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  1. Article ; Online: Purification of andibenin and a chromanone analogue from rhizospheric

    Khattak, Saeed Ullah / Iqbal, Zafar / Ahmad, Jamshaid / Shi, Yanbin / Rehman, Irshad Ur

    Mycologia

    2024  , Page(s) 1–15

    Abstract: The discovery of bioactive compounds from fungal natural sources holds immense potential for the development of novel therapeutics. The present study investigates the extracts of soil- ... ...

    Abstract The discovery of bioactive compounds from fungal natural sources holds immense potential for the development of novel therapeutics. The present study investigates the extracts of soil-borne
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 281335-x
    ISSN 1557-2536 ; 0027-5514
    ISSN (online) 1557-2536
    ISSN 0027-5514
    DOI 10.1080/00275514.2024.2324620
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1291: Show issues Location:
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  2. Article ; Online: Uptake, translocation, and nutrient efficiency of nano-bonechar as a plant growth regulator in hydroponics and soil systems.

    Shahid, Saher / Imtiaz, Hina / Rashid, Jamshaid / Xu, Ming / Vithanage, Meththika / Ahmad, Mahtab

    Environmental research

    2024  Volume 251, Issue Pt 2, Page(s) 118695

    Abstract: The use of nanotechnology in terms of nanoparticles, carbon nanotubes, and quantum dots, when exposed to the plants, helps increase their productivity. It is worth the effort to comprehend the fate of these nanoparticles in plants. Bonechar derived from ... ...

    Abstract The use of nanotechnology in terms of nanoparticles, carbon nanotubes, and quantum dots, when exposed to the plants, helps increase their productivity. It is worth the effort to comprehend the fate of these nanoparticles in plants. Bonechar derived from bones is a rich source of C, P, Ca
    Language English
    Publishing date 2024-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
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  3. Article ; Online: Preparation and Evaluation of a Self-Emulsifying Drug Delivery System for Improving the Solubility and Permeability of Ticagrelor.

    Aziz, Anam / Zaman, Muhammad / Khan, Mahtab Ahmad / Jamshaid, Talha / Butt, Muhammad Hammad / Hameed, Huma / Rahman, Muhammad Shafeeq Ur / Shoaib, Qurat-Ul-Ain

    ACS omega

    2024  Volume 9, Issue 9, Page(s) 10522–10538

    Abstract: Ticagrelor (TCG) is a BCS class IV antiplatelet drug used to prevent platelet aggregation in patients with acute coronary syndrome, having poor solubility and permeability. The goal of this study was to develop a self-nanoemulsifying drug delivery system ...

    Abstract Ticagrelor (TCG) is a BCS class IV antiplatelet drug used to prevent platelet aggregation in patients with acute coronary syndrome, having poor solubility and permeability. The goal of this study was to develop a self-nanoemulsifying drug delivery system (SNEDDS) of TCG to improve its solubility and permeability. The excipients were selected based on the maximum solubility of TCG and observed by UV spectrophotometer. Different combinations of oil, surfactant, and co-surfactant (1:1, 2:1, and 3:1) were used to prepare TCG-SNEDDS formulations, and pseudo-ternary phase diagrams were plotted. The nanoemulsion region was observed. Clove oil (10-20%), Tween-80 (45-70%), and PEG-400 (20-45%) were used as an oil, surfactant, and co-surfactant, respectively. The selected formulations (F1, F2, F3, F4, F5, and F6) were analyzed for ζ potential, polydispersity index (PDI), ζ size, self-emulsification test, cloud point determination, thermodynamic studies, entrapment efficiency, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), scanning electron microscopy (SEM),
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Illicit sale of controlled drugs at community pharmacy/medical stores of Punjab, Pakistan: A road to demolition of public health.

    Bashir, Irfan / Ahmad, Mahmood / Jamshaid, Muhammad / Zaman, Muhammad

    Heliyon

    2021  Volume 7, Issue 5, Page(s) e07031

    Abstract: Sale of controlled drugs without prescription is a burning issue in developing countries like Pakistan. Illicit sale practices lead towards drug abuse and misuse among youngsters and negatively impact the health of youth and economy of any country. ... ...

    Abstract Sale of controlled drugs without prescription is a burning issue in developing countries like Pakistan. Illicit sale practices lead towards drug abuse and misuse among youngsters and negatively impact the health of youth and economy of any country. Present study aims to highlight the illicit sale practices at community pharmacies/drug stores of Punjab, Pakistan. Study was conducted at community pharmacies/drug stores (n = 200) of Punjab, Pakistan. Sales men at pharmacies/drugs stores were interviewed and then their statements were cross verified by sending fake customers at their community pharmacies to check the extent of illicit sale practices by them. Gathered data was analyzed using SPPS-22. Out of 200 pharmacies, pharmacists were physically present at 5% of pharmacies (n = 200), rest of the 95% pharmacies (n = 190) were being run by non-qualified persons and were found to be engaged in illicit sale practices. Controlled drugs were being provided to customers without prescription, which is a dilemma and need to be addressed for effective policy making. Physical presence of pharmacists at community pharmacies/drug stores is necessary to overcome the illicit sale practices. Effective policy must be developed and implemented by Governmental Authorities to prevent the youth from hazards associated with drug abuse and misuse.
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e07031
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  5. Article ; Online: In-silico investigation of RPS6KB1 associated cancer inhibitor: a drug repurposing study.

