.14787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Electrospun-Based Membranes as a Key Tool to Prevent Respiratory Infections.

    Guerreiro, Sara F C / Ferreira, Carolina A M / Valente, Joana F A / Patrício, Tatiana M F / Alves, Nuno M F / Dias, Juliana R

    Polymers

    2022  Volume 14, Issue 18

    Abstract: The use of electrospun meshes has been proposed as highly efficient protective equipment to prevent respiratory infections. Those infections can result from the activity of micro-organisms and other small dust particles, such as those resulting from air ... ...

    Abstract The use of electrospun meshes has been proposed as highly efficient protective equipment to prevent respiratory infections. Those infections can result from the activity of micro-organisms and other small dust particles, such as those resulting from air pollution, that impair the respiratory tract, induce cellular damage and compromise breathing capacity. Therefore, electrospun meshes can contribute to promoting air-breathing quality and controlling the spread of such epidemic-disrupting agents due to their intrinsic characteristics, namely, low pore size, and high porosity and surface area. In this review, the mechanisms behind the pathogenesis of several stressors of the respiratory system are covered as well as the strategies adopted to inhibit their action. The main goal is to discuss the performance of antimicrobial electrospun nanofibers by comparing the results already reported in the literature. Further, the main aspects of the certification of filtering systems are highlighted, and the expected technology developments in the industry are also discussed.
    Language English
    Publishing date 2022-09-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14183787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Advanced Face Mask Filters Based on PCL Electrospun Meshes Dopped with Antimicrobial MgO and CuO Nanoparticles.

    Ferreira, Carolina A M / Guerreiro, Sara F C / Valente, Joana F A / Patrício, Tatiana M F / Alves, Nuno / Mateus, Artur / Dias, Juliana R

    Polymers

    2022  Volume 14, Issue 16

    Abstract: The pandemic situation caused by coronavirus clearly demonstrated the need for alternatives able to protect the respiratory tract and inactivate the infectious agents. Based on this, antibacterial face-mask filters of polycaprolactone (PCL) dopped with ... ...

    Abstract The pandemic situation caused by coronavirus clearly demonstrated the need for alternatives able to protect the respiratory tract and inactivate the infectious agents. Based on this, antibacterial face-mask filters of polycaprolactone (PCL) dopped with magnesium oxide (MgO) and copper oxide (CuO) nanoparticles (NPs) were produced using an electrospinning technique. A morphological analysis of electrospun meshes evaluated the success of nanoparticles' incorporation as well as the average fibers' diameters (481 ± 272 nm). The performance of electrospun nanofibers was also assessed in terms of tensile strength (0.88 ± 0.25 MPa), water vapor permeability (11,178.66 ± 35.78 g·m
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14163329
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  9. Article ; Online: TANGO2 Deficiency Disorder: Two Cases of Developmental Delay Preceding Metabolic Crisis.

    Dias, Joana Valente / Carvalho, Ana Araújo / Freixo, João Parente / Antunes, Diana / Martins, Ana Antunes / Painho, Teresa / Jacinto, Sandra

    Pediatric neurology

    2023  Volume 147, Page(s) 52–55

    Abstract: Background: TANGO2 deficiency disorder is a rare genetic disease caused by biallelic defects in TANGO2 gene.: Methods: We report the clinical phenotype of two children with TANGO2 deficiency disorder.: Results: Patient 1 is a female child ... ...

    Abstract Background: TANGO2 deficiency disorder is a rare genetic disease caused by biallelic defects in TANGO2 gene.
    Methods: We report the clinical phenotype of two children with TANGO2 deficiency disorder.
    Results: Patient 1 is a female child presenting with developmental delay and microcephaly during the second year of life, who evolved with severe cognitive impairment, facial dysmorphisms, spastic paraparesis, and atonic seizures. At age 13 years, she was hospitalized due to an episode of rhabdomyolysis complicated with cardiac arrhythmia and hypothyroidism. Patient 2 is a female child with dysmorphic facial features, cleft palate, and developmental delay who was diagnosed with DiGeorge syndrome. At age three years, she presented with an acute episode of severe rhabdomyolysis in the context of human herpesvirus 6 infection. After the resolution of this acute episode, she maintained recurrent muscle weakness with axial hypotonia and progressive spasticity of the lower extremities. In both patients, diagnosis of TANGO2 deficiency disorder was only confirmed after an acute metabolic crisis.
    Conclusions: A high index of suspicion for TANGO2 deficiency disorder is needed in patients with developmental delay or other neurological symptoms and episodic rhabdomyolysis.
    MeSH term(s) Child ; Humans ; Female ; Adolescent ; Child, Preschool ; Microcephaly/complications ; Microcephaly/genetics ; Seizures ; Phenotype ; DiGeorge Syndrome ; Rhabdomyolysis/etiology ; Rhabdomyolysis/genetics
    Language English
    Publishing date 2023-07-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2023.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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