LIVIVO - Search results -

Search results

Result 1 - 10 of total 20

Search options

Article ; Online: Antiviral activity of immunosuppressors alone and in combination against human adenovirus and cytomegalovirus.

Carretero-Ledesma, Marta / Aguilar-Guisado, Manuela / Berastegui-Cabrera, Judith / Balsera-Manzanero, María / Pachón, Jerónimo / Cordero, Elisa / Sánchez-Céspedes, Javier

International journal of antimicrobial agents

2024 Volume 63, Issue 5, Page(s) 107116

Abstract: Human adenovirus (HAdV) and cytomegalovirus (HCMV) cause high morbidity and mortality in patients undergoing solid organ transplantation (SOT) and haematopoietic stem cell transplantation (HSCT). Immunosuppressors are used universally to prevent graft-vs- ...

Abstract	Human adenovirus (HAdV) and cytomegalovirus (HCMV) cause high morbidity and mortality in patients undergoing solid organ transplantation (SOT) and haematopoietic stem cell transplantation (HSCT). Immunosuppressors are used universally to prevent graft-vs-host disease in HSCT and graft rejection in SOT. The long-term use of these drugs is associated with a high risk of infection, but there is also evidence of their specific interference with viral infection. This study evaluated the antiviral activity of immunosuppressors commonly used in clinical practice in SOT and HSCT recipients in vitro to determine whether their use could be associated with reduced risk of HAdV and HCMV infection. Cyclophosphamide, tacrolimus, cyclosporine, mycophenolic acid, methotrexate, everolimus and sirolimus presented antiviral activity, with 50% inhibitory concentration (IC
Language	English
Publishing date	2024-02-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107116
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection.

Xu, Jimin / Berastegui-Cabrera, Judith / Chen, Haiying / Pachón, Jerónimo / Zhou, Jia / Sánchez-Céspedes, Javier

Journal of medicinal chemistry

2020 Volume 63, Issue 6, Page(s) 3142–3160

Abstract: The effective treatment of adenovirus (HAdV) infections in immunocompromised patients still poses great challenges. Herein, we reported our continued efforts to optimize a series of salicylamide derivatives as potent inhibitors of HAdV infection. Of ... ...

Abstract	The effective treatment of adenovirus (HAdV) infections in immunocompromised patients still poses great challenges. Herein, we reported our continued efforts to optimize a series of salicylamide derivatives as potent inhibitors of HAdV infection. Of these, nine compounds (
MeSH term(s)	A549 Cells ; Adenoviruses, Human/drug effects ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; Antiviral Agents/toxicity ; DNA/metabolism ; DNA Replication/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Salicylamides/chemical synthesis ; Salicylamides/pharmacology ; Salicylamides/toxicity ; Structure-Activity Relationship ; Virus Internalization/drug effects
Chemical Substances	Antiviral Agents ; Salicylamides ; DNA (9007-49-2)
Language	English
Publishing date	2020-02-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.9b01950
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: In vitro co-infection by cytomegalovirus improves the antiviral activity of ganciclovir against human adenovirus.

Aguilar-Guisado, Manuela / Marrugal-Lorenzo, José Antonio / Berastegui-Cabrera, Judith / Merino, Laura / Pachón, Jerónimo / Sánchez-Céspedes, Javier

International journal of antimicrobial agents

2020 Volume 56, Issue 2, Page(s) 106046

Abstract: Human adenovirus (HAdV) infection has an important clinical impact in the immunosuppressed population and is associated with high morbidity and mortality rates. The lack of a specific, safe and effective antiviral treatment against HAdV makes necessary ... ...