    Rajendrasozhan, Saravanan / Ahmad, Irfan / Obaidur Rab, Safia / Alshahrani, Mohammad Y / Abdullah Almuqri, Eman / Ahmad Siddiqui, Jamshaid / Mushtaque, Md

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–8

    Abstract: The ribosomal protein S6 kinase beta-1 (RPS6KB1), also known as p70S6 kinase, plays a crucial role in various disease-related conditions such as diabetes, obesity, and cancer. Its activity is regulated by phosphorylation events, including phosphorylation ...

    Abstract The ribosomal protein S6 kinase beta-1 (RPS6KB1), also known as p70S6 kinase, plays a crucial role in various disease-related conditions such as diabetes, obesity, and cancer. Its activity is regulated by phosphorylation events, including phosphorylation of Threonine 389 in the hydrophobic motif by the mammalian target of rapamycin complex 1 (mTORC1) and phosphorylation of Threonine 229 in the activation loop by PDK1 (phosphoinositide-dependent kinase 1). However, other phenomena connected to RPS6KB1 remain unknown. In this study, we employed virtual screening and molecular docking techniques on the molecules in the ZINC library to identify potential inhibitors. Molecular dynamics (MD) simulations and MMGBSA calculations were carried out on promising compounds to determine their binding affinity and stability. We also evaluated the drug-likeness properties of the selected compounds. A comparative study between the native RPS6KB1 structure, co-crystal ligands, and the shortlisted molecules from the ZINC dataset was carried out. The identified molecules possess significant potential for future
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2304679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
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  6. Article ; Online: A Review Of Mri Appearances Of Lipiodol In Conventional Tace (Ctace) Treated Hepatocellular Carcinomas.

    Khan, Zahid Amin / Rana, Atif Iqbal / Rauf, Maria / Anwar, Jamshaid / Ali, Haider / Afzal, Ahmad Ammar

    Journal of Ayub Medical College, Abbottabad : JAMC

    2024  Volume 35Suppl 1, Issue 4, Page(s) S740–S745

    Abstract: Background: The global burden of patients affected by chronic liver disease (CLD) has shown a steady rise over the last few decades and is now considered the 11th most frequent cause of death globally. In addition, as the world population is facing ... ...

    Abstract Background: The global burden of patients affected by chronic liver disease (CLD) has shown a steady rise over the last few decades and is now considered the 11th most frequent cause of death globally. In addition, as the world population is facing increased obesity rates coupled with alcohol consumption, these rates are predicted to continue to rise. The Objective was to assess the appearance of Lipiodol retention upon different MRI sequences with a special focus on non-contrast sequences. Lipiodol Trans-arterial chemoembolization (TACE) has become the standard treatment for unresectable hepatocellular carcinoma (HCC) without vascular invasion. However, data regarding Lipiodol TACE imaging via MRI is limited and results are not familiar to radiologists for regular assessment of treatment response.
    Methods: After IRB and EC approval, we included all those patients who underwent TACE treatment with Lipiodol and chemotherapeutic agent; having both 4-6-week post-treatment CT and MRI imaging. This criterion was fulfilled by a total of 25 patients. Only lipiodol-containing areas within the lesion were noted for signal intensities on all MRI sequences and labelled as hyperintense, isointense, hypointense and mixed intensity. Data was entered and analyzed by SPSS v27. Frequencies and percentages were calculated for qualitative data.
    Results: The most sensitive sequence in detecting Lipiodol retention was Fat suppressed T1 imaging sequence, with low signal intensity seen on T1 weighted fat-suppressed sequences in up to 76% of lesions. While on non-fat suppressed T1 weighted images, 60% of Lipiodol retention areas appeared hyperintense. 52% of lesions showed a hypointense appearance on the T2 weighted sequence. A much more variable appearance was seen in Diffusion-weighted imaging sequences demanding cautious interpretation. MR patterns were clearer in patients having more than 50% lipiodol retention on CT and lesion size more than 2 cm. .
    Conclusion: While MRI is deemed as a reliable and most useful imaging modality for assessing HCC's following lipiodol TACE it requires cautious interpretation with knowledge of variable signal appearance seen on different imaging sequences.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/therapy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/therapy ; Ethiodized Oil/therapeutic use ; Chemoembolization, Therapeutic/methods ; Magnetic Resonance Imaging/methods ; Chlorotrianisene
    Chemical Substances Ethiodized Oil (8008-53-5) ; Chlorotrianisene (6V5034L121)
    Language English
    Publishing date 2024-02-26
    Publishing country Pakistan
    Document type Review ; Journal Article
    ZDB-ID 2192473-9
    ISSN 1819-2718 ; 1025-9589
    ISSN (online) 1819-2718
    ISSN 1025-9589
    DOI 10.55519/JAMC-S4-11966
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    Zs.A 6109: Show issues Location:
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  7. Article ; Online: Correction to: Cyclic guanosine monophosphate improves salt tolerance in Solanum lycopersicum.

    Bibi, Gulnaz / Shafique, Iqra / Ali, Sartaj / Ahmad, Raza / Shah, Mohammad Maroof / Naqvi, Tatheer Alam / Zeb, Iftikhar / Maathuis, Frans J M / Hussain, Jamshaid

    Journal of plant research

    2023  Volume 137, Issue 1, Page(s) 159–160

    Language English
    Publishing date 2023-10-03
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 2077362-6
    ISSN 1618-0860 ; 0918-9440
    ISSN (online) 1618-0860
    ISSN 0918-9440
    DOI 10.1007/s10265-023-01497-x
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  8. Article ; Online: Parametric optimization of durable sheeting fabric using Taguchi Grey Relational Analysis

    Hafsa Jamshaid / Naseer Ahmad / Uzair Hussain / Rajesh Mishra

    Journal of King Saud University: Science, Vol 34, Iss 4, Pp 102004- (2022)

    2022  

    Abstract: Objectives: The present work describes the application of Taguchi Grey Relational Analysis in order to optimize the durability of sheeting fabrics. The existing study investigates the multi-response optimization of certain parameters of yarn process ... ...

    Abstract Objectives: The present work describes the application of Taguchi Grey Relational Analysis in order to optimize the durability of sheeting fabrics. The existing study investigates the multi-response optimization of certain parameters of yarn process including FL, RS and RT on tensile strength, tear strength and abrasion resistance of durable fabric sheets after washing. Methods: In the development process L9 orthogonal array in Taguchi design was used. The results have been analyzed by using statistical multi-response optimization technique, grey relational analysis to set the process parameters and to decide the simultaneous optimization of responses including tensile strength, tear strength and abrasion resistance. In addition, the analysis of variance (ANOVA) was used to determine the most significant factors. Reference sheeting fabric with same construction parameters was also tested. Results: The results show a greater improvement in parameters of developed samples quality. The experimental results show parameter fiber length has the most significant effect on the multiple performance characteristics. Conclusions: The developed fabric sheet having durable life would help to reduce consumption of resources of both consumers and manufacturers. Manufacturers can have great chance to establish their image and can increase the profit margin over products. Therefore, the integration of grey relational analysis and the Taguchi Method can be applicable for the optimization of process parameters and help to conserve resources by extending the lifetime of sheeting fabrics.
    Keywords Durability ; Sheeting fabrics ; Ring yarn ; Resource conservation ; Taguchi method ; Grey relational analysis ; Science (General) ; Q1-390
    Subject code 600
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  9. Article ; Online: Exploration of Effects of Graduated Compression Stocking Structures on Performance Properties Using Principal Component Analysis: A Promising Method for Simultaneous Optimization of Properties.

    Jamshaid, Hafsa / Mishra, Rajesh Kumar / Ahmad, Naseer / Nadeem, Muhammad / Muller, Miroslav / Kolar, Viktor

    Polymers

    2022  Volume 14, Issue 10

    Abstract: This paper focuses on the comfort properties of graduated and preventive compression stockings for people who work long hours in standing postures and for athletes for proper blood circulation. The present study was conducted in order to investigate the ... ...

    Abstract This paper focuses on the comfort properties of graduated and preventive compression stockings for people who work long hours in standing postures and for athletes for proper blood circulation. The present study was conducted in order to investigate the effects of the yarn insertion density and inlaid stitches on the performance of the compression stockings. The effects of these parameters on the thermo-physiological comfort properties were tested with standard and developed methods of testing. All compression stockings were maintained with class 1 pressure as per German standards. The structural parameters of the knitted fabric structures were investigated. The stretching and recovery properties were also investigated to determine the performance properties. The theoretical pressure was predicated using the Laplace's law by testing the stockings' tensile properties. The compression interface pressures of all stockings were also investigated using a medical stocking tester (MST) from Salzmann AG, St. Gallen, Switzerland. Correlation between the theoretical pressures and pressures measured using the MST system were also assessed. The current research used a multi-response optimization technique, i.e., principal component analysis (PCA), to identify the best structure based on the optimalization of the above-mentioned properties. The results also revealed that samples with higher insertion density levels exhibit better comfort properties. The results showed that sample R1 was the best sample, followed by R2 and P. In addition, all developed stocking samples exhibited better comfort properties than the control sample from the market.
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14102045
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  10. Article: Current Status and the Epidemiology of Malaria in the Middle East Region and Beyond.

    Al-Awadhi, Mohammad / Ahmad, Suhail / Iqbal, Jamshaid

    Microorganisms

    2021  Volume 9, Issue 2

    Abstract: Vector-borne parasitic infectious diseases are important causes of morbidity and mortality globally. Malaria is one of the most common vector-borne parasitic infection and is caused by ... ...

    Abstract Vector-borne parasitic infectious diseases are important causes of morbidity and mortality globally. Malaria is one of the most common vector-borne parasitic infection and is caused by five
    Language English
    Publishing date 2021-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9020338
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