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  1. Article ; Online: Drug treatment of COVID-19 infection.

    Lui, Grace / Guaraldi, Giovanni

    Current opinion in pulmonary medicine

    2023  Volume 29, Issue 3, Page(s) 174–183

    Abstract: Purpose of review: COVID-19 pandemic has caused more than 6.6 million deaths globally. Tremendous efforts have been committed for the development of new and repurposed drugs for the treatment of COVID-19. Although different international and national ... ...

    Abstract Purpose of review: COVID-19 pandemic has caused more than 6.6 million deaths globally. Tremendous efforts have been committed for the development of new and repurposed drugs for the treatment of COVID-19. Although different international and national guidelines share consensus in the management of COVID-19 disease with different levels of severity, new challenges have emerged, steering the need for ongoing research in advancing the clinical management of COVID-19.
    Recent findings: This review focuses on recent data from randomized trials and postmarketing real-world evidence for the treatment of mild to moderate disease in the outpatient setting and patients hospitalized for COVID-19 with varying level of severity. Relevant data for treatment of the latest omicron sub-variants in people who received vaccination are presented. Challenges in special populations, including immunocompromised hosts, patients with renal failure and pregnant women, are also discussed.
    Summary: Treatment of COVID-19 should be personalized according to host characteristics, degree of severity and available treatment options.
    MeSH term(s) Female ; Humans ; Pregnancy ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/therapy ; COVID-19 Drug Treatment ; Pandemics ; SARS-CoV-2 ; Vaccination ; COVID-19 Vaccines/therapeutic use
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4900: Show issues Location:
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  2. Article ; Online: Letter: Rethinking the lower incidence of HCC in HIV-infected patients-A closer look at confounding factors. Authors' reply.

    Wong, Grace Lai-Hung / Hui, Vicki Wing-Ki / Hui, Yee-Tak / Lui, Grace Chung-Yan

    Alimentary pharmacology & therapeutics

    2023  Volume 58, Issue 9, Page(s) 958–959

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/epidemiology ; Liver Neoplasms/epidemiology ; Incidence ; HIV Infections/complications ; HIV Infections/epidemiology
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17713
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    Zs.A 2206: Show issues Location:
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  3. Article ; Online: Current practice and recommendations for management of hepatitis B virus in people living with HIV in Asia.

    Lui, Grace Chung-Yan / Wong, Grace Lai-Hung / Yang, Hung-Chih / Sheng, Wang-Huei / Lee, Sun Hee

    HIV medicine

    2023  Volume 24, Issue 10, Page(s) 1035–1044

    Abstract: Background: The prevalence of HIV and hepatitis B virus (HBV) co-infection is higher in Asia than in Europe and North America and varies significantly between different regions within Asia. Important routes of transmission of both these infections ... ...

    Abstract Background: The prevalence of HIV and hepatitis B virus (HBV) co-infection is higher in Asia than in Europe and North America and varies significantly between different regions within Asia. Important routes of transmission of both these infections include high-risk unprotected sexual contact, intravenous drug use, and transmission of maternal infection perinatally or in early childhood. While life expectancy among people living with HIV has been extended with effective antiretroviral therapy (ART), HBV-induced liver injury and complications have emerged as a leading cause of morbidity and mortality in people living with HIV.
    Objectives: This article describes the prevalence of co-infection, current clinical practice, and recommendations for the management of people living with HIV-HBV co-infection in Asia.
    Results and conclusions: Screening for HBV should occur at the time of HIV diagnosis; however, HBV screening rates in people living with HIV in Asia vary widely by region. Similarly, people with HBV should be screened for HIV before initiation of HBV antiviral therapy. People with HIV-HBV co-infection should be assessed for liver damage and risk factors for liver disease and be monitored regularly for liver complications and HBV DNA. Medical treatment with ART is lifelong and includes tenofovir and lamivudine or emtricitabine, unless intolerant or contraindicated, as these are active against both HIV and HBV. HBV vaccination programmes are effective in reducing co-infection rates. Mother-to-child transmission can be prevented through measures such as vaccination, antenatal screening, and treatment of pregnant women who are infected.
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001932-4
    ISSN 1468-1293 ; 1464-2662
    ISSN (online) 1468-1293
    ISSN 1464-2662
    DOI 10.1111/hiv.13545
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    Zs.A 5441: Show issues Location:
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  4. Article ; Online: Bacterial infections in patients with COVID-19: the impact of procalcitonin testing on antibiotics prescription in the real world.

    Lui, Grace Cy / Cheung, Catherine Sk / Yip, Terry Cf / Lai, Mandy Sm / Li, Timothy Cm / Wong, Grace Lh

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 106

    Abstract: Background: Bacterial infections are not prevalent among patients hospitalized with COVID-19, while unnecessary prescription of antibiotics was commonly observed. This study aimed to determine the impact of procalcitonin testing on antibiotics ... ...

    Abstract Background: Bacterial infections are not prevalent among patients hospitalized with COVID-19, while unnecessary prescription of antibiotics was commonly observed. This study aimed to determine the impact of procalcitonin testing on antibiotics prescription in the real-world setting.
    Methods: We performed a territory-wide retrospective cohort study involving all laboratory-confirmed patients hospitalized in public hospitals in Hong Kong in 2020 with COVID-19. We determined the prevalence of bacterial co-infections (documented infections within 72 h of admission) and secondary bacterial infections (infections after 72 h of admission) and antibiotics consumption, and the correlation between procalcitonin testing and antibiotics prescription.
    Results: The cohort included 8666 patients, with mean age 45.3 ± 19.9 years, 48.5% male, and comorbidities in 26.9%. Among 2688 patients with bacterial cultures performed, 147 (5.5%) had bacterial co-infections, and 222 (8.3%) had secondary bacterial infections. Antibiotics were prescribed for 2773 (32.0%) patients during the hospital admission. Procalcitonin tests were performed for 2543 (29.3%) patients. More patients with procalcitonin testing received antibiotics (65.9% vs. 17.9%, p < 0.001). Procalcitonin testing was associated with 5-fold increased risk of antibiotics prescription after adjusting for confounding variables. At hospital level, procalcitonin testing correlated with antibiotics prescription. Patients with procalcitonin level < 0.5 ng/mL had a lower probability of antibiotics initiation and shorter duration of antibiotics therapy.
    Conclusions: Procalcitonin testing was not associated with lower prescription of antibiotics. Patients with low procalcitonin level had lower antibiotics exposure, supporting the use of procalcitonin to exclude bacterial infections aiding early stopping of antibiotics among patients hospitalized with COVID-19.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Aged ; Female ; Procalcitonin ; Calcitonin ; COVID-19 ; Anti-Bacterial Agents/therapeutic use ; Coinfection/drug therapy ; Retrospective Studies ; Bacterial Infections/drug therapy ; Biomarkers
    Chemical Substances Procalcitonin ; Calcitonin (9007-12-9) ; Anti-Bacterial Agents ; Biomarkers
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08849-x
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  5. Article: Preclinical and clinical studies of a tumor targeting IL-12 immunocytokine.

    Minnar, Christine M / Lui, Grace / Gulley, James L / Schlom, Jeffrey / Gameiro, Sofia R

    Frontiers in oncology

    2024  Volume 13, Page(s) 1321318

    Abstract: The clinical success of immune checkpoint inhibitors (ICIs) has demonstrated the promise and challenges of cancer immunotherapy. There is an unmet need to develop novel cancer therapies that can provide clinical benefit for most patients with solid ... ...

    Abstract The clinical success of immune checkpoint inhibitors (ICIs) has demonstrated the promise and challenges of cancer immunotherapy. There is an unmet need to develop novel cancer therapies that can provide clinical benefit for most patients with solid malignancies, which harbor innate or acquired resistance to ICIs. Interleukin-12 (IL-12) is a promising cytokine for cancer therapy given its direct stimulatory effects on innate and adaptive immunity. However, unfavorable pharmacokinetics and a narrow therapeutic index render recombinant IL-12 (rIL-12) less attractive as a cancer therapy. NHS-IL12 is a fusion protein of IL-12 and NHS76 (human IgG1) antibody engineered to target single and double stranded DNA present in necrotic areas solid tumors. In preclinical tumor models, NHS-IL12 elicited significant Th1 immune activation and tumor suppressive effects, primarily mediated by NK and CD8
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1321318
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  6. Article ; Online: Efficient large-scale screening of viral pathogens by fragment length identification of pooled nucleic acid samples (FLIPNAS).

    Feng, Xianzhen / Zhuang, Xinyu / Lui, Grace / Hsing, I-Ming

    The Analyst

    2023  Volume 148, Issue 8, Page(s) 1743–1751

    Abstract: The necessity for the large-scale screening of viral pathogens has been amply demonstrated during the COVID-19 pandemic. During this time, SARS-CoV-2 nucleic acid pooled testing, such as Dorfman-based group testing, was widely adopted in response to the ... ...

    Abstract The necessity for the large-scale screening of viral pathogens has been amply demonstrated during the COVID-19 pandemic. During this time, SARS-CoV-2 nucleic acid pooled testing, such as Dorfman-based group testing, was widely adopted in response to the sudden increased demand for detection. However, the current approach still necessitates the individual retesting of positive pools. Here, we established an efficient method termed the fragment-length identification of pooled nucleic acid samples (FLIPNAS), where all subsamples (
    MeSH term(s) Humans ; COVID-19/diagnosis ; SARS-CoV-2 ; Pandemics ; Specimen Handling/methods ; Sensitivity and Specificity
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d3an00058c
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    Zs.A 2423: Show issues Location:
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  7. Article: Reply to Allaire, M.; Thabut, D. Comment on "Wu et al. Baveno VII Criteria Is an Accurate Risk Stratification Tool to Predict High-Risk Varices Requiring Intervention and Hepatic Events in Patients with Advanced Hepatocellular Carcinoma.

    Wu, Claudia Wing-Kwan / Yip, Terry Cheuk-Fung / Wong, Vincent Wai-Sun / Wong, Grace Lai-Hung / Liu, Ken / Lui, Rashid Nok-Shun

    Cancers

    2024  Volume 16, Issue 4

    Abstract: We thank Allaire et al [ ... ]. ...

    Abstract We thank Allaire et al [...].
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16040725
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  8. Article ; Online: Reply to Boglione et al.

    Lui, Grace C Y / Wong, Grace L H

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2019  Volume 71, Issue 6, Page(s) 1584–1585

    MeSH term(s) Antiviral Agents ; Coinfection ; Hepatitis B ; Humans ; Tuberculosis
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2019-12-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz1201
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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  9. Article ; Online: Exploiting an Interleukin-15 Heterodimeric Agonist (N803) for Effective Immunotherapy of Solid Malignancies.

    Lui, Grace / Minnar, Christine M / Soon-Shiong, Patrick / Schlom, Jeffrey / Gameiro, Sofia R

    Cells

    2023  Volume 12, Issue 12

    Abstract: Identifying effective immunotherapies for solid tumors remains challenging despite the significant clinical responses observed in subsets of patients treated with immune checkpoint inhibitors. Interleukin-15 (IL-15) is a promising cytokine for the ... ...

    Abstract Identifying effective immunotherapies for solid tumors remains challenging despite the significant clinical responses observed in subsets of patients treated with immune checkpoint inhibitors. Interleukin-15 (IL-15) is a promising cytokine for the treatment of cancer as it stimulates NK and CD8
    MeSH term(s) Humans ; BCG Vaccine ; Interleukin-15 ; Nivolumab ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Immune Checkpoint Inhibitors ; Lung Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology ; Mycobacterium bovis ; Immunotherapy
    Chemical Substances BCG Vaccine ; Interleukin-15 ; Nivolumab (31YO63LBSN) ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12121611
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  10. Article ; Online: Minimal Risk of Drug-Induced Liver Injury With Molnupiravir and Ritonavir-Boosted Nirmatrelvir.

    Wong, Grace Lai-Hung / Hui, Vicki Wing-Ki / Yip, Terry Cheuk-Fung / Lui, Grace Chung-Yan / Hui, David Shu-Cheong / Wong, Vincent Wai-Sun

    Gastroenterology

    2022  Volume 164, Issue 1, Page(s) 151–153

    MeSH term(s) Humans ; Ritonavir/adverse effects ; Hydroxylamines ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Antiviral Agents/adverse effects
    Chemical Substances molnupiravir (YA84KI1VEW) ; nirmatrelvir (7R9A5P7H32) ; Ritonavir (O3J8G9O825) ; Hydroxylamines ; Antiviral Agents
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Letter
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.09.008
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