Abstract	Human adenovirus (HAdV) infection has an important clinical impact in the immunosuppressed population and is associated with high morbidity and mortality rates. The lack of a specific, safe and effective antiviral treatment against HAdV makes necessary the search for new therapeutic options. The aim of this study was to evaluate the in vitro activity of ganciclovir (GCV) against HAdV in co-infection by human cytomegalovirus (HCMV) and HAdV in cellular cultures. Quantitative real-time polymerase chain reaction (qPCR) was used to measure HAdV and HCMV DNA replication efficiency in monocultures and in co-infection situations in the presence of both cidofovir (CDV) and GCV. The effects of GCV and CDV were also evaluated in a burst assay (used to measure the production of virus particles) for both viruses, alone and in combination. GCV decreased by 1-log the HAdV DNA replication efficiency in co-infection with HCMV compared with its activity in HAdV monoculture. The burst assay showed that the reductions in virus yield in the presence of GCV were higher for HCMV and co-infection than for HAdV in monoculture (145.2±35.5- vs. 116.4±27.3- vs. 23.0±10.0-fold, respectively, P<0.05). The improved anti-HAdV activity of GCV during co-infection may be because of the more efficient phosphorylation of GCV by the HCMV protein kinase, UL97. Patients treated with GCV as pre-emptive therapy for HCMV infection may be considered as low-risk for developing HAdV infections; however, further evaluations are required to confirm these results.
MeSH term(s)	A549 Cells ; Adenovirus Infections, Human/drug therapy ; Adenovirus Infections, Human/virology ; Adenoviruses, Human/drug effects ; Adenoviruses, Human/genetics ; Antiviral Agents/pharmacology ; Cell Line ; Cidofovir/pharmacology ; Coinfection/drug therapy ; Coinfection/virology ; Cytomegalovirus/drug effects ; Cytomegalovirus/genetics ; DNA, Viral/metabolism ; Ganciclovir/pharmacology ; Humans ; Inhibitory Concentration 50 ; Phosphorylation ; Phosphotransferases (Alcohol Group Acceptor)/chemistry
Chemical Substances	Antiviral Agents ; DNA, Viral ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; ganciclovir kinase (EC 2.7.1.-) ; Cidofovir (JIL713Q00N) ; Ganciclovir (P9G3CKZ4P5)
Language	English
Publishing date	2020-06-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2020.106046
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome.

Xu, Jimin / Berastegui-Cabrera, Judith / Carretero-Ledesma, Marta / Chen, Haiying / Xue, Yu / Wold, Eric A / Pachón, Jerónimo / Zhou, Jia / Sánchez-Céspedes, Javier

International journal of molecular sciences

2021 Volume 22, Issue 4

Abstract: Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array of symptoms from mild respiratory illnesses to disseminated and life-threatening infections in immunocompromised individuals. However, no antiviral drug has been ... ...

Abstract	Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array of symptoms from mild respiratory illnesses to disseminated and life-threatening infections in immunocompromised individuals. However, no antiviral drug has been approved specifically for the treatment of HAdV infections. Herein, we report our continued efforts to optimize salicylamide derivatives and discover compound
MeSH term(s)	A549 Cells ; Adenoviruses, Human/drug effects ; Adenoviruses, Human/physiology ; Antiviral Agents/pharmacology ; Drug Discovery ; Endosomes/drug effects ; Endosomes/virology ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Niclosamide/chemistry ; Niclosamide/pharmacology ; Salicylamides/chemistry ; Salicylamides/pharmacology ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Viral Tropism ; Virus Internalization/drug effects ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; Salicylamides ; Small Molecule Libraries ; Niclosamide (8KK8CQ2K8G)
Language	English
Publishing date	2021-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22041617
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol.

Mazzotta, Sarah / Berastegui-Cabrera, Judith / Vega-Holm, Margarita / García-Lozano, María Del Rosario / Carretero-Ledesma, Marta / Aiello, Francesca / Vega-Pérez, José Manuel / Pachón, Jerónimo / Iglesias-Guerra, Fernando / Sánchez-Céspedes, Javier

Bioorganic chemistry

2021 Volume 114, Page(s) 105095

Abstract: Nowadays there is not an effective drug for the treatment of infections caused by human adenovirus (HAdV) which supposes a clinical challenge, especially for paediatric and immunosuppressed patients. Here, we describe the design, synthesis and biological ...

Abstract	Nowadays there is not an effective drug for the treatment of infections caused by human adenovirus (HAdV) which supposes a clinical challenge, especially for paediatric and immunosuppressed patients. Here, we describe the design, synthesis and biological evaluation as anti-adenovirus agents of a new library (57 compounds) of diester, monoester and triazole derivatives based on 3-amino-1,2-propanediol skeleton. Seven compounds (17, 20, 26, 34, 44, 60 and 66) were selected based on their high anti-HAdV activity at low micromolar concentration (IC
MeSH term(s)	Adenoviridae/drug effects ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cell Line ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Propanolamines/chemical synthesis ; Propanolamines/chemistry ; Propanolamines/pharmacology ; Structure-Activity Relationship
Chemical Substances	Antiviral Agents ; Propanolamines ; 1-aminopropanediol (616-30-8)
Language	English
Publishing date	2021-06-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2021.105095
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4207: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Repositioning salicylanilide anthelmintic drugs to treat adenovirus infections.

