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Book ; Online: Anal Incontinence

Docimo, Ludovico / Brusciano, Luigi

Clinical Management and Surgical Techniques

(Updates in Surgery)

2023

Series title	Updates in Surgery
Keywords	Surgery ; Gastroenterology ; Urology & urogenital medicine ; Neurosciences ; Life sciences: general issues ; Radiology ; Continence mechanism ; Fecal incontinence ; Pelviperineal disorders ; Anal sphincter ; Continence Surgery
Language	0\|e
Size	1 electronic resource (211 pages)
Publisher	Springer Nature
Publishing place	Cham
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021620056
ISBN	9783031083921 ; 303108392X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Ileostomy versus colostomy: impact on functional outcomes after total mesorectal excision for rectal cancer.

Martellucci, Jacopo / Balestri, Riccardo / Brusciano, Luigi / Iacopini, Veronica / Puccini, Marco / Docimo, Ludovico / Cianchi, Fabio / Buccianti, Piero / Prosperi, Paolo

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2023 Volume 25, Issue 8, Page(s) 1686–1693

Abstract: Aim: Even if a defunctioning stoma mitigates the serious consequences of anastomotic leakage after total mesorectal excision (TME) for rectal cancer, the presence of a temporary stoma or having a stoma for a prolonged period of time may also be a ... ...

Abstract	Aim: Even if a defunctioning stoma mitigates the serious consequences of anastomotic leakage after total mesorectal excision (TME) for rectal cancer, the presence of a temporary stoma or having a stoma for a prolonged period of time may also be a determining factor for further morbidities and poor bowel function. The aim of this study was to evaluate the impact of diverting stomas on clinical and functional outcomes after TME, comparing ileostomy or colostomy effects. Methods: All consecutive patients who underwent TME for rectal cancer between March 2017 and December 2020 in three Italian referral centres were enrolled in the present study. For every patient sex, age, stage of the tumour, neoadjuvant therapy, surgical technique, anastomotic technique, the presence of a diverting stoma, perioperative complications and functional postoperative status were recorded. Considering the diverting stoma, the kind of stoma, length of time before closure and stoma related complications were evaluated. Results: During the study period 416 consecutive patients (63% men) were included. Preoperative neoadjuvant therapy was performed in 79%. A minimally invasive approach was performed in >95% of patients. Temporary stoma was performed during the operation in 387 patients (93%) (ileostomy 71%, colostomy 21%). The stoma was closed in 84% of patients. The median time from surgery to stoma closure was 145 days. No difference was found between ileostomy and colostomy in overall morbidity after stoma creation and closure. Moreover, increased postoperative functional disturbance seemed to be significantly proportional to the attending time for closure for ileostomy. Conclusion: The presence of a defunctioning stoma seems to have a negative impact on functional bowel activity, especially for delayed closure for ileostomy. This should be considered when the kind of stoma (ileostomy vs. colostomy) is selected for each patient.
MeSH term(s)	Male ; Humans ; Female ; Ileostomy/adverse effects ; Colostomy/methods ; Surgical Stomas/pathology ; Rectal Neoplasms/pathology ; Anastomotic Leak/etiology ; Anastomosis, Surgical/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16657
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Article: De Novo Gastroesophageal Reflux Disease Symptoms Are Infrequent after Sleeve Gastrectomy at 2-Year Follow-Up Using a Comprehensive Preoperative Esophageal Assessment.

Tolone, Salvatore / Conzo, Giovanni / Flagiello, Luigi / Gambardella, Claudio / Lucido, Francesco Saverio / Brusciano, Luigi / Parisi, Simona / De Bortoli, Nicola / Savarino, Edoardo Vincenzo / Del Genio, Gianmattia / Docimo, Ludovico

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Pathological obesity is a growing public health concern, and its association with gastroesophageal reflux disease (GERD) poses challenges in selecting the appropriate bariatric procedure. Sleeve gastrectomy (SG) has become a popular choice due to its ... ...

