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Article ; Online: Thymoquinone potentiates anti-cancer effects of cisplatin in oral squamous cell carcinoma via targeting oxidative stress.

Fath, Mohsen Karami / Nasiri, Kamyar / Ghasemzadeh, Shabnam / Nejati, Seyedeh Tabasom / Ghafari, Nima / Masouleh, Sahand Saeidpour / Dadgar, Esmaeel / Kazemi, Kimia Sadat / Esfahaniani, Mahla

Chemical biology & drug design

2024 Volume 103, Issue 3, Page(s) e14492

Abstract: Recent evidence has proved that thymoquinone as a natural polyphenol has great anticancer and anti-proliferative effects in cancer cells. In this study, we aimed to examine the effects of thymoquinone on increasing cisplatin-induced apoptosis human oral ... ...

Abstract	Recent evidence has proved that thymoquinone as a natural polyphenol has great anticancer and anti-proliferative effects in cancer cells. In this study, we aimed to examine the effects of thymoquinone on increasing cisplatin-induced apoptosis human oral squamous cell carcinoma cells and its underlying molecular mechanisms. SCC-25 cancer cells treated by thymoquinone and cisplatin with different concentrations. Cell viability will determine by using MTT assay. The concentrations of reactive oxygen species (ROS) and antioxidant activities were determined using specific related kits. DNA damage, lipid, and protein oxidation were assessed. Real-time PCR and Western blot analysis will be used to determine the expression of apoptosis-related proteins including Bax, Bcl-2, and caspase-3. Combination of thymoquinone and cisplatin suppressed synergistically SCC-25 cancer cell viability and induced apoptosis in dose-depended manner. Cell treatment with combination of thymoquinone and cisplatin led to accumulation of ROS within cells and increase in the intracellular levels of DNA damage, protein and lipid peroxidation. In addition, the combination of thymoquinone and cisplatin modulated the mRNA and protein expression levels of apoptosis-related proteins including Bax, Bcl-2, and caspase-3. Thymoquinone potentiated cisplatin anti-cancer effect on OSCC by inducing oxidative stress in cells.
MeSH term(s)	Humans ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Squamous Cell Carcinoma of Head and Neck ; Caspase 3/genetics ; Caspase 3/metabolism ; Reactive Oxygen Species/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; Mouth Neoplasms/drug therapy ; Apoptosis ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Apoptosis Regulatory Proteins/metabolism ; Oxidative Stress ; Head and Neck Neoplasms ; Cell Line, Tumor ; Benzoquinones
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Caspase 3 (EC 3.4.22.-) ; thymoquinone (O60IE26NUF) ; Reactive Oxygen Species ; bcl-2-Associated X Protein ; Proto-Oncogene Proteins c-bcl-2 ; Apoptosis Regulatory Proteins ; Benzoquinones
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2216600-2
ISSN	1747-0285 ; 1747-0277
ISSN (online)	1747-0285
ISSN	1747-0277
DOI	10.1111/cbdd.14492
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Article ; Online: Clodronic Acid has Strong Inhibitory Interactions with the Urease Enzyme of Helicobacter Pylori: Computer-aided Design and in vitro Confirmation.

Fath, Mohsen Karami / Khalili, Saeed / Boojar, Masoud Mashhadi Akbar / Hashemi, Zahra Sadat / Zarei, Mahboubeh

Current computer-aided drug design

2023

Abstract: Background: Helicobacter Pylori (HP) infection could lead to various gastrointestinal diseases. Urease is the most important virulence factor of HP. It protects the bacterium against gastric acid.: Objective: Therefore, we aimed to design urease ... ...