Marrugal-Lorenzo, José A / Serna-Gallego, Ana / Berastegui-Cabrera, Judith / Pachón, Jerónimo / Sánchez-Céspedes, Javier

Scientific reports

2019 Volume 9, Issue 1, Page(s) 17

Abstract: The repositioning of drugs already approved by regulatory agencies for other indications is an emerging alternative for the development of new antimicrobial therapies. The repositioning process involves lower risks and costs than the de novo development ... ...

Abstract	The repositioning of drugs already approved by regulatory agencies for other indications is an emerging alternative for the development of new antimicrobial therapies. The repositioning process involves lower risks and costs than the de novo development of novel antimicrobial drugs. Currently, infections by adenovirus show a steady increment with a high clinical impact in immunosuppressed and immunocompetent patients. The lack of a safe and efficacious drug to treat these infections supports the search for new antiviral drugs. Here we evaluated the anti-adenovirus activity of niclosanide, oxyclozanide, and rafoxanide, three salicylanilide anthelmintic drugs. Also, we carried out the cytotoxicity evaluation and partial characterization of the mechanism of action of these drugs. The salicylanilide anthelmintic drugs showed significant anti-adenovirus activity at low micromolar concentrations with little cytotoxicity. Moreover, our mechanistic assays suggest differences in the way the drugs exert anti-adenovirus activity. Niclosamide and rafoxanide target transport of the HAdV particle from the endosome to the nuclear envelope, whilst oxyclozanide specifically targets adenovirus immediately early gene E1A transcription. Data suggests that the studied salicylanilide anthelmintic drugs could be suitable for further clinical evaluation for the development of new antiviral drugs to treat infections by adenovirus in immunosuppressed patients and in immunocompetent individuals with community-acquired pneumonia.
MeSH term(s)	A549 Cells ; Adenoviridae/drug effects ; Adenoviridae Infections/drug therapy ; Antiviral Agents/pharmacology ; Community-Acquired Infections/drug therapy ; Drug Repositioning ; HEK293 Cells ; Humans ; Niclosamide/pharmacology ; Oxyclozanide/pharmacology ; Rafoxanide/pharmacology
Chemical Substances	Antiviral Agents ; Oxyclozanide (1QS9G4876X) ; Rafoxanide (22F4FLA7DH) ; Niclosamide (8KK8CQ2K8G)
Keywords	covid19
Language	English
Publishing date	2019-01-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-37290-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Discovery of Novel Substituted

Xu, Jimin / Berastegui-Cabrera, Judith / Ye, Na / Carretero-Ledesma, Marta / Pachón-Díaz, Jerónimo / Chen, Haiying / Pachón-Ibáñez, Maria Eugenia / Sánchez-Céspedes, Javier / Zhou, Jia

Journal of medicinal chemistry

2020 Volume 63, Issue 21, Page(s) 12830–12852

Abstract: An effective therapy for human adenovirus (HAdV) infections in immunocompromised patients and healthy individuals with community-acquired pneumonia remains an unmet medical need. We herein reported a series of novel ... ...

Abstract	An effective therapy for human adenovirus (HAdV) infections in immunocompromised patients and healthy individuals with community-acquired pneumonia remains an unmet medical need. We herein reported a series of novel substituted
MeSH term(s)	Adenoviruses, Human/drug effects ; Adenoviruses, Human/physiology ; Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Benzamides/chemistry ; Benzamides/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cricetinae ; Drug Evaluation, Preclinical ; Humans ; Lethal Dose 50 ; Structure-Activity Relationship ; Virus Internalization/drug effects ; Virus Replication/drug effects
Chemical Substances	5-chloro-2-hydroxybenzamide ; Antiviral Agents ; Benzamides
Language	English
Publishing date	2020-10-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.0c01226
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: In vitro co-infection by cytomegalovirus improves the antiviral activity of ganciclovir against human adenovirus

Aguilar-Guisado, Manuela / Marrugal-Lorenzo, José Antonio / Berastegui-Cabrera, Judith / Merino, Laura / Pachón, Jerónimo / Sánchez-Céspedes, Javier