Abstract	Pathological obesity is a growing public health concern, and its association with gastroesophageal reflux disease (GERD) poses challenges in selecting the appropriate bariatric procedure. Sleeve gastrectomy (SG) has become a popular choice due to its simplicity and effectiveness in weight loss. However, concerns regarding postoperative GERD have been raised. This study aimed to evaluate the association between preoperative assessment of esophageal function and the risk of developing postoperative GERD in patients undergoing SG. A comprehensive evaluation was conducted, including symptom assessment, upper endoscopy, high-resolution esophageal manometry (HRM), and 24 h esophageal pH impedance monitoring (MII-pH). A total of 500 obese patients were included, and their data were compared with 25 healthy volunteers. This study revealed that patients without GERD symptoms, normal endoscopy, HRM, and MII-pH were suitable candidates for SG, with low risk of developing postoperative GERD. The addition of fundoplication techniques to SG may be considered in patients with mild reflux or those at risk of developing it. This study emphasizes the importance of preoperative evaluation in selecting the appropriate bariatric procedure to minimize the risk of postoperative GERD and expand the indications for SG in obese patients.
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020545
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Article: One Anastomosis Gastric Bypass vs. Sleeve Gastrectomy in the Remission of Type 2 Diabetes Mellitus: A Retrospective Analysis on 3 Years of Follow-Up.

Gambardella, Claudio / Mongardini, Federico Maria / Paolicelli, Maddalena / Lucido, Francesco Saverio / Tolone, Salvatore / Brusciano, Luigi / Parisi, Simona / Esposito, Rosetta / Iovino, Francesco / Nazzaro, Luca / Pizza, Francesco / Docimo, Ludovico

Journal of clinical medicine

2024 Volume 13, Issue 3

Abstract: Background. ...

Abstract	Background.
Language	English
Publishing date	2024-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13030899
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Article ; Online: Rare axillary cancer of unknown primary originating from the breast of a 64‑year‑old male patient: A case report and literature review.

Parisi, Simona / Gambardella, Claudio / Ruggiero, Roberto / Tolone, Salvatore / Iovino, Francesco / Lucido, Francesco Saverio / Fisone, Francesca / Lanza Volpe, Mariachiara / Cozzolino, Giovanni / Mongardini, Federico Maria / Brusciano, Luigi / Andrea, Ronchi / Docimo, Ludovico

Oncology letters

2024 Volume 27, Issue 2, Page(s) 86

Abstract: Cancers of unknown primary (CUPs) are a heterogeneous group of tumors characterized by a difficult diagnosis. The primitive tumor remains unknown, whereas metastases are the most common manifestation. Occult male breast cancers are very rare types of ... ...

Abstract	Cancers of unknown primary (CUPs) are a heterogeneous group of tumors characterized by a difficult diagnosis. The primitive tumor remains unknown, whereas metastases are the most common manifestation. Occult male breast cancers are very rare types of CUPs. The present study describes the case of a 64-year-old man affected by a CUP of presumed mammary origin. The aim of the article and the present review was to focus on their management. To the best of our knowledge, only thirteen cases have been reported in the literature. Because no specific guidelines are available, various approaches have been applied, influencing the treatment and the prognosis of patients with CUP.
Language	English
Publishing date	2024-01-05
Publishing country	Greece
Document type	Case Reports
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2024.14220
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Article ; Online: The Dynamic Transperineal Ultrasound Era of the Evaluation of Obstructed Defecation Syndrome.

Martellucci, Jacopo / Brusciano, Luigi

Diseases of the colon and rectum

2016 Volume 59, Issue 8, Page(s) 800–803

MeSH term(s)	Constipation/diagnostic imaging ; Constipation/etiology ; Defecography ; Female ; Humans ; Intussusception/complications ; Intussusception/diagnostic imaging ; Magnetic Resonance Imaging ; Pelvic Floor/diagnostic imaging ; Pelvic Organ Prolapse/complications ; Pelvic Organ Prolapse/diagnostic imaging ; Perineum/diagnostic imaging ; Rectocele/complications ; Rectocele/diagnostic imaging ; Syndrome ; Ultrasonography
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1097/DCR.0000000000000586
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Article ; Online: IPOM plus versus IPOM standard in incisional hernia repair: results of a prospective multicenter trial.

Pizza, F / D'Antonio, D / Lucido, F S / Brusciano, L / Mongardini, F M / Dell'Isola, C / Brillantino, A / Docimo, L / Gambardella, C

Hernia : the journal of hernias and abdominal wall surgery

2023 Volume 27, Issue 3, Page(s) 695–704

Abstract: Purpose: Laparoscopic ventral hernia repair is a well-established technique with satisfying outcomes even at long term for the treatment of incisional and ventral hernia. However, the literature debate is still ongoing regarding the preferred surgical ... ...

Abstract	Purpose: Laparoscopic ventral hernia repair is a well-established technique with satisfying outcomes even at long term for the treatment of incisional and ventral hernia. However, the literature debate is still ongoing regarding the preferred surgical technique. Nowadays, two approaches are commonly adopted: the intraperitoneal onlay mesh repair (sIPOM) and the intraperitoneal onlay mesh reinforcement with defect closure before mesh placement (pIPOM). The aim of this prospective analysis is to compare the postoperative outcomes of patients treated for incisional hernia (IH) with sIPOM and pIPOM after 36 months follow-up in terms of recurrence, quality of life and wound events. Methods: Patients receiving pIPOM and sIPOM for IH were actively followed up for 36 months. At the outpatient clinic, hernia recurrence (HR), mesh bulging (MB), quality of life with the Gastrointestinal Quality of Life Index (GIQLI) and wound events were assessed. Results: Between January 2015 and January 2019, 98 patients underwent a pIPOM and 89 underwent an sIPOM. At 36 months, nine patients (4 in pIPOM and 5 in sIPOM) experienced an HR, while MB was recorded in four patients in pIPOM and nine in sIPOM. No statistically significant difference could be identified also in terms of final GIQLI score and wound events. Conclusions: LVHR with or without fascial closure, also in our study, provides satisfactory results in terms of safety and efficacy. The discordant results in the literature are probably related to independent variables such as the type of mesh, the type of suture and closure technique. Therefore, was the funeral of sIPOM done too early? STUDY DATASET IS AVAILABLE ON CLINICALTRIALS. Gov id: NCT05712213.
MeSH term(s)	Humans ; Hernia, Ventral/surgery ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Incisional Hernia/surgery ; Laparoscopy/methods ; Quality of Life ; Recurrence ; Surgical Mesh/adverse effects
Language	English
Publishing date	2023-05-07
Publishing country	France
Document type	Multicenter Study ; Journal Article
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-023-02802-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Safety and efficacy of topical drug-free cream in subjects with hemorrhoidal disease: a randomized, double blind, clinical trial.

Sturiale, Alessandro / Fralleone, Lisa / Cafaro, Danilo / Gallo, Gaetano / Brusciano, Luigi / Celedon Porzio, Felipe / Venkataratnaiah Setty, Sreedhara / Naldini, Gabriele

Minerva gastroenterology

2022 Volume 68, Issue 4, Page(s) 407–414

Abstract: Background: Hemorrhoidal disease (HD) is one of the most common anorectal benign disorder affecting millions of people around the world. Grade I-II HD are generally treated with a conservative approach with topical products such as creams and ointments ... ...

Abstract	Background: Hemorrhoidal disease (HD) is one of the most common anorectal benign disorder affecting millions of people around the world. Grade I-II HD are generally treated with a conservative approach with topical products such as creams and ointments considered a safe and effective option to treat mild symptoms. The aim of the present study was to assess the safety and efficacy of a topical medical device (Lenoid Methods: This study is a randomized, double blind, placebo-controlled, 2-weeks clinical trial. Patients affected by I-II grade symptomatic HD were enrolled in the study and then randomly assigned to Lenoid Results: A total of 68 patients were screened and 60 (30 in each group) were enrolled into the study. All patients belonging to LA showed a statistically significant improvement of each symptom after 7 and 14 days of treatment when compared to PA (P<0.001). Furthermore, subjective improvement of change in overall assessment of disease was observed in the LA but not in the PA. No serious adverse events were recorded. Conclusions: The tested product was found safe and effective in improving clinical signs and symptoms in patients with grade I-II HD.
Language	English
Publishing date	2022-05-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062713-8
ISSN	2724-5365
ISSN (online)	2724-5365
DOI	10.23736/S2724-5985.22.03173-4
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Article: Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review.

Parisi, Simona / Gambardella, Claudio / Iovino, Francesco / Ruggiero, Roberto / Lucido, Francesco Saverio / Nesta, Giusiana / Tolone, Salvatore / Brusciano, Luigi / Fisone, Francesca / Mongardini, Federico Maria / Cozzolino, Giovanni / Della Corte, Carminia Maria / Napolitano, Stefania / Orditura, Michele / Esposito, Rosetta / Docimo, Ludovico

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Breast angiosarcoma is a rare malignancy, accounting for less than 1% of all soft tissue cancers. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS). Despite multimodal treatment, angiosarcomas represent an ... ...

Abstract	Breast angiosarcoma is a rare malignancy, accounting for less than 1% of all soft tissue cancers. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS). Despite multimodal treatment, angiosarcomas represent an incurable disease for many patients and a significant cause of deterioration in their quality of life. Surgery is a cornerstone in management, but high recurrence rates are reported. Electrochemotherapy (ECT) is a practicable locoregional treatment for patients with advanced angiosarcoma as part of a multimodal therapeutic strategy. The palliative benefits of ECT include optimal patient compliance, good local hemostasis control, and positive local responses. Since only 22 cases are described in the literature, we reported a rare case of RAS treated with ECT after a multidisciplinary approach, including Next Generation Sequencing (NGS). A literature review on the feasibility of ECT in RAS management was also performed.
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020567
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Article ; Online: Role of Inflammatory Biomarkers (NLR, LMR, PLR) in the Prognostication of Malignancy in Indeterminate Thyroid Nodules.

Gambardella, Claudio / Mongardini, Federico Maria / Paolicelli, Maddalena / Bentivoglio, Davide / Cozzolino, Giovanni / Ruggiero, Roberto / Pizza, Alessandra / Tolone, Salvatore / Del Genio, Gianmattia / Parisi, Simona / Brusciano, Luigi / Cerbara, Loredana / Docimo, Ludovico / Lucido, Francesco Saverio

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: Indeterminate follicular thyroid lesions (Thyr 3A and 3B) account for 10% to 30% of all cytopathologic diagnoses, and their unpredictable behavior represents a hard clinical challenge. The possibility to preoperatively predict malignancy is largely ... ...

Abstract	Indeterminate follicular thyroid lesions (Thyr 3A and 3B) account for 10% to 30% of all cytopathologic diagnoses, and their unpredictable behavior represents a hard clinical challenge. The possibility to preoperatively predict malignancy is largely advocated to establish a tailored surgery, preventing diagnostic thyroidectomy. We analyzed the role of the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR) and the lymphocyte-to-monocyte ratio (LMR) as prognostic factors of malignancy for indeterminate thyroid nodules. In patients affected by cytological Thyr 3A/3B nodules, NLR, PLR and LMR were retrospectively compared and correlated with definitive pathology malignancy, utilizing student's
MeSH term(s)	Humans ; Thyroid Nodule/diagnosis ; Thyroid Nodule/pathology ; Neutrophils/pathology ; Monocytes/pathology ; Retrospective Studies ; Biomarkers ; Lymphocytes/pathology
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076466
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