Abstract	Background: Helicobacter Pylori (HP) infection could lead to various gastrointestinal diseases. Urease is the most important virulence factor of HP. It protects the bacterium against gastric acid. Objective: Therefore, we aimed to design urease inhibitors as drugs against HP infection. Methods: The DrugBank-approved library was assigned with 3D conformations and the structure of the urease was prepared. Using a re-docking strategy, the proper settings were determined for docking by PyRx and GOLD software. Virtual screening was performed to select the best inhibitory drugs based on binding affinity, FitnessScore, and binding orientation to critical amino acids of the active site. The best inhibitory drug was then evaluated by IC50 and the diameter of the zone of inhibition for bacterial growth. Results: The structures of prepared drugs were screened against urease structure using the determined settings. Clodronic acid was determined to be the best-identified drug, due to higher PyRx binding energy, better GOLD FitnessScore, and interaction with critical amino acids of urease. In vitro results were also in line with the computational data. IC50 values of Clodronic acid and Acetohydroxamic Acid (AHA) were 29.78 ± 1.13 and 47.29 ± 2.06 μg/ml, respectively. Diameters of the zones of inhibition were 18 and 15 mm for Clodronic acid and AHA, respectively. Conclusion: Clodronic acid has better HP urease inhibition potential than AHA. Given its approved status, the development of a repurposed drug based on Clodronic acid would require less time and cost. Further, in vivo studies would unveil the efficacy of Clodronic acid as a urease inhibitor.
Language	English
Publishing date	2023-11-10
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6697
ISSN (online)	1875-6697
DOI	10.2174/0115734099271837231026064439
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Article ; Online: The role of hypoxia-inducible factors in breast cancer stem cell specification.

Karami Fath, Mohsen / Garousi, Setareh / Mottahedi, Mehran / Ghasemzadeh, Nasim / Salmani, Kiana / Olfati, Fatemeh / Beit Saeed, Miad / Sotoudeh, Sina / Barati, Ghasem

Pathology, research and practice

2023 Volume 243, Page(s) 154349

Abstract: Breast tumor is heterogeneous cancer with high morbidity and mortality rates, particularly in developing countries. Despite new efforts to reduce the breast cancer implications, the number of newly diagnosed cases is increasing worldwide. It is believed ... ...

Abstract	Breast tumor is heterogeneous cancer with high morbidity and mortality rates, particularly in developing countries. Despite new efforts to reduce the breast cancer implications, the number of newly diagnosed cases is increasing worldwide. It is believed that cancer stem cells (CSCs) are responsible for the implication of cancers including breast cancer. Although CSCs compose a small population in tumor bulks, they play a crucial role in tumor initiation, progression, metastasis, and chemotherapeutic resistance. These events are mediated by the hypoxia-inducible factor (HIF) pathway which regulates the transcription of genes involved in CSC maintenance and tumorigenesis. In this review, we discussed the mechanisms by which hypoxia- or chemotherapy-induced HIFs promote breast CSC specification.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Hypoxia/metabolism ; Carcinogenesis/metabolism ; Neoplastic Stem Cells/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Cell Line, Tumor ; Cell Hypoxia
Chemical Substances	Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2023-01-30
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154349
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Article ; Online: The therapeutic effect of MSCs and their extracellular vesicles on neuroblastoma.

Karami Fath, Mohsen / Bagherzadeh Torbati, Samaneh Mohammad / Saqagandomabadi, Vahid / Yousefi Afshar, Omid / Khalilzad, Mohammad / Abedi, Sara / Moliani, Afshin / Daneshdoust, Danyal / Barati, Ghasem

Progress in biophysics and molecular biology

2024 Volume 187, Page(s) 51–60

Abstract: Neuroblastoma is a common inflammatory-related cancer during infancy. Standard treatment modalities including surgical interventions, high-dose chemotherapy, radiotherapy, and immunotherapy are not able to increase survival rate and reduce tumor relapse ... ...

Abstract	Neuroblastoma is a common inflammatory-related cancer during infancy. Standard treatment modalities including surgical interventions, high-dose chemotherapy, radiotherapy, and immunotherapy are not able to increase survival rate and reduce tumor relapse in high-risk patients. Mesenchymal stem cells (MSCs) are known for their tumor-targeting and immunomodulating properties. MSCs could be engineered to express anticancer agents (i.e., growth factors, cytokines, pro-apoptotic agents) or deliver oncolytic viruses in the tumor microenvironment. As many functions of MSCs are mediated through their secretome, researchers have tried to use extracellular vesicles (EVs) from MSCs for targeted therapy of neuroblastoma. Here, we reviewed the studies to figure out whether the use of MSCs could be worthwhile in neuroblastoma therapy or not. Native MSCs have shown a promoting or inhibiting role in cancers including neuroblastoma. Therefore, MSCs are proposed as a vehicle to deliver anticancer agents such as oncolytic viruses to the neuroblastoma tumor microenvironment. Although modified MSCs or their EVs have been shown to suppress the tumorigenesis of neuroblastoma, further pre-clinical and clinical studies are required to come to a conclusion.
MeSH term(s)	Humans ; Oncolytic Viruses ; Neuroblastoma/therapy ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Mesenchymal Stem Cells/metabolism ; Antineoplastic Agents ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/pathology ; Tumor Microenvironment
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	209302-9
ISSN	1873-1732 ; 0079-6107
ISSN (online)	1873-1732
ISSN	0079-6107
DOI	10.1016/j.pbiomolbio.2024.02.004
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Article ; Online: Roles of Mesenchymal Stem Cells in Breast Cancer Therapy: Engineered Stem Cells and Exosomal Cell-Free Based Therapy.

Fath, Mohsen Karami / Zadian, Seyed Sajjad / Torbati, Samaneh Mohammad Bagherzadeh / Saqagandomabadi, Vahid / Afshar, Omid Yousefi / Khalilzad, Mohammad / Abedi, Sara / Moliani, Afshin / Barati, Ghasem

Current molecular medicine

2024

Abstract: Breast cancer has a high prevalence among women, with a high mortality rate. The number of people who suffer from breast cancer disease is increasing, whereas metastatic cancers are mostly incurable, and existing therapies have unfavorable side effects. ... ...

Abstract	Breast cancer has a high prevalence among women, with a high mortality rate. The number of people who suffer from breast cancer disease is increasing, whereas metastatic cancers are mostly incurable, and existing therapies have unfavorable side effects. For an extended duration, scientists have dedicated their efforts to exploring the potential of mesenchymal stem cells (MSCs) for the treatment of metastatic cancers, including breast cancer. MSCs could be genetically engineered to boost their anticancer potency. Furthermore, MSCs can transport oncolytic viruses, suicide genes, and anticancer medicines to tumors. Extracellular vesicles (EVs) are MSC products that have attracted scientist's attention as a cell-free treatment. This study narratively reviews the current state of knowledge on engineered MSCs and their EVs as promising treatments for breast cancer.
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064873-X
ISSN	1875-5666 ; 1566-5240
ISSN (online)	1875-5666
ISSN	1566-5240
DOI	10.2174/0115665240274818231207054037
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Article ; Online: Evaluation of Differentiation Quality of Several Differentiation Inducers of Bone Marrow-derived Mesenchymal Stem Cells to Nerve Cells by Assessing Expression of Beta-tubulin 3 Marker: A Systematic Review.

Fath, Mohsen Karami / Zahedi, Farhad / Hashemi, Zahra Sadat / Khalili, Saeed

Current stem cell research & therapy

2021 Volume 16, Issue 8, Page(s) 994–1004

Abstract: Neurological diseases have different etiological causes. Contemporary, developing an effective treatment for these diseases is an ongoing challenge. Cell therapy is recognized as one of the promising solutions for the treatment of these diseases. Amongst ...

Abstract	Neurological diseases have different etiological causes. Contemporary, developing an effective treatment for these diseases is an ongoing challenge. Cell therapy is recognized as one of the promising solutions for the treatment of these diseases. Amongst various types of stem cells, bone marrow-derived mesenchymal stem cells (BM-MSC) are known to be the most widely used stem cells. These cells are endowed with appealing properties such as the ability to differentiate into other cell types, including the muscle, liver, glial, and nerve cells. In this review study, we have systematically evaluated the ability of a variety of chemical compounds used in the last ten years to differentiate BM-MSCs into neurons by examining the expression level of beta-tubulin 3 protein. The present study is a systematic search performed at three separate databases, including PubMed, ScienceDirect, and Embase from August 2009 to August 2019. The search results in the three mentioned databases were 323 articles and finally, 8 articles were selected and carefully examined considering the inclusion and exclusion criteria. The results showed that different chemical compounds such as ROCK inhibitors, sex steroid hormones, bFGF, NGF, Noggin, 4 OHT, TSA, VPA, Antidepressants, Neurosteroids (Dex and E2), and DHA are involved in different signaling pathways, such as ERK, AKT, BMP, DHA / GPR40, Rho-dependent phosphorylation, and histone deacetylase inhibitors. Further investigation of these signaling pathways may open the way for better differentiation of BM-MSCs into neurons.
MeSH term(s)	Bone Marrow ; Bone Marrow Cells ; Cell Differentiation ; Humans ; Mesenchymal Stem Cells/cytology ; Neurons/cytology ; Tubulin/analysis
Chemical Substances	Tubulin
Language	English
Publishing date	2021-03-02
Publishing country	United Arab Emirates
Document type	Journal Article ; Systematic Review
ZDB-ID	2251937-3
ISSN	2212-3946 ; 1574-888X
ISSN (online)	2212-3946
ISSN	1574-888X
DOI	10.2174/1574888X16666210303150814
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Article ; Online: Hypoxia-circular RNA crosstalk to promote breast cancer.

Karami Fath, Mohsen / Shafieyari, Saba / Ardalani, Nasim / Moumivand, Farzane / Kaviani Charati, Hossein / Zareei, Mohammad / Mansoori Nia, Arash / Zokaei, Maryam / Barati, Ghasem

Pathology, research and practice

2023 Volume 244, Page(s) 154402

Abstract: The expression of hypoxia-inducible factors (HIFs), particularly HIF-1, plays a major role in the adaptation of solid tumors to hypoxic conditions. The activation of the HIF pathway results in an expression of genes involved in the promotion of cell ... ...

Abstract	The expression of hypoxia-inducible factors (HIFs), particularly HIF-1, plays a major role in the adaptation of solid tumors to hypoxic conditions. The activation of the HIF pathway results in an expression of genes involved in the promotion of cell growth, proliferation, vascularization, metastasis, and therapeutic resistance. Circular RNA (CircRNA) is considered as a major regulator of gene expression. CircRNAs could regulate the HIF-1 pathway in cancer cells. In addition, they might be regulated by the HIF-1 pathway to promote cancer progression. Therefore, the crosstalk between hypoxia and circRNA might be involved in the pathogenesis of cancers, including breast cancer. In this review, we discussed the function of HIF-related circRNAs in the progression, angiogenesis, metabolic reprogramming, and stemness maintenance of breast cancer. In addition, the correlation between HIF-related circRNAs and clinical features of breast cancer is reviewed.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; RNA, Circular/genetics ; Hypoxia/metabolism ; Neovascularization, Pathologic/genetics ; Cell Proliferation ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Gene Expression Regulation, Neoplastic/genetics
Chemical Substances	RNA, Circular ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2023-03-05
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154402
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Article ; Online: Recent advancements to engineer mesenchymal stem cells and their extracellular vesicles for targeting and destroying tumors.

Karami Fath, Mohsen / Moayedi Banan, Zahra / Barati, Reza / Mohammadrezakhani, Omid / Ghaderi, Aliasghar / Hatami, Ali / Ghiabi, Shamim / Zeidi, Nazanin / Asgari, Katayoon / Payandeh, Zahra / Barati, Ghasem

Progress in biophysics and molecular biology

2023 Volume 178, Page(s) 1–16

Abstract: Mesenchymal stem cells (MSCs) have the ability to migrate into tumor sites and release growth factors to modulate the tumor microenvironment. MSC therapy have shown a dual role in cancers, promoting or inhibiting. However, MSCs could be used as a carrier ...

Abstract	Mesenchymal stem cells (MSCs) have the ability to migrate into tumor sites and release growth factors to modulate the tumor microenvironment. MSC therapy have shown a dual role in cancers, promoting or inhibiting. However, MSCs could be used as a carrier of anticancer agents for targeted tumor therapy. Recent technical improvements also allow engineering MSCs to improve tumor-targeting properties, protect anticancer agents, and decrease the cytotoxicity of drugs. While some of MSC functions are mediated through their secretome, MSCs-derived extracellular vesicles (EVs) are also proposed as a possible viechle for cancer therapy. EVs allow efficient loading of anticancer agents and have an intrinsic ability to target tumor cells, making them suitable for targeted therapy of tumors. In addition, the specificity and selectivity of EVs to the tumor sites could be enhanced by surface modification. In this review, we addressed the current approaches used for engineering MSCs and EVs to effectively target tumor sites and deliver anticancer agents.
MeSH term(s)	Humans ; Extracellular Vesicles/metabolism ; Mesenchymal Stem Cells/metabolism ; Neoplasms/metabolism ; Antineoplastic Agents ; Tumor Microenvironment
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-02-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	209302-9
ISSN	1873-1732 ; 0079-6107
ISSN (online)	1873-1732
ISSN	0079-6107
DOI	10.1016/j.pbiomolbio.2023.02.001
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Article ; Online: The functional role of circular RNAs in the pathogenesis of retinoblastoma: a new potential biomarker and therapeutic target?

Karami Fath, Mohsen / Pourbagher Benam, Sasan / Kouhi Esfahani, Niloofar / Shahkarami, Negar / Shafa, Shahriyar / Bagheri, Hossein / Shafagh, Seyyed-Ghavam / Payandeh, Zahra / Barati, Ghasem

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2023 Volume 25, Issue 8, Page(s) 2350–2364

Abstract: Retinoblastoma (RB) is a common cancer in infants and children. It is a curable disease; however, a delayed diagnosis or treatment makes the treatment difficult. Genetic mutations have a central role in the pathogenesis of RB. Genetic materials such as ... ...

Abstract	Retinoblastoma (RB) is a common cancer in infants and children. It is a curable disease; however, a delayed diagnosis or treatment makes the treatment difficult. Genetic mutations have a central role in the pathogenesis of RB. Genetic materials such as RNAs (coding and non-coding RNAs) are also involved in the progression of the tumor. Circular RNA (circRNA) is the most recently identified RNA and is involved in regulating gene expression mainly through "microRNA sponges". The dysregulation of circRNAs has been observed in several diseases and tumors. Also, various studies have shown that circRNAs expression is changed in RB tissues. Due to their role in the pathogenesis of the disease, circRNAs might be helpful as a diagnostic or prognostic biomarker in patients with RB. In addition, circRNAs could be a suitable therapeutic target to treat RB in a targeted therapy approach.
MeSH term(s)	Child ; Infant ; Humans ; RNA, Circular/genetics ; Retinoblastoma/genetics ; Retinoblastoma/therapy ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Biomarkers ; Retinal Neoplasms/genetics ; Retinal Neoplasms/therapy
Chemical Substances	RNA, Circular ; MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-03-31
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-023-03144-2
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Article: Current understanding of epigenetics role in melanoma treatment and resistance.

Karami Fath, Mohsen / Azargoonjahromi, Ali / Soofi, Asma / Almasi, Faezeh / Hosseinzadeh, Shahnaz / Khalili, Saeed / Sheikhi, Kamran / Ferdousmakan, Saeid / Owrangi, Soroor / Fahimi, Minoovash / Zalpoor, Hamidreza / Nabi Afjadi, Mohsen / Payandeh, Zahra / Pourzardosht, Navid

Cancer cell international

2022 Volume 22, Issue 1, Page(s) 313

Abstract: Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in melanocytes. Several factors have been considered to be involved in melanoma progression, including genetic alteration, processes of damaged DNA repair, and changes ... ...

Abstract	Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in melanocytes. Several factors have been considered to be involved in melanoma progression, including genetic alteration, processes of damaged DNA repair, and changes in mechanisms of cell growth and proliferation. Epigenetics is the other factor with a crucial role in melanoma development. Epigenetic changes have become novel targets for treating patients suffering from melanoma. These changes can alter the expression of microRNAs and their interaction with target genes, which involves cell growth, differentiation, or even death. Given these circumstances, we conducted the present review to discuss the melanoma risk factors and represent the current knowledge about the factors related to its etiopathogenesis. Moreover, various epigenetic pathways, which are involved in melanoma progression, treatment, and chemo-resistance, as well as employed epigenetic factors as a solution to the problems, will be discussed in detail.
Language	English
Publishing date	2022-10-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-022-02738-0
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