International journal of antimicrobial agents. 2020 Aug., v. 56, no. 2

2020

Abstract	Human adenovirus (HAdV) infection has an important clinical impact in the immunosuppressed population and is associated with high morbidity and mortality rates. The lack of a specific, safe and effective antiviral treatment against HAdV makes necessary the search for new therapeutic options. The aim of this study was to evaluate the in vitro activity of ganciclovir (GCV) against HAdV in co-infection by human cytomegalovirus (HCMV) and HAdV in cellular cultures. Quantitative real-time polymerase chain reaction (qPCR) was used to measure HAdV and HCMV DNA replication efficiency in monocultures and in co-infection situations in the presence of both cidofovir (CDV) and GCV. The effects of GCV and CDV were also evaluated in a burst assay (used to measure the production of virus particles) for both viruses, alone and in combination. GCV decreased by 1-log the HAdV DNA replication efficiency in co-infection with HCMV compared with its activity in HAdV monoculture. The burst assay showed that the reductions in virus yield in the presence of GCV were higher for HCMV and co-infection than for HAdV in monoculture (145.2±35.5- vs. 116.4±27.3- vs. 23.0±10.0-fold, respectively, P<0.05). The improved anti-HAdV activity of GCV during co-infection may be because of the more efficient phosphorylation of GCV by the HCMV protein kinase, UL97. Patients treated with GCV as pre-emptive therapy for HCMV infection may be considered as low-risk for developing HAdV infections; however, further evaluations are required to confirm these results.
Keywords	DNA replication ; Human betaherpesvirus 5 ; Mastadenovirus ; anti-infective agents ; antiviral properties ; assays ; mixed infection ; morbidity ; mortality ; patients ; phosphorylation ; population ; protein kinases ; quantitative polymerase chain reaction ; therapeutics ; virion ; viruses
Language	English
Dates of publication	2020-08
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-light
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2020.106046
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Serinol-Based Benzoic Acid Esters as New Scaffolds for the Development of Adenovirus Infection Inhibitors: Design, Synthesis, and

Mazzotta, Sarah / Berastegui-Cabrera, Judith / Carullo, Gabriele / Vega-Holm, Margarita / Carretero-Ledesma, Marta / Mendolia, Lara / Aiello, Francesca / Iglesias-Guerra, Fernando / Pachón, Jerónimo / Vega-Pérez, José Manuel / Sánchez-Céspedes, Javier

ACS infectious diseases

2020 Volume 7, Issue 6, Page(s) 1433–1444

Abstract: Over the years, human adenovirus (HAdV) has progressively been recognized as a significant viral pathogen. Traditionally associated with self-limited respiratory, gastrointestinal, and conjunctival infections, mainly in immunocompromised patients, HAdV ... ...

Abstract	Over the years, human adenovirus (HAdV) has progressively been recognized as a significant viral pathogen. Traditionally associated with self-limited respiratory, gastrointestinal, and conjunctival infections, mainly in immunocompromised patients, HAdV is currently considered to be a pathogen presenting significant morbidity and mortality in both immunosuppressed and otherwise healthy individuals. Currently available therapeutic options are limited because of their lack of effectivity and related side effects. In this context, there is an urgent need to develop effective anti-HAdV drugs with suitable therapeutic indexes. In this work, we identified new serinol-derived benzoic acid esters as novel scaffolds for the inhibition of HAdV infections. A set of 38 compounds were designed and synthesized, and their antiviral activity and cytotoxicity were evaluated. Four compounds (
MeSH term(s)	Adenoviridae Infections/drug therapy ; Benzoic Acid ; Esters ; Humans ; Propanolamines ; Propylene Glycols
Chemical Substances	Esters ; Propanolamines ; Propylene Glycols ; Benzoic Acid (8SKN0B0MIM) ; serinol (IC94L30J8M)
Language	English
Publishing date	2020-10-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2373-8227
ISSN (online)	2373-8227
DOI	10.1021/acsinfecdis.0c00515
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome.

Salto-Alejandre, Sonsoles / Berastegui-Cabrera, Judith / Camacho-Martínez, Pedro / Infante-Domínguez, Carmen / Carretero-Ledesma, Marta / Crespo-Rivas, Juan Carlos / Márquez, Eduardo / Lomas, José Manuel / Bueno, Claudio / Amaya, Rosario / Lepe, José Antonio / Cisneros, José Miguel / Pachón, Jerónimo / Cordero, Elisa / Sánchez-Céspedes, Javier

Scientific reports

2021 Volume 11, Issue 1, Page(s) 12931

Abstract: The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient's hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR ... ...

Abstract	The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient's hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in nasopharyngeal swabs. Quantitative Synthetic SARS-CoV-2 RNA cycle threshold values were used to calculate the viral load in log
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Female ; Follow-Up Studies ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Nasopharynx/virology ; Patient Admission ; Prognosis ; Prospective Studies ; RNA, Viral/genetics ; Real-Time Polymerase Chain Reaction ; Risk Factors ; SARS-CoV-2/genetics ; Severity of Illness Index ; Viral Load/methods
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-92400